{ "vercy": "1.0-draft", "publication": { "status": "research-draft", "adjudicationStatus": "unreviewed", "publishableCanonical": false, "generatedAt": "2026-09-12T09:40:00Z", "providers": [ "Codex" ], "breadth": "recalled by Codex without web access - no source was read", "missingProviders": [], "pass": 2, "cost": { "grok": { "seconds": 18.1, "error": "Reading additional input from stdin...\nOpenAI Codex v0.153.4\n--------\nworkdir: R:\\02_PROJECTS\\02_Meta_Models_Platforms\\Ver.cy\\current\\thing-registry-backlog\nmodel: gpt-6-astra\nprovider: openai\napproval: never\nsandbox: read-only\nreasoning effort: none\nreasoning summaries: none\nsession id: 01a094fb-b8d2-7420-bb31-93507c74bc47\n--------\nuser\nDescribe what is already known about one registered thing. Answer as JSON only, no prose around it.\n\nThing: fenbufen\nSense to describe: (none recorded)\nDomain code: PHY.MAT\nAlso known as: (none)\n\n\nContext for this batch of 1001 things:\n# Batch 043: 1001 regist", "usd": 0.0, "recall": true }, "codex": { "seconds": 81.5, "error": "Reading additional input from stdin...\nOpenAI Codex v0.153.4\n--------\nworkdir: R:\\02_PROJECTS\\02_Meta_Models_Platforms\\Ver.cy\\current\\thing-registry-backlog\nmodel: gpt-6-astra\nprovider: openai\napproval: never\nsandbox: read-only\nreasoning effort: none\nreasoning summaries: none\nsession id: 01a094fb-b8c4-78c1-8357-9af0d5f74e9e\n--------\nuser\nYou are drafting a Vercy meta-model for one registered thing. Answer as JSON only, no prose around it.\n\nThing: fenbufen\nRegistry id: vr.tr.fenbufen\nPlane / domain: PHY / PHY.MAT\nRegistry definition: (none recorded)\nNames folded into this entry: (none)\n\n\nContex" } }, "enrichment": { "pass": 3, "engine": "claude", "producedAt": "2026-10-06T12:00:00Z", "ingestedAt": "2026-10-06T08:54:23+00:00", "fields": [ "agent_conduct", "ethics", "failure_modes_and_hazards", "owners", "visual_identification" ] }, "gate": { "passed": true, "version": "1.0", "at": "2026-10-07T10:10:28+00:00", "evidence": [ "completeness 1.00", "sense: Wikidata description", "2 live sources", "review by codex: pass" ] } }, "metaModel": { "id": "THING-Q2304195", "registryId": "vr.tr.fenbufen", "name": "fenbufen", "version": "0.1.0-research.1", "entryKind": "thing", "family": "Thing Registry", "domain": [ "PHY.MAT" ], "status": "research-draft" }, "canonicalUrl": "https://ver.cy/models/thing/q2304195/", "model": { "registry_id": "vr.tr.fenbufen", "name": "fenbufen", "purpose": "Enable an AI agent to recognise fenbufen, assess the identity and condition of a sample, and determine which handling or use decisions its evidence supports.", "definition": "Fenbufen is a small-molecule nonsteroidal anti-inflammatory drug of the arylbutanoic acid class that acts as a prodrug, with activity mediated substantially by its metabolite felbinac.", "scope_statement": "This model owns vr.tr.fenbufen in PHY / PHY.MAT: the chemical substance and evidence about its material forms, quality, behaviour, hazards and permitted uses, with links to products and biological transformations.", "in_scope": [ "Molecular identity, identifiers and boundaries between fenbufen and related substances", "Sample composition, purity, grade and analytical identity evidence", "Physical form and condition-dependent chemical properties", "Stability, storage and degradation evidence", "Substance-level biological activity, hazards and jurisdiction-specific regulatory identity" ], "out_of_scope": [ "Finished tablets, capsules, brands, excipients and product release specifications", "Patient diagnosis, prescribing, dosing and treatment selection", "Manufacturing routes, production equipment and process operation", "Independent models of metabolites, salts and isotopically labelled analogues", "Clinical trials, healthcare organisations and distribution businesses" ], "distinguishing_features": [ "Match the molecular connectivity of 4-oxo-4-(4-phenylphenyl)butanoic acid, including its biphenyl group and keto-acid side chain; a similar drug name is insufficient. [PubChem: Fenbufen](https://pubchem.ncbi.nlm.nih.gov/compound/Fenbufen)", "Reconcile CAS 36330-85-5 and PubChem CID 3335 with the structure rather than accepting either identifier alone. [PubChem: Fenbufen](https://pubchem.ncbi.nlm.nih.gov/compound/Fenbufen)", "Check the formula C16H14O3 and molecular weight 254.28 g/mol as supporting evidence, while requiring connectivity evidence to exclude isomers. [PubChem: Fenbufen](https://pubchem.ncbi.nlm.nih.gov/compound/Fenbufen)", "Determine whether the record describes the parent substance, a salt, a labelled analytical standard, a transformation product or a formulation containing fenbufen before treating records as equivalent." ], "characteristics": [ { "name": "Molecular identity", "kind": "category", "unit_or_values": "Validated structure, formula, stereochemical and isotopic specification, and reconciled identifiers", "why_it_matters": "Prevents related compounds and differently specified materials from being merged into the fenbufen record." }, { "name": "Material form", "kind": "state", "unit_or_values": "Free acid or related form; solid or solution; characterised crystal form; temperature, pressure and solvent", "why_it_matters": "Defines which property measurements apply to the sample." }, { "name": "Fenbufen assay", "kind": "measurement", "unit_or_values": "% mass fraction or mg/g, with method, uncertainty and as-is or dry basis", "why_it_matters": "Measures actual content without equating chromatographic area percentage with mass purity." }, { "name": "Impurity profile", "kind": "measurement", "unit_or_values": "Individual and total impurities in % or mg/kg; identification status and quantitation limits", "why_it_matters": "Supports grade assessment and distinguishes fenbufen content from related substances or degradation products." }, { "name": "Thermal behaviour", "kind": "measurement", "unit_or_values": "Melting range and decomposition onset in °C; method, pressure and sample form", "why_it_matters": "Helps assess identity and processing limits without assuming heating produces clean boiling." }, { "name": "Solubility and ionisation", "kind": "measurement", "unit_or_values": "Solubility in mg/mL or mol/L; pKa; solvent, pH, temperature and method", "why_it_matters": "Supports solution preparation and interpretation of behaviour associated with the carboxylic acid group." }, { "name": "Storage qualification", "kind": "state", "unit_or_values": "Within supported conditions, excursion under review, retest required, failed or unknown", "why_it_matters": "Connects storage history and stability evidence to whether the material remains usable." }, { "name": "Biological transformation and activity", "kind": "relation", "unit_or_values": "Parent-to-product or substance-to-target relation, with species, biological system and evidence", "why_it_matters": "Prevents activity measured after metabolism from being automatically attributed to unchanged fenbufen." }, { "name": "Hazard and regulatory applicability", "kind": "category", "unit_or_values": "Classification or authorisation, authority, jurisdiction, material scope, effective date and source", "why_it_matters": "Separates chemical handling obligations from permissions applying to medicinal products." } ], "affordances": [ "Reconcile a supplier or laboratory record with the registered fenbufen identity.", "Assess whether a particular lot meets a stated analytical or material-use requirement.", "Select evidence-supported dissolution, storage and handling conditions.", "Flag identity conflicts, unexplained impurities and storage excursions for investigation.", "Trace activity claims to the tested substance and biological system.", "Check whether documented restrictions apply to the intended material use and jurisdiction." ], "agent_conduct": { "may": [ "Explain fenbufen as an NSAID prodrug and its regulatory history, from official sources.", "Report warnings and side effects from official labelling where it is still authorized." ], "must_not": [ "Recommend, dose or adjust fenbufen for a specific person.", "Advise combining NSAIDs or taking them against a clinician's advice.", "Advise obtaining it where it has been withdrawn or without a prescription where one is required.", "Present it as free of serious side effects." ], "requires_human": [ "Starting or changing anti-inflammatory treatment for a patient." ] }, "ethics": { "considerations": [ "NSAIDs can cause serious stomach bleeding and kidney harm, especially in older people.", "Withdrawn medicines sold online put buyers at risk." ], "affected_parties": [ "Patients with pain or inflammation", "Older people", "Prescribers and pharmacists" ] }, "owners": { "steward": "The prescriber and the pharmacist for each patient; medicines regulators authorize products.", "master_systems": [ "National medicines registers" ] }, "visual_identification": [ "Identified by product label, active ingredient name and pack details rather than by appearance alone." ], "failure_modes_and_hazards": [ "Gastrointestinal bleeding.", "Skin reactions.", "Kidney harm." ], "what_it_is_for": [ "Fenbufen is encountered in pharmaceutical and pharmacological contexts as a nonsteroidal anti-inflammatory compound associated with treatment of pain and inflammation.", "Research involving fenbufen includes its conversion to active metabolites and the relationship between metabolism and drug effects.", "Material samples may be used in analytical testing, reference comparisons and pharmaceutical quality assessment." ], "standards_and_regulation": [ "The Anatomical Therapeutic Chemical classification maintained by the WHO Collaborating Centre for Drug Statistics Methodology assigns fenbufen code M01AE05 within propionic acid derivatives." ] }, "sources": [ { "id": "wikidata", "title": "Wikidata item Q2304195: fenbufen", "url": "https://www.wikidata.org/wiki/Q2304195", "url_status": "live", "what_it_supports": "identity and sense of the item", "checked_by": "wikidata-api" }, { "id": "wikipedia-en", "title": "Wikipedia: Fenbufen", "url": "https://en.wikipedia.org/wiki/Fenbufen", "url_status": "live", "what_it_supports": "general description of the item", "checked_by": "wikidata-api sitelink" } ], "structure": { "bundles": [ { "id": "fenbufen-identity", "name": "Fenbufen identity", "description": "Establish the chemical identity represented by the registry entry and the limits of equivalent naming.", "rationale": "A drug name, supplier label or identifier can refer to records with different material scopes.", "layers": [ { "id": "structure-and-identifiers", "name": "Structure and identifiers", "description": "Resolve names and identifiers against a chemically explicit reference.", "findings": [ { "id": "identity-concordance", "name": "Identity concordance", "description": "Record whether structural and identifier evidence consistently identifies fenbufen.", "questions": [ { "text": "What verified structure defines fenbufen, including the positions of the biphenyl attachment, ketone and carboxylic acid?", "kind": "definition", "id": "identity-concordance-q01" }, { "text": "Which authoritative records reconcile the CAS, PubChem, EC and other identifiers, and where do they disagree?", "kind": "provenance", "id": "identity-concordance-q02" } ] } ] }, { "id": "related-material-boundaries", "name": "Related material boundaries", "description": "Separate the parent chemical identity from related substances and containing products.", "findings": [ { "id": "parent-and-related-records", "name": "Parent and related records", "description": "Require an explicit relationship before transferring evidence from a related material.", "questions": [ { "text": "Does this record describe fenbufen itself, a salt, an isotopically labelled analogue, a transformation product or a formulation?", "kind": "boundary", "id": "parent-and-related-records-q01" }, { "text": "Which related records should be linked, and which evidence applies only to their specific material form?", "kind": "boundary", "id": "parent-and-related-records-q02" } ] } ] } ] }, { "id": "fenbufen-lot-quality", "name": "Fenbufen lot quality", "description": "Connect sample identity, assay and impurities to a documented intended use.", "rationale": "A fenbufen label does not establish purity, analytical suitability or pharmaceutical suitability.", "layers": [ { "id": "analytical-confirmation", "name": "Analytical confirmation", "description": "Evaluate whether measurements establish fenbufen identity and content.", "findings": [ { "id": "identity-and-assay-evidence", "name": "Identity and assay evidence", "description": "Keep identity confirmation distinct from quantitative content measurement.", "questions": [ { "text": "Which spectral or chromatographic observations confirm fenbufen against a qualified reference?", "kind": "measurement", "id": "identity-and-assay-evidence-q01" }, { "text": "What assay measures fenbufen content, and how are water, residual solvents and response factors accounted for?", "kind": "measurement", "id": "identity-and-assay-evidence-q02" } ] } ] }, { "id": "impurities-and-grade", "name": "Impurities and grade", "description": "Assess related substances and the evidence behind the assigned grade.", "findings": [ { "id": "use-specific-quality", "name": "Use-specific quality", "description": "Tie acceptance decisions to identified impurities and an applicable specification.", "questions": [ { "text": "Which fenbufen-related impurities are identified, which remain unknown, and what are their measured amounts?", "kind": "measurement", "id": "use-specific-quality-q01" }, { "text": "Which specification and lot-specific evidence justify accepting this material for the proposed use?", "kind": "action", "id": "use-specific-quality-q02" } ] } ] } ] }, { "id": "fenbufen-physical-behaviour", "name": "Fenbufen physical behaviour", "description": "Describe the conditions under which physical and solution properties are meaningful.", "rationale": "Fenbufen property values must be tied to material form, solvent and measurement conditions.", "layers": [ { "id": "solid-and-thermal-state", "name": "Solid and thermal state", "description": "Characterise solid form and response to heating without assuming undocumented constants.", "findings": [ { "id": "form-dependent-thermal-properties", "name": "Form-dependent thermal properties", "description": "Associate observed transitions with the actual sample and experimental method.", "questions": [ { "text": "What evidence establishes the sample's crystalline, amorphous, hydrated or solvated state?", "kind": "measurement", "id": "form-dependent-thermal-properties-q01" }, { "text": "What melting, decomposition or boiling behaviour is experimentally established, at what pressure and for which form?", "kind": "measurement", "id": "form-dependent-thermal-properties-q02" } ] } ] }, { "id": "dissolution-and-ionisation", "name": "Dissolution and ionisation", "description": "Relate solution preparation to measured solubility and acid-base behaviour.", "findings": [ { "id": "conditioned-solution-properties", "name": "Conditioned solution properties", "description": "Distinguish intrinsic properties from values changed by pH, solvent or preparation history.", "questions": [ { "text": "What solubility and pKa measurements exist, with solvent, pH, temperature and method specified?", "kind": "measurement", "id": "conditioned-solution-properties-q01" }, { "text": "Which conditions support the required fenbufen concentration, and how is precipitation or chemical change checked?", "kind": "action", "id": "conditioned-solution-properties-q02" } ] } ] } ] }, { "id": "fenbufen-stability", "name": "Fenbufen stability", "description": "Connect storage history and degradation evidence to continued material suitability.", "rationale": "Fresh solid, stored material and prepared solutions require separately supported stability decisions.", "layers": [ { "id": "degradation-evidence", "name": "Degradation evidence", "description": "Identify demonstrated changes under defined stress or storage conditions.", "findings": [ { "id": "chemical-integrity-over-time", "name": "Chemical integrity over time", "description": "Record degradation observations without treating possible pathways as established findings.", "questions": [ { "text": "Which changes in fenbufen assay or impurity profile are demonstrated under light, heat, moisture or solution exposure?", "kind": "measurement", "id": "chemical-integrity-over-time-q01" }, { "text": "Which observed products are confirmed degradation products rather than pre-existing impurities or analytical artefacts?", "kind": "provenance", "id": "chemical-integrity-over-time-q02" } ] } ] }, { "id": "storage-and-retest", "name": "Storage and retest", "description": "Translate applicable stability evidence into material disposition.", "findings": [ { "id": "supported-storage-decisions", "name": "Supported storage decisions", "description": "Evaluate packaging, storage excursions and retest requirements for the particular material.", "questions": [ { "text": "Which storage conditions and retest interval are supported for this fenbufen grade, container and physical form?", "kind": "provenance", "id": "supported-storage-decisions-q01" }, { "text": "After an excursion or extended solution storage, what evidence is required before reuse?", "kind": "action", "id": "supported-storage-decisions-q02" } ] } ] } ] }, { "id": "fenbufen-biological-relations", "name": "Fenbufen biological relations", "description": "Structure evidence about biological transformation and activity at substance level.", "rationale": "An agent must distinguish the administered or tested parent compound from the species responsible for an observed effect.", "layers": [ { "id": "parent-product-relations", "name": "Parent-product relations", "description": "Track proposed or demonstrated biological conversions with their experimental context.", "findings": [ { "id": "transformation-attribution", "name": "Transformation attribution", "description": "Require evidence for each link between fenbufen and a biological transformation product.", "questions": [ { "text": "Which primary studies establish fenbufen's transformation products, including the proposed relationship to felbinac?", "kind": "provenance", "id": "transformation-attribution-q01" }, { "text": "In which species, tissues or experimental systems was each conversion demonstrated?", "kind": "boundary", "id": "transformation-attribution-q02" } ] } ] }, { "id": "activity-attribution", "name": "Activity attribution", "description": "Keep activity measurements attached to the tested chemical species and assay.", "findings": [ { "id": "parent-versus-product-activity", "name": "Parent versus product activity", "description": "Prevent organism-level effects from becoming unsupported direct-target claims.", "questions": [ { "text": "Which activity measurements concern unchanged fenbufen, isolated transformation products or a metabolically active system?", "kind": "boundary", "id": "parent-versus-product-activity-q01" }, { "text": "What concentrations, endpoints and controls support each claimed target interaction or biological effect?", "kind": "measurement", "id": "parent-versus-product-activity-q02" } ] } ] } ] }, { "id": "fenbufen-handling-and-status", "name": "Fenbufen handling and status", "description": "Determine applicable handling controls and regulatory constraints from traceable evidence.", "rationale": "Substance hazards, workplace limits and medicinal-product permissions answer different questions.", "layers": [ { "id": "chemical-hazard-controls", "name": "Chemical hazard controls", "description": "Evaluate hazard documentation for the actual fenbufen material being handled.", "findings": [ { "id": "applicable-hazard-evidence", "name": "Applicable hazard evidence", "description": "Attach classifications and controls to their source, jurisdiction and material scope.", "questions": [ { "text": "What current SDS or authoritative classification applies to this fenbufen material, and what evidence supports its hazard statements?", "kind": "provenance", "id": "applicable-hazard-evidence-q01" }, { "text": "Are substance-specific occupational limits available, and which documented controls apply to weighing, solution preparation and disposal?", "kind": "action", "id": "applicable-hazard-evidence-q02" } ] } ] }, { "id": "jurisdiction-and-use", "name": "Jurisdiction and use", "description": "Separate chemical inventory identity from permissions governing particular uses or products.", "findings": [ { "id": "dated-regulatory-applicability", "name": "Dated regulatory applicability", "description": "Record the authority and date behind each status claim without extending product approval to bulk material.", "questions": [ { "text": "Which official records establish fenbufen's chemical inventory identity and applicable restrictions in the relevant jurisdiction?", "kind": "provenance", "id": "dated-regulatory-applicability-q01" }, { "text": "Does each status statement concern the substance, an ingredient use or a particular medicinal product, and when was it verified?", "kind": "boundary", "id": "dated-regulatory-applicability-q02" } ] } ] } ] }, { "id": "evidence-and-external-alignment", "name": "Evidence and external alignment", "description": "What the world already says about this thing, gathered so the model can be checked against it.", "rationale": "A model that cannot be lined up against existing standards, identifiers and practice cannot be adopted by anyone who already uses them.", "layers": [ { "id": "reported-evidence", "name": "Reported evidence", "description": "Findings from the breadth pass, kept separate from the structural claims.", "findings": [ { "id": "evidence-confidence-notes", "name": "Check these first", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "This description is recalled knowledge, not a source-verified research record.", "Check current national authorization, product labeling and any applicable pharmacopoeial monograph.", "Verify measured physical constants, purity specifications and substance-specific hazard classifications before adding them." ], "questions": [ { "id": "evidence-confidence-notes-q01", "text": "Which of these check these first hold for the sense of fenbufen this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-identifiers", "name": "Identifiers and schemes", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ { "scheme": "CAS Registry Number", "value_or_pattern": "36330-85-5", "note": "Identifies fenbufen as a chemical substance." }, { "scheme": "International Nonproprietary Name (WHO)", "value_or_pattern": "fenbufen", "note": "Generic name of the pharmaceutical substance." }, { "scheme": "Molecular formula", "value_or_pattern": "C16H14O3", "note": "Formula of the neutral parent compound." } ], "questions": [ { "id": "evidence-identifiers-q01", "text": "Which of these identifiers and schemes hold for the sense of fenbufen this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-real-world-use", "name": "Real-world use", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "Historically used as an oral anti-inflammatory and analgesic medicine for arthritic and other musculoskeletal conditions." ], "questions": [ { "id": "evidence-real-world-use-q01", "text": "Which of these real-world use hold for the sense of fenbufen this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-measurements", "name": "Typical measurements", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ { "quantity": "Molar mass", "typical_range": "254.28", "unit": "g/mol" } ], "questions": [ { "id": "evidence-measurements-q01", "text": "Which of these typical measurements hold for the sense of fenbufen this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-failure-modes-and-hazards", "name": "Failure modes and hazards", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "Gastrointestinal ulceration and bleeding associated with systemic NSAID use.", "Renal impairment and fluid retention associated with systemic NSAID use.", "Hypersensitivity reactions, including bronchospasm in susceptible individuals.", "Interaction with some fluoroquinolone antibiotics can increase the risk of seizures." ], "questions": [ { "id": "evidence-failure-modes-and-hazards-q01", "text": "Which of these failure modes and hazards hold for the sense of fenbufen this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-regional-variation", "name": "Regional variation", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "Marketing authorization and availability depend on jurisdiction; historical therapeutic use does not establish current approval." ], "questions": [ { "id": "evidence-regional-variation-q01", "text": "Which of these regional variation hold for the sense of fenbufen this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-neighbours", "name": "Neighbouring kinds and how to tell them apart", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ { "name": "felbinac", "difference": "Felbinac is biphenylacetic acid, an active metabolite of fenbufen, rather than the parent prodrug." }, { "name": "fenoprofen", "difference": "Fenoprofen is a distinct arylpropionic acid NSAID with different molecular connectivity; the similar name does not indicate chemical identity." }, { "name": "fenbufen-containing medicine", "difference": "A medicine includes a specified dose, formulation and excipients; fenbufen denotes the active chemical substance." } ], "questions": [ { "id": "evidence-neighbours-q01", "text": "Which of these neighbouring kinds and how to tell them apart hold for the sense of fenbufen this model covers, and on what evidence?", "kind": "provenance" } ] } ] } ] } ] }, "openQuestions": [ "Which authoritative identity records and any existing Vercy model should serve as the canonical reference for vr.tr.fenbufen?", "Which solid forms, melting ranges, decomposition behaviour, solubilities and pKa values are supported by reproducible measurements?", "Which applicable quality standards establish assay methods, impurity limits and requirements for reference, research or pharmaceutical grades?", "Which primary studies resolve fenbufen-to-felbinac transformation and distinguish parent activity from transformation-product activity?", "What current jurisdiction-specific hazard classifications, exposure limits, storage requirements and use restrictions apply to the material being assessed?" ], "statistics": { "bundles": 7, "layers": 13, "findings": 19, "questions": 31 } }