{ "vercy": "1.0-draft", "publication": { "status": "research-draft", "adjudicationStatus": "unreviewed", "publishableCanonical": false, "generatedAt": "2026-09-12T10:04:12Z", "providers": [ "Codex" ], "breadth": "recalled by Codex without web access - no source was read", "missingProviders": [], "pass": 2, "cost": { "grok": { "seconds": 20.7, "error": "Reading additional input from stdin...\nOpenAI Codex v0.153.4\n--------\nworkdir: R:\\02_PROJECTS\\02_Meta_Models_Platforms\\Ver.cy\\current\\thing-registry-backlog\nmodel: gpt-6-astra\nprovider: openai\napproval: never\nsandbox: read-only\nreasoning effort: none\nreasoning summaries: none\nsession id: 01a09511-c210-7e73-b121-88bf786e163e\n--------\nuser\nDescribe what is already known about one registered thing. Answer as JSON only, no prose around it.\n\nThing: GPCR, family 3, metabotropic glutamate receptor\nSense to describe: (none recorded)\nDomain code: PHY.MAT\nAlso known as: (none)\n\n\nContext for this batch o", "usd": 0.0, "recall": true }, "codex": { "seconds": 88.6, "error": "Reading additional input from stdin...\nOpenAI Codex v0.153.4\n--------\nworkdir: R:\\02_PROJECTS\\02_Meta_Models_Platforms\\Ver.cy\\current\\thing-registry-backlog\nmodel: gpt-6-astra\nprovider: openai\napproval: never\nsandbox: read-only\nreasoning effort: none\nreasoning summaries: none\nsession id: 01a09511-c200-7612-afb6-97e9dec3b8a2\n--------\nuser\nYou are drafting a Vercy meta-model for one registered thing. Answer as JSON only, no prose around it.\n\nThing: GPCR, family 3, metabotropic glutamate receptor\nRegistry id: vr.tr.gpcr-family-3-metabotropic-glutamate-receptor\nPlane / domain: PHY / PHY.MAT\nRegist" } }, "enrichment": { "pass": 3, "engine": "claude", "producedAt": "2026-10-06T12:00:00Z", "ingestedAt": "2026-10-06T08:41:26+00:00", "fields": [ "agent_conduct", "ethics", "failure_modes_and_hazards", "owners", "standards_and_regulation" ] }, "gate": { "passed": true, "version": "1.0", "at": "2026-10-07T10:10:28+00:00", "evidence": [ "completeness 1.00", "sense: Wikidata description", "2 live sources", "review by codex: pass" ] } }, "metaModel": { "id": "THING-Q2033959", "registryId": "vr.tr.gpcr-family-3-metabotropic-glutamate-receptor", "name": "GPCR, family 3, metabotropic glutamate receptor", "version": "0.1.0-research.1", "entryKind": "thing", "family": "Thing Registry", "domain": [ "PHY.MAT" ], "status": "research-draft" }, "canonicalUrl": "https://ver.cy/models/thing/q2033959/", "model": { "registry_id": "vr.tr.gpcr-family-3-metabotropic-glutamate-receptor", "name": "GPCR, family 3, metabotropic glutamate receptor", "purpose": "Enable an agent to recognize metabotropic glutamate receptor family members, assess their molecular and functional state, and choose interpretable characterization or modulation actions.", "definition": "Metabotropic glutamate receptors are a family of class C (family 3) G protein-coupled membrane receptors that detect extracellular glutamate and regulate intracellular signalling and neuronal excitability rather than directly forming an ion channel.", "scope_statement": "This draft models the protein-family concept registered as vr.tr.gpcr-family-3-metabotropic-glutamate-receptor in PHY / PHY.MAT, including member identification, receptor architecture, signaling, localization and experimental interpretation; its exact registry-to-family accession mapping remains unresolved.", "in_scope": [ "Protein-family membership, species, receptor subtype and isoform identity", "Glutamate-recognition domains, membrane topology and receptor assembly", "Ligand occupancy, receptor conformation and functional competence", "G-protein coupling and measured downstream responses", "Cellular localization, trafficking and receptor-specific experimental evidence" ], "out_of_scope": [ "Glutamate synthesis, metabolism and bulk chemical specifications", "Ionotropic glutamate receptor channels", "Other class C GPCR families except as identification controls", "GRM gene regulation and inheritance beyond links needed to identify receptor products", "Whole neural circuits, diseases and therapeutic efficacy", "Commercial reagent formulation, manufacturing and chemical hazard classification" ], "distinguishing_features": [ "Require evidence identifying the metabotropic glutamate receptor branch; a generic class C GPCR annotation alone is insufficient.", "Separate the label 'family 3' from the individual subtype mGlu3 and from pharmacological group III.", "Distinguish metabotropic signaling from an intrinsic glutamate-gated ion-channel mechanism using receptor annotation and functional evidence.", "Use sequence-supported extracellular ligand-recognition and seven-transmembrane architecture as a combined identification test, while flagging fragments and engineered constructs.", "Assign mammalian subtypes to group I, II or III only after establishing member identity; the conventional grouping is documented in the [NC-IUPHAR receptor guide](https://pmc.ncbi.nlm.nih.gov/articles/PMC2884589/)." ], "characteristics": [ { "name": "Member identity", "kind": "relation", "unit_or_values": "Protein accession and version, organism, gene identifier, subtype, isoform", "why_it_matters": "Prevents evidence from different species or receptor products being merged." }, { "name": "Family assignment confidence", "kind": "category", "unit_or_values": "Curated membership; sequence-supported prediction; ambiguous; contradicted", "why_it_matters": "Separates recognized family members from candidates needing validation." }, { "name": "Pharmacological group", "kind": "category", "unit_or_values": "I; II; III; unresolved; assignment not applicable", "why_it_matters": "Organizes subtype comparisons without confusing group III with GPCR family 3." }, { "name": "Construct completeness", "kind": "state", "unit_or_values": "Full-length native sequence; splice variant; fragment; tagged; mutated; chimeric", "why_it_matters": "Engineered or incomplete receptors may not preserve native pharmacology or coupling." }, { "name": "Domain boundaries and topology", "kind": "relation", "unit_or_values": "Residue intervals for extracellular domains, transmembrane helices and intracellular regions", "why_it_matters": "Locates changes that may affect recognition, membrane insertion or signal transmission." }, { "name": "Assembly composition", "kind": "relation", "unit_or_values": "Identified protomers, stoichiometry, homomeric or heteromeric assignment, evidence method", "why_it_matters": "Links measured behavior to the receptor assembly actually examined." }, { "name": "Ligand affinity", "kind": "measurement", "unit_or_values": "Kd or Ki in mol/L, with ligand, binding model and assay conditions", "why_it_matters": "Quantifies binding without treating response potency as affinity." }, { "name": "Functional potency and efficacy", "kind": "measurement", "unit_or_values": "EC50 or IC50 in mol/L; maximum response in assay units or relative to a named reference", "why_it_matters": "Supports comparisons only when endpoint, expression and experimental context are compatible." }, { "name": "Observed signaling partner", "kind": "relation", "unit_or_values": "G-protein family or subunit, downstream effector, assay system and evidence", "why_it_matters": "Prevents expected group-level coupling from substituting for measurements." }, { "name": "Surface availability", "kind": "measurement", "unit_or_values": "Surface fraction, receptors per cell or calibrated surface-label signal", "why_it_matters": "Distinguishes defective signaling from insufficient receptor delivery to the membrane." }, { "name": "Functional state", "kind": "state", "unit_or_values": "Basal; ligand-bound; signaling-active; desensitized; internalized; unresolved", "why_it_matters": "Makes state assignments conditional on the observations that support them." } ], "affordances": [ "Classify a candidate protein against the family while preserving uncertain subtype assignments.", "Map variants and construct edits to receptor domains and prioritize functional checks.", "Choose binding and signaling measurements suited to the identified receptor and experimental system.", "Compare orthosteric and allosteric perturbations using explicit ligand, endpoint and concentration context.", "Diagnose whether an absent response reflects receptor identity, surface availability, coupling or assay limitations.", "Attach subtype-specific findings to this family model without creating duplicate registry concepts." ], "agent_conduct": { "may": [ "Explain the structure, signalling and roles of metabotropic glutamate receptors from scientific sources.", "Summarise research and clinical trials involving these receptors with citations." ], "must_not": [ "Recommend unapproved compounds acting on these receptors for personal use.", "Present early research results as proven treatments.", "Interpret a person's genetic test result on a receptor gene as a diagnosis.", "Assist in making or using substances that act on these receptors to harm people." ], "requires_human": [ "Using receptor research for decisions about a patient's treatment." ] }, "ethics": { "considerations": [ "Hope for new treatments for brain disorders can be exploited by unproven claims.", "Research involving animals and patients must weigh welfare and consent." ], "affected_parties": [ "Patients with neurological or psychiatric conditions", "Research participants", "Laboratory animals" ] }, "owners": { "steward": "Nobody owns the receptors; researchers answer for their data and drug developers for their products.", "master_systems": [ "Protein and gene databases" ] }, "failure_modes_and_hazards": [ "Drugs acting on these receptors have failed in trials after promising early results.", "Altered receptor function is linked to several neurological disorders." ], "standards_and_regulation": [ "IUPHAR/BPS receptor nomenclature, International Union of Basic and Clinical Pharmacology." ], "what_it_is_for": [ "Metabotropic glutamate receptors occur in cell membranes and are studied especially for their roles in nervous system signalling.", "They are encountered in molecular neuroscience and pharmacological research investigating how glutamate changes cellular signalling and neuronal activity." ], "visual_identification": [ "Molecular structure representations typically show a large extracellular ligand-binding domain connected to a seven-transmembrane domain.", "Structures commonly show paired receptor subunits, a feature shared with other class C G protein-coupled receptors.", "These receptors lack the ion-conducting pore arrangement of ionotropic glutamate receptors, but family identification still requires molecular evidence." ] }, "sources": [ { "id": "wikidata", "title": "Wikidata item Q2033959: GPCR, family 3, metabotropic glutamate receptor", "url": "https://www.wikidata.org/wiki/Q2033959", "url_status": "live", "what_it_supports": "identity and sense of the item", "checked_by": "wikidata-api" }, { "id": "wikipedia-en", "title": "Wikipedia: Metabotropic glutamate receptor", "url": "https://en.wikipedia.org/wiki/Metabotropic_glutamate_receptor", "url_status": "live", "what_it_supports": "general description of the item", "checked_by": "wikidata-api sitelink" } ], "structure": { "bundles": [ { "id": "family-and-member-identity", "name": "Family and member identity", "description": "Resolve what the registry label denotes and which receptor products belong to it.", "rationale": "The label can be confused with a single subtype or pharmacological group, causing systematic misclassification.", "layers": [ { "id": "registry-boundary", "name": "Registry boundary", "description": "Establish the family-level referent and its relationship to neighboring receptor concepts.", "findings": [ { "id": "family-label-resolution", "name": "Family label resolution", "description": "Treat the supplied name as a family-level working interpretation until its originating accession is verified.", "questions": [ { "text": "Which originating database accession and definition generated this exact registry label?", "kind": "provenance", "id": "family-label-resolution-q01" }, { "text": "Does the accession represent a whole protein family, a domain signature or a narrower subfamily?", "kind": "boundary", "id": "family-label-resolution-q02" }, { "text": "Does an existing Vercy world model already own this receptor-family concept?", "kind": "boundary", "id": "family-label-resolution-q03" } ] } ] }, { "id": "member-resolution", "name": "Member resolution", "description": "Identify the biological sequence underlying each receptor observation.", "findings": [ { "id": "subtype-species-and-isoform", "name": "Subtype, species and isoform", "description": "Keep species, sequence version, subtype and splice form attached to every member-specific assertion.", "questions": [ { "text": "Which protein accession, organism and isoform identify the receptor studied?", "kind": "definition", "id": "subtype-species-and-isoform-q01" }, { "text": "What curated annotation or sequence evidence supports its subtype and family membership?", "kind": "provenance", "id": "subtype-species-and-isoform-q02" }, { "text": "Is its group assignment established for this lineage or extrapolated from mammalian nomenclature?", "kind": "boundary", "id": "subtype-species-and-isoform-q03" } ] } ] } ] }, { "id": "receptor-architecture-and-assembly", "name": "Receptor architecture and assembly", "description": "Represent the physical receptor that connects extracellular recognition to membrane signaling.", "rationale": "Domain integrity and assembly composition determine whether a preparation can support the function being attributed to it.", "layers": [ { "id": "domain-integrity", "name": "Domain integrity", "description": "Resolve ligand-recognition, connecting and membrane-spanning regions in the actual sequence.", "findings": [ { "id": "recognition-to-membrane-continuity", "name": "Recognition-to-membrane continuity", "description": "Record evidence for the extracellular Venus flytrap region, cysteine-rich connecting region and seven-transmembrane region, including missing or modified segments.", "questions": [ { "text": "Which residue intervals support each expected domain and membrane helix?", "kind": "measurement", "id": "recognition-to-membrane-continuity-q01" }, { "text": "Which truncations, substitutions or tags could interrupt ligand recognition or conformational transmission?", "kind": "boundary", "id": "recognition-to-membrane-continuity-q02" } ] } ] }, { "id": "protomer-assembly", "name": "Protomer assembly", "description": "Identify the interacting receptor units represented by an experiment or structure.", "findings": [ { "id": "assembly-evidence", "name": "Assembly evidence", "description": "Require evidence for protomer composition and distinguish physical association from a functionally demonstrated receptor assembly.", "questions": [ { "text": "Which receptor protomers and stoichiometry are supported by the preparation?", "kind": "definition", "id": "assembly-evidence-q01" }, { "text": "Does the evidence demonstrate proximity, stable association or functional cooperation?", "kind": "measurement", "id": "assembly-evidence-q02" }, { "text": "Could overexpression, purification or stabilizing mutations have altered the observed assembly?", "kind": "boundary", "id": "assembly-evidence-q03" } ] } ] } ] }, { "id": "ligand-recognition-and-modulation", "name": "Ligand recognition and modulation", "description": "Separate ligand binding from the changes in receptor activity that binding produces.", "rationale": "Glutamate-site occupancy, allosteric modulation and downstream potency require different evidence and cannot share one undifferentiated activity value.", "layers": [ { "id": "orthosteric-recognition", "name": "Orthosteric recognition", "description": "Describe recognition and competition at the endogenous ligand site.", "findings": [ { "id": "binding-and-activation-separation", "name": "Binding and activation separation", "description": "Maintain independent records of ligand affinity, occupancy and functional response.", "questions": [ { "text": "What evidence places the ligand at the glutamate-recognition site?", "kind": "provenance", "id": "binding-and-activation-separation-q01" }, { "text": "Were affinity and response potency measured separately, and under which conditions?", "kind": "measurement", "id": "binding-and-activation-separation-q02" }, { "text": "What reference agonist and baseline define the ligand's efficacy?", "kind": "measurement", "id": "binding-and-activation-separation-q03" } ] } ] }, { "id": "allosteric-effects", "name": "Allosteric effects", "description": "Describe modulation outside the orthosteric site without assuming identical behavior across subtypes.", "findings": [ { "id": "context-dependent-modulation", "name": "Context-dependent modulation", "description": "Record positive, negative or neutral modulation and any intrinsic agonist activity as experimentally separate properties.", "questions": [ { "text": "Does the compound change agonist potency, maximum response, basal signaling or more than one of these?", "kind": "measurement", "id": "context-dependent-modulation-q01" }, { "text": "Which agonist, receptor subtype and concentration range were used to establish the effect?", "kind": "provenance", "id": "context-dependent-modulation-q02" }, { "text": "Which additional subtype controls are needed before using the compound as a selective probe?", "kind": "action", "id": "context-dependent-modulation-q03" } ] } ] } ] }, { "id": "coupling-and-functional-state", "name": "Coupling and functional state", "description": "Connect receptor activation to measured intracellular signaling and its time dependence.", "rationale": "A receptor's expected coupling does not by itself establish the pathway responsible for a particular assay response.", "layers": [ { "id": "signal-transduction", "name": "Signal transduction", "description": "Track receptor-to-G-protein and G-protein-to-effector relationships.", "findings": [ { "id": "coupling-evidence", "name": "Coupling evidence", "description": "Use group classification to guide experiments while retaining direct coupling and downstream readouts as distinct evidence.", "questions": [ { "text": "Which G-protein partner was directly measured, and which was inferred from calcium, inositol phosphate or cyclic AMP responses?", "kind": "measurement", "id": "coupling-evidence-q01" }, { "text": "Were native coupling partners or engineered promiscuous G proteins used?", "kind": "provenance", "id": "coupling-evidence-q02" }, { "text": "Which perturbation would establish that the response depends on this receptor and the proposed pathway?", "kind": "action", "id": "coupling-evidence-q03" } ] } ] }, { "id": "activation-dynamics", "name": "Activation dynamics", "description": "Distinguish occupancy, conformation and signaling over time.", "findings": [ { "id": "state-assignment", "name": "State assignment", "description": "State labels must identify their evidence modality; a structural example is the antagonist-bound inactive mGlu2 preparation described by [PDBe entry 7mtq](https://www.ebi.ac.uk/pdbe/entry/pdb/7mtq).", "questions": [ { "text": "Is the assigned state supported by structure, conformational sensing, G-protein engagement or downstream activity?", "kind": "provenance", "id": "state-assignment-q01" }, { "text": "How do response onset, decay and recovery depend on exposure and washout time?", "kind": "measurement", "id": "state-assignment-q02" }, { "text": "What evidence distinguishes desensitization from ligand loss, receptor internalization or assay exhaustion?", "kind": "boundary", "id": "state-assignment-q03" } ] } ] } ] }, { "id": "cellular-context-and-assay-interpretation", "name": "Cellular context and assay interpretation", "description": "Place receptor behavior in the membrane, cell type and experimental preparation where it was observed.", "rationale": "Localization and experimental context can change the interpretation of an apparently identical receptor response.", "layers": [ { "id": "localization-and-trafficking", "name": "Localization and trafficking", "description": "Separate receptor production from delivery, retention and removal at the relevant membrane.", "findings": [ { "id": "available-receptor-pool", "name": "Available receptor pool", "description": "Record total abundance, surface availability and supported subcellular location separately.", "questions": [ { "text": "Which cell type and membrane compartment contain the receptor, and how was localization established?", "kind": "provenance", "id": "available-receptor-pool-q01" }, { "text": "What fraction of receptor is surface-accessible before and after stimulation?", "kind": "measurement", "id": "available-receptor-pool-q02" }, { "text": "Does reduced signaling persist after accounting for receptor abundance and trafficking?", "kind": "boundary", "id": "available-receptor-pool-q03" } ] } ] }, { "id": "experimental-transferability", "name": "Experimental transferability", "description": "Determine which conclusions survive changes in construct, host system and readout.", "findings": [ { "id": "receptor-specific-validation", "name": "Receptor-specific validation", "description": "Keep evidence from purified receptors, heterologous cells and native tissue distinguishable, with controls for endogenous glutamate-responsive targets.", "questions": [ { "text": "Which host cells, construct modifications, buffer conditions and readout define this result?", "kind": "provenance", "id": "receptor-specific-validation-q01" }, { "text": "Which controls exclude endogenous receptors, off-target ligand effects and expression artifacts?", "kind": "boundary", "id": "receptor-specific-validation-q02" }, { "text": "What orthogonal experiment is needed before transferring the conclusion to a native receptor context?", "kind": "action", "id": "receptor-specific-validation-q03" } ] } ] } ] }, { "id": "evidence-and-external-alignment", "name": "Evidence and external alignment", "description": "What the world already says about this thing, gathered so the model can be checked against it.", "rationale": "A model that cannot be lined up against existing standards, identifiers and practice cannot be adopted by anyone who already uses them.", "layers": [ { "id": "reported-evidence", "name": "Reported evidence", "description": "Findings from the breadth pass, kept separate from the structural claims.", "findings": [ { "id": "evidence-confidence-notes", "name": "Check these first", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "The registry label may denote a protein-family database entry; its original identifier should be checked before fixing its taxonomic scope.", "The eight-subtype classification given here is the conventional mammalian classification.", "This is a receptor family, not a single bulk chemical substance: molecular mass, ligand potency and other numerical properties require a specified subtype, organism, isoform and experimental context." ], "questions": [ { "id": "evidence-confidence-notes-q01", "text": "Which of these check these first hold for the sense of GPCR, family 3, metabotropic glutamate receptor this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-kinds", "name": "Kinds and varieties", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "Group I: mGlu1 and mGlu5", "Group II: mGlu2 and mGlu3", "Group III: mGlu4, mGlu6, mGlu7 and mGlu8" ], "questions": [ { "id": "evidence-kinds-q01", "text": "Which of these kinds and varieties hold for the sense of GPCR, family 3, metabotropic glutamate receptor this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-identifiers", "name": "Identifiers and schemes", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ { "scheme": "IUPHAR receptor nomenclature", "value_or_pattern": "mGlu1-mGlu8", "note": "Names the eight mammalian receptor subtypes; mGluR1-mGluR8 is also widely used." }, { "scheme": "HGNC gene symbols", "value_or_pattern": "GRM1-GRM8", "note": "Approved symbols for the human genes encoding these receptor subtypes, not identifiers for individual protein isoforms." } ], "questions": [ { "id": "evidence-identifiers-q01", "text": "Which of these identifiers and schemes hold for the sense of GPCR, family 3, metabotropic glutamate receptor this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-real-world-use", "name": "Real-world use", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "Targets in research on synaptic transmission, plasticity and neuronal excitability.", "Targets for experimental agonists, antagonists and allosteric modulators in drug discovery.", "Receptor assays used to characterize ligand potency, efficacy and subtype selectivity." ], "questions": [ { "id": "evidence-real-world-use-q01", "text": "Which of these real-world use hold for the sense of GPCR, family 3, metabotropic glutamate receptor this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-failure-modes-and-hazards", "name": "Failure modes and hazards", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "Pathogenic variants in individual receptor genes can disrupt neurological or sensory function; GRM6 dysfunction can cause congenital stationary night blindness.", "Limited ligand selectivity can make effects mediated by several receptor subtypes appear attributable to only one.", "Measured signalling responses depend on receptor expression, coupling partners and assay conditions, complicating comparisons between experimental systems." ], "questions": [ { "id": "evidence-failure-modes-and-hazards-q01", "text": "Which of these failure modes and hazards hold for the sense of GPCR, family 3, metabotropic glutamate receptor this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-neighbours", "name": "Neighbouring kinds and how to tell them apart", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ { "name": "Class C G protein-coupled receptors", "difference": "The broader family also includes receptors such as GABA-B and calcium-sensing receptors; metabotropic glutamate receptors are its glutamate-responsive branch." }, { "name": "Ionotropic glutamate receptors", "difference": "AMPA, NMDA and kainate receptors are ligand-gated ion channels, whereas metabotropic glutamate receptors signal through G proteins." }, { "name": "Glutamate", "difference": "Glutamate is the small-molecule ligand; the receptor is a membrane protein that recognizes it." }, { "name": "Metabotropic glutamate receptor 3", "difference": "mGlu3 is one subtype encoded by GRM3; 'family 3' denotes the broader GPCR class and does not mean subtype 3." } ], "questions": [ { "id": "evidence-neighbours-q01", "text": "Which of these neighbouring kinds and how to tell them apart hold for the sense of GPCR, family 3, metabotropic glutamate receptor this model covers, and on what evidence?", "kind": "provenance" } ] } ] } ] } ] }, "openQuestions": [ "Which authoritative accession corresponds to the exact registry label, and does it identify a family or a sequence signature?", "Does the existing Vercy catalogue already cover this concept under a synonym requiring linkage instead of a separate publication?", "What taxonomic range does the originating family entry cover, and how should members outside mammalian mGlu1-mGlu8 nomenclature be represented?", "Which proposed heteromeric assemblies have sufficient native-context evidence to support family-level modeling?", "Which architecture, coupling and trafficking assertions are conserved across verified members, and which require subtype-, isoform- or assay-specific qualification?" ], "statistics": { "bundles": 6, "layers": 11, "findings": 16, "questions": 35 } }