{ "vercy": "1.0-draft", "publication": { "status": "research-draft", "adjudicationStatus": "unreviewed", "publishableCanonical": false, "generatedAt": "2026-09-13T05:44:28Z", "providers": [ "Claude" ], "breadth": "written by Claude from model knowledge without web access - no source was read, every claim is a lead to verify", "pass": 2, "wave": 3, "engine": "claude", "enrichment": { "pass": 3, "engine": "claude", "producedAt": "2026-10-06T10:00:00Z", "ingestedAt": "2026-10-06T07:09:42+00:00", "fields": [ "agent_conduct", "ethics", "owners" ] } }, "metaModel": { "id": "THING-Q1981276", "registryId": "vr.tr.neuroendocrine-tumor", "name": "neuroendocrine tumor", "version": "0.2.0-wave.3", "entryKind": "thing", "family": "Thing Registry", "domain": [ "XCT.STA" ], "status": "research-draft" }, "canonicalUrl": "https://ver.cy/models/thing/q1981276/", "model": { "registry_id": "vr.tr.neuroendocrine-tumor", "name": "neuroendocrine tumor", "purpose": "Let an agent explain neuroendocrine tumours and their classification in neutral clinical terms, relay diagnosis, grading and treatment options in general from oncology guidelines, describe functioning tumours and syndromes, and route people with symptoms or diagnoses to specialist centres.", "definition": "A neoplasm arising from neuroendocrine cells, which have features of both nerve and hormone-producing cells, occurring most often in the gastrointestinal tract, pancreas and lungs as gastroenteropancreatic neuroendocrine neoplasms and bronchial tumours, and also in sites such as the aortic body, ranging from well-differentiated, slow-growing tumours, formerly called carcinoids or apudomas, to poorly differentiated carcinomas, and including functioning tumours such as VIPomas, insulinomas and gastrinomas that secrete hormones; neuroendocrine tumours are rare, graded by proliferation and treated by surgery, somatostatin analogues, targeted and radionuclide therapy.", "what_it_is_for": "Not applicable; a disease group.", "affordances": [ "explain classification", "relay diagnosis and treatment in general", "describe functioning tumours", "route to specialists" ], "distinguishing_features": [ "Neuroendocrine cell origin", "Wide spectrum of behaviour", "Hormone secretion in some", "Rare disease" ], "appearance": "Not a visible object; tumours seen on imaging.", "visual_identification": [ "Neoplasm of neuroendocrine cells", "Gastroenteropancreatic neuroendocrine neoplasms, gastrointestinal neuroendocrine tumours, VIPoma, apudoma, aortic body neoplasms", "Adenocarcinomas arise from glandular epithelium; pheochromocytoma and paraganglioma are related but classified separately" ], "physical_properties": [ { "quantity": "incidence", "typical_range": "about 5-7", "unit": "per 100000 per year", "note": "rising with detection" }, { "quantity": "grading", "typical_range": "G1, G2, G3", "unit": "note", "note": "by Ki-67 and mitotic count" }, { "quantity": "key marker", "typical_range": "chromogranin A", "unit": "note", "note": "blood test" } ], "families_and_kinds": [ "gastroenteropancreatic neuroendocrine neoplasms of the gut and pancreas", "lung neuroendocrine tumours including typical and atypical carcinoids", "functioning tumours such as VIPoma, insulinoma, gastrinoma and glucagonoma", "well-differentiated tumours formerly called carcinoids and apudomas", "poorly differentiated neuroendocrine carcinomas", "tumours of paraganglia such as aortic body neoplasms" ], "related_models": [ { "relation": "is a kind of", "target": "endocrine gland cancer", "why": "in registry terms, for malignant forms" }, { "relation": "is a kind of", "target": "rare disease", "why": "in registry terms" }, { "relation": "arises from", "target": "neuroendocrine cell", "why": "in many organs" }, { "relation": "is treated with", "target": "somatostatin analogue", "why": "among other therapies" } ], "identifiers": [ { "scheme": "ICD-11", "value_or_pattern": "2D10-2D12 and site codes", "note": "neuroendocrine neoplasms" }, { "scheme": "MeSH", "value_or_pattern": "D018358", "note": "neuroendocrine tumors" } ], "standards_and_regulation": [ "WHO classification of neuroendocrine neoplasms", "ENETS and NANETS guidelines", "Orphan disease and rare cancer frameworks" ], "failure_modes_and_hazards": [ "Agents giving personal medical advice", "Delayed diagnosis of slow-growing tumours", "Outdated terms such as carcinoid causing confusion" ], "in_scope": [], "out_of_scope": [], "characteristics": [], "agent_conduct": { "may": [ "Explain neuroendocrine tumours, their sites and grading, citing oncology sources.", "Point people to specialist centres and patient organizations." ], "must_not": [ "Diagnose, stage or predict survival for a person.", "Recommend unproven treatments.", "Disclose a person's diagnosis without consent." ], "requires_human": [ "Any advice that affects a person's treatment choices." ] }, "ethics": { "considerations": [ "These tumours are often diagnosed late, and misinformation can delay care.", "Cancer diagnoses are sensitive personal health data." ], "affected_parties": [ "Patients", "Families and carers" ] }, "owners": { "steward": "Nobody owns the disease; each patient's care is with their clinicians.", "master_systems": [ "Cancer registries" ] } }, "sources": [ { "id": "wikidata", "title": "Wikidata item Q1981276: neuroendocrine tumor", "url": "https://www.wikidata.org/wiki/Q1981276", "url_status": "live", "what_it_supports": "identity and sense of the item", "checked_by": "wikidata-api" }, { "id": "wikipedia-en", "title": "Wikipedia: Neuroendocrine tumor", "url": "https://en.wikipedia.org/wiki/Neuroendocrine_tumor", "url_status": "live", "what_it_supports": "general description of the item", "checked_by": "wikidata-api sitelink" } ], "structure": { "bundles": [ { "id": "help", "name": "Help", "description": "Care first.", "rationale": "Safety.", "layers": [ { "id": "symptoms", "name": "Symptoms", "description": "Symptoms.", "findings": [ { "id": "symptoms-finding", "name": "Symptoms", "description": "Symptoms.", "questions": [ { "text": "Why do persistent flushing, diarrhoea, hypoglycaemia or unexplained abdominal symptoms need clinical assessment, in general terms?", "kind": "action" }, { "text": "Is the user describing their own symptoms or diagnosis, which needs a clinician or specialist centre?", "kind": "boundary" } ] } ] }, { "id": "centres", "name": "Centres", "description": "Specialist centres.", "findings": [ { "id": "centres-finding", "name": "Centres", "description": "Centres.", "questions": [ { "text": "Why are neuroendocrine tumours managed in specialist centres, and what patient organisations exist?", "kind": "provenance" }, { "text": "Which entry fits neuroendocrine tumour patient support?", "kind": "action" } ] } ] } ] }, { "id": "understand", "name": "Understand", "description": "The tumours.", "rationale": "Clinical.", "layers": [ { "id": "classification", "name": "Classification", "description": "Classification.", "findings": [ { "id": "classification-finding", "name": "Classification", "description": "Classification.", "questions": [ { "text": "How are neuroendocrine neoplasms classified by site, differentiation and grade under the WHO system?", "kind": "definition" }, { "text": "Is the question about neuroendocrine tumours, adenocarcinoma or paraganglioma?", "kind": "boundary" } ] } ] }, { "id": "functioning", "name": "Functioning", "description": "Functioning tumours.", "findings": [ { "id": "functioning-finding", "name": "Functioning", "description": "Functioning.", "questions": [ { "text": "What are VIPoma, insulinoma, gastrinoma and carcinoid syndrome, in general terms?", "kind": "definition" }, { "text": "Which entry fits the specific tumour?", "kind": "action" } ] } ] } ] }, { "id": "care", "name": "Care", "description": "Diagnosis and treatment.", "rationale": "Clinical.", "layers": [ { "id": "diagnosis", "name": "Diagnosis", "description": "Diagnosis.", "findings": [ { "id": "diagnosis-finding", "name": "Diagnosis", "description": "Diagnosis.", "questions": [ { "text": "How are neuroendocrine tumours diagnosed with markers, imaging including somatostatin receptor scans and biopsy?", "kind": "provenance" }, { "text": "Which references are standard?", "kind": "provenance" } ] } ] }, { "id": "treatment", "name": "Treatment", "description": "Treatment.", "findings": [ { "id": "treatment-finding", "name": "Treatment", "description": "Treatment.", "questions": [ { "text": "What treatments exist, from surgery and somatostatin analogues to targeted drugs and peptide receptor radionuclide therapy, in general terms?", "kind": "provenance" }, { "text": "Which sources are cited?", "kind": "provenance" } ] } ] } ] }, { "id": "context", "name": "Context", "description": "Research and history.", "rationale": "Context.", "layers": [ { "id": "research", "name": "Research", "description": "Research.", "findings": [ { "id": "research-finding", "name": "Research", "description": "Research.", "questions": [ { "text": "What research addresses neuroendocrine tumour biology and new therapies, with findings attributed?", "kind": "provenance" }, { "text": "Which entry fits theranostics?", "kind": "action" } ] } ] }, { "id": "history", "name": "History", "description": "History.", "findings": [ { "id": "history-finding", "name": "History", "description": "History.", "questions": [ { "text": "How did the concepts of carcinoid, APUD cells and apudoma develop?", "kind": "provenance" }, { "text": "Which entry fits the history of oncology?", "kind": "action" } ] } ] } ] } ] }, "openQuestions": [ "Should VIPoma and gastroenteropancreatic neuroendocrine neoplasm be separate primary entries?", "How should oncology guidelines be linked?", "The registry entry has merged aliases naming subtypes and an obsolete term; should they be split off?" ], "statistics": { "bundles": 4, "layers": 8, "findings": 8, "questions": 16 } }