{ "vercy": "1.0-draft", "publication": { "status": "research-draft", "adjudicationStatus": "unreviewed", "publishableCanonical": false, "generatedAt": "2026-09-12T10:41:59Z", "providers": [ "Codex" ], "breadth": "recalled by Codex without web access - no source was read", "missingProviders": [], "pass": 2, "cost": { "grok": { "seconds": 19.3, "error": "Reading additional input from stdin...\nOpenAI Codex v0.153.4\n--------\nworkdir: R:\\02_PROJECTS\\02_Meta_Models_Platforms\\Ver.cy\\current\\thing-registry-backlog\nmodel: gpt-6-astra\nprovider: openai\napproval: never\nsandbox: read-only\nreasoning effort: none\nreasoning summaries: none\nsession id: 01a09534-a7a0-7630-926a-20f5f08e3cd1\n--------\nuser\nDescribe what is already known about one registered thing. Answer as JSON only, no prose around it.\n\nThing: kaempferide\nSense to describe: (none recorded)\nDomain code: PHY.MAT\nAlso known as: (none)\n\n\nContext for this batch of 1001 things:\n# Batch 043: 1001 reg", "usd": 0.0, "recall": true }, "codex": { "seconds": 68.7, "error": "Reading additional input from stdin...\nOpenAI Codex v0.153.4\n--------\nworkdir: R:\\02_PROJECTS\\02_Meta_Models_Platforms\\Ver.cy\\current\\thing-registry-backlog\nmodel: gpt-6-astra\nprovider: openai\napproval: never\nsandbox: read-only\nreasoning effort: none\nreasoning summaries: none\nsession id: 01a09534-a7a6-72d2-861d-ab2eb9836d8f\n--------\nuser\nYou are drafting a Vercy meta-model for one registered thing. Answer as JSON only, no prose around it.\n\nThing: kaempferide\nRegistry id: vr.tr.kaempferide\nPlane / domain: PHY / PHY.MAT\nRegistry definition: (none recorded)\nNames folded into this entry: (none)\n\n\n" } }, "enrichment": { "pass": 3, "engine": "claude", "producedAt": "2026-10-06T12:00:00Z", "ingestedAt": "2026-10-06T08:55:52+00:00", "fields": [ "agent_conduct", "ethics", "failure_modes_and_hazards", "owners", "visual_identification" ] }, "gate": { "passed": true, "version": "1.0", "at": "2026-10-07T10:10:29+00:00", "evidence": [ "completeness 1.00", "sense: Wikidata description", "2 live sources", "review by codex: pass" ] } }, "metaModel": { "id": "THING-Q3116775", "registryId": "vr.tr.kaempferide", "name": "kaempferide", "version": "0.1.0-research.1", "entryKind": "thing", "family": "Thing Registry", "domain": [ "PHY.MAT" ], "status": "research-draft" }, "canonicalUrl": "https://ver.cy/models/thing/q3116775/", "model": { "registry_id": "vr.tr.kaempferide", "name": "kaempferide", "purpose": "Enable an agent to identify kaempferide, assess the quality and condition of a particular sample, and determine whether evidence supports its intended handling or use.", "definition": "Kaempferide is a naturally occurring O-methylated flavonol corresponding to kaempferol with its 4′-hydroxy group converted to a methoxy group.", "scope_statement": "This model owns the chemical identity of kaempferide under vr.tr.kaempferide in PHY / PHY.MAT, together with sample composition, analytical verification, physical condition, provenance and evidence governing use.", "in_scope": [ "Kaempferide molecular identity and distinction from related flavonoids", "Sample purity, impurities, residual solvents and water content", "Analytical identification and quantitative determination", "Physical form, dissolution, stability and storage conditions", "Source provenance and sample-specific handling or use constraints" ], "out_of_scope": [ "Complete models of kaempferol or other methylated flavonoids", "Botanical species and extracts containing kaempferide", "Manufacturing and extraction processes as independently managed systems", "Finished supplements, medicines and other formulations", "Clinical treatment protocols and organism-level disease models" ], "distinguishing_features": [ "Require the 4'-O-methyl derivative of kaempferol, with hydroxyl groups at positions 3, 5 and 7; this substitution pattern defines kaempferide. See [ChEBI CHEBI:6099](https://www.ebi.ac.uk/chebi/CHEBI%3A6099).", "Check the neutral formula C16H12O6 and molecular weight 300.26 g/mol against the proposed structure; formula agreement alone cannot resolve positional isomers. See [PubChem CID 5281666](https://pubchem.ncbi.nlm.nih.gov/compound/5281666).", "Require evidence locating methylation on the 4'-oxygen, rather than accepting an unspecified methylkaempferol name or mass match.", "Distinguish the free aglycone from glycosides, charged species and mixtures that merely contain kaempferide.", "Cross-check CAS 491-54-3 and PubChem CID 5281666 against the structure rather than relying on a supplier label alone. See [PubChem identity record](https://pubchem.ncbi.nlm.nih.gov/compound/5281666)." ], "characteristics": [ { "name": "Structural identity", "kind": "category", "unit_or_values": "Kaempferol 4'-O-methyl ether; confirmed, provisional or contradicted", "why_it_matters": "The methylation position distinguishes kaempferide from related structures." }, { "name": "Identifier concordance", "kind": "state", "unit_or_values": "Structure, registry and supplier identifiers agree, conflict or remain unchecked", "why_it_matters": "Conflicting identifiers can associate data with a different chemical species." }, { "name": "Kaempferide content", "kind": "measurement", "unit_or_values": "Mass fraction in %, with as-received or dry basis and assay method", "why_it_matters": "Actual content determines the amount available for preparation and interpretation." }, { "name": "Chromatographic purity", "kind": "measurement", "unit_or_values": "Area % with detector, wavelength, integration rules and method", "why_it_matters": "Area purity must be distinguished from an absolute mass assay." }, { "name": "Impurity profile", "kind": "measurement", "unit_or_values": "Identified and unidentified components in %, mg/g or ppm, with detection limits", "why_it_matters": "Related flavonoids and processing residues can affect identification and experimental results." }, { "name": "Physical form", "kind": "state", "unit_or_values": "Observed phase; crystalline or amorphous status; hydration or solvation where established", "why_it_matters": "Sample form affects weighing, dissolution and comparability." }, { "name": "Conditional solubility", "kind": "measurement", "unit_or_values": "mg/mL or mol/L with solvent composition, pH, temperature and equilibration time", "why_it_matters": "A preparation is usable only when its dissolved concentration is known." }, { "name": "Thermal behavior", "kind": "measurement", "unit_or_values": "Transition or decomposition temperature in °C with method and conditions", "why_it_matters": "Thermal observations support characterization without assuming a transferable melting or boiling point." }, { "name": "Sample provenance", "kind": "relation", "unit_or_values": "Links to supplier, lot, certificate, isolation or synthesis record and analytical evidence", "why_it_matters": "Evidence must be traceable to the material actually used." }, { "name": "Handling and use evidence", "kind": "state", "unit_or_values": "Documented, incomplete, conflicting or unassessed for a specified use and jurisdiction", "why_it_matters": "Neither a biological activity report nor missing hazard data establishes suitability." } ], "affordances": [ "Resolve a named sample to kaempferide using structure and analytical evidence.", "Accept, quarantine or reject a lot against an explicit identity and purity specification.", "Calculate preparation amounts from measured content and verify the resulting dissolved concentration.", "Select storage and handling conditions supported by sample-specific evidence.", "Compare research observations while accounting for purity, vehicle and exposure conditions.", "Link kaempferide-containing materials to this identity without treating the whole material as kaempferide." ], "agent_conduct": { "may": [ "Describe kaempferide and its occurrence in plants from chemical sources.", "Report research findings on it with the level of evidence stated." ], "must_not": [ "Claim it cures or prevents disease on the basis of laboratory or animal studies alone.", "Recommend doses of supplements or extracts containing it.", "Confuse it with kaempferol when reporting properties." ], "requires_human": [ "Advising a person to take a plant extract for a health condition." ] }, "ethics": { "considerations": [ "Natural product claims can mislead sick people into poor choices.", "Precise naming of related flavonoids keeps research reliable." ], "affected_parties": [ "Supplement buyers", "Researchers" ] }, "owners": { "steward": "Nobody owns the compound; makers answer for products that contain it.", "master_systems": [] }, "visual_identification": [ "A yellow crystalline solid; identified by laboratory analysis." ], "failure_modes_and_hazards": [ "Unregulated extracts may vary in content and purity." ], "what_it_is_for": [ "Kaempferide is encountered in natural product chemistry when researchers isolate and characterize plant constituents.", "Analytical laboratories may use authenticated samples as reference materials for identifying or quantifying the compound in extracts.", "Experimental studies examine its chemical and biological properties without establishing that a sample is suitable for therapeutic use." ], "standards_and_regulation": [ "The Globally Harmonized System of Classification and Labelling of Chemicals, issued by the United Nations, provides a framework for evaluating and communicating chemical hazards where implemented." ] }, "sources": [ { "id": "wikidata", "title": "Wikidata item Q3116775: kaempferide", "url": "https://www.wikidata.org/wiki/Q3116775", "url_status": "live", "what_it_supports": "identity and sense of the item", "checked_by": "wikidata-api" }, { "id": "wikipedia-en", "title": "Wikipedia: Kaempferide", "url": "https://en.wikipedia.org/wiki/Kaempferide", "url_status": "live", "what_it_supports": "general description of the item", "checked_by": "wikidata-api sitelink" } ], "structure": { "bundles": [ { "id": "molecular-identity", "name": "Molecular identity", "description": "Establish the chemical entity represented by the registry entry.", "rationale": "Closely related flavonoid names and substitution patterns can cause incorrect identification.", "layers": [ { "id": "substitution-pattern", "name": "Substitution pattern", "description": "Resolve the flavonol structure and methylation position.", "findings": [ { "id": "four-prime-o-methyl-identity", "name": "4'-O-methyl identity", "description": "Kaempferide is the 4'-O-methyl derivative of kaempferol. See [ChEBI](https://www.ebi.ac.uk/chebi/CHEBI%3A6099).", "questions": [ { "text": "Does the assigned structure retain hydroxyl groups at 3, 5 and 7 and place the methoxy group at 4'?", "kind": "definition", "id": "four-prime-o-methyl-identity-q01" }, { "text": "What evidence distinguishes this assignment from another O-methylkaempferol positional isomer?", "kind": "measurement", "id": "four-prime-o-methyl-identity-q02" } ] } ] }, { "id": "identifier-and-species-boundaries", "name": "Identifier and species boundaries", "description": "Connect names and identifiers while distinguishing related chemical forms.", "findings": [ { "id": "structure-anchored-record", "name": "Structure-anchored record", "description": "Resolve identifier matches against the neutral parent structure and record related forms explicitly.", "questions": [ { "text": "Do the supplier identifiers and structure resolve to CAS 491-54-3 and PubChem CID 5281666?", "kind": "provenance", "id": "structure-anchored-record-q01" }, { "text": "Is the material free kaempferide, a glycoside, a salt or an extract containing it?", "kind": "boundary", "id": "structure-anchored-record-q02" } ] } ] } ] }, { "id": "sample-composition", "name": "Sample composition", "description": "Describe how much kaempferide a lot contains and what accompanies it.", "rationale": "A nominal kaempferide sample cannot be judged solely by its compound name.", "layers": [ { "id": "content-and-grade", "name": "Content and grade", "description": "Separate measured content from vendor purity claims.", "findings": [ { "id": "assay-basis", "name": "Assay basis", "description": "Record absolute content separately from chromatographic area purity and grade labels.", "questions": [ { "text": "What kaempferide mass fraction was measured, by which method and with what uncertainty?", "kind": "measurement", "id": "assay-basis-q01" }, { "text": "Does the stated purity describe peak area, dry material or the sample as received?", "kind": "definition", "id": "assay-basis-q02" } ] } ] }, { "id": "accompanying-components", "name": "Accompanying components", "description": "Account for related flavonoids and non-analyte material.", "findings": [ { "id": "impurity-accounting", "name": "Impurity accounting", "description": "Investigate kaempferol, other methylated flavonoids, residual solvents and water as possible accompanying components without presuming their presence.", "questions": [ { "text": "Which related flavonoids and unidentified peaks are detected, and at what levels?", "kind": "measurement", "id": "impurity-accounting-q01" }, { "text": "What water and residual-solvent measurements are available for this lot?", "kind": "measurement", "id": "impurity-accounting-q02" } ] } ] } ] }, { "id": "analytical-verification", "name": "Analytical verification", "description": "Connect structural identity and concentration claims to discriminating measurements.", "rationale": "A mass match or single chromatographic peak may leave methylation position and purity unresolved.", "layers": [ { "id": "structural-confirmation", "name": "Structural confirmation", "description": "Evaluate complementary evidence for kaempferide identity.", "findings": [ { "id": "orthogonal-identification", "name": "Orthogonal identification", "description": "Record how mass spectrometry, NMR and reference comparisons support the structural assignment.", "questions": [ { "text": "Which NMR assignments or correlations support attachment of the methoxy group at 4'?", "kind": "measurement", "id": "orthogonal-identification-q01" }, { "text": "Which independent measurements support the assignment, and which alternatives remain unresolved?", "kind": "boundary", "id": "orthogonal-identification-q02" } ] } ] }, { "id": "quantitative-method", "name": "Quantitative method", "description": "Establish whether kaempferide can be measured reliably in the relevant sample matrix.", "findings": [ { "id": "selective-calibration", "name": "Selective calibration", "description": "Capture calibration traceability, chromatographic separation and matrix-dependent performance.", "questions": [ { "text": "Which characterized kaempferide reference material anchors the calibration?", "kind": "provenance", "id": "selective-calibration-q01" }, { "text": "Does the method resolve kaempferide from relevant co-occurring flavonoids and quantify recovery or matrix effects?", "kind": "measurement", "id": "selective-calibration-q02" } ] } ] } ] }, { "id": "physical-state-and-preparation", "name": "Physical state and preparation", "description": "Describe the solid material and its behavior during solution preparation.", "rationale": "Nominal weighed amounts do not establish the concentration or condition of a kaempferide preparation.", "layers": [ { "id": "solid-form-and-thermal-behavior", "name": "Solid form and thermal behavior", "description": "Tie physical observations to the tested sample and conditions.", "findings": [ { "id": "conditioned-physical-properties", "name": "Conditioned physical properties", "description": "Record physical form and thermal measurements without assigning unsupported universal constants.", "questions": [ { "text": "What evidence establishes the sample's crystallinity, hydration or solvation state?", "kind": "measurement", "id": "conditioned-physical-properties-q01" }, { "text": "Are reported thermal events melting, solvent loss or decomposition, and under what measurement conditions?", "kind": "measurement", "id": "conditioned-physical-properties-q02" } ] } ] }, { "id": "dissolution-and-persistence", "name": "Dissolution and persistence", "description": "Track whether prepared kaempferide remains dissolved and chemically intact.", "findings": [ { "id": "usable-solution-state", "name": "Usable solution state", "description": "Record solvent-dependent concentration, precipitation observations and stability over the intended use interval.", "questions": [ { "text": "What dissolved concentration is verified at the specified solvent composition, pH and temperature?", "kind": "measurement", "id": "usable-solution-state-q01" }, { "text": "What measurements after storage or dilution establish that the preparation remains intact and free of precipitation?", "kind": "measurement", "id": "usable-solution-state-q02" }, { "text": "What preparation and storage interval is supported by those observations?", "kind": "action", "id": "usable-solution-state-q03" } ] } ] } ] }, { "id": "provenance-and-use-evidence", "name": "Provenance and use evidence", "description": "Connect the actual sample to its origin, research claims and handling documentation.", "rationale": "Evidence about an extract, a related flavonoid or an unspecified lot must not silently become evidence about this kaempferide sample.", "layers": [ { "id": "origin-and-claim-attribution", "name": "Origin and claim attribution", "description": "Trace isolated or synthesized material and distinguish compound-level observations from mixture-level results.", "findings": [ { "id": "sample-linked-evidence", "name": "Sample-linked evidence", "description": "Link provenance and reported biological observations to identified material and explicit experimental conditions.", "questions": [ { "text": "Which isolation or synthesis record and lot-specific analysis establish the origin of this material?", "kind": "provenance", "id": "sample-linked-evidence-q01" }, { "text": "Was a reported effect measured using characterized kaempferide or a mixture containing it?", "kind": "boundary", "id": "sample-linked-evidence-q02" }, { "text": "What purity, vehicle, concentration and exposure conditions qualify the reported observation?", "kind": "measurement", "id": "sample-linked-evidence-q03" } ] } ] }, { "id": "handling-and-regulatory-status", "name": "Handling and regulatory status", "description": "Record applicable documentation and distinguish missing information from affirmative safety evidence.", "findings": [ { "id": "documented-use-constraints", "name": "Documented use constraints", "description": "Assess handling and intended-use decisions through dated, jurisdiction-specific records for the supplied material.", "questions": [ { "text": "Which current SDS and authoritative records support the material's hazard classification and regulatory identifiers?", "kind": "provenance", "id": "documented-use-constraints-q01" }, { "text": "Are kaempferide-specific exposure limits established in the applicable jurisdiction, or is their status unresolved?", "kind": "boundary", "id": "documented-use-constraints-q02" }, { "text": "Which handling, storage, disposal and intended-use decisions are supported by the available documentation?", "kind": "action", "id": "documented-use-constraints-q03" } ] } ] } ] }, { "id": "evidence-and-external-alignment", "name": "Evidence and external alignment", "description": "What the world already says about this thing, gathered so the model can be checked against it.", "rationale": "A model that cannot be lined up against existing standards, identifiers and practice cannot be adopted by anyone who already uses them.", "layers": [ { "id": "reported-evidence", "name": "Reported evidence", "description": "Findings from the breadth pass, kept separate from the structural claims.", "findings": [ { "id": "evidence-confidence-notes", "name": "Check these first", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "This description is recalled knowledge; no sources were consulted.", "Registry identifiers, physical constants, hazard classifications and jurisdiction-specific regulatory status require verification.", "Analytical use requires a reference material with documented identity and purity; no grade or purity is implied here." ], "questions": [ { "id": "evidence-confidence-notes-q01", "text": "Which of these check these first hold for the sense of kaempferide this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-identifiers", "name": "Identifiers and schemes", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ { "scheme": "Molecular formula", "value_or_pattern": "C16H12O6", "note": "Formula of the neutral compound." }, { "scheme": "Systematic chemical nomenclature", "value_or_pattern": "3,5,7-trihydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one", "note": "Specifies the positions of the hydroxy and methoxy groups." } ], "questions": [ { "id": "evidence-identifiers-q01", "text": "Which of these identifiers and schemes hold for the sense of kaempferide this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-real-world-use", "name": "Real-world use", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "Reference compound for identifying and quantifying kaempferide in phytochemical analyses.", "Research compound in studies of flavonoid chemistry and biological activity." ], "questions": [ { "id": "evidence-real-world-use-q01", "text": "Which of these real-world use hold for the sense of kaempferide this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-measurements", "name": "Typical measurements", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ { "quantity": "Molar mass", "typical_range": "300.26", "unit": "g/mol" } ], "questions": [ { "id": "evidence-measurements-q01", "text": "Which of these typical measurements hold for the sense of kaempferide this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-failure-modes-and-hazards", "name": "Failure modes and hazards", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "Confusion with other methylated flavonols can cause analytical misidentification; molecular formula or mass alone does not establish the methylation position.", "Experimental biological activity does not establish clinical efficacy or safety." ], "questions": [ { "id": "evidence-failure-modes-and-hazards-q01", "text": "Which of these failure modes and hazards hold for the sense of kaempferide this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-neighbours", "name": "Neighbouring kinds and how to tell them apart", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ { "name": "Kaempferol", "difference": "Kaempferol has a hydroxy group at the 4′ position; kaempferide has a methoxy group there." }, { "name": "Isokaempferide", "difference": "Isokaempferide is the 3-O-methyl derivative of kaempferol, whereas kaempferide is the 4′-O-methyl derivative." }, { "name": "Kaempferide glycosides", "difference": "Glycosides contain an attached sugar residue; kaempferide itself is the aglycone." } ], "questions": [ { "id": "evidence-neighbours-q01", "text": "Which of these neighbouring kinds and how to tell them apart hold for the sense of kaempferide this model covers, and on what evidence?", "kind": "provenance" } ] } ] } ] } ] }, "openQuestions": [ "Which EC and other regulatory identifiers are authoritative for neutral kaempferide, and do any linked records instead describe a charged or otherwise different species?", "What experimentally established solubility, thermal behavior and solid-form data are available with sufficient conditions and sample characterization to be reusable?", "Which storage conditions and solution lifetimes are supported by direct stability measurements, including testing for precipitation and chemical change?", "What current hazard classifications, toxicology evidence and occupational exposure limits apply to kaempferide in the intended jurisdiction and use?", "Which reported natural occurrences and biological effects are supported by structurally confirmed kaempferide rather than tentative annotations, extracts or related flavonoids?" ], "statistics": { "bundles": 6, "layers": 11, "findings": 16, "questions": 29 } }