{ "vercy": "1.0-draft", "publication": { "status": "research-draft", "adjudicationStatus": "unreviewed", "publishableCanonical": false, "generatedAt": "2026-09-13T06:25:25Z", "providers": [ "Claude" ], "breadth": "written by Claude from model knowledge without web access - no source was read, every claim is a lead to verify", "pass": 2, "wave": 3, "engine": "claude", "enrichment": { "pass": 3, "engine": "claude", "producedAt": "2026-10-06T10:00:00Z", "ingestedAt": "2026-10-06T07:07:17+00:00", "fields": [ "agent_conduct", "ethics", "owners" ] }, "gate": { "passed": true, "version": "1.0", "at": "2026-10-06T19:51:57+00:00", "evidence": [ "completeness 1.00", "sense: Wikidata description", "2 live sources", "review by codex: pass" ] } }, "metaModel": { "id": "THING-Q23498511", "registryId": "vr.tr.quinazoline-alkaloid", "name": "quinazoline alkaloid", "version": "0.2.0-wave.3", "entryKind": "thing", "family": "Thing Registry", "domain": [ "PHY.MAT" ], "status": "research-draft" }, "canonicalUrl": "https://ver.cy/models/thing/q23498511/", "model": { "registry_id": "vr.tr.quinazoline-alkaloid", "name": "quinazoline alkaloid", "purpose": "Let an agent explain quinazoline alkaloids and their structure, relay sources, biosynthesis and reported activities from natural product chemistry references, describe derived drugs, and distinguish quinazoline alkaloids from synthetic quinazoline drugs and from quinoline and quinazolinone compounds.", "definition": "A class of alkaloids containing the quinazoline ring system, a fused benzene and pyrimidine bicycle, produced by plants such as Adhatoda vasica, Peganum harmala and Dichroa febrifuga and by fungi and microorganisms, including vasicine, febrifugine, tryptoquivaline and fumiquinazoline types and complex spiro-fused compounds such as those named systematically in the registry aliases; quinazoline alkaloids show bronchodilator, antimalarial and cytotoxic activities in research and inspired synthetic drugs.", "what_it_is_for": "Not applicable; a chemical class.", "affordances": [ "explain structure and sources", "relay biosynthesis and activities", "describe derived drugs", "distinguish related compounds" ], "distinguishing_features": [ "Quinazoline core", "Plant and fungal origin", "Anthranilate biosynthesis", "Drug inspiration" ], "appearance": "Not a visible object; crystalline compounds from plants and fungi.", "visual_identification": [ "Alkaloids with a quinazoline core", "Vasicine, febrifugine, tryptoquivalines, fumiquinazolines, spiro-fused indole quinazolines", "Synthetic quinazolines such as gefitinib are drugs; quinolines are a different bicycle; quinazolinones are oxidised forms" ], "physical_properties": [ { "quantity": "core", "typical_range": "quinazoline, benzo-fused pyrimidine", "unit": "structure", "note": "" }, { "quantity": "sources", "typical_range": "Acanthaceae, Zygophyllaceae, Hydrangeaceae, Aspergillus", "unit": "list", "note": "" }, { "quantity": "biosynthetic precursor", "typical_range": "anthranilic acid", "unit": "note", "note": "" } ], "families_and_kinds": [ "simple quinazoline alkaloids such as vasicine and vasicinone", "febrifugine and halofuginone types", "fungal quinazolines such as tryptoquivalines and fumiquinazolines", "spiro-fused indole quinazolines such as those named in the registry", "pyrroloquinazolines and other fused types" ], "related_models": [ { "relation": "is a kind of", "target": "alkaloid", "why": "in registry terms" }, { "relation": "is a kind of", "target": "quinazoline", "why": "derivatives in registry terms" }, { "relation": "is produced by", "target": "Justicia adhatoda", "why": "among other plants" }, { "relation": "inspired", "target": "halofuginone", "why": "a synthetic derivative" } ], "identifiers": [], "standards_and_regulation": [ "Herbal medicine regulations for vasicine-containing plants", "Research chemical handling rules" ], "failure_modes_and_hazards": [ "Confusing natural alkaloids with synthetic quinazoline drugs", "Overstating laboratory activities as clinical effects", "Toxicity of febrifugine and related compounds" ], "in_scope": [], "out_of_scope": [], "characteristics": [], "agent_conduct": { "may": [ "Describe the quinazoline alkaloid class, its ring system and the plants and fungi that make it.", "Report published findings with their source, stating whether they are laboratory or clinical." ], "must_not": [ "Give guidance on extracting, concentrating or dosing these alkaloids from plants.", "Recommend plants such as Peganum harmala or Dichroa febrifuga as remedies.", "Present laboratory activity of an alkaloid as a proven treatment.", "Confuse natural quinazoline alkaloids with approved synthetic quinazoline drugs." ], "requires_human": [ "Any use of these compounds or source plants with people or animals." ] }, "ethics": { "considerations": [ "Some of these alkaloids are toxic, and the plants that hold them are used in traditional medicine where harm can follow.", "Traditional knowledge of source plants belongs to communities who should share in its benefits." ], "affected_parties": [ "People using herbal remedies", "Communities holding traditional plant knowledge", "Researchers" ] }, "owners": { "steward": "Nobody owns the class; the holder of a regulated product answers for that product.", "master_systems": [ "Chemical compound databases" ] } }, "sources": [ { "id": "wikidata", "title": "Wikidata item Q23498511: quinazoline alkaloid", "url": "https://www.wikidata.org/wiki/Q23498511", "url_status": "live", "what_it_supports": "identity and sense of the item", "checked_by": "wikidata-api" }, { "id": "wikipedia-en", "title": "Wikipedia: Quinazoline alkaloids", "url": "https://en.wikipedia.org/wiki/Quinazoline_alkaloids", "url_status": "live", "what_it_supports": "general description of the item", "checked_by": "wikidata-api sitelink" } ], "structure": { "bundles": [ { "id": "understand", "name": "Understand", "description": "What quinazoline alkaloids are.", "rationale": "Science.", "layers": [ { "id": "definition", "name": "Definition", "description": "Definition and structure.", "findings": [ { "id": "definition-finding", "name": "Definition", "description": "Definition.", "questions": [ { "text": "What are quinazoline alkaloids, and how do they differ from synthetic quinazoline drugs, quinolines and quinazolinones?", "kind": "definition" }, { "text": "Is the question about the class, a specific compound or a synthetic drug?", "kind": "boundary" } ] } ] }, { "id": "members", "name": "Members", "description": "Members.", "findings": [ { "id": "members-finding", "name": "Members", "description": "Members.", "questions": [ { "text": "What are vasicine, febrifugine, tryptoquivalines, fumiquinazolines and the spiro-fused compounds named in the registry?", "kind": "definition" }, { "text": "Which entry fits the specific compound?", "kind": "action" } ] } ] } ] }, { "id": "biology", "name": "Biology", "description": "Sources and biosynthesis.", "rationale": "Science.", "layers": [ { "id": "sources", "name": "Sources", "description": "Sources.", "findings": [ { "id": "sources-finding", "name": "Sources", "description": "Sources.", "questions": [ { "text": "Which plants, fungi and bacteria produce quinazoline alkaloids?", "kind": "provenance" }, { "text": "Which references are standard?", "kind": "provenance" } ] } ] }, { "id": "biosynthesis", "name": "Biosynthesis", "description": "Biosynthesis.", "findings": [ { "id": "biosynthesis-finding", "name": "Biosynthesis", "description": "Biosynthesis.", "questions": [ { "text": "How are quinazoline alkaloids made from anthranilic acid and amino acids?", "kind": "provenance" }, { "text": "Which sources are cited?", "kind": "provenance" } ] } ] } ] }, { "id": "research", "name": "Research", "description": "Activities and drugs.", "rationale": "Attribution.", "layers": [ { "id": "activity", "name": "Activity", "description": "Reported activities.", "findings": [ { "id": "activity-finding", "name": "Activity", "description": "Activity.", "questions": [ { "text": "What bronchodilator, antimalarial and cytotoxic activities have been reported, and at what stage of evidence, with findings attributed?", "kind": "provenance" }, { "text": "Is the presentation careful not to overstate clinical relevance?", "kind": "boundary" } ] } ] }, { "id": "drugs", "name": "Drugs", "description": "Derived drugs.", "findings": [ { "id": "drugs-finding", "name": "Drugs", "description": "Drugs.", "questions": [ { "text": "How did febrifugine lead to halofuginone, and what other drugs derive from the class?", "kind": "provenance" }, { "text": "Which entry fits halofuginone?", "kind": "action" } ] } ] } ] }, { "id": "context", "name": "Context", "description": "Traditional use and history.", "rationale": "Context.", "layers": [ { "id": "traditional", "name": "Traditional", "description": "Traditional medicine.", "findings": [ { "id": "traditional-finding", "name": "Traditional", "description": "Traditional.", "questions": [ { "text": "How have Adhatoda and Dichroa been used in Ayurvedic and Chinese medicine, as sources describe, and what evidence exists?", "kind": "provenance" }, { "text": "Is the user asking about their own use of herbal products, which needs a clinician?", "kind": "boundary" } ] } ] }, { "id": "history", "name": "History", "description": "History.", "findings": [ { "id": "history-finding", "name": "History", "description": "History.", "questions": [ { "text": "How were quinazoline alkaloids discovered and studied?", "kind": "provenance" }, { "text": "Which entry fits the history of natural products?", "kind": "action" } ] } ] } ] } ] }, "openQuestions": [ "Should vasicine and febrifugine be separate primary entries?", "How should natural product references be linked?", "The registry entry has merged aliases naming compounds by systematic names; should they be split off?" ], "statistics": { "bundles": 4, "layers": 8, "findings": 8, "questions": 16 } }