{ "vercy": "1.0-draft", "publication": { "status": "research-draft", "adjudicationStatus": "unreviewed", "publishableCanonical": false, "generatedAt": "2026-09-12T10:50:02Z", "providers": [ "Codex" ], "breadth": "recalled by Codex without web access - no source was read", "missingProviders": [], "pass": 2, "cost": { "grok": { "seconds": 18.6, "error": "Reading additional input from stdin...\nOpenAI Codex v0.153.4\n--------\nworkdir: R:\\02_PROJECTS\\02_Meta_Models_Platforms\\Ver.cy\\current\\thing-registry-backlog\nmodel: gpt-6-astra\nprovider: openai\napproval: never\nsandbox: read-only\nreasoning effort: none\nreasoning summaries: none\nsession id: 01a0953b-d1ee-7e40-adf1-9560b53164bb\n--------\nuser\nDescribe what is already known about one registered thing. Answer as JSON only, no prose around it.\n\nThing: L-agaritine\nSense to describe: (none recorded)\nDomain code: PHY.MAT\nAlso known as: (none)\n\n\nContext for this batch of 1001 things:\n# Batch 043: 1001 reg", "usd": 0.0, "recall": true }, "codex": { "seconds": 82.1, "error": "Reading additional input from stdin...\nOpenAI Codex v0.153.4\n--------\nworkdir: R:\\02_PROJECTS\\02_Meta_Models_Platforms\\Ver.cy\\current\\thing-registry-backlog\nmodel: gpt-6-astra\nprovider: openai\napproval: never\nsandbox: read-only\nreasoning effort: none\nreasoning summaries: none\nsession id: 01a0953b-d1f5-75d0-ba8b-d22b5f404cb7\n--------\nuser\nYou are drafting a Vercy meta-model for one registered thing. Answer as JSON only, no prose around it.\n\nThing: L-agaritine\nRegistry id: vr.tr.l-agaritine\nPlane / domain: PHY / PHY.MAT\nRegistry definition: (none recorded)\nNames folded into this entry: (none)\n\n\n" } }, "enrichment": { "pass": 3, "engine": "claude", "producedAt": "2026-10-06T12:00:00Z", "ingestedAt": "2026-10-06T08:48:47+00:00", "fields": [ "agent_conduct", "ethics", "failure_modes_and_hazards", "owners", "visual_identification" ] }, "gate": { "passed": true, "version": "1.0", "at": "2026-10-07T10:10:28+00:00", "evidence": [ "completeness 1.00", "sense: Wikidata description", "2 live sources", "review by codex: pass" ] } }, "metaModel": { "id": "THING-Q2315302", "registryId": "vr.tr.l-agaritine", "name": "L-agaritine", "version": "0.1.0-research.1", "entryKind": "thing", "family": "Thing Registry", "domain": [ "PHY.MAT" ], "status": "research-draft" }, "canonicalUrl": "https://ver.cy/models/thing/q2315302/", "model": { "registry_id": "vr.tr.l-agaritine", "name": "L-agaritine", "purpose": "Enable an agent to recognise L-agaritine, assess the identity and condition of material containing it, and judge its suitability for analysis, storage or controlled research.", "definition": "L-agaritine is a naturally occurring aromatic hydrazine derivative in Agaricus mushrooms, consisting of L-glutamic acid whose side-chain carboxyl group forms a hydrazide with 4-(hydroxymethyl)phenylhydrazine.", "scope_statement": "This model owns the substance identity of L-agaritine under vr.tr.l-agaritine in PHY / PHY.MAT, including stereochemistry, sample quality, condition-dependent behaviour, analytical evidence and constraints on use.", "in_scope": [ "Molecular identity, L stereochemistry and identifier reconciliation", "Purity, concentration and matrix-qualified sample composition", "Physical state, solubility and stability under recorded conditions", "Detection, quantification and discrimination from related compounds", "Evidence connecting parent substance, transformation products and hazards", "Substance-specific storage, handling and regulatory applicability" ], "out_of_scope": [ "Taxonomy, cultivation and whole-organism biology of source mushrooms", "Overall composition, nutrition and safety of mushroom foods", "Manufacturing processes and complete synthesis protocols", "Independent models of degradation products, metabolites and enzymes", "Clinical diagnosis or treatment of poisoning", "Analytical instruments as devices" ], "distinguishing_features": [ "Match molecular connectivity to the gamma-carboxyl hydrazide of L-glutamic acid bearing a para-hydroxymethylphenyl group; the name alone is insufficient. Identity reference: [PubChem Agaritine](https://pubchem.ncbi.nlm.nih.gov/compound/Agaritine).", "Require the L configuration at the amino-acid stereocentre; a matching molecular formula does not distinguish an opposite enantiomer or racemate.", "Use C12H17N3O4 and approximately 267.28 g/mol as consistency checks alongside structure, rather than as unique identification.", "Distinguish intact L-agaritine from free glutamate, related aromatic hydrazines and analytical derivatives by evidence for the complete parent structure.", "Treat a mushroom extract containing L-agaritine as a mixture with a measured constituent, not as an instance of pure L-agaritine." ], "characteristics": [ { "name": "Structure and stereochemical identity", "kind": "category", "unit_or_values": "Stereo-explicit structure; confirmed L form, stereochemistry unresolved or conflicting", "why_it_matters": "Determines whether evidence concerns this registered substance." }, { "name": "External chemical identifiers", "kind": "relation", "unit_or_values": "PubChem CID 439517; CAS 2757-90-6; additional identifiers with source and structure match", "why_it_matters": "Connects records while exposing mismatches involving chemical forms or synonyms." }, { "name": "Intact parent content", "kind": "measurement", "unit_or_values": "Mass fraction in % for isolated material; mg/kg or µmol/kg for matrices; mg/L or mmol/L for solutions", "why_it_matters": "Separates actual L-agaritine content from nominal sample mass or extract concentration." }, { "name": "Stereochemical purity", "kind": "measurement", "unit_or_values": "Enantiomeric excess in % or enantiomer ratio, with method; unmeasured permitted", "why_it_matters": "Chemical purity alone does not establish purity of the L form." }, { "name": "Matrix and origin", "kind": "relation", "unit_or_values": "Isolated solid, prepared solution, fungal tissue or extract; source specimen or preparation lot", "why_it_matters": "Matrix and provenance affect interpretation of concentration, stability and analytical recovery." }, { "name": "Physical form and thermal behaviour", "kind": "state", "unit_or_values": "Observed phase, hydration or solvation status; thermal event in °C with method and decomposition assessment", "why_it_matters": "Prevents treating an unqualified thermal event as a dependable melting or boiling point." }, { "name": "Solubility under specified conditions", "kind": "measurement", "unit_or_values": "g/L or mol/L with solvent, pH, temperature and equilibration time", "why_it_matters": "Supports preparation choices and detection of incomplete dissolution." }, { "name": "Parent retention during storage or processing", "kind": "measurement", "unit_or_values": "% remaining after a stated duration, with temperature, pH, light, atmosphere and matrix", "why_it_matters": "Establishes whether the current material still supports its assigned concentration." }, { "name": "Analytical result quality", "kind": "category", "unit_or_values": "Confirmed, tentative, quantified, below quantification limit or unresolved; linked validation evidence", "why_it_matters": "Prevents tentative detection or non-detection from becoming an unsupported quantitative claim." }, { "name": "Hazard and regulatory evidence status", "kind": "state", "unit_or_values": "Source-specific classification, jurisdiction, date, endpoint and chemical form; unresolved where unverified", "why_it_matters": "Supports decisions without equating missing classification with demonstrated safety." } ], "affordances": [ "Reconcile a supplier, literature or registry record against stereo-explicit L-agaritine identity.", "Assess whether a lot can serve as an analytical reference for a stated measurement.", "Calculate matrix-qualified L-agaritine content with recovery, dilution and uncertainty accounted for.", "Compare storage or processing observations using intact-parent retention and transformation evidence.", "Accept, reanalyse or quarantine a sample according to identity, purity and stability evidence.", "Determine which documented handling constraints apply to the material and proposed research activity." ], "agent_conduct": { "may": [ "Describe agaritine and its occurrence in mushrooms from scientific and food safety sources.", "Report the findings of food safety assessments on it without overstating them." ], "must_not": [ "Claim that eating ordinary cultivated mushrooms is proven to cause cancer.", "Dismiss reported concerns about it without citing the assessments.", "Present it as a medicine or supplement with health benefits it has not been shown to have." ], "requires_human": [ "Publishing dietary advice about it for a specific person or population." ] }, "ethics": { "considerations": [ "Food safety messages about common foods can cause needless fear or false reassurance.", "Evidence on its long-term effect in humans is limited and should be stated as such." ], "affected_parties": [ "People who eat mushrooms", "Growers and food producers" ] }, "owners": { "steward": "Nobody owns the substance; food safety authorities assess it in food.", "master_systems": [] }, "visual_identification": [ "Not identifiable by sight; it occurs in mushroom tissue and is confirmed by laboratory analysis." ], "failure_modes_and_hazards": [ "Some animal studies raised concern about carcinogenic potential of it and related hydrazines.", "Content varies with mushroom species, storage and cooking." ], "what_it_is_for": [ "L-agaritine is encountered in studies of mushroom composition and the effects of storage and food processing on mushroom constituents.", "Analytical and toxicological research examines it in mushroom extracts or characterized reference materials, with identity and stability affecting interpretation." ], "standards_and_regulation": [ "The Globally Harmonized System of Classification and Labelling of Chemicals, issued by the United Nations Economic Commission for Europe, provides the framework for evaluating and communicating hazards of laboratory chemical supplies where adopted." ] }, "sources": [ { "id": "wikidata", "title": "Wikidata item Q2315302: L-agaritine", "url": "https://www.wikidata.org/wiki/Q2315302", "url_status": "live", "what_it_supports": "identity and sense of the item", "checked_by": "wikidata-api" }, { "id": "wikipedia-en", "title": "Wikipedia: Agaritine", "url": "https://en.wikipedia.org/wiki/Agaritine", "url_status": "live", "what_it_supports": "general description of the item", "checked_by": "wikidata-api sitelink" } ], "structure": { "bundles": [ { "id": "molecular-identity", "name": "Molecular identity", "description": "Establish which chemical entity the L-agaritine name denotes.", "rationale": "The glutamyl linkage, aromatic substitution and L configuration must all agree before records can be combined.", "layers": [ { "id": "connectivity-and-stereochemistry", "name": "Connectivity and stereochemistry", "description": "Resolve the defining molecular structure and evidence for its configuration.", "findings": [ { "id": "parent-structure-match", "name": "Parent structure match", "description": "Require evidence for the intact glutamyl aromatic hydrazide and its L stereochemistry.", "questions": [ { "text": "Does the assigned structure preserve the gamma-glutamyl linkage and para-hydroxymethylphenyl substitution?", "kind": "definition", "id": "parent-structure-match-q01" }, { "text": "What evidence establishes the L configuration rather than merely assigning the familiar agaritine name?", "kind": "measurement", "id": "parent-structure-match-q02" } ] } ] }, { "id": "identifiers-and-chemical-forms", "name": "Identifiers and chemical forms", "description": "Align external records without confusing representation changes with different materials.", "findings": [ { "id": "identifier-and-form-boundary", "name": "Identifier and form boundary", "description": "Evaluate synonyms, ionic representations, salts and solvated material against the registered parent.", "questions": [ { "text": "Which authoritative records associate each supplied CAS, PubChem, ChEBI or EC identifier with the same stereo-explicit structure?", "kind": "provenance", "id": "identifier-and-form-boundary-q01" }, { "text": "Is a differing record a protonation representation of L-agaritine, a salt or solvate, or a chemically different derivative requiring a separate relation?", "kind": "boundary", "id": "identifier-and-form-boundary-q02" } ] } ] } ] }, { "id": "material-origin-and-quality", "name": "Material origin and quality", "description": "Describe the actual material in which L-agaritine is being assessed.", "rationale": "Isolated standards, solutions and mushroom extracts require different evidence before their reported contents are comparable.", "layers": [ { "id": "origin-and-matrix", "name": "Origin and matrix", "description": "Connect the analyte to a specimen or preparation history.", "findings": [ { "id": "traceable-material-context", "name": "Traceable material context", "description": "Record origin and matrix without assigning properties of the whole mushroom to the isolated compound.", "questions": [ { "text": "Does the material originate from a documented synthesis, isolated natural product or identified fungal specimen?", "kind": "provenance", "id": "traceable-material-context-q01" }, { "text": "For fungal material, which species, tissue, fresh or dry mass basis and processing history qualify the L-agaritine result?", "kind": "measurement", "id": "traceable-material-context-q02" } ] } ] }, { "id": "purity-and-assigned-content", "name": "Purity and assigned content", "description": "Distinguish parent content from water, solvent, impurities and stereochemical uncertainty.", "findings": [ { "id": "usable-parent-content", "name": "Usable parent content", "description": "Determine the amount of intact L-agaritine available for the intended analytical or research use.", "questions": [ { "text": "Is the reported purity a calibrated mass fraction, chromatographic area percentage or another quantity, and are water and residual solvent included?", "kind": "measurement", "id": "usable-parent-content-q01" }, { "text": "Which related compounds, degradation products or unresolved stereoisomers limit this lot's suitability as a reference material?", "kind": "action", "id": "usable-parent-content-q02" } ] } ] } ] }, { "id": "physical-behaviour-and-stability", "name": "Physical behaviour and stability", "description": "Qualify physical properties and changes in intact-parent content by experimental conditions.", "rationale": "A nominal L-agaritine concentration is useful only if dissolution and preservation of the parent compound are established.", "layers": [ { "id": "phase-and-solution-behaviour", "name": "Phase and solution behaviour", "description": "Record measured phase, solubility and thermal properties for a specified material.", "findings": [ { "id": "condition-qualified-properties", "name": "Condition-qualified properties", "description": "Separate observed physical behaviour from unsupported handbook-style constants.", "questions": [ { "text": "What solubility is measured in the intended solvent at the specified pH and temperature, and is intact L-agaritine verified after equilibration?", "kind": "measurement", "id": "condition-qualified-properties-q01" }, { "text": "Do reported thermal values describe melting, solvent loss or decomposition, and is any boiling-point claim experimentally justified?", "kind": "measurement", "id": "condition-qualified-properties-q02" } ] } ] }, { "id": "storage-and-processing-change", "name": "Storage and processing change", "description": "Track parent retention through handling, extraction and storage.", "findings": [ { "id": "stability-window", "name": "Stability window", "description": "Define a supported period of use for each material and solution condition.", "questions": [ { "text": "How does intact-parent content change with time under the recorded temperature, pH, light, oxygen and matrix conditions?", "kind": "measurement", "id": "stability-window-q01" }, { "text": "What evidence supports storage duration, sample preparation timing and a reanalysis or rejection threshold for this lot?", "kind": "action", "id": "stability-window-q02" } ] } ] } ] }, { "id": "analytical-recognition-and-quantification", "name": "Analytical recognition and quantification", "description": "Determine whether an analytical signal identifies and measures intact L-agaritine.", "rationale": "Complex extracts, related compounds and losses during preparation can make apparent agaritine content misleading.", "layers": [ { "id": "identity-selectivity", "name": "Identity selectivity", "description": "Assess discrimination of the parent compound from coexisting substances.", "findings": [ { "id": "orthogonal-identity-evidence", "name": "Orthogonal identity evidence", "description": "Combine appropriate structural and separation evidence, retaining unresolved stereochemistry explicitly.", "questions": [ { "text": "Which reference-standard comparisons, mass-spectral features or NMR observations establish intact L-agaritine in this sample?", "kind": "measurement", "id": "orthogonal-identity-evidence-q01" }, { "text": "Can the method distinguish related hydrazines, coeluting matrix components and stereoisomers, and which distinctions remain unresolved?", "kind": "boundary", "id": "orthogonal-identity-evidence-q02" } ] } ] }, { "id": "quantitative-validity", "name": "Quantitative validity", "description": "Qualify reported concentrations by calibration, recovery and sample preservation.", "findings": [ { "id": "defensible-analyte-result", "name": "Defensible analyte result", "description": "Require evidence that reported content reflects the original sample within stated uncertainty.", "questions": [ { "text": "What calibration traceability, extraction recovery, matrix effect and preparation-time loss support the reported concentration?", "kind": "measurement", "id": "defensible-analyte-result-q01" }, { "text": "What detection limit, quantification limit and uncertainty apply, and how is a result below either limit represented?", "kind": "measurement", "id": "defensible-analyte-result-q02" } ] } ] } ] }, { "id": "transformation-hazards-and-use", "name": "Transformation, hazards and use", "description": "Connect substance-specific transformation and hazard evidence to defensible handling decisions.", "rationale": "Evidence for the parent, products, assay systems and mushroom mixtures must remain distinguishable when judging what may be done.", "layers": [ { "id": "parent-and-product-attribution", "name": "Parent and product attribution", "description": "Separate disappearance of L-agaritine from identification and effects of its products.", "findings": [ { "id": "transformation-evidence", "name": "Transformation evidence", "description": "Require direct support for proposed chemical or enzymatic changes and their relevance.", "questions": [ { "text": "Which products are directly identified after L-agaritine transformation, under what conditions, and with what mass-balance support?", "kind": "measurement", "id": "transformation-evidence-q01" }, { "text": "Does a reported biological effect concern purified parent, a characterized product, an activated assay mixture or a whole mushroom extract?", "kind": "boundary", "id": "transformation-evidence-q02" } ] } ] }, { "id": "handling-and-regulatory-applicability", "name": "Handling and regulatory applicability", "description": "Apply verified hazard information to a specified form, concentration and activity.", "findings": [ { "id": "evidence-based-use-constraints", "name": "Evidence-based use constraints", "description": "Record the basis and limits of handling decisions without inventing classifications or exposure thresholds.", "questions": [ { "text": "Which current authoritative classifications, supplier safety records and occupational limits explicitly apply to this L-agaritine material and jurisdiction?", "kind": "provenance", "id": "evidence-based-use-constraints-q01" }, { "text": "Given the documented material and activity, what containment, storage, waste handling or specialist review is required before use?", "kind": "action", "id": "evidence-based-use-constraints-q02" } ] } ] } ] }, { "id": "evidence-and-external-alignment", "name": "Evidence and external alignment", "description": "What the world already says about this thing, gathered so the model can be checked against it.", "rationale": "A model that cannot be lined up against existing standards, identifiers and practice cannot be adopted by anyone who already uses them.", "layers": [ { "id": "reported-evidence", "name": "Reported evidence", "description": "Findings from the breadth pass, kept separate from the structural claims.", "findings": [ { "id": "evidence-confidence-notes", "name": "Check these first", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "This description is recalled knowledge; no sources were consulted.", "Verify CAS and PubChem identifiers, physical constants, and any applicable hazard classification before completing the substance record.", "Check primary evidence for degradation conditions and toxicological findings, distinguishing isolated agaritine from its metabolites and whole-mushroom exposure." ], "questions": [ { "id": "evidence-confidence-notes-q01", "text": "Which of these check these first hold for the sense of L-agaritine this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-identifiers", "name": "Identifiers and schemes", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ { "scheme": "Molecular formula", "value_or_pattern": "C12H17N3O4", "note": "Describes elemental composition but does not uniquely identify connectivity or stereochemistry." } ], "questions": [ { "id": "evidence-identifiers-q01", "text": "Which of these identifiers and schemes hold for the sense of L-agaritine this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-real-world-use", "name": "Real-world use", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "Analyte in studies of mushroom composition and changes during storage or food processing.", "Research substance in investigations of mushroom-derived hydrazines and their biological effects." ], "questions": [ { "id": "evidence-real-world-use-q01", "text": "Which of these real-world use hold for the sense of L-agaritine this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-measurements", "name": "Typical measurements", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ { "quantity": "Molar mass", "typical_range": "267.28", "unit": "g/mol" } ], "questions": [ { "id": "evidence-measurements-q01", "text": "Which of these typical measurements hold for the sense of L-agaritine this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-failure-modes-and-hazards", "name": "Failure modes and hazards", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "Degradation during sample storage or preparation can change the measured agaritine content.", "Potential genotoxicity and carcinogenicity of agaritine and its transformation products are toxicological research concerns; this does not establish a human risk magnitude." ], "questions": [ { "id": "evidence-failure-modes-and-hazards-q01", "text": "Which of these failure modes and hazards hold for the sense of L-agaritine this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-neighbours", "name": "Neighbouring kinds and how to tell them apart", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ { "name": "L-glutamic acid", "difference": "L-glutamic acid has a free side-chain carboxyl group; L-agaritine has that group converted into a substituted hydrazide." }, { "name": "4-(Hydroxymethyl)phenylhydrazine", "difference": "This compound lacks the L-glutamyl portion present in L-agaritine." }, { "name": "Agaricus bisporus", "difference": "Agaricus bisporus is a mushroom species that can contain agaritine; L-agaritine is an individual chemical constituent." } ], "questions": [ { "id": "evidence-neighbours-q01", "text": "Which of these neighbouring kinds and how to tell them apart hold for the sense of L-agaritine this model covers, and on what evidence?", "kind": "provenance" } ] } ] } ] } ] }, "openQuestions": [ "Do authoritative identity records consistently distinguish L-agaritine from stereochemically unspecified agaritine, ionic representations and separately registered chemical forms?", "Which primary measurements establish solubility, thermal behaviour and stability for characterized L-agaritine rather than an incompletely specified extract or preparation?", "Which analytical methods adequately preserve and quantify intact L-agaritine while resolving relevant interferences and establishing stereochemical identity?", "Which transformation products are directly demonstrated under storage, food processing and biological conditions, and how much of each observed effect can be attributed to the parent?", "What current jurisdiction-specific hazard classifications, EC identity and occupational exposure limits are actually documented, and which remain unassigned or unverified?" ], "statistics": { "bundles": 6, "layers": 11, "findings": 16, "questions": 26 } }