{ "vercy": "1.0-draft", "publication": { "status": "research-draft", "adjudicationStatus": "unreviewed", "publishableCanonical": false, "generatedAt": "2026-09-12T08:29:29Z", "providers": [ "Codex" ], "breadth": "recalled by Codex without web access - no source was read", "missingProviders": [], "pass": 2, "cost": { "grok": { "seconds": 18.6, "error": "Reading additional input from stdin...\nOpenAI Codex v0.153.4\n--------\nworkdir: R:\\02_PROJECTS\\02_Meta_Models_Platforms\\Ver.cy\\current\\thing-registry-backlog\nmodel: gpt-6-astra\nprovider: openai\napproval: never\nsandbox: read-only\nreasoning effort: none\nreasoning summaries: none\nsession id: 01a094bb-3d9b-7632-99db-0f92649f0564\n--------\nuser\nDescribe what is already known about one registered thing. Answer as JSON only, no prose around it.\n\nThing: cefsulodin\nSense to describe: (none recorded)\nDomain code: PHY.MAT\nAlso known as: (none)\n\n\nContext for this batch of 1001 things:\n# Batch 043: 1001 regi", "usd": 0.0, "recall": true }, "codex": { "seconds": 75.7, "error": "Reading additional input from stdin...\nOpenAI Codex v0.153.4\n--------\nworkdir: R:\\02_PROJECTS\\02_Meta_Models_Platforms\\Ver.cy\\current\\thing-registry-backlog\nmodel: gpt-6-astra\nprovider: openai\napproval: never\nsandbox: read-only\nreasoning effort: none\nreasoning summaries: none\nsession id: 01a094bb-3d8e-7cb1-96b9-0a126b3def0d\n--------\nuser\nYou are drafting a Vercy meta-model for one registered thing. Answer as JSON only, no prose around it.\n\nThing: cefsulodin\nRegistry id: vr.tr.cefsulodin\nPlane / domain: PHY / PHY.MAT\nRegistry definition: (none recorded)\nNames folded into this entry: (none)\n\n\nCo" } }, "enrichment": { "pass": 3, "engine": "claude", "producedAt": "2026-10-06T12:00:00Z", "ingestedAt": "2026-10-06T08:52:57+00:00", "fields": [ "agent_conduct", "ethics", "failure_modes_and_hazards", "owners", "visual_identification" ] }, "gate": { "passed": true, "version": "1.0", "at": "2026-10-07T10:10:29+00:00", "evidence": [ "completeness 1.00", "sense: Wikidata description", "2 live sources", "review by codex: pass" ] } }, "metaModel": { "id": "THING-Q2943815", "registryId": "vr.tr.cefsulodin", "name": "cefsulodin", "version": "0.1.0-research.1", "entryKind": "thing", "family": "Thing Registry", "domain": [ "PHY.MAT" ], "status": "research-draft" }, "canonicalUrl": "https://ver.cy/models/thing/q2943815/", "model": { "registry_id": "vr.tr.cefsulodin", "name": "cefsulodin", "purpose": "Enable an agent to recognise cefsulodin, assess the identity and condition of a particular material, and determine whether evidence supports its intended use.", "definition": "Cefsulodin is a semisynthetic third-generation cephalosporin antibiotic with a relatively narrow antibacterial spectrum, notably including Pseudomonas aeruginosa, that inhibits bacterial cell-wall synthesis.", "scope_statement": "This model owns cefsulodin as the registered chemical substance vr.tr.cefsulodin in PHY / PHY.MAT, including molecular identity, material form, quality, stability, antibacterial evidence and handling constraints, while relating salts, hydrates and preparations without treating them as interchangeable.", "in_scope": [ "Cefsulodin molecular identity, stereochemistry and source-qualified identifiers", "Parent-substance, salt and hydrate distinctions relevant to supplied materials", "Batch composition, purity, water content and antibacterial potency", "Physical state, dissolution conditions and chemical stability", "Condition-specific antibacterial evidence and material-use restrictions" ], "out_of_scope": [ "Finished medicinal products, their excipients and packaging systems", "Patient diagnosis, prescribing, dosing and treatment decisions", "Manufacturing routes and production equipment", "Complete bacterial organism and resistance-system models", "Complete culture-medium formulations and microbiological procedures" ], "distinguishing_features": [ "Require a structure match to cefsulodin, including its pyridinium-substituted cephalosporin identity; membership in the cephalosporin class alone is insufficient. [PubChem](https://pubchem.ncbi.nlm.nih.gov/compound/Cefsulodin)", "Check counterions and hydration explicitly: PubChem records cefsulodin sodium separately from cefsulodin. [PubChem: cefsulodin sodium](https://pubchem.ncbi.nlm.nih.gov/compound/656644)", "Compare stereochemical specification as well as connectivity before accepting a synonym or supplier identifier as an exact identity match.", "Distinguish a cefsulodin material from a formulated preparation by identifying other constituents and the basis on which cefsulodin content is reported.", "Use analytical identity evidence to distinguish cefsulodin from other antibiotics; a similar antibacterial response does not establish chemical identity." ], "characteristics": [ { "name": "Molecular identity", "kind": "category", "unit_or_values": "Structure representation with explicit stereochemistry, charge and protonation", "why_it_matters": "Prevents name-based substitution of a related cephalosporin or differently specified chemical entity." }, { "name": "Identifier provenance", "kind": "relation", "unit_or_values": "CAS, PubChem CID and EC identifier where verified, each linked to its source and chemical form", "why_it_matters": "An identifier must resolve to the represented form before it can support procurement or record matching." }, { "name": "Material form", "kind": "category", "unit_or_values": "Parent substance, specified salt, specified hydrate or unresolved form", "why_it_matters": "Form determines the appropriate formula mass and interpretation of weighed quantities." }, { "name": "Cefsulodin content", "kind": "measurement", "unit_or_values": "% mass fraction or mg/g, with as-is, dry or parent-equivalent basis and assay method", "why_it_matters": "A weighed material amount is not necessarily the same as its cefsulodin amount." }, { "name": "Water and residual constituents", "kind": "measurement", "unit_or_values": "% water; residual solvent and impurity concentrations with methods", "why_it_matters": "These constituents affect concentration calculations and material suitability." }, { "name": "Physical and solution state", "kind": "state", "unit_or_values": "Solid or solution; solvent, concentration, pH, temperature and preparation time when applicable", "why_it_matters": "Dissolution and stability evidence applies only to sufficiently comparable conditions." }, { "name": "Chemical integrity", "kind": "measurement", "unit_or_values": "% intact cefsulodin and quantified degradation products, with method and sampling time", "why_it_matters": "Appearance alone cannot establish that stored or prepared material remains suitable." }, { "name": "Antibacterial activity", "kind": "measurement", "unit_or_values": "MIC in µg/mL or another explicitly defined assay endpoint, linked to strain and test conditions", "why_it_matters": "Activity cannot be inferred reliably from the antibiotic name alone." }, { "name": "Handling and use status", "kind": "category", "unit_or_values": "Source-supported hazard classification, permitted-use category and applicable jurisdiction/date", "why_it_matters": "Chemical identity does not itself establish a material's handling requirements or authorisation for a particular use." } ], "affordances": [ "Reconcile a labelled material with cefsulodin identity using structure, form and analytical evidence.", "Calculate parent-equivalent quantities when assay, counterion and hydration information are sufficient.", "Compare a batch against requirements for a specified analytical or antibacterial application.", "Evaluate whether storage or solution history requires retesting before use.", "Compare antibacterial measurements only after checking strain, method and concentration basis.", "Flag unresolved identity, quality or handling evidence that prevents a justified material-use decision." ], "agent_conduct": { "may": [ "Describe cefsulodin, its antibacterial spectrum and its laboratory use in selective media.", "Report its authorization status, which differs between countries." ], "must_not": [ "Recommend it or a dose for a person.", "Supply it outside the regulated medicines chain.", "Encourage antibiotic use that is not needed, which fuels resistance." ], "requires_human": [ "Any decision to treat an infection with it." ] }, "ethics": { "considerations": [ "Misuse of antibiotics breeds resistance that harms everyone.", "People with penicillin or cephalosporin allergy face serious reactions." ], "affected_parties": [ "Patients", "The public at risk of resistant infection" ] }, "owners": { "steward": "The marketing authorization holder or supplier; regulators and prescribers control its use.", "master_systems": [ "Medicines regulators' product registers" ] }, "visual_identification": [ "Usually a white powder for solution or a supplement in laboratory media.", "Identified by label and analysis, not appearance." ], "failure_modes_and_hazards": [ "Allergic reactions, including anaphylaxis, in sensitive people.", "Misuse contributes to antibiotic resistance." ], "what_it_is_for": [ "Cefsulodin is encountered in antibacterial research and laboratory microbiology, including selective culture media.", "Its identity and antibacterial activity are relevant when interpreting experimental materials and records of cephalosporin use." ], "standards_and_regulation": [ "The Anatomical Therapeutic Chemical classification, maintained by the World Health Organization Collaborating Centre for Drug Statistics Methodology, classifies cefsulodin among third-generation cephalosporins." ] }, "sources": [ { "id": "wikidata", "title": "Wikidata item Q2943815: cefsulodin", "url": "https://www.wikidata.org/wiki/Q2943815", "url_status": "live", "what_it_supports": "identity and sense of the item", "checked_by": "wikidata-api" }, { "id": "wikipedia-en", "title": "Wikipedia: Cefsulodin", "url": "https://en.wikipedia.org/wiki/Cefsulodin", "url_status": "live", "what_it_supports": "general description of the item", "checked_by": "wikidata-api sitelink" } ], "structure": { "bundles": [ { "id": "cefsulodin-identity", "name": "Cefsulodin identity", "description": "Establish which molecular entity the registered name and supplied material denote.", "rationale": "Cefsulodin names and identifiers must resolve to a chemically specified entity before other evidence can be applied.", "layers": [ { "id": "molecular-recognition", "name": "Molecular recognition", "description": "Recognise cefsulodin through molecular structure and stereochemistry.", "findings": [ { "id": "structure-supported-identity", "name": "Structure-supported identity", "description": "Record the authoritative structure and distinguish exact matches from incomplete stereochemical or charge representations.", "questions": [ { "text": "What connectivity and stereochemistry define the cefsulodin entity represented here?", "kind": "definition", "id": "structure-supported-identity-q01" }, { "text": "Which reference and analytical evidence support the material's assignment to that entity?", "kind": "provenance", "id": "structure-supported-identity-q02" } ] } ] }, { "id": "chemical-form-boundary", "name": "Chemical form boundary", "description": "Resolve the relationship between cefsulodin and supplied salt or hydrate forms.", "findings": [ { "id": "form-specific-identifiers", "name": "Form-specific identifiers", "description": "Keep identifiers and formula masses attached to the exact chemical form rather than pooling them under the common name.", "questions": [ { "text": "Does each identifier denote the parent substance, a sodium salt, a hydrate or an incompletely specified entity?", "kind": "boundary", "id": "form-specific-identifiers-q01" }, { "text": "Which source verifies the counterion, hydration and formula associated with that identifier?", "kind": "provenance", "id": "form-specific-identifiers-q02" } ] } ] } ] }, { "id": "cefsulodin-material-quality", "name": "Cefsulodin material quality", "description": "Determine what a particular batch contains and how much usable cefsulodin it represents.", "rationale": "Purity, assay basis and material grade determine whether a cefsulodin batch can support a proposed application.", "layers": [ { "id": "content-and-equivalence", "name": "Content and equivalence", "description": "Connect weighed material to a defensible cefsulodin quantity.", "findings": [ { "id": "assay-basis", "name": "Assay basis", "description": "Interpret reported cefsulodin content using the chemical form, water content and assay denominator.", "questions": [ { "text": "What cefsulodin content was measured, by which method, and on an as-is, dry or parent-equivalent basis?", "kind": "measurement", "id": "assay-basis-q01" }, { "text": "What corrections are justified when converting the supplied mass into cefsulodin-equivalent concentration?", "kind": "action", "id": "assay-basis-q02" } ] } ] }, { "id": "impurities-and-grade", "name": "Impurities and grade", "description": "Assess non-cefsulodin constituents and application-specific quality requirements.", "findings": [ { "id": "batch-suitability", "name": "Batch suitability", "description": "Relate impurity results and documented grade to the intended application without treating analytical purity as universal suitability.", "questions": [ { "text": "Which related substances, degradation products, residual solvents and other constituents were measured, and at what levels?", "kind": "measurement", "id": "batch-suitability-q01" }, { "text": "Which quality requirements must this batch meet for the proposed use, and which remain unverified?", "kind": "action", "id": "batch-suitability-q02" } ] } ] } ] }, { "id": "cefsulodin-state-and-stability", "name": "Cefsulodin state and stability", "description": "Assess physical properties and chemical integrity under the material's actual conditions.", "rationale": "Properties of one cefsulodin form or preparation cannot automatically establish the condition of another.", "layers": [ { "id": "physical-property-context", "name": "Physical property context", "description": "Attach dissolution and thermal observations to the tested chemical form and conditions.", "findings": [ { "id": "conditioned-property-evidence", "name": "Conditioned property evidence", "description": "Separate measured properties from estimates, and distinguish thermal decomposition from melting or boiling.", "questions": [ { "text": "What solubility was measured for this cefsulodin form, in which solvent, at what pH and temperature?", "kind": "measurement", "id": "conditioned-property-evidence-q01" }, { "text": "Do reported thermal values describe melting, dehydration or decomposition, and is a boiling point experimentally meaningful?", "kind": "boundary", "id": "conditioned-property-evidence-q02" } ] } ] }, { "id": "storage-and-preparation-history", "name": "Storage and preparation history", "description": "Track conditions that determine whether stability evidence remains applicable.", "findings": [ { "id": "integrity-at-use", "name": "Integrity at use", "description": "Use elapsed time, environmental history and analytical evidence to judge the condition of solid or dissolved cefsulodin.", "questions": [ { "text": "What temperature, moisture, light exposure and solution conditions has this material experienced since testing or preparation?", "kind": "provenance", "id": "integrity-at-use-q01" }, { "text": "Which validated stability evidence supports continued use, and when is repeat identity, content or potency testing required?", "kind": "action", "id": "integrity-at-use-q02" } ] } ] } ] }, { "id": "cefsulodin-antibacterial-evidence", "name": "Cefsulodin antibacterial evidence", "description": "Represent antibacterial performance as evidence tied to organisms and experimental conditions.", "rationale": "Broad spectrum labels cannot establish whether a particular cefsulodin material will produce an intended antibacterial effect.", "layers": [ { "id": "organism-specific-activity", "name": "Organism-specific activity", "description": "Record measured responses without turning species-level descriptions into guarantees.", "findings": [ { "id": "strain-and-assay-response", "name": "Strain and assay response", "description": "Bind each activity result to the tested strain, material and assay.", "questions": [ { "text": "Which organism and strain were tested, and what activity endpoint and concentration basis were reported?", "kind": "measurement", "id": "strain-and-assay-response-q01" }, { "text": "Which medium, inoculum, incubation conditions, controls and cefsulodin batch underlie the result?", "kind": "provenance", "id": "strain-and-assay-response-q02" } ] } ] }, { "id": "activity-interpretation", "name": "Activity interpretation", "description": "Separate observed inhibition from mechanism, resistance and application claims.", "findings": [ { "id": "supported-performance-inference", "name": "Supported performance inference", "description": "Require evidence before transferring an activity result to another strain, assay or application.", "questions": [ { "text": "What direct evidence supports any claimed cefsulodin target interaction or resistance mechanism in the tested organism?", "kind": "provenance", "id": "supported-performance-inference-q01" }, { "text": "What additional validation is needed before applying this result to the proposed antibacterial use?", "kind": "action", "id": "supported-performance-inference-q02" } ] } ] } ] }, { "id": "cefsulodin-handling-and-use", "name": "Cefsulodin handling and use", "description": "Connect the identified material to supported handling requirements and use boundaries.", "rationale": "A cefsulodin research material, a reference standard and an authorised medicinal preparation have different evidence requirements.", "layers": [ { "id": "material-specific-hazards", "name": "Material-specific hazards", "description": "Use safety information applicable to the actual form and preparation.", "findings": [ { "id": "documented-handling-constraints", "name": "Documented handling constraints", "description": "Record source-supported hazard classifications and exposure controls, preserving unknowns where data are absent.", "questions": [ { "text": "What current safety document covers this exact cefsulodin material, including any documented sensitisation hazards?", "kind": "provenance", "id": "documented-handling-constraints-q01" }, { "text": "Which handling, exposure-control and disposal measures apply to its quantity, physical form and intended operation?", "kind": "action", "id": "documented-handling-constraints-q02" } ] } ] }, { "id": "authorised-application-boundary", "name": "Authorised application boundary", "description": "Distinguish chemical suitability from permission and qualification for a particular application.", "findings": [ { "id": "use-status-evidence", "name": "Use status evidence", "description": "Attach supplier restrictions and regulatory assertions to their material, jurisdiction and date.", "questions": [ { "text": "What documentation establishes this material's research, reference-standard or medicinal-use status?", "kind": "provenance", "id": "use-status-evidence-q01" }, { "text": "Does the proposed use concern this substance or a separately qualified formulation, and what requirements govern that boundary?", "kind": "boundary", "id": "use-status-evidence-q02" } ] } ] } ] }, { "id": "evidence-and-external-alignment", "name": "Evidence and external alignment", "description": "What the world already says about this thing, gathered so the model can be checked against it.", "rationale": "A model that cannot be lined up against existing standards, identifiers and practice cannot be adopted by anyone who already uses them.", "layers": [ { "id": "reported-evidence", "name": "Reported evidence", "description": "Findings from the breadth pass, kept separate from the structural claims.", "findings": [ { "id": "evidence-confidence-notes", "name": "Check these first", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "This description is recalled knowledge; no sources were consulted.", "Verify CAS and database identifiers against the precise parent, salt and hydration state before assigning them.", "Current clinical availability, authorization, susceptibility criteria and material-specific hazard classifications require verification." ], "questions": [ { "id": "evidence-confidence-notes-q01", "text": "Which of these check these first hold for the sense of cefsulodin this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-identifiers", "name": "Identifiers and schemes", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ { "scheme": "International Nonproprietary Name (INN)", "value_or_pattern": "cefsulodin", "note": "Names the active substance; salt and hydration state require separate specification." } ], "questions": [ { "id": "evidence-identifiers-q01", "text": "Which of these identifiers and schemes hold for the sense of cefsulodin this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-real-world-use", "name": "Real-world use", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "Historically used to treat susceptible bacterial infections, particularly those involving Pseudomonas aeruginosa.", "Used as a selective antimicrobial component of cefsulodin-irgasan-novobiocin (CIN) agar for isolating Yersinia enterocolitica.", "Used in laboratory studies of bacterial cell-wall synthesis and antibiotic susceptibility." ], "questions": [ { "id": "evidence-real-world-use-q01", "text": "Which of these real-world use hold for the sense of cefsulodin this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-failure-modes-and-hazards", "name": "Failure modes and hazards", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "Can cause hypersensitivity reactions associated with beta-lactam antibiotics.", "Bacterial resistance can make treatment ineffective; activity cannot be inferred from species identification alone.", "Its narrow antibacterial spectrum leaves many organisms outside reliable coverage.", "Degradation of the beta-lactam structure can reduce potency during unsuitable storage or preparation." ], "questions": [ { "id": "evidence-failure-modes-and-hazards-q01", "text": "Which of these failure modes and hazards hold for the sense of cefsulodin this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-neighbours", "name": "Neighbouring kinds and how to tell them apart", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ { "name": "Cefsulodin sodium", "difference": "The sodium salt is a distinct material form; its composition and formula mass differ from those of the parent substance." }, { "name": "Ceftazidime", "difference": "A chemically distinct antipseudomonal cephalosporin with a broader antibacterial spectrum." }, { "name": "CIN agar", "difference": "A formulated microbiological culture medium containing cefsulodin and other ingredients, rather than the antibiotic substance itself." } ], "questions": [ { "id": "evidence-neighbours-q01", "text": "Which of these neighbouring kinds and how to tell them apart hold for the sense of cefsulodin this model covers, and on what evidence?", "kind": "provenance" } ] } ] } ] } ] }, "openQuestions": [ "Which authoritative structure and identifier mapping should anchor vr.tr.cefsulodin, especially where records differ in stereochemical, charge, salt or hydrate representation?", "What experimentally supported solubility, thermal behaviour and stability limits apply to each relevant supplied form and solution condition?", "Which impurity specifications and assay methods reliably connect cefsulodin chemical content with antibacterial potency for the intended applications?", "How should conflicting broad-spectrum and narrow-spectrum descriptions be resolved using organism- and strain-specific primary evidence? [PubChem](https://pubchem.ncbi.nlm.nih.gov/compound/Cefsulodin)", "Which verified EC identifiers, GHS classifications, occupational exposure limits and current use authorisations apply to the exact material and jurisdiction, and which are unavailable?" ], "statistics": { "bundles": 6, "layers": 11, "findings": 15, "questions": 25 } }