{ "vercy": "1.0-draft", "publication": { "status": "research-draft", "adjudicationStatus": "unreviewed", "publishableCanonical": false, "generatedAt": "2026-09-07T10:23:50Z", "providers": [ "Codex", "Grok" ], "missingProviders": [], "pass": 2, "cost": { "grok": { "usd": 0.00233478, "turns": 1, "seconds": 22.7, "error": null }, "codex": { "seconds": 91.0, "error": "Reading additional input from stdin...\nOpenAI Codex v0.153.3\n--------\nworkdir: R:\\02_PROJECTS\\02_Meta_Models_Platforms\\Ver.cy\\current\\thing-registry-backlog\nmodel: gpt-6-astra\nprovider: openai\napproval: never\nsandbox: read-only\nreasoning effort: none\nreasoning summaries: none\nsession id: 01a07b63-e7b9-71b0-bf4c-2a3056d6a189\n--------\nuser\nYou are drafting a Vercy meta-model for one registered thing. Answer as JSON only, no prose around it.\n\nThing: (−)-nicotine\nRegistry id: vr.tr.nicotine\nPlane / domain: PHY / PHY.MAT\nRegistry definition: (none recorded)\nNames folded into this entry: (none)\n\nA V" } }, "enrichment": { "pass": 3, "engine": "claude", "producedAt": "2026-10-06T11:00:00Z", "ingestedAt": "2026-10-06T08:14:57+00:00", "fields": [ "agent_conduct", "ethics", "failure_modes_and_hazards", "owners", "standards_and_regulation", "visual_identification" ] }, "gate": { "passed": true, "version": "1.0", "at": "2026-10-07T10:10:29+00:00", "evidence": [ "completeness 1.00", "sense: Wikidata description", "2 live sources", "review by codex: pass" ] } }, "metaModel": { "id": "THING-Q28086552", "registryId": "vr.tr.nicotine", "name": "(−)-nicotine", "version": "0.1.0-research.1", "entryKind": "thing", "family": "Thing Registry", "domain": [ "PHY.MAT" ], "status": "research-draft" }, "canonicalUrl": "https://ver.cy/models/thing/q28086552/", "model": { "registry_id": "vr.tr.nicotine", "name": "(−)-nicotine", "purpose": "Enable an AI agent to identify (−)-nicotine, assess the identity and condition of material containing it, and determine whether a proposed handling or use is supported by evidence.", "definition": "The naturally occurring (S)-enantiomer of nicotine, a pyridine-pyrrolidine alkaloid that is the principal psychoactive constituent of Nicotiana species and a high-affinity agonist of nicotinic acetylcholine receptors.", "scope_statement": "This model owns the stereospecific substance identity of (−)-nicotine under vr.tr.nicotine and the evidence needed to assess its presence, chemical form, quantity, condition and handling constraints in a particular material.", "in_scope": [ "Stereochemical identity and discrimination from other nicotine compositions", "Free-base identity and relations to protonated nicotine, salts and mixtures", "Nicotine assay, enantiomeric composition and relevant impurities", "Material condition, storage history and analytical evidence of change", "Substance-specific handling constraints and suitability for a declared use" ], "out_of_scope": [ "Tobacco plants, cultivation and whole-leaf composition", "Complete formulations and delivery performance of nicotine-containing products", "Patient treatment, dosing, dependence and clinical outcomes", "Detailed synthesis, extraction and purification processes", "Complete models of nicotine salts, metabolites and other alkaloids", "Facility-wide chemical safety and waste-management systems" ], "distinguishing_features": [ "Require evidence for the S-configured nicotine structure, rather than accepting an unspecified nicotine label: PubChem identifies (−)-nicotine with (S)-3-(1-methylpyrrolidin-2-yl)pyridine. [PubChem](https://pubchem.ncbi.nlm.nih.gov/compound/L-Nicotine)", "Use an enantioselective measurement to distinguish S-enriched nicotine from R-nicotine and racemic nicotine; a total-nicotine assay alone does not establish the claimed stereochemical composition.", "Check protonation, counterions and composition to distinguish neat free-base material from a nicotine salt or nicotine-containing solution.", "Require analytical discrimination from related alkaloids and transformation products; a product name, colour or nominal molecular mass alone is insufficient.", "Treat optical rotation as condition-dependent supporting evidence, recording wavelength, temperature, solvent and concentration before comparing results." ], "characteristics": [ { "name": "Stereospecific identity confidence", "kind": "state", "unit_or_values": "claimed | supported | conflicting | unresolved", "why_it_matters": "Determines whether the material can be identified specifically as (−)-nicotine." }, { "name": "Nicotine enantiomer composition", "kind": "measurement", "unit_or_values": "S and R mole fractions or percentages, with method and uncertainty", "why_it_matters": "Separates stereochemical purity from overall chemical purity." }, { "name": "Chemical presentation", "kind": "category", "unit_or_values": "free base | protonated species in solution | identified salt | mixed | unresolved", "why_it_matters": "Prevents treating every nicotine-bearing material as neat free-base nicotine." }, { "name": "Counterion or host matrix", "kind": "relation", "unit_or_values": "identified counterion, solvent, formulation or biological matrix", "why_it_matters": "Provides context for interpreting assay, speciation and handling evidence." }, { "name": "Nicotine content", "kind": "measurement", "unit_or_values": "mg, mg/g, mg/mL or mol/L, explicitly stating total nicotine versus S-nicotine and free-base-equivalent versus salt basis", "why_it_matters": "Prevents incompatible quantities from being compared or substituted." }, { "name": "Optical rotation", "kind": "measurement", "unit_or_values": "observed degrees or specific rotation with convention, wavelength, temperature, solvent and concentration", "why_it_matters": "Supports stereochemical assessment only when measurement conditions are interpretable." }, { "name": "Solution acidity and nicotine speciation", "kind": "measurement", "unit_or_values": "pH where applicable; estimated or measured species fractions with medium, temperature and method", "why_it_matters": "Connects the nicotine moiety to its actual chemical state in the material." }, { "name": "Impurity and transformation-product profile", "kind": "measurement", "unit_or_values": "identified substances and concentrations, reporting limits and unresolved analytical signals", "why_it_matters": "Supports decisions about contamination, deterioration and fitness for use." }, { "name": "Storage and exposure history", "kind": "relation", "unit_or_values": "dated temperature, light, air, moisture, container and opening records", "why_it_matters": "Allows current analytical results to be interpreted against the material's history." }, { "name": "Disposition for intended use", "kind": "state", "unit_or_values": "unassessed | accepted for specified use | restricted | quarantined | rejected", "why_it_matters": "Makes acceptance conditional on a declared use, supporting evidence and applicable requirements." } ], "affordances": [ "Resolve a nicotine identity claim against structural and stereochemical evidence.", "Request and interpret assays that distinguish total nicotine, S-nicotine and relevant impurities.", "Compare nicotine quantities after verifying chemical form and reporting basis.", "Link the substance to a salt, formulation or sample without conflating their identities.", "Assess whether storage history or analytical changes require retesting or quarantine.", "Route proposed handling, transfer or disposal through applicable substance-specific controls." ], "agent_conduct": { "may": [ "Describe nicotine's effects, risks and regulation from health sources.", "Direct people to cessation support services." ], "must_not": [ "Provide guidance on extracting, concentrating or mixing nicotine.", "Market or recommend nicotine products to minors.", "Claim nicotine products are harmless.", "Advise on dosing nicotine replacement without health guidance." ], "requires_human": [ "Recommending a cessation treatment plan." ] }, "ethics": { "considerations": [ "Nicotine is highly addictive, and the tobacco industry targeted young people.", "Concentrated liquids can poison children." ], "affected_parties": [ "Children", "Smokers and vapers", "Families" ] }, "owners": { "steward": "Producers of nicotine products; health authorities regulate them.", "master_systems": [] }, "visual_identification": [ "A colourless to pale yellow oily liquid that browns in air.", "Present in tobacco and labelled e-liquids." ], "failure_modes_and_hazards": [ "Poisoning, especially of children, from concentrated liquids.", "Addiction." ], "standards_and_regulation": [ "WHO Framework Convention on Tobacco Control, World Health Organization." ], "what_it_is_for": [ "Naturally occurring (S)-nicotine is encountered in tobacco plants, tobacco-derived materials and products containing nicotine.", "It is also used in pharmacological research and nicotine replacement medicines, where chemical identity, purity and formulation determine the material's intended role." ] }, "sources": [ { "id": "wikidata", "title": "Wikidata item Q28086552: (−)-nicotine", "url": "https://www.wikidata.org/wiki/Q28086552", "url_status": "live", "what_it_supports": "identity and sense of the item", "checked_by": "wikidata-api" }, { "id": "wikipedia-en", "title": "Wikipedia: Nicotine", "url": "https://en.wikipedia.org/wiki/Nicotine", "url_status": "live", "what_it_supports": "general description of the item", "checked_by": "wikidata-api sitelink" } ], "structure": { "bundles": [ { "id": "nicotine-stereochemical-identity", "name": "Nicotine stereochemical identity", "description": "Establishes whether the evidence identifies the registered S-configured nicotine substance.", "rationale": "The minus sign carries identity information that generic nicotine records can omit.", "layers": [ { "id": "molecular-identity", "name": "Molecular identity", "description": "Connects the name to an explicitly stereochemical molecular identity.", "findings": [ { "id": "structure-and-identifier-agreement", "name": "Structure and identifier agreement", "description": "Record whether structural evidence and identifiers consistently designate (−)-nicotine.", "questions": [ { "text": "Does the assigned structure explicitly specify S configuration at nicotine's stereogenic centre?", "kind": "definition", "id": "structure-and-identifier-agreement-q01" }, { "text": "Which authoritative identity record and sample-specific evidence support that assignment?", "kind": "provenance", "id": "structure-and-identifier-agreement-q02" } ] } ] }, { "id": "enantiomer-discrimination", "name": "Enantiomer discrimination", "description": "Separates verified stereochemical composition from an unqualified nicotine assay.", "findings": [ { "id": "s-and-r-composition", "name": "S and R composition", "description": "Record the measured enantiomer proportions and the limitations of supporting evidence.", "questions": [ { "text": "What S and R proportions were measured, by which enantioselective method and with what detection limits?", "kind": "measurement", "id": "s-and-r-composition-q01" }, { "text": "If optical rotation supports identification, are its conditions and reference comparison recorded?", "kind": "measurement", "id": "s-and-r-composition-q02" }, { "text": "What use-specific acceptance rule distinguishes acceptable S-enriched material from an unresolved or mixed-enantiomer sample?", "kind": "boundary", "id": "s-and-r-composition-q03" } ] } ] } ] }, { "id": "nicotine-form-and-matrix", "name": "Nicotine form and matrix", "description": "Locates the nicotine identity within its actual chemical presentation.", "rationale": "Free base, protonated nicotine and nicotine-bearing mixtures require different interpretations of the same nicotine claim.", "layers": [ { "id": "protonation-and-counterions", "name": "Protonation and counterions", "description": "Records evidence for the material's nicotine species and salt relationships.", "findings": [ { "id": "chemical-form-assignment", "name": "Chemical form assignment", "description": "Keep free-base identity distinct from the identity of a complete salt or solution.", "questions": [ { "text": "Is nicotine present as free base, protonated species or a mixture, and what establishes this?", "kind": "definition", "id": "chemical-form-assignment-q01" }, { "text": "Where a salt is claimed, which counterion and stoichiometry are established, and which neighbouring model owns the complete salt?", "kind": "boundary", "id": "chemical-form-assignment-q02" } ] } ] }, { "id": "matrix-dependent-state", "name": "Matrix-dependent state", "description": "Records the medium needed to interpret nicotine's state in a sample.", "findings": [ { "id": "medium-and-speciation-evidence", "name": "Medium and speciation evidence", "description": "Attach solvent, acidity and temperature context to claims about nicotine species.", "questions": [ { "text": "What solvent or host matrix contains the nicotine, and is its composition adequately known?", "kind": "provenance", "id": "medium-and-speciation-evidence-q01" }, { "text": "Which measured conditions and validated assumptions support any reported unprotonated fraction?", "kind": "measurement", "id": "medium-and-speciation-evidence-q02" } ] } ] } ] }, { "id": "nicotine-assay-and-composition", "name": "Nicotine assay and composition", "description": "Determines how much relevant nicotine is present and what accompanies it.", "rationale": "A concentration without stereochemical and chemical-form basis can misrepresent the registered substance.", "layers": [ { "id": "quantity-basis", "name": "Quantity basis", "description": "Makes nicotine measurements comparable without silently changing their meaning.", "findings": [ { "id": "assay-meaning-and-conversion", "name": "Assay meaning and conversion", "description": "Record the analyte, denominator and conversion basis of every nicotine quantity.", "questions": [ { "text": "Does the reported value quantify total nicotine, S-nicotine, free-base-equivalent nicotine or the mass of a complete salt?", "kind": "measurement", "id": "assay-meaning-and-conversion-q01" }, { "text": "Are concentration basis, uncertainty and any density or stoichiometry needed for conversion available?", "kind": "measurement", "id": "assay-meaning-and-conversion-q02" } ] } ] }, { "id": "analytical-selectivity", "name": "Analytical selectivity", "description": "Tests whether the analytical evidence separates nicotine from accompanying substances.", "findings": [ { "id": "impurities-and-assay-interference", "name": "Impurities and assay interference", "description": "Record relevant impurities, unresolved signals and limitations of the nicotine assay.", "questions": [ { "text": "Which related alkaloids, residual process materials or transformation products were sought and quantified?", "kind": "measurement", "id": "impurities-and-assay-interference-q01" }, { "text": "What demonstrates that matrix effects or unresolved compounds do not invalidate the reported nicotine result?", "kind": "provenance", "id": "impurities-and-assay-interference-q02" } ] } ] } ] }, { "id": "nicotine-condition-and-history", "name": "Nicotine condition and history", "description": "Connects present composition to production, storage and subsequent changes.", "rationale": "Neither an origin claim nor an old certificate establishes the current condition of a nicotine sample.", "layers": [ { "id": "origin-and-lot-continuity", "name": "Origin and lot continuity", "description": "Separates material provenance from chemical identity and preserves sample traceability.", "findings": [ { "id": "origin-claim-evidence", "name": "Origin claim evidence", "description": "Record extraction or synthesis claims without using them as substitutes for stereochemical measurement.", "questions": [ { "text": "What evidence supports the claimed nicotine origin and connects the tested sample to the supplied lot?", "kind": "provenance", "id": "origin-claim-evidence-q01" }, { "text": "Is origin relevant to the intended use, and has it been kept separate from proof of S configuration and purity?", "kind": "boundary", "id": "origin-claim-evidence-q02" } ] } ] }, { "id": "change-during-storage", "name": "Change during storage", "description": "Assesses whether the material remains supported by its existing qualification evidence.", "findings": [ { "id": "condition-change-and-retest", "name": "Condition change and retest", "description": "Compare exposure history and current measurements with a documented baseline.", "questions": [ { "text": "What air, light, moisture, temperature and container exposures occurred after the last qualifying assay?", "kind": "provenance", "id": "condition-change-and-retest-q01" }, { "text": "Have nicotine assay, impurity profile or physical observations changed relative to the baseline?", "kind": "measurement", "id": "condition-change-and-retest-q02" }, { "text": "Which evidence-based criterion requires retesting, quarantine or rejection?", "kind": "action", "id": "condition-change-and-retest-q03" } ] } ] } ] }, { "id": "nicotine-handling-and-use-decisions", "name": "Nicotine handling and use decisions", "description": "Connects the assessed material to a specific proposed operation and its applicable controls.", "rationale": "Nicotine can be absorbed through skin and presents serious toxicity hazards, making exposure context relevant to handling decisions. [CDC/NIOSH](https://www.cdc.gov/niosh/ershdb/emergencyresponsecard_29750028.html)", "layers": [ { "id": "exposure-context", "name": "Exposure context", "description": "Identifies how the proposed operation could expose people to the actual nicotine-bearing material.", "findings": [ { "id": "operation-specific-controls", "name": "Operation-specific controls", "description": "Use the material's concentration, form and operation to identify applicable handling requirements.", "questions": [ { "text": "What nicotine quantity, concentration, matrix and potential exposure routes are involved in the proposed operation?", "kind": "measurement", "id": "operation-specific-controls-q01" }, { "text": "Which current safety data and approved procedure establish the required containment, protective equipment and incident response?", "kind": "action", "id": "operation-specific-controls-q02" } ] } ] }, { "id": "use-specific-disposition", "name": "Use-specific disposition", "description": "Makes acceptance or restriction explicit for a named purpose.", "findings": [ { "id": "qualification-and-permitted-next-step", "name": "Qualification and permitted next step", "description": "Record the evidence and authority supporting analysis, use, transfer, continued storage or disposal.", "questions": [ { "text": "Which identity, enantiomeric composition, assay and impurity requirements apply to the declared use?", "kind": "boundary", "id": "qualification-and-permitted-next-step-q01" }, { "text": "Do the available results and applicable jurisdictional requirements support the proposed action, or require restriction or further review?", "kind": "action", "id": "qualification-and-permitted-next-step-q02" } ] } ] } ] }, { "id": "evidence-and-external-alignment", "name": "Evidence and external alignment", "description": "What the world already says about this thing, gathered so the model can be checked against it.", "rationale": "A model that cannot be lined up against existing standards, identifiers and practice cannot be adopted by anyone who already uses them.", "layers": [ { "id": "reported-evidence", "name": "Reported evidence", "description": "Findings from the breadth pass, kept separate from the structural claims.", "findings": [ { "id": "evidence-kinds", "name": "Kinds and varieties", "description": "Reported by the breadth pass; each item needs checking against its source before it becomes normative.", "evidence": [ "tobacco-leaf alkaloid", "pharmaceutical nicotine (NRT)", "e-liquid / vaping nicotine", "synthetic (S)-nicotine", "nicotine salt", "pesticide-grade nicotine" ], "questions": [ { "id": "evidence-kinds-q01", "text": "Which of these kinds and varieties hold for the sense of (−)-nicotine this model covers, and on what evidence?", "kind": "provenance" } ] } ] } ] } ] }, "openQuestions": [ "Does the registry intend this entry to own only neutral (S)-nicotine, or also nicotine-moiety records within protonated forms and salts?", "What enantiomeric acceptance thresholds and analytical methods are appropriate for each intended use?", "Which impurity and transformation-product panels are required for the relevant origins, matrices and grades?", "What validated storage, container-compatibility and retest criteria apply to each material presentation?", "Which jurisdiction, product category and operational setting determine the applicable handling, transfer and disposal requirements?" ], "statistics": { "bundles": 6, "layers": 11, "findings": 11, "questions": 23 } }