{
  "vercy": "1.0-draft",
  "publication": {
    "status": "research-draft",
    "adjudicationStatus": "unreviewed",
    "publishableCanonical": false,
    "generatedAt": "2026-09-11T21:45:44Z",
    "providers": [
      "Claude"
    ],
    "breadth": "written by Claude from model knowledge without web access - no source was read, every claim is a lead to verify",
    "pass": 2,
    "wave": 2,
    "engine": "claude",
    "enrichment": {
      "pass": 3,
      "engine": "claude",
      "producedAt": "2026-10-05T23:50:00Z",
      "ingestedAt": "2026-10-05T20:49:36+00:00",
      "fields": [
        "agent_conduct",
        "ethics",
        "owners"
      ]
    }
  },
  "metaModel": {
    "id": "THING-Q304484",
    "registryId": "vr.tr.programmed-cell-death",
    "name": "programmed cell death",
    "version": "0.2.0-wave.2",
    "entryKind": "thing",
    "family": "Thing Registry",
    "domain": [
      "ACT.PRC"
    ],
    "status": "research-draft"
  },
  "canonicalUrl": "https://ver.cy/models/thing/q304484/",
  "model": {
    "registry_id": "vr.tr.programmed-cell-death",
    "name": "programmed cell death",
    "purpose": "Let an agent explain the forms and mechanisms of programmed cell death, describe its roles in development, immunity and disease, and support learning and research at a general level.",
    "definition": "The regulated death of a cell triggered by internal signals as part of development, tissue maintenance or defence, including apoptosis, autophagic cell death, programmed necrosis such as necroptosis and pyroptosis, and death in response to reactive oxygen species or symbionts; programmed cell death shapes organs, removes damaged cells and is disrupted in cancer and degenerative disease.",
    "what_it_is_for": "Regulated removal of cells.",
    "affordances": [
      "explain forms of programmed cell death",
      "describe mechanisms and pathways",
      "relate to development and disease",
      "support learning and research"
    ],
    "distinguishing_features": [
      "Genetically regulated",
      "Multiple pathways",
      "Developmental role",
      "Disease relevance"
    ],
    "appearance": "Not visible without microscopy; cell shrinkage, fragmentation or swelling depending on form.",
    "visual_identification": [
      "Regulated, signal-driven death",
      "Multiple forms",
      "Accidental necrosis from injury is unregulated"
    ],
    "physical_properties": [],
    "families_and_kinds": [
      "apoptosis",
      "autophagic cell death",
      "necroptosis and pyroptosis",
      "ferroptosis and other forms",
      "programmed cell death in plants and single-celled organisms"
    ],
    "related_models": [
      {
        "relation": "is a kind of",
        "target": "cell death",
        "why": "category"
      },
      {
        "relation": "is related to",
        "target": "multicellular organism",
        "why": "developmental role"
      },
      {
        "relation": "is related to",
        "target": "immune disorder",
        "why": "disrupted regulation"
      },
      {
        "relation": "is related to",
        "target": "diapedesis",
        "why": "another cellular process in immunity"
      }
    ],
    "identifiers": [],
    "standards_and_regulation": [
      "Nomenclature recommendations for cell death",
      "Research ethics rules"
    ],
    "failure_modes_and_hazards": [
      "Confusing regulated and accidental death",
      "Oversimplifying pathways",
      "Agents giving medical advice on therapies"
    ],
    "in_scope": [],
    "out_of_scope": [],
    "characteristics": [],
    "agent_conduct": {
      "may": [
        "Explain the forms of programmed cell death and their roles, citing biological sources.",
        "Distinguish regulated cell death from accidental necrosis in explanations."
      ],
      "must_not": [
        "Give medical advice about therapies that target cell death pathways.",
        "Oversimplify pathways in ways that misrepresent evidence.",
        "Present early-stage research as a proven cure."
      ],
      "requires_human": [
        "Treatment decisions for cancer or degenerative disease."
      ]
    },
    "ethics": {
      "considerations": [
        "Patients hope for cures, and overstated research claims exploit that hope.",
        "Accurate science teaching helps people understand disease."
      ],
      "affected_parties": [
        "Patients",
        "Students",
        "Researchers"
      ]
    },
    "owners": {
      "steward": "Nobody: a biological process described by science.",
      "master_systems": []
    }
  },
  "sources": [
    {
      "id": "wikidata",
      "title": "Wikidata item Q304484: programmed cell death",
      "url": "https://www.wikidata.org/wiki/Q304484",
      "url_status": "live",
      "what_it_supports": "identity and sense of the item",
      "checked_by": "wikidata-api"
    },
    {
      "id": "wikipedia-en",
      "title": "Wikipedia: Programmed cell death",
      "url": "https://en.wikipedia.org/wiki/Programmed_cell_death",
      "url_status": "live",
      "what_it_supports": "general description of the item",
      "checked_by": "wikidata-api sitelink"
    }
  ],
  "structure": {
    "bundles": [
      {
        "id": "forms",
        "name": "Forms",
        "description": "Kinds of cell death.",
        "rationale": "Classification.",
        "layers": [
          {
            "id": "types",
            "name": "Types",
            "description": "Forms.",
            "findings": [
              {
                "id": "types-finding",
                "name": "Types",
                "description": "Forms.",
                "questions": [
                  {
                    "text": "How do apoptosis, autophagic death, necroptosis, pyroptosis and ferroptosis differ, according to nomenclature recommendations?",
                    "kind": "definition"
                  },
                  {
                    "text": "How is regulated death distinguished from accidental necrosis?",
                    "kind": "definition"
                  }
                ]
              }
            ]
          },
          {
            "id": "mechanisms",
            "name": "Mechanisms",
            "description": "Pathways.",
            "findings": [
              {
                "id": "mechanisms-finding",
                "name": "Mechanisms",
                "description": "Pathways.",
                "questions": [
                  {
                    "text": "Which signalling pathways and molecules such as caspases drive each form?",
                    "kind": "definition"
                  },
                  {
                    "text": "How is the process controlled?",
                    "kind": "definition"
                  }
                ]
              }
            ]
          }
        ]
      },
      {
        "id": "roles",
        "name": "Roles",
        "description": "In the organism.",
        "rationale": "Function.",
        "layers": [
          {
            "id": "development",
            "name": "Development",
            "description": "Development and maintenance.",
            "findings": [
              {
                "id": "development-finding",
                "name": "Development",
                "description": "Development.",
                "questions": [
                  {
                    "text": "How does programmed cell death shape development, such as digit formation, and maintain tissues?",
                    "kind": "definition"
                  },
                  {
                    "text": "How does it operate in immunity and against infection?",
                    "kind": "definition"
                  }
                ]
              }
            ]
          },
          {
            "id": "other",
            "name": "Other",
            "description": "Beyond animals.",
            "findings": [
              {
                "id": "other-finding",
                "name": "Other",
                "description": "Other organisms.",
                "questions": [
                  {
                    "text": "How does programmed cell death occur in plants, fungi and single-celled organisms, including responses to symbionts?",
                    "kind": "provenance"
                  },
                  {
                    "text": "What is its evolutionary origin?",
                    "kind": "provenance"
                  }
                ]
              }
            ]
          }
        ]
      },
      {
        "id": "disease",
        "name": "Disease",
        "description": "Cell death and disease.",
        "rationale": "General information.",
        "layers": [
          {
            "id": "cancer",
            "name": "Cancer",
            "description": "Cancer and degeneration.",
            "findings": [
              {
                "id": "cancer-finding",
                "name": "Cancer",
                "description": "Disease.",
                "questions": [
                  {
                    "text": "How is programmed cell death disrupted in cancer and neurodegeneration, according to research?",
                    "kind": "provenance"
                  },
                  {
                    "text": "Is the user asking about their own condition?",
                    "kind": "boundary"
                  }
                ]
              }
            ]
          },
          {
            "id": "therapy",
            "name": "Therapy",
            "description": "Therapeutic targeting.",
            "findings": [
              {
                "id": "therapy-finding",
                "name": "Therapy",
                "description": "Therapy.",
                "questions": [
                  {
                    "text": "Which therapies target cell death pathways, in general terms?",
                    "kind": "provenance"
                  },
                  {
                    "text": "Which entry fits a specific medicine?",
                    "kind": "action"
                  }
                ]
              }
            ]
          }
        ]
      },
      {
        "id": "learn",
        "name": "Learn",
        "description": "Study.",
        "rationale": "Education.",
        "layers": [
          {
            "id": "methods",
            "name": "Methods",
            "description": "Research methods.",
            "findings": [
              {
                "id": "methods-finding",
                "name": "Methods",
                "description": "Methods.",
                "questions": [
                  {
                    "text": "How is cell death studied and measured in the laboratory?",
                    "kind": "provenance"
                  },
                  {
                    "text": "Which markers are used?",
                    "kind": "provenance"
                  }
                ]
              }
            ]
          },
          {
            "id": "history",
            "name": "History",
            "description": "Discovery.",
            "findings": [
              {
                "id": "history-finding",
                "name": "History",
                "description": "History.",
                "questions": [
                  {
                    "text": "How was programmed cell death discovered, and which work was recognised?",
                    "kind": "provenance"
                  },
                  {
                    "text": "Which misconceptions arise in teaching?",
                    "kind": "provenance"
                  }
                ]
              }
            ]
          }
        ]
      }
    ]
  },
  "openQuestions": [
    "Should apoptosis be a separate entry?",
    "How should nomenclature committees be linked?",
    "How should therapy information be linked?"
  ],
  "statistics": {
    "bundles": 4,
    "layers": 8,
    "findings": 8,
    "questions": 16
  }
}