{
  "vercy": "1.0-draft",
  "publication": {
    "status": "research-draft",
    "adjudicationStatus": "unreviewed",
    "publishableCanonical": false,
    "generatedAt": "2026-09-12T21:17:39Z",
    "providers": [
      "Claude"
    ],
    "breadth": "written by Claude from model knowledge without web access - no source was read, every claim is a lead to verify",
    "pass": 2,
    "wave": 3,
    "engine": "claude",
    "enrichment": {
      "pass": 3,
      "engine": "claude",
      "producedAt": "2026-10-06T10:00:00Z",
      "ingestedAt": "2026-10-06T07:00:59+00:00",
      "fields": [
        "agent_conduct",
        "ethics",
        "owners"
      ]
    },
    "gate": {
      "passed": true,
      "version": "1.0",
      "at": "2026-10-06T19:51:57+00:00",
      "evidence": [
        "completeness 1.00",
        "sense: Wikidata description",
        "2 live sources",
        "review by codex: pass"
      ]
    }
  },
  "metaModel": {
    "id": "THING-Q2355306",
    "registryId": "vr.tr.tissue-development",
    "name": "tissue development",
    "version": "0.2.0-wave.3",
    "entryKind": "thing",
    "family": "Thing Registry",
    "domain": [
      "ACT.PRC"
    ],
    "status": "research-draft"
  },
  "canonicalUrl": "https://ver.cy/models/thing/q2355306/",
  "model": {
    "registry_id": "vr.tr.tissue-development",
    "name": "tissue development",
    "purpose": "Let an agent explain tissue development as a category of developmental process, distinguish it from organ development and morphogenesis, relay Gene Ontology definitions and research findings with attribution, and route to specific tissue entries.",
    "definition": "The biological process by which a tissue forms and matures from progenitor cells, through proliferation, differentiation, organisation and remodelling, in embryonic development, growth, regeneration and repair; examples include the development of the skin, lymphoid tissue, mineralised tissues, the endosperm in plants and specialised tissues such as the decidua in pregnancy.",
    "what_it_is_for": "Not for anything; the process that forms tissues.",
    "affordances": [
      "explain the process and its stages",
      "distinguish tissue development from organ and cell development",
      "relay ontology definitions",
      "route to specific tissues"
    ],
    "distinguishing_features": [
      "Tissue-level process",
      "Stages from progenitors to mature tissue",
      "Occurs in development, growth and repair",
      "Defined in ontologies"
    ],
    "appearance": "Not visible as a single thing; seen in the appearance and maturation of tissues over time.",
    "visual_identification": [
      "Formation and maturation of a tissue",
      "Proliferation, differentiation and organisation",
      "Organ development is at a higher level; cell differentiation at a lower level"
    ],
    "physical_properties": [],
    "families_and_kinds": [
      "epithelial and integument development",
      "connective and mineralised tissue development",
      "muscle and nervous tissue development",
      "lymphoid tissue formation",
      "plant tissue development such as endosperm",
      "specialised processes such as decidualisation"
    ],
    "related_models": [
      {
        "relation": "is a kind of",
        "target": "anatomical structure development",
        "why": "the ontology parent"
      },
      {
        "relation": "is part of",
        "target": "organ development",
        "why": "the higher level"
      },
      {
        "relation": "involves",
        "target": "cell differentiation",
        "why": "a component process"
      },
      {
        "relation": "is studied by",
        "target": "developmental biology",
        "why": "the discipline"
      }
    ],
    "identifiers": [
      {
        "scheme": "Gene Ontology",
        "value_or_pattern": "GO:0009888",
        "note": "tissue development"
      }
    ],
    "standards_and_regulation": [
      "Gene Ontology definitions",
      "Research ethics rules for embryo and tissue research"
    ],
    "failure_modes_and_hazards": [
      "Confusing levels of development",
      "Developmental disorders when tissue development fails",
      "Presenting hypotheses as established"
    ],
    "in_scope": [],
    "out_of_scope": [],
    "characteristics": [],
    "agent_conduct": {
      "may": [
        "Explain how tissues form, mature and repair, citing developmental biology sources.",
        "Distinguish tissue development from organ and whole-organism development.",
        "Mark hypotheses about developmental mechanisms as hypotheses."
      ],
      "must_not": [
        "Present research hypotheses about tissue development as established fact.",
        "Give clinical advice about a developmental disorder in a specific person.",
        "Present experimental regenerative therapies as proven treatments.",
        "Assist in work that manipulates human embryos outside lawful, ethically approved research."
      ],
      "requires_human": [
        "Using developmental findings in clinical or reproductive decisions."
      ]
    },
    "ethics": {
      "considerations": [
        "Research on embryos and regeneration raises real ethical questions that need oversight.",
        "Overhyped regenerative claims are used to sell unproven treatments to vulnerable patients."
      ],
      "affected_parties": [
        "Patients and families",
        "Researchers",
        "The public"
      ]
    },
    "owners": {
      "steward": "Nobody owns the process; the scientific community maintains the knowledge.",
      "master_systems": []
    }
  },
  "sources": [
    {
      "id": "wikidata",
      "title": "Wikidata item Q2355306: tissue development",
      "url": "https://www.wikidata.org/wiki/Q2355306",
      "url_status": "live",
      "what_it_supports": "identity and sense of the item",
      "checked_by": "wikidata-api"
    },
    {
      "id": "wikipedia-en",
      "title": "Wikipedia: Histogenesis",
      "url": "https://en.wikipedia.org/wiki/Histogenesis",
      "url_status": "live",
      "what_it_supports": "general description of the item",
      "checked_by": "wikidata-api sitelink"
    }
  ],
  "structure": {
    "bundles": [
      {
        "id": "concept",
        "name": "Concept",
        "description": "What tissue development is.",
        "rationale": "Definition.",
        "layers": [
          {
            "id": "definition",
            "name": "Definition",
            "description": "Definition and levels.",
            "findings": [
              {
                "id": "definition-finding",
                "name": "Definition",
                "description": "Definition.",
                "questions": [
                  {
                    "text": "What is tissue development, and how does it relate to organ development and cell differentiation?",
                    "kind": "definition"
                  },
                  {
                    "text": "Is the question about a tissue, an organ or a cell type?",
                    "kind": "boundary"
                  }
                ]
              }
            ]
          },
          {
            "id": "stages",
            "name": "Stages",
            "description": "Stages.",
            "findings": [
              {
                "id": "stages-finding",
                "name": "Stages",
                "description": "Stages.",
                "questions": [
                  {
                    "text": "What stages does tissue development pass through?",
                    "kind": "definition"
                  },
                  {
                    "text": "Which entry fits the specific tissue?",
                    "kind": "action"
                  }
                ]
              }
            ]
          }
        ]
      },
      {
        "id": "mechanisms",
        "name": "Mechanisms",
        "description": "How tissues form.",
        "rationale": "Mechanism.",
        "layers": [
          {
            "id": "cells",
            "name": "Cells",
            "description": "Cell behaviours.",
            "findings": [
              {
                "id": "cells-finding",
                "name": "Cells",
                "description": "Cells.",
                "questions": [
                  {
                    "text": "Which cell behaviours and signals drive tissue formation, with findings attributed?",
                    "kind": "provenance"
                  },
                  {
                    "text": "Which entry fits morphogenesis?",
                    "kind": "action"
                  }
                ]
              }
            ]
          },
          {
            "id": "regeneration",
            "name": "Regeneration",
            "description": "Repair and regeneration.",
            "findings": [
              {
                "id": "regeneration-finding",
                "name": "Regeneration",
                "description": "Regeneration.",
                "questions": [
                  {
                    "text": "How do tissues develop during repair and regeneration?",
                    "kind": "provenance"
                  },
                  {
                    "text": "Which references are standard?",
                    "kind": "provenance"
                  }
                ]
              }
            ]
          }
        ]
      },
      {
        "id": "kinds",
        "name": "Kinds",
        "description": "Across tissues and organisms.",
        "rationale": "Scope.",
        "layers": [
          {
            "id": "animal",
            "name": "Animal",
            "description": "Animal tissues.",
            "findings": [
              {
                "id": "animal-finding",
                "name": "Animal",
                "description": "Animal.",
                "questions": [
                  {
                    "text": "How do epithelial, connective, muscle and nervous tissues develop?",
                    "kind": "provenance"
                  },
                  {
                    "text": "Which entry fits a specific tissue type?",
                    "kind": "action"
                  }
                ]
              }
            ]
          },
          {
            "id": "plant",
            "name": "Plant",
            "description": "Plant tissues.",
            "findings": [
              {
                "id": "plant-finding",
                "name": "Plant",
                "description": "Plant.",
                "questions": [
                  {
                    "text": "How do plant tissues such as endosperm develop?",
                    "kind": "provenance"
                  },
                  {
                    "text": "Which entry fits plant development?",
                    "kind": "action"
                  }
                ]
              }
            ]
          }
        ]
      },
      {
        "id": "study",
        "name": "Study",
        "description": "Research and teaching.",
        "rationale": "Study.",
        "layers": [
          {
            "id": "research",
            "name": "Research",
            "description": "Research and medicine.",
            "findings": [
              {
                "id": "research-finding",
                "name": "Research",
                "description": "Research.",
                "questions": [
                  {
                    "text": "How is tissue development studied, and how does it inform tissue engineering, in general terms?",
                    "kind": "provenance"
                  },
                  {
                    "text": "Which entry fits tissue engineering?",
                    "kind": "action"
                  }
                ]
              }
            ]
          },
          {
            "id": "teach",
            "name": "Teach",
            "description": "Teaching.",
            "findings": [
              {
                "id": "teach-finding",
                "name": "Teach",
                "description": "Teaching.",
                "questions": [
                  {
                    "text": "How is tissue development taught in histology and developmental biology?",
                    "kind": "action"
                  },
                  {
                    "text": "Which misconceptions arise?",
                    "kind": "provenance"
                  }
                ]
              }
            ]
          }
        ]
      }
    ]
  },
  "openQuestions": [
    "Should each tissue development process be a separate entry?",
    "How should ontology terms be linked?",
    "The registry entry has merged aliases for specific tissues and plant processes; should they be split off?"
  ],
  "statistics": {
    "bundles": 4,
    "layers": 8,
    "findings": 8,
    "questions": 16
  }
}