{ "vercy": "1.0-draft", "publication": { "status": "research-draft", "adjudicationStatus": "unreviewed", "publishableCanonical": false, "generatedAt": "2026-09-12T09:18:21Z", "providers": [ "Codex" ], "breadth": "recalled by Codex without web access - no source was read", "missingProviders": [], "pass": 2, "cost": { "grok": { "seconds": 23.2, "error": "Reading additional input from stdin...\nOpenAI Codex v0.153.4\n--------\nworkdir: R:\\02_PROJECTS\\02_Meta_Models_Platforms\\Ver.cy\\current\\thing-registry-backlog\nmodel: gpt-6-astra\nprovider: openai\napproval: never\nsandbox: read-only\nreasoning effort: none\nreasoning summaries: none\nsession id: 01a094e7-e199-7851-8d65-e8a6b38b1985\n--------\nuser\nDescribe what is already known about one registered thing. Answer as JSON only, no prose around it.\n\nThing: dothiepin\nSense to describe: (none recorded)\nDomain code: PHY.MAT\nAlso known as: (none)\n\n\nContext for this batch of 1001 things:\n# Batch 043: 1001 regis", "usd": 0.0, "recall": true }, "codex": { "seconds": 82.5, "error": "Reading additional input from stdin...\nOpenAI Codex v0.153.4\n--------\nworkdir: R:\\02_PROJECTS\\02_Meta_Models_Platforms\\Ver.cy\\current\\thing-registry-backlog\nmodel: gpt-6-astra\nprovider: openai\napproval: never\nsandbox: read-only\nreasoning effort: none\nreasoning summaries: none\nsession id: 01a094e7-e1a5-7fa0-93db-382c037b1f38\n--------\nuser\nYou are drafting a Vercy meta-model for one registered thing. Answer as JSON only, no prose around it.\n\nThing: dothiepin\nRegistry id: vr.tr.dothiepin\nPlane / domain: PHY / PHY.MAT\nRegistry definition: (none recorded)\nNames folded into this entry: (none)\n\n\nCont" } }, "enrichment": { "pass": 3, "engine": "claude", "producedAt": "2026-10-06T12:00:00Z", "ingestedAt": "2026-10-06T08:42:12+00:00", "fields": [ "agent_conduct", "ethics", "failure_modes_and_hazards", "owners", "visual_identification" ] }, "revisions": [ { "at": "2026-10-07T11:27:39+00:00", "engine": "codex", "fields": [ "definition", "distinguishing_features", "failure_modes_and_hazards", "in_scope", "scope_statement", "visual_identification" ], "answering_review": "e79be1a1c8c07a2d92709f77bccceb8cee5c1441c6bef6523b132d7f622e1deb" }, { "at": "2026-10-08T18:49:14+00:00", "engine": "codex", "fields": [ "owners" ], "answering_review": "942a328e40c4afb3b38460f2c00924e29285ef9a9f786e4be874dfabb4401caf" } ], "gate": { "passed": true, "version": "1.0", "at": "2026-10-08T18:54:38+00:00", "evidence": [ "completeness 1.00", "sense: Wikidata description", "2 live sources", "review by codex: pass" ] } }, "metaModel": { "id": "THING-Q27116967", "registryId": "vr.tr.dothiepin", "name": "dothiepin", "version": "0.1.0-research.1", "entryKind": "thing", "family": "Thing Registry", "domain": [ "PHY.MAT" ], "status": "research-draft" }, "canonicalUrl": "https://ver.cy/models/thing/q27116967/", "model": { "registry_id": "vr.tr.dothiepin", "name": "dothiepin", "purpose": "Enable an agent to recognise dothiepin, assess the identity and condition of a material containing it, and determine evidence-supported handling or use constraints.", "definition": "Dothiepin, in this sense, denotes the pair of cis-trans geometric isomers of a sulfur-containing tricyclic compound with a dimethylaminopropylidene side chain, rather than a particular medicinal substance or formulation.", "scope_statement": "This model owns vr.tr.dothiepin as the cis-trans isomer pair, including the molecular identity shared by its members, their distinct configurations, material composition and relationships to salt forms and medicinal dosulepin records; properties of one isomer or product are not automatically attributed to the pair.", "in_scope": [ "Name reconciliation and structure-specific identifiers distinguish the isomer pair from individual isomers and medicinal dosulepin records.", "Free-base identity and geometric configuration distinguish the two isomers and their relationships to salt forms.", "Batch composition, assay, impurities and material grade include evidence of isomer composition.", "Physical properties and stability are attributed to the identified isomer or documented mixture under recorded conditions.", "Substance hazards and jurisdiction-specific restrictions are attributed to the relevant isomer, mixture or salt using dated evidence." ], "out_of_scope": [ "Finished tablets, capsules, brands and their excipient compositions", "Patient-specific diagnosis, prescribing, dosing and treatment monitoring", "Manufacturing plant design and synthesis process execution", "Independent models of metabolites, degradation products or related antidepressants", "Commercial suppliers and distribution organisations" ], "distinguishing_features": [ "The given sense denotes both cis-trans isomers rather than selecting a single configuration or assuming a mixture of fixed composition.", "The shared sulfur-containing dibenzothiepin structure and dimethylaminopropylidene side chain distinguish the pair from other tricyclic compounds.", "The free-base formula C19H21NS differs from the hydrochloride formula C19H22ClNS, so salt identity must be explicit when comparing properties.", "Molecular formula alone cannot distinguish the geometric isomers, and an individual Z-dothiepin record does not represent the whole pair.", "A dosulepin medicine record describes its declared ingredient and formulation rather than establishing the identity or properties of both isomers." ], "characteristics": [ { "name": "Resolved chemical identity", "kind": "relation", "unit_or_values": "Registry id linked to verified name, structure, CAS number, PubChem CID and EC number where established", "why_it_matters": "Prevents synonym duplication and the attachment of salt-specific evidence to the wrong chemical entity." }, { "name": "Material form", "kind": "category", "unit_or_values": "Free base; hydrochloride; other evidenced salt; mixture; unresolved", "why_it_matters": "Controls interpretation of composition, assay, physical properties and mass equivalence." }, { "name": "Geometric configuration", "kind": "category", "unit_or_values": "E; Z; measured mixture; unspecified", "why_it_matters": "A formula or generic name does not uniquely establish the configuration represented by a sample." }, { "name": "Dothiepin content", "kind": "measurement", "unit_or_values": "% w/w or mg/g, with free-base or salt basis and as-is, dried or anhydrous basis", "why_it_matters": "Makes assay comparisons and substance-equivalent calculations interpretable." }, { "name": "Related-substance profile", "kind": "measurement", "unit_or_values": "Individual and total impurities in % or mg/kg, with method and quantification limits", "why_it_matters": "Distinguishes usable material from contaminated, degraded or insufficiently characterised material." }, { "name": "Physical condition", "kind": "state", "unit_or_values": "Observed phase, appearance and solid-form assignment at recorded temperature and pressure", "why_it_matters": "Supports comparison with form-specific specifications and detection of material changes." }, { "name": "Thermal behaviour", "kind": "measurement", "unit_or_values": "Melting, transition or decomposition temperature in °C; boiling temperature only with pressure and evidence", "why_it_matters": "Avoids applying a thermal constant from another salt, form or measurement condition." }, { "name": "Solubility", "kind": "measurement", "unit_or_values": "mg/mL or mol/L with solvent, pH, temperature and material form", "why_it_matters": "Supports preparation and analytical work without assuming that free base and hydrochloride behave identically." }, { "name": "Grade and disposition", "kind": "state", "unit_or_values": "Documented grade and intended use; pending assessment; released; quarantined; rejected", "why_it_matters": "A chemical identity match alone does not qualify a batch for an intended use." }, { "name": "Applicable hazard and regulatory evidence", "kind": "relation", "unit_or_values": "Dated SDS, classification, exposure-limit source and jurisdiction-specific authority record", "why_it_matters": "Makes restrictions traceable to the actual form, activity and jurisdiction." } ], "affordances": [ "Resolve dothiepin and dosulepin references to the registered substance while flagging ambiguous salt or configuration assignments.", "Compare a batch with an evidenced specification and identify missing tests before release.", "Calculate free-base-equivalent content when salt stoichiometry, water content and assay basis are established.", "Select analytical and storage conditions supported for the identified material form.", "Flag degradation, impurity or identity discrepancies for quarantine and investigation.", "Route medicinal-use questions to a linked product or clinical model with the relevant substance constraints." ], "agent_conduct": { "may": [ "Explain what dosulepin is and its approved uses, citing official product information.", "Report documented safety warnings, including the risk in overdose." ], "must_not": [ "Prescribe, start, stop or change doses of dosulepin for a person.", "Provide any information that helps a person use it to harm themselves or others.", "Recommend combining it with other substances.", "Ignore signs that a person may be at risk of suicide." ], "requires_human": [ "Any treatment decision, made by the prescriber.", "Responding to a person in crisis, which needs urgent human and emergency support." ] }, "ethics": { "considerations": [ "Antidepressants help many people, yet this one is dangerous in overdose, so care is essential.", "People with depression deserve treatment without stigma." ], "affected_parties": [ "People with depression", "Families", "Prescribers" ] }, "owners": { "steward": "Chemical data curators maintain records of the isomer pair, while material custodians are responsible for records of particular samples.", "master_systems": [ "Chemical identity registries distinguish the isomer pair from individual isomers and salt forms.", "Material composition records document the isomer composition of particular samples.", "Medicines regulator product registers provide related medicinal context rather than defining the isomer pair." ] }, "visual_identification": [ "Appearance alone cannot distinguish the cis-trans isomers or establish their proportions in a material.", "Medicine packaging and imprints identify a labelled product but do not establish the chemical identity or composition of the isomer pair." ], "failure_modes_and_hazards": [ "Attributing medicinal dosulepin properties to both isomers without supporting evidence can misrepresent their hazards.", "Medicinal dosulepin overdose can cause life-threatening heart rhythm problems and seizures.", "Medicinal dosulepin side effects include drowsiness that can impair driving." ], "what_it_is_for": [ "This substance is encountered in pharmaceutical reference materials, analytical laboratories and medicinal products containing its hydrochloride salt.", "Material identification distinguishes the stated isomer composition and salt form because a substance name alone does not establish the composition of a sample." ], "standards_and_regulation": [ "The Anatomical Therapeutic Chemical classification maintained by the WHO Collaborating Centre for Drug Statistics Methodology lists dosulepin under code N06AA16." ] }, "sources": [ { "id": "wikidata", "title": "Wikidata item Q27116967: dothiepin", "url": "https://www.wikidata.org/wiki/Q27116967", "url_status": "live", "what_it_supports": "identity and sense of the item", "checked_by": "wikidata-api" }, { "id": "wikipedia-en", "title": "Wikipedia: Dosulepin", "url": "https://en.wikipedia.org/wiki/Dosulepin", "url_status": "live", "what_it_supports": "general description of the item", "checked_by": "wikidata-api sitelink" } ], "structure": { "bundles": [ { "id": "dothiepin-identity", "name": "Dothiepin identity", "description": "Establish which chemical entity a dothiepin reference or sample represents.", "rationale": "Name equivalence, salt form and geometric configuration must be resolved before other evidence can be applied.", "layers": [ { "id": "names-and-identifiers", "name": "Names and identifiers", "description": "Reconcile registry identity with external chemical records.", "findings": [ { "id": "dosulepin-name-resolution", "name": "Dosulepin name resolution", "description": "Record evidence linking dothiepin and dosulepin while preserving the exact chemical scope of each external identifier.", "questions": [ { "text": "Which authoritative record establishes that the encountered dothiepin or dosulepin name denotes this registered substance?", "kind": "definition", "id": "dosulepin-name-resolution-q01" }, { "text": "Do the proposed CAS number, PubChem CID and EC number identify the same structure, configuration and salt status?", "kind": "provenance", "id": "dosulepin-name-resolution-q02" } ] } ] }, { "id": "structure-and-form-boundaries", "name": "Structure and form boundaries", "description": "Distinguish molecular configuration and protonation or salt form.", "findings": [ { "id": "configuration-and-salt-assignment", "name": "Configuration and salt assignment", "description": "Require explicit form and configuration assignments rather than inferring them from the generic name.", "questions": [ { "text": "Does structural evidence identify E-dothiepin, Z-dothiepin, a mixture or an unspecified configuration?", "kind": "measurement", "id": "configuration-and-salt-assignment-q01" }, { "text": "Is the material free base or hydrochloride, and what evidence establishes counterion identity and stoichiometry?", "kind": "boundary", "id": "configuration-and-salt-assignment-q02" }, { "text": "Does this form belong as a qualified material record under vr.tr.dothiepin or link to an already registered neighbouring entity?", "kind": "boundary", "id": "configuration-and-salt-assignment-q03" } ] } ] } ] }, { "id": "dothiepin-composition-and-quality", "name": "Dothiepin composition and quality", "description": "Describe how much identified dothiepin is present and what accompanies it.", "rationale": "Salt basis, geometric composition and related substances affect whether a sample meets its intended specification.", "layers": [ { "id": "assay-and-equivalence", "name": "Assay and equivalence", "description": "Make the reported content and its calculation basis explicit.", "findings": [ { "id": "interpretable-dothiepin-content", "name": "Interpretable dothiepin content", "description": "Attach each assay to an analytical method, reference standard and declared free-base or salt basis.", "questions": [ { "text": "What dothiepin content was measured, by which method and against which qualified reference standard?", "kind": "measurement", "id": "interpretable-dothiepin-content-q01" }, { "text": "Is the result expressed as free base or hydrochloride, and on an as-is, dried or anhydrous basis?", "kind": "definition", "id": "interpretable-dothiepin-content-q02" }, { "text": "Are composition and water-content data sufficient to calculate a defensible free-base-equivalent amount?", "kind": "action", "id": "interpretable-dothiepin-content-q03" } ] } ] }, { "id": "impurities-and-grade", "name": "Impurities and grade", "description": "Assess material quality against a stated use and specification.", "findings": [ { "id": "related-substance-qualification", "name": "Related-substance qualification", "description": "Record measured related substances, geometric-isomer content and other contaminants without assuming a universal impurity panel.", "questions": [ { "text": "Which related compounds, geometric isomers, residual solvents and other contaminants does the applicable specification require measuring?", "kind": "definition", "id": "related-substance-qualification-q01" }, { "text": "What results, detection limits and acceptance criteria support the declared dothiepin grade?", "kind": "measurement", "id": "related-substance-qualification-q02" }, { "text": "Should the batch be released, quarantined or rejected for its documented intended use?", "kind": "action", "id": "related-substance-qualification-q03" } ] } ] } ] }, { "id": "dothiepin-physical-state-and-stability", "name": "Dothiepin physical state and stability", "description": "Connect physical behaviour and stability evidence to the identified material form.", "rationale": "Properties attributed only to 'dothiepin' can conceal differences between free base, hydrochloride and particular samples.", "layers": [ { "id": "form-specific-properties", "name": "Form-specific properties", "description": "Record measured physical properties with sufficient experimental context.", "findings": [ { "id": "qualified-physical-constants", "name": "Qualified physical constants", "description": "Treat phase, thermal behaviour and solubility as conditional measurements rather than unqualified constants.", "questions": [ { "text": "Which phase and solid form were observed for the identified dothiepin material at the stated temperature and pressure?", "kind": "measurement", "id": "qualified-physical-constants-q01" }, { "text": "Does the reported thermal event represent melting, a solid-state transition or decomposition, and which form was tested?", "kind": "measurement", "id": "qualified-physical-constants-q02" }, { "text": "What solubility was measured for this form in the specified solvent, pH and temperature?", "kind": "measurement", "id": "qualified-physical-constants-q03" } ] } ] }, { "id": "storage-and-change", "name": "Storage and change", "description": "Determine whether storage history remains compatible with material quality.", "findings": [ { "id": "evidenced-stability-envelope", "name": "Evidenced stability envelope", "description": "Derive storage and retest decisions from relevant stability evidence, with observed changes kept distinct from proposed degradation mechanisms.", "questions": [ { "text": "Which studies establish temperature, light, moisture and container requirements for this dothiepin form and grade?", "kind": "provenance", "id": "evidenced-stability-envelope-q01" }, { "text": "Have storage excursions changed assay, impurity profile, appearance or physical form?", "kind": "measurement", "id": "evidenced-stability-envelope-q02" }, { "text": "What evidence supports continued use, retesting or rejection after an excursion or elapsed retest date?", "kind": "action", "id": "evidenced-stability-envelope-q03" } ] } ] } ] }, { "id": "dothiepin-biological-and-hazard-context", "name": "Dothiepin biological and hazard context", "description": "Connect substance-level biological activity and toxicity evidence to appropriate handling decisions.", "rationale": "Dothiepin is pharmacologically active, and clinical toxicity information must be interpreted alongside material-specific occupational evidence.", "layers": [ { "id": "activity-and-analyte-boundaries", "name": "Activity and analyte boundaries", "description": "Identify the scope and subject of pharmacological or analytical evidence.", "findings": [ { "id": "parent-and-metabolite-separation", "name": "Parent and metabolite separation", "description": "Keep parent-substance observations distinct from metabolite and formulation observations; product information identifies metabolites including northiaden and dosulepin-S-oxide. [Product information](https://www.medicines.org.uk/emc/product/101606/smpc)", "questions": [ { "text": "Does the cited activity or toxicity result concern parent dothiepin, a salt preparation, a metabolite or a finished medicine?", "kind": "boundary", "id": "parent-and-metabolite-separation-q01" }, { "text": "Can the analytical method distinguish parent dothiepin from the metabolites or related substances relevant to the sample?", "kind": "measurement", "id": "parent-and-metabolite-separation-q02" } ] } ] }, { "id": "toxicity-and-exposure-controls", "name": "Toxicity and exposure controls", "description": "Identify applicable toxicity evidence and justified controls for the actual activity.", "findings": [ { "id": "context-specific-hazard-assessment", "name": "Context-specific hazard assessment", "description": "A reviewed UK product label highlights overdose toxicity; bulk handling still requires its own relevant hazard and exposure evidence. [Product information](https://www.medicines.org.uk/emc/product/14303/smpc)", "questions": [ { "text": "Which current SDS and classification sources apply to the actual dothiepin form and composition?", "kind": "provenance", "id": "context-specific-hazard-assessment-q01" }, { "text": "Is an authoritative occupational exposure limit available, and what route, averaging period and jurisdiction does it cover?", "kind": "measurement", "id": "context-specific-hazard-assessment-q02" }, { "text": "Which containment, protective equipment and spill-response measures are justified for the planned quantity and operation?", "kind": "action", "id": "context-specific-hazard-assessment-q03" } ] } ] } ] }, { "id": "dothiepin-use-eligibility", "name": "Dothiepin use eligibility", "description": "Determine whether a documented batch can enter a proposed use under applicable requirements.", "rationale": "Chemical identity and historical medicinal use do not establish present authorisation or batch suitability.", "layers": [ { "id": "jurisdiction-and-use", "name": "Jurisdiction and use", "description": "Resolve requirements for the proposed substance activity.", "findings": [ { "id": "dated-authority-and-product-links", "name": "Dated authority and product links", "description": "Attach regulatory conclusions to a jurisdiction, date, material form and intended activity, linking finished medicines to their own records.", "questions": [ { "text": "Which dated authority records govern the proposed manufacture, import, supply or research use of this dothiepin material?", "kind": "provenance", "id": "dated-authority-and-product-links-q01" }, { "text": "Does the evidence authorise a particular hydrochloride medicinal product, a substance activity or both?", "kind": "boundary", "id": "dated-authority-and-product-links-q02" }, { "text": "Which unresolved requirement prevents the proposed use from proceeding?", "kind": "action", "id": "dated-authority-and-product-links-q03" } ] } ] }, { "id": "batch-disposition-evidence", "name": "Batch disposition evidence", "description": "Combine identity, quality and storage records into a traceable use decision.", "findings": [ { "id": "qualified-material-release", "name": "Qualified material release", "description": "Require evidence appropriate to the intended dothiepin use before recording a batch as suitable.", "questions": [ { "text": "Can the material be traced to a supplier lot, certificate of analysis and relevant receipt or storage records?", "kind": "provenance", "id": "qualified-material-release-q01" }, { "text": "Do identity, assay, impurity and stability records satisfy the specification for the proposed use?", "kind": "action", "id": "qualified-material-release-q02" }, { "text": "Which missing evidence or failed criterion requires quarantine, rejection or further assessment?", "kind": "action", "id": "qualified-material-release-q03" } ] } ] } ] }, { "id": "evidence-and-external-alignment", "name": "Evidence and external alignment", "description": "What the world already says about this thing, gathered so the model can be checked against it.", "rationale": "A model that cannot be lined up against existing standards, identifiers and practice cannot be adopted by anyone who already uses them.", "layers": [ { "id": "reported-evidence", "name": "Reported evidence", "description": "Findings from the breadth pass, kept separate from the structural claims.", "findings": [ { "id": "evidence-confidence-notes", "name": "Check these first", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "This is recalled knowledge; no sources were consulted.", "Verify registry identifiers separately for the free base and hydrochloride salt, including any stereochemical qualifications.", "Current national authorisations, prescribing restrictions, pharmacopoeial requirements and physical-property measurements require verification." ], "questions": [ { "id": "evidence-confidence-notes-q01", "text": "Which of these check these first hold for the sense of dothiepin this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-kinds", "name": "Kinds and varieties", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "Dothiepin free base", "Dothiepin hydrochloride" ], "questions": [ { "id": "evidence-kinds-q01", "text": "Which of these kinds and varieties hold for the sense of dothiepin this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-identifiers", "name": "Identifiers and schemes", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ { "scheme": "International Nonproprietary Name (INN)", "value_or_pattern": "dosulepin", "note": "Names the same active substance as dothiepin." }, { "scheme": "British Approved Name (historical)", "value_or_pattern": "dothiepin", "note": "Older name encountered in prescribing records and pharmaceutical literature." }, { "scheme": "Molecular formula", "value_or_pattern": "C19H21NS", "note": "Free base; the hydrochloride salt has a different formula and molar mass." } ], "questions": [ { "id": "evidence-identifiers-q01", "text": "Which of these identifiers and schemes hold for the sense of dothiepin this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-real-world-use", "name": "Real-world use", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "Treatment of depressive illness in jurisdictions where medicinal products containing it are authorised.", "Historically used for depression accompanied by anxiety." ], "questions": [ { "id": "evidence-real-world-use-q01", "text": "Which of these real-world use hold for the sense of dothiepin this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-measurements", "name": "Typical measurements", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ { "quantity": "Molar mass of free base", "typical_range": "295.44", "unit": "g/mol" }, { "quantity": "Molar mass of anhydrous hydrochloride salt", "typical_range": "331.90", "unit": "g/mol" } ], "questions": [ { "id": "evidence-measurements-q01", "text": "Which of these typical measurements hold for the sense of dothiepin this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-failure-modes-and-hazards", "name": "Failure modes and hazards", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "Overdose can cause life-threatening cardiac conduction disturbances, arrhythmias, seizures and coma.", "Anticholinergic effects include dry mouth, constipation, blurred vision and urinary retention.", "Sedation and impaired alertness can affect driving and machinery operation.", "Orthostatic hypotension can contribute to dizziness and falls.", "Interactions with monoamine oxidase inhibitors and other serotonergic medicines can cause serious toxicity." ], "questions": [ { "id": "evidence-failure-modes-and-hazards-q01", "text": "Which of these failure modes and hazards hold for the sense of dothiepin this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-regional-variation", "name": "Regional variation", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "Dothiepin and dosulepin occur as alternative names in national and historical medicine records.", "Marketing authorisation, availability and prescribing restrictions differ between jurisdictions." ], "questions": [ { "id": "evidence-regional-variation-q01", "text": "Which of these regional variation hold for the sense of dothiepin this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-neighbours", "name": "Neighbouring kinds and how to tell them apart", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ { "name": "Dothiepin hydrochloride", "difference": "The hydrochloride is a salt of dothiepin; distinguish salt mass and composition from those of the free base." }, { "name": "Dosulepin", "difference": "An alternative name for the same substance, not a separate chemical entity." }, { "name": "Amitriptyline", "difference": "A related tricyclic antidepressant whose central ring lacks the sulfur atom present in dothiepin." }, { "name": "Dothiepin-containing medicinal product", "difference": "A formulated dosage form includes a specified amount of active ingredient and excipients; it is not the isolated substance." } ], "questions": [ { "id": "evidence-neighbours-q01", "text": "Which of these neighbouring kinds and how to tell them apart hold for the sense of dothiepin this model covers, and on what evidence?", "kind": "provenance" } ] } ] } ] } ] }, "openQuestions": [ "Does the authoritative registry intend vr.tr.dothiepin to specify a particular geometric configuration or a broader parent-substance identity, and is there an existing world model to reuse?", "Which CAS and EC identifiers are verified for the intended configuration and free-base or hydrochloride form, and which identifiers are ambiguous?", "Which current compendial or otherwise qualified specifications establish assay methods, related-substance panels, isomer limits and grade requirements?", "What measured phase, melting or decomposition, solubility and storage-stability data are available for each relevant form, and is any boiling-point value experimentally meaningful?", "Which current jurisdiction-specific hazard classifications, occupational exposure limits and use restrictions apply to the actual material and proposed activity?" ], "statistics": { "bundles": 6, "layers": 11, "findings": 18, "questions": 36 } }