{ "vercy": "1.0-draft", "publication": { "status": "research-draft", "adjudicationStatus": "unreviewed", "publishableCanonical": false, "generatedAt": "2026-09-13T20:00:38Z", "providers": [ "Claude" ], "breadth": "written by Claude from model knowledge without web access - no source was read, every claim is a lead to verify", "pass": 2, "wave": 4, "engine": "claude", "enrichment": { "pass": 3, "engine": "claude", "producedAt": "2026-10-06T10:00:00Z", "ingestedAt": "2026-10-06T07:36:19+00:00", "fields": [ "agent_conduct", "ethics", "owners" ] }, "gate": { "passed": true, "version": "1.0", "at": "2026-10-06T19:51:57+00:00", "evidence": [ "completeness 1.00", "sense: Wikidata description", "2 live sources", "review by codex: pass" ] } }, "metaModel": { "id": "THING-Q23900578", "registryId": "vr.tr.amelia", "name": "amelia", "version": "0.2.0-wave.4", "entryKind": "thing", "family": "Thing Registry", "domain": [ "ACT.PRC" ], "status": "research-draft" }, "canonicalUrl": "https://ver.cy/models/thing/q23900578/", "model": { "registry_id": "vr.tr.amelia", "name": "amelia", "purpose": "Let an agent explain amelia and related limb absences in general terms, relay causes, diagnosis and support from medical genetics and disability sources, point families to genetic counselling, rehabilitation and peer support, and distinguish amelia from phocomelia, meromelia, amputation and amniotic band sequence.", "definition": "A rare congenital condition in which one or more limbs are completely absent, part of the spectrum of limb reduction defects, including tetra-amelia with all four limbs absent, sometimes autosomal recessive and linked to genes such as WNT3, amelia of the lower limb, and related absences of distal parts such as acheiria, absence of the hands, apodia, absence of the feet, abrachia, absence of the arms, and acheiropody, an inherited absence of hands and feet described in Brazil; causes include genetic factors and historically teratogens such as thalidomide. The model uses respectful, person-centred language.", "what_it_is_for": "Not applicable; a congenital condition.", "affordances": [ "explain in general terms", "relay causes and support", "describe named forms", "point to counselling and support" ], "distinguishing_features": [ "Complete limb absence", "Congenital", "Genetic or environmental causes", "Very rare" ], "appearance": "Absence of one or more limbs present from birth.", "visual_identification": [ "Congenital absence of a limb", "Acheiria, abrachia, acheiropody, autosomal recessive amelia, amelia of lower limb, apodia", "Phocomelia has shortened limbs; meromelia is partial absence; amputation is acquired; amniotic bands constrict limbs" ], "physical_properties": [ { "quantity": "tetra-amelia gene", "typical_range": "WNT3", "unit": "gene", "note": "autosomal recessive form" }, { "quantity": "thalidomide period", "typical_range": "late 1950s to early 1960s", "unit": "note", "note": "" }, { "quantity": "prenatal detection", "typical_range": "ultrasound", "unit": "note", "note": "" } ], "families_and_kinds": [ "tetra-amelia", "single-limb amelia", "distal absences such as acheiria and apodia", "acheiropody", "syndromic and non-syndromic forms" ], "related_models": [ { "relation": "is a kind of", "target": "dysmelia", "why": "in registry terms" }, { "relation": "is related to", "target": "phocomelia", "why": "" }, { "relation": "can be caused by", "target": "thalidomide", "why": "historically" }, { "relation": "is contrasted with", "target": "amputation", "why": "" } ], "identifiers": [], "standards_and_regulation": [ "Birth defect surveillance programmes", "Drug safety regulation after thalidomide", "Disability rights law" ], "failure_modes_and_hazards": [ "Stigmatising language", "Diagnosing individuals remotely", "Neglecting family support needs" ], "in_scope": [], "out_of_scope": [], "characteristics": [], "agent_conduct": { "may": [ "Explain amelia and related limb absences in general terms, relaying causes and support from medical sources.", "Use respectful person-first or identity-first language as the person prefers.", "Point families to genetic counselling and support organisations." ], "must_not": [ "Diagnose a fetus or child from images or descriptions.", "Use stigmatising language about people with limb differences.", "Advise families on pregnancy decisions.", "Blame parents for the condition." ], "requires_human": [ "Any decision on prenatal testing or pregnancy." ] }, "ethics": { "considerations": [ "People with limb differences face stigma and barriers.", "Families need honest, non-judgemental information." ], "affected_parties": [ "People with limb differences", "Families", "Expectant parents" ] }, "owners": { "steward": "Nobody owns a condition; clinicians and genetic services care for those affected.", "master_systems": [ "Congenital anomaly registries" ] } }, "sources": [ { "id": "wikidata", "title": "Wikidata item Q23900578: amelia", "url": "https://www.wikidata.org/wiki/Q23900578", "url_status": "live", "what_it_supports": "identity and sense of the item", "checked_by": "wikidata-api" }, { "id": "wikipedia-en", "title": "Wikipedia: Amelia (birth defect)", "url": "https://en.wikipedia.org/wiki/Amelia_%28birth_defect%29", "url_status": "live", "what_it_supports": "general description of the item", "checked_by": "wikidata-api sitelink" } ], "structure": { "bundles": [ { "id": "understand", "name": "Understand", "description": "What amelia is.", "rationale": "Attribution.", "layers": [ { "id": "definition", "name": "Definition", "description": "Definition.", "findings": [ { "id": "definition-finding", "name": "Definition", "description": "Definition.", "questions": [ { "text": "What is amelia, and how does it differ from phocomelia, meromelia, amputation and amniotic band sequence?", "kind": "definition" }, { "text": "Is the question from a family after a prenatal finding, in which case genetic counselling and specialist teams can help?", "kind": "boundary" } ] } ] }, { "id": "forms", "name": "Forms", "description": "Named forms.", "findings": [ { "id": "forms-finding", "name": "Forms", "description": "Forms.", "questions": [ { "text": "What are acheiria, abrachia, acheiropody, apodia, lower-limb amelia and autosomal recessive amelia?", "kind": "definition" }, { "text": "Which entry fits the specific form?", "kind": "action" } ] } ] } ] }, { "id": "medical", "name": "Medical", "description": "Causes and diagnosis.", "rationale": "Attribution.", "layers": [ { "id": "causes", "name": "Causes", "description": "Causes.", "findings": [ { "id": "causes-finding", "name": "Causes", "description": "Causes.", "questions": [ { "text": "What genetic and environmental causes are described?", "kind": "provenance" }, { "text": "Which references are standard?", "kind": "provenance" } ] } ] }, { "id": "diagnosis", "name": "Diagnosis", "description": "Diagnosis.", "findings": [ { "id": "diagnosis-finding", "name": "Diagnosis", "description": "Diagnosis.", "questions": [ { "text": "How are limb reduction defects detected and assessed?", "kind": "provenance" }, { "text": "Which sources are cited?", "kind": "provenance" } ] } ] } ] }, { "id": "living", "name": "Living", "description": "Living with limb difference.", "rationale": "Attribution.", "layers": [ { "id": "rehab", "name": "Rehabilitation", "description": "Rehabilitation.", "findings": [ { "id": "rehab-finding", "name": "Rehabilitation", "description": "Rehabilitation.", "questions": [ { "text": "What occupational therapy, adaptive tools and prosthetics options exist?", "kind": "provenance" }, { "text": "Which entry fits prosthesis?", "kind": "action" } ] } ] }, { "id": "community", "name": "Community", "description": "Peer support.", "findings": [ { "id": "community-finding", "name": "Community", "description": "Community.", "questions": [ { "text": "Which organisations support people with limb differences, and what do disabled people say about their lives?", "kind": "provenance" }, { "text": "Which entry fits limb difference?", "kind": "action" } ] } ] } ] }, { "id": "context", "name": "Context", "description": "History.", "rationale": "Context.", "layers": [ { "id": "thalidomide", "name": "Thalidomide", "description": "Thalidomide.", "findings": [ { "id": "thalidomide-finding", "name": "Thalidomide", "description": "Thalidomide.", "questions": [ { "text": "How did the thalidomide tragedy change drug regulation?", "kind": "provenance" }, { "text": "Which entry fits thalidomide scandal?", "kind": "action" } ] } ] }, { "id": "notable", "name": "Notable people", "description": "Notable people.", "findings": [ { "id": "notable-finding", "name": "Notable people", "description": "Notable people.", "questions": [ { "text": "Which public figures with limb differences have spoken about their experiences?", "kind": "provenance" }, { "text": "Which entry fits disability rights movement?", "kind": "action" } ] } ] } ] } ] }, "openQuestions": [ "Should the named distal absences be separate entries?", "How should Orphanet and OMIM be linked?", "How should disability-led perspectives be linked?" ], "statistics": { "bundles": 4, "layers": 8, "findings": 8, "questions": 16 } }