{ "vercy": "1.0-draft", "publication": { "status": "research-draft", "adjudicationStatus": "unreviewed", "publishableCanonical": false, "generatedAt": "2026-09-12T11:04:53Z", "providers": [ "Codex" ], "breadth": "recalled by Codex without web access - no source was read", "missingProviders": [], "pass": 2, "cost": { "grok": { "seconds": 20.0, "error": "Reading additional input from stdin...\nOpenAI Codex v0.153.4\n--------\nworkdir: R:\\02_PROJECTS\\02_Meta_Models_Platforms\\Ver.cy\\current\\thing-registry-backlog\nmodel: gpt-6-astra\nprovider: openai\napproval: never\nsandbox: read-only\nreasoning effort: none\nreasoning summaries: none\nsession id: 01a09549-95d8-7fb1-b92d-63d70e927455\n--------\nuser\nDescribe what is already known about one registered thing. Answer as JSON only, no prose around it.\n\nThing: m-chlorophenylpiperazine\nSense to describe: (none recorded)\nDomain code: PHY.MAT\nAlso known as: (none)\n\n\nContext for this batch of 1001 things:\n# Batch ", "usd": 0.0, "recall": true }, "codex": { "seconds": 71.3, "error": "Reading additional input from stdin...\nOpenAI Codex v0.153.4\n--------\nworkdir: R:\\02_PROJECTS\\02_Meta_Models_Platforms\\Ver.cy\\current\\thing-registry-backlog\nmodel: gpt-6-astra\nprovider: openai\napproval: never\nsandbox: read-only\nreasoning effort: none\nreasoning summaries: none\nsession id: 01a09549-95d4-7ce3-b550-afb9eb41c6bf\n--------\nuser\nYou are drafting a Vercy meta-model for one registered thing. Answer as JSON only, no prose around it.\n\nThing: m-chlorophenylpiperazine\nRegistry id: vr.tr.m-chlorophenylpiperazine\nPlane / domain: PHY / PHY.MAT\nRegistry definition: (none recorded)\nNames folded " } }, "enrichment": { "pass": 3, "engine": "claude", "producedAt": "2026-10-06T12:00:00Z", "ingestedAt": "2026-10-06T08:53:40+00:00", "fields": [ "agent_conduct", "ethics", "failure_modes_and_hazards", "owners", "visual_identification" ] }, "gate": { "passed": true, "version": "1.0", "at": "2026-10-07T10:10:29+00:00", "evidence": [ "completeness 1.00", "sense: Wikidata description", "2 live sources", "review by codex: pass" ] } }, "metaModel": { "id": "THING-Q286112", "registryId": "vr.tr.m-chlorophenylpiperazine", "name": "m-chlorophenylpiperazine", "version": "0.1.0-research.1", "entryKind": "thing", "family": "Thing Registry", "domain": [ "PHY.MAT" ], "status": "research-draft" }, "canonicalUrl": "https://ver.cy/models/thing/q286112/", "model": { "registry_id": "vr.tr.m-chlorophenylpiperazine", "name": "m-chlorophenylpiperazine", "purpose": "Enable an agent to identify m-chlorophenylpiperazine, assess the form and quality of a particular sample, and determine evidence-supported handling, analytical and research actions.", "definition": "m-Chlorophenylpiperazine (mCPP) is a synthetic arylpiperazine, specifically 1-(3-chlorophenyl)piperazine, that acts at several serotonin receptor subtypes and is also formed as a metabolite of trazodone and nefazodone.", "scope_statement": "This model owns the chemical identity of m-chlorophenylpiperazine (vr.tr.m-chlorophenylpiperazine; PHY / PHY.MAT), its material states and sample attributes, and the evidence needed to interpret its biological activity and permitted uses; salts are recorded as explicitly related forms without assuming that the registry folds them into this entry.", "in_scope": [ "Molecular identity, synonyms and differentiation from other chlorophenylpiperazine isomers", "Free-base identity and explicit relationships to protonated, salt and solvated forms", "Sample composition, purity, concentration and analytical identification", "Physical properties, stability and storage conditions for the specified material form", "Biological activity, metabolic provenance and limits of exposure interpretation", "Form-specific hazards and jurisdiction-specific restrictions on intended actions" ], "out_of_scope": [ "Finished tablets, mixtures and commercial products containing mCPP", "Complete models of trazodone and other precursor medicines", "Manufacturing routes and synthesis procedures", "Clinical diagnosis, prescribing and human dosing protocols", "Complete serotonin receptor and metabolic enzyme models", "General laboratory operations and waste-management systems" ], "distinguishing_features": [ "The phenyl-ring chlorine occupies the meta, or 3-, position relative to the piperazine attachment; ortho and para chlorophenylpiperazines require separate identification.", "The defining connectivity is 1-(3-chlorophenyl)piperazine, with the aryl group attached to a piperazine nitrogen. The free base has formula C10H13ClN2, CAS 6640-24-0 and PubChem CID 1355. [PubChem identity record](https://pubchem.ncbi.nlm.nih.gov/compound/1355)", "The abbreviation mCPP must resolve to meta-chlorophenylpiperazine rather than being interpreted as a methyl-substituted chlorophenylpiperazine.", "The hydrochloride is a related material form with its own composition and identifier, rather than an interchangeable free-base mass standard. [PubChem monohydrochloride record](https://pubchem.ncbi.nlm.nih.gov/compound/25681)", "Detection of mCPP does not alone establish direct consumption because it can occur as a trazodone metabolite. [PubChem biological-role description](https://pubchem.ncbi.nlm.nih.gov/compound/1355)" ], "characteristics": [ { "name": "Structural identity", "kind": "category", "unit_or_values": "1-(3-chlorophenyl)piperazine; structure identifier and source", "why_it_matters": "Prevents name-based confusion with positional isomers and other substituted piperazines." }, { "name": "Material form", "kind": "category", "unit_or_values": "Free base, identified salt, solvate, solution or unresolved form", "why_it_matters": "Determines which composition, property values and mass conversions apply." }, { "name": "Molar mass", "kind": "measurement", "unit_or_values": "g/mol; free base 196.67, with separate values for identified salts", "why_it_matters": "Supports amount-of-substance calculations only when matched to the material form. [PubChem molecular-weight record](https://pubchem.ncbi.nlm.nih.gov/compound/1355)" }, { "name": "Assay and impurity profile", "kind": "measurement", "unit_or_values": "Mass fraction or molar fraction; analytical area percentage recorded separately", "why_it_matters": "Distinguishes actual mCPP content from detector response and identifies relevant contaminants." }, { "name": "Solution concentration", "kind": "measurement", "unit_or_values": "mol/L or mg/mL; solvent and free-base-equivalent versus salt-mass basis", "why_it_matters": "Makes results comparable and prevents concentration errors caused by ambiguous labeling." }, { "name": "Physical state and transition data", "kind": "state", "unit_or_values": "Observed phase; temperature in °C; pressure in kPa; melting, boiling or decomposition event", "why_it_matters": "Prevents physical constants from being transferred between different forms or conditions." }, { "name": "Solubility and ionization", "kind": "measurement", "unit_or_values": "Solubility in g/L or mol/L; pKa; solvent, pH, temperature and method", "why_it_matters": "Supports interpretation of dissolution, extraction and assay behavior." }, { "name": "Analytical identification confidence", "kind": "state", "unit_or_values": "Unconfirmed, presumptive, confirmed or conflicting; methods and reference material", "why_it_matters": "Separates a candidate chemical match from evidence resolving the meta isomer." }, { "name": "Biological activity evidence", "kind": "relation", "unit_or_values": "Target, species, assay, endpoint, concentration and supporting study", "why_it_matters": "Keeps receptor binding, functional activity and organism-level effects distinct." }, { "name": "Occurrence and metabolic provenance", "kind": "relation", "unit_or_values": "Sample matrix, collection time, precursor-drug evidence and provenance confidence", "why_it_matters": "Supports interpretation of mCPP detected in biological or manufactured samples." }, { "name": "Hazard and regulatory status", "kind": "category", "unit_or_values": "Classification, material form, jurisdiction, intended action, authority and effective date", "why_it_matters": "Allows handling and authorization decisions without treating historical or foreign classifications as universally applicable." } ], "affordances": [ "Resolve an mCPP label against structural identifiers and flag positional-isomer ambiguity.", "Compare a sample with an authenticated reference and record the strength of identification.", "Calculate substance amount or free-base-equivalent concentration from verified form and assay.", "Assess whether storage history and analytical quality support an intended laboratory use.", "Interpret detection alongside precursor-drug and sample-matrix evidence.", "Check whether a proposed acquisition, transfer, analysis or disposal is supported by current local requirements." ], "agent_conduct": { "may": [ "Describe mCPP, its pharmacology and its role as a drug metabolite from scientific sources.", "Report its legal status as stated in the relevant jurisdiction's law." ], "must_not": [ "Assist in making, obtaining, dosing or using it recreationally.", "Help pass it off as another drug or hide it in pills sold to people.", "Present it as a safe alternative to other drugs." ], "requires_human": [ "Interpreting a drug test result that detects it in a named person." ] }, "ethics": { "considerations": [ "It has been sold disguised as other drugs, exposing people to effects they did not choose.", "A positive test can come from prescribed medicines, so results can wrong people." ], "affected_parties": [ "People who use drugs", "Patients taking medicines that produce it", "People tested for drugs" ] }, "owners": { "steward": "Nobody owns the compound; drug control and medicines authorities regulate it.", "master_systems": [] }, "visual_identification": [ "Not reliably identifiable by sight; confirmed only by laboratory analysis." ], "failure_modes_and_hazards": [ "Can cause anxiety, headache and other unpleasant effects.", "Adulterated pills expose people to unknown substances." ], "what_it_is_for": [ "The compound is encountered in serotonin receptor research and in studies of drug metabolism.", "Analytical laboratories may examine it in reference materials or biological samples when investigating exposure to the compound or medicines that produce it as a metabolite." ], "standards_and_regulation": [ "The Globally Harmonized System of Classification and Labelling of Chemicals, issued by the United Nations, provides the framework for chemical hazard communication where adopted into applicable law." ] }, "sources": [ { "id": "wikidata", "title": "Wikidata item Q286112: m-chlorophenylpiperazine", "url": "https://www.wikidata.org/wiki/Q286112", "url_status": "live", "what_it_supports": "identity and sense of the item", "checked_by": "wikidata-api" }, { "id": "wikipedia-en", "title": "Wikipedia: Meta-Chlorophenylpiperazine", "url": "https://en.wikipedia.org/wiki/Meta-Chlorophenylpiperazine", "url_status": "live", "what_it_supports": "general description of the item", "checked_by": "wikidata-api sitelink" } ], "structure": { "bundles": [ { "id": "mcpp-identity-and-boundaries", "name": "mCPP identity and boundaries", "description": "Establish the exact chemical entity represented by the registry name.", "rationale": "The abbreviation, chlorine position and salt form can each produce a materially different identification.", "layers": [ { "id": "molecular-connectivity", "name": "Molecular connectivity", "description": "Resolve the structure behind the substance name.", "findings": [ { "id": "meta-isomer-resolution", "name": "Meta-isomer resolution", "description": "Require structure-level evidence that resolves the chlorine position and piperazine attachment.", "questions": [ { "text": "Does the recorded structure place chlorine at phenyl position 3 relative to the nitrogen-linked piperazine group?", "kind": "definition", "id": "meta-isomer-resolution-q01" }, { "text": "Which authoritative identifier or authenticated standard resolves this sample as mCPP rather than an ortho or para isomer?", "kind": "provenance", "id": "meta-isomer-resolution-q02" } ] } ] }, { "id": "parent-and-related-forms", "name": "Parent and related forms", "description": "Separate the parent identity from salts and preparations.", "findings": [ { "id": "form-specific-identity", "name": "Form-specific identity", "description": "Record counterions and solvation explicitly while retaining the relationship to the mCPP parent.", "questions": [ { "text": "Is the material the free base, an identified salt or a preparation whose chemical form remains unresolved?", "kind": "definition", "id": "form-specific-identity-q01" }, { "text": "Does the registry represent this salt separately, and which identifiers belong to the supplied form rather than the parent?", "kind": "boundary", "id": "form-specific-identity-q02" } ] } ] } ] }, { "id": "mcpp-sample-and-analysis", "name": "mCPP sample and analysis", "description": "Connect chemical identity to measured content in a particular sample.", "rationale": "An mCPP label alone establishes neither isomer identity nor usable concentration.", "layers": [ { "id": "identification-evidence", "name": "Identification evidence", "description": "Evaluate analytical specificity and reference provenance.", "findings": [ { "id": "isomer-discriminating-confirmation", "name": "Isomer-discriminating confirmation", "description": "Require evidence that the analytical method distinguishes relevant chlorophenylpiperazine alternatives.", "questions": [ { "text": "Which measurements distinguish mCPP from other chlorophenylpiperazine isomers in this matrix?", "kind": "measurement", "id": "isomer-discriminating-confirmation-q01" }, { "text": "What reference-material identity, lot and supporting documentation anchor the assignment?", "kind": "provenance", "id": "isomer-discriminating-confirmation-q02" } ] } ] }, { "id": "content-and-matrix", "name": "Content and matrix", "description": "Represent the amount of mCPP and the substances accompanying it.", "findings": [ { "id": "quantitative-basis", "name": "Quantitative basis", "description": "Distinguish assay, concentration and chromatographic response, including their uncertainty and mass basis.", "questions": [ { "text": "What mCPP content was measured, with which units, calibration, uncertainty and free-base or salt basis?", "kind": "measurement", "id": "quantitative-basis-q01" }, { "text": "Which positional isomers, residual solvents or other constituents could affect identification or intended use?", "kind": "measurement", "id": "quantitative-basis-q02" } ] } ] } ] }, { "id": "mcpp-physical-state-and-stability", "name": "mCPP physical state and stability", "description": "Describe form-dependent properties and changes during storage or preparation.", "rationale": "Physical constants and solution behavior are useful only when tied to the actual mCPP form and conditions.", "layers": [ { "id": "conditional-physical-properties", "name": "Conditional physical properties", "description": "Attach phase, transition and solution measurements to their experimental conditions.", "findings": [ { "id": "form-matched-properties", "name": "Form-matched properties", "description": "Retain uncertainty when a reported value lacks material-form or method information.", "questions": [ { "text": "Which phase and melting, boiling or decomposition measurements apply to this exact mCPP form, at what pressure and purity?", "kind": "measurement", "id": "form-matched-properties-q01" }, { "text": "What measured solubility or ionization data apply at the intended solvent composition, pH and temperature?", "kind": "measurement", "id": "form-matched-properties-q02" } ] } ] }, { "id": "storage-and-change", "name": "Storage and change", "description": "Track whether a sample remains suitable over time.", "findings": [ { "id": "stability-supported-use", "name": "Stability-supported use", "description": "Base storage and retest decisions on evidence for the supplied material or solution.", "questions": [ { "text": "What stability evidence supports the stated storage conditions and expiry or retest interval for this form?", "kind": "provenance", "id": "stability-supported-use-q01" }, { "text": "Do storage excursions, appearance changes or assay drift require reanalysis before further use?", "kind": "action", "id": "stability-supported-use-q02" } ] } ] } ] }, { "id": "mcpp-biological-interpretation", "name": "mCPP biological interpretation", "description": "Separate measured biological activity from conclusions about origin and exposure.", "rationale": "mCPP has serotonergic activity and can be formed metabolically, so neither its effects nor its provenance should be inferred from its name alone.", "layers": [ { "id": "activity-context", "name": "Activity context", "description": "Bind pharmacological statements to particular experimental systems.", "findings": [ { "id": "endpoint-specific-activity", "name": "Endpoint-specific activity", "description": "Record target-level and organism-level evidence separately rather than treating serotonergic activity as one universal effect.", "questions": [ { "text": "Which receptor or transporter endpoint was measured, in which species and assay system, at what concentration?", "kind": "measurement", "id": "endpoint-specific-activity-q01" }, { "text": "Does the evidence demonstrate binding, functional activation, inhibition or an organism-level response?", "kind": "boundary", "id": "endpoint-specific-activity-q02" } ] } ] }, { "id": "metabolic-origin", "name": "Metabolic origin", "description": "Interpret occurrence in relation to possible precursor medicines and sample timing.", "findings": [ { "id": "detection-versus-origin", "name": "Detection versus origin", "description": "Keep detection separate from attribution to direct exposure or metabolic formation.", "questions": [ { "text": "What precursor-drug, co-metabolite and collection-time evidence accompanies the mCPP result?", "kind": "provenance", "id": "detection-versus-origin-q01" }, { "text": "Can the available evidence distinguish metabolic formation from direct exposure, or must origin remain unresolved?", "kind": "boundary", "id": "detection-versus-origin-q02" } ] } ] } ] }, { "id": "mcpp-hazards-and-permitted-actions", "name": "mCPP hazards and permitted actions", "description": "Support handling and use decisions for the identified material in a specified jurisdiction.", "rationale": "Chemical hazard classification, biological activity and legal control answer different questions and require separate evidence.", "layers": [ { "id": "material-specific-hazards", "name": "Material-specific hazards", "description": "Resolve safety information for the actual form, concentration and solvent.", "findings": [ { "id": "applicable-hazard-evidence", "name": "Applicable hazard evidence", "description": "Use attributable hazard information without assigning unsupported classifications or exposure thresholds.", "questions": [ { "text": "Which current safety data and GHS classifications explicitly cover this mCPP form and preparation?", "kind": "provenance", "id": "applicable-hazard-evidence-q01" }, { "text": "Which documented controls apply to the proposed operation, and is a substance-specific exposure limit established or unlocated?", "kind": "action", "id": "applicable-hazard-evidence-q02" } ] } ] }, { "id": "jurisdiction-and-purpose", "name": "Jurisdiction and purpose", "description": "Evaluate permissions against current rules and the intended operation.", "findings": [ { "id": "dated-action-authorization", "name": "Dated action authorization", "description": "Record the authority and scope of restrictions without extrapolating from another country or historical report.", "questions": [ { "text": "Which current rules cover mCPP, its salts and the proposed activity in the relevant jurisdiction?", "kind": "provenance", "id": "dated-action-authorization-q01" }, { "text": "What authorization or documented conditions, if any, must be satisfied before acquisition, transfer, research use or disposal?", "kind": "action", "id": "dated-action-authorization-q02" } ] } ] } ] }, { "id": "evidence-and-external-alignment", "name": "Evidence and external alignment", "description": "What the world already says about this thing, gathered so the model can be checked against it.", "rationale": "A model that cannot be lined up against existing standards, identifiers and practice cannot be adopted by anyone who already uses them.", "layers": [ { "id": "reported-evidence", "name": "Reported evidence", "description": "Findings from the breadth pass, kept separate from the structural claims.", "findings": [ { "id": "evidence-confidence-notes", "name": "Check these first", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "This is recalled knowledge; no sources were consulted.", "Verify registry identifiers, physical constants and hazard classifications separately for the free base and each salt.", "Receptor-specific activity depends on the assay; avoid treating mCPP as a selective probe without checking the experimental literature." ], "questions": [ { "id": "evidence-confidence-notes-q01", "text": "Which of these check these first hold for the sense of m-chlorophenylpiperazine this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-kinds", "name": "Kinds and varieties", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "Free base", "Hydrochloride salt" ], "questions": [ { "id": "evidence-kinds-q01", "text": "Which of these kinds and varieties hold for the sense of m-chlorophenylpiperazine this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-identifiers", "name": "Identifiers and schemes", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ { "scheme": "Chemical nomenclature", "value_or_pattern": "1-(3-chlorophenyl)piperazine", "note": "The chlorine substituent is meta to the piperazine attachment on the phenyl ring." }, { "scheme": "Molecular formula", "value_or_pattern": "C10H13ClN2", "note": "Formula of the neutral free base; not a unique structural identifier." }, { "scheme": "Common abbreviation", "value_or_pattern": "mCPP", "note": "Also written m-CPP." } ], "questions": [ { "id": "evidence-identifiers-q01", "text": "Which of these identifiers and schemes hold for the sense of m-chlorophenylpiperazine this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-real-world-use", "name": "Real-world use", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "Research probe for serotonergic function in pharmacological and psychiatric studies.", "Analyte in studies of trazodone and nefazodone metabolism.", "Encountered in illicit recreational drug products, including tablets represented as ecstasy." ], "questions": [ { "id": "evidence-real-world-use-q01", "text": "Which of these real-world use hold for the sense of m-chlorophenylpiperazine this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-measurements", "name": "Typical measurements", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ { "quantity": "Molar mass of the free base", "typical_range": "196.68", "unit": "g/mol" } ], "questions": [ { "id": "evidence-measurements-q01", "text": "Which of these typical measurements hold for the sense of m-chlorophenylpiperazine this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-failure-modes-and-hazards", "name": "Failure modes and hazards", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "Can provoke anxiety, panic-like symptoms, headache and nausea.", "Can cause cardiovascular effects, including increased heart rate and blood pressure.", "Serotonergic toxicity is a concern, particularly with other serotonergic substances.", "Its presence in misrepresented drug products creates uncertainty about composition and exposure.", "Confusing the free base with a salt causes errors in mass-based concentration calculations." ], "questions": [ { "id": "evidence-failure-modes-and-hazards-q01", "text": "Which of these failure modes and hazards hold for the sense of m-chlorophenylpiperazine this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-regional-variation", "name": "Regional variation", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "Legal controls may differ by jurisdiction; a status assigned to another piperazine should not be assumed to apply to mCPP." ], "questions": [ { "id": "evidence-regional-variation-q01", "text": "Which of these regional variation hold for the sense of m-chlorophenylpiperazine this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-neighbours", "name": "Neighbouring kinds and how to tell them apart", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ { "name": "o-Chlorophenylpiperazine", "difference": "Chlorine occupies the 2-position of the phenyl ring rather than the 3-position." }, { "name": "p-Chlorophenylpiperazine", "difference": "Chlorine occupies the 4-position of the phenyl ring rather than the 3-position." }, { "name": "Phenylpiperazine", "difference": "Lacks the chlorine substituent on the phenyl ring." }, { "name": "Trazodone", "difference": "A structurally larger antidepressant that can be metabolized to mCPP; it is not the same substance." } ], "questions": [ { "id": "evidence-neighbours-q01", "text": "Which of these neighbouring kinds and how to tell them apart hold for the sense of m-chlorophenylpiperazine this model covers, and on what evidence?", "kind": "provenance" } ] } ] } ] } ] }, "openQuestions": [ "Does the registry intend this entry to cover only the parent compound, or also particular salts, and does an existing Vercy world model already own that scope?", "Which EC identifiers, form-specific physical constants, solubility values and stability limits can be supported by sources that identify material form and measurement conditions?", "Which current GHS classifications and occupational exposure limits, if any, apply to the free base and the particular salts or solutions encountered?", "Which validated analytical methods resolve the meta isomer and quantify it reliably in the intended matrices?", "Which target-specific biological findings and current jurisdictional restrictions are sufficiently supported for the intended research or handling decisions?" ], "statistics": { "bundles": 6, "layers": 11, "findings": 18, "questions": 28 } }