{ "vercy": "1.0-draft", "publication": { "status": "research-draft", "adjudicationStatus": "unreviewed", "publishableCanonical": false, "generatedAt": "2026-09-12T10:44:16Z", "providers": [ "Codex" ], "breadth": "recalled by Codex without web access - no source was read", "missingProviders": [], "pass": 2, "cost": { "grok": { "seconds": 16.9, "error": "Reading additional input from stdin...\nOpenAI Codex v0.153.4\n--------\nworkdir: R:\\02_PROJECTS\\02_Meta_Models_Platforms\\Ver.cy\\current\\thing-registry-backlog\nmodel: gpt-6-astra\nprovider: openai\napproval: never\nsandbox: read-only\nreasoning effort: none\nreasoning summaries: none\nsession id: 01a09536-d2fb-7772-8059-13eed0d4f4e0\n--------\nuser\nDescribe what is already known about one registered thing. Answer as JSON only, no prose around it.\n\nThing: kavain\nSense to describe: (none recorded)\nDomain code: PHY.MAT\nAlso known as: (none)\n\n\nContext for this batch of 1001 things:\n# Batch 043: 1001 register", "usd": 0.0, "recall": true }, "codex": { "seconds": 63.3, "error": "Reading additional input from stdin...\nOpenAI Codex v0.153.4\n--------\nworkdir: R:\\02_PROJECTS\\02_Meta_Models_Platforms\\Ver.cy\\current\\thing-registry-backlog\nmodel: gpt-6-astra\nprovider: openai\napproval: never\nsandbox: read-only\nreasoning effort: none\nreasoning summaries: none\nsession id: 01a09536-d308-7a13-bbfd-1fd063380007\n--------\nuser\nYou are drafting a Vercy meta-model for one registered thing. Answer as JSON only, no prose around it.\n\nThing: kavain\nRegistry id: vr.tr.kavain\nPlane / domain: PHY / PHY.MAT\nRegistry definition: (none recorded)\nNames folded into this entry: (none)\n\n\nContext fo" } }, "enrichment": { "pass": 3, "engine": "claude", "producedAt": "2026-10-06T12:00:00Z", "ingestedAt": "2026-10-06T08:52:08+00:00", "fields": [ "agent_conduct", "ethics", "failure_modes_and_hazards", "owners", "visual_identification" ] }, "gate": { "passed": true, "version": "1.0", "at": "2026-10-07T10:10:30+00:00", "evidence": [ "completeness 1.00", "sense: Wikidata description", "2 live sources", "review by codex: pass" ] } }, "metaModel": { "id": "THING-Q3194310", "registryId": "vr.tr.kavain", "name": "kavain", "version": "0.1.0-research.1", "entryKind": "thing", "family": "Thing Registry", "domain": [ "PHY.MAT" ], "status": "research-draft" }, "canonicalUrl": "https://ver.cy/models/thing/q3194310/", "model": { "registry_id": "vr.tr.kavain", "name": "kavain", "purpose": "Enable an agent to recognise kavain, assess the identity and condition of a particular sample, and determine its suitability for an intended use from documented evidence.", "definition": "Kavain is a kavalactone found in kava (Piper methysticum), with molecular formula C14H14O3, and is one of the constituents studied for the plant's central nervous system activity.", "scope_statement": "This model owns the substance-level identity, stereochemical specification, composition, physical condition, analytical evidence and use constraints of kavain within vr.tr.kavain, PHY/PHY.MAT; the undefined registry name does not by itself settle whether a record denotes a particular enantiomer or racemic material.", "in_scope": [ "Kavain molecular identity and explicitly specified stereochemical form", "Sample purity, kavain content and accompanying kavalactones or other impurities", "Physical properties, phase and stability under recorded conditions", "Analytical confirmation and traceability of kavain samples and reference materials", "Evidence supporting handling restrictions and suitability for a stated use" ], "out_of_scope": [ "Piper methysticum cultivation, taxonomy and whole-plant characteristics", "Kava beverages, extracts and supplements as finished products", "Other kavalactones and kavain metabolites as independently identified substances", "Extraction or synthesis processes as complete operational models", "Clinical treatment decisions and efficacy claims for kava products" ], "distinguishing_features": [ "Confirm the molecular structure rather than matching the word kavain: the (+)-kavain record specifies C14H14O3 and a molar mass of 230.26 g/mol. [PubChem](https://pubchem.ncbi.nlm.nih.gov/compound/Kavain)", "Resolve enantiomeric composition explicitly; an achiral identity assay cannot establish whether material is a specified enantiomer or a racemate.", "Differentiate kavain from dihydrokavain by structure and validated analytical evidence; dihydrokavain has formula C14H16O3. [PubChem](https://pubchem.ncbi.nlm.nih.gov/compound/10220256)", "Distinguish a kavain substance sample from a kava extract by recording the full sample matrix and quantified kavain content.", "Require chromatographic discrimination from neighbouring kavalactones instead of treating a total-kavalactone result as a kavain-specific measurement." ], "characteristics": [ { "name": "Structure and stereochemical identity", "kind": "category", "unit_or_values": "Structure identifier with absolute configuration and alkene geometry; stereochemistry unspecified when unresolved", "why_it_matters": "Prevents name matching from silently equating different stereochemical materials." }, { "name": "External identity mappings", "kind": "relation", "unit_or_values": "CAS, PubChem CID, EC and other identifiers, each linked to its source and represented structure", "why_it_matters": "Supplier, regulatory and research records must refer to the same chemical form." }, { "name": "Kavain assay", "kind": "measurement", "unit_or_values": "% mass fraction or mg/g, with method, uncertainty and as-received or dry basis", "why_it_matters": "Establishes how much kavain the material contains without confusing peak area with mass purity." }, { "name": "Enantiomeric composition", "kind": "measurement", "unit_or_values": "Enantiomer ratio or enantiomeric excess %, with chiral method and assignment evidence", "why_it_matters": "Determines whether the sample meets a stereochemical specification." }, { "name": "Impurity profile", "kind": "measurement", "unit_or_values": "Individual related compounds, residual solvents and water in %, mg/kg or another stated unit; detection limits recorded", "why_it_matters": "Separates kavain-related effects and suitability from contributions of contaminants." }, { "name": "Material presentation", "kind": "state", "unit_or_values": "Solid, solution or other observed state; solvent and concentration where applicable", "why_it_matters": "Determines how the material can be sampled, measured and stored." }, { "name": "Physical property evidence", "kind": "measurement", "unit_or_values": "Melting range in °C, solubility in g/L or mol/L, and thermal data with pressure, solvent, method and stereochemical form", "why_it_matters": "Supports sample comparison and preparation while preventing transfer of values between incompatible conditions." }, { "name": "Storage and stability status", "kind": "state", "unit_or_values": "Within supported conditions, excursion recorded, retest required or degraded; linked dates and analytical evidence", "why_it_matters": "Connects the sample's current condition to defensible use decisions." }, { "name": "Use and handling constraints", "kind": "relation", "unit_or_values": "Applicable safety documents, hazard classifications, exposure limits if established, jurisdiction, intended use and effective date", "why_it_matters": "Avoids treating missing hazard information or research availability as permission for a particular use." } ], "affordances": [ "Match a candidate kavain record to a structure and flag unresolved stereochemistry.", "Compare a sample with a kavain specification using assay, chiral composition and impurity evidence.", "Select analytical checks that distinguish kavain from accompanying kavalactones.", "Assess whether a proposed solvent and concentration are supported by solubility and stability evidence.", "Flag a stored sample for retesting after an excursion or unsupported holding period.", "Determine whether available documentation supports the intended use or leaves a decision unresolved." ], "agent_conduct": { "may": [ "Explain kavain as a kavalactone found in kava and summarize research on it with sources.", "Report regulatory status of kava products in a jurisdiction from official sources." ], "must_not": [ "Recommend kavain or kava extracts to treat anxiety or other conditions in place of a clinician.", "Encourage combining kava products with alcohol or sedative medicines.", "Present kavain as proven safe for the liver.", "Help evade import or sale restrictions on kava products." ], "requires_human": [ "Using kava products for a person with liver disease or on interacting medicines." ] }, "ethics": { "considerations": [ "Kava has deep cultural meaning in Pacific Island communities, beyond its chemistry.", "Health claims for psychoactive plant compounds can mislead vulnerable people." ], "affected_parties": [ "Consumers of kava products", "Pacific Island communities", "People with liver disease" ] }, "owners": { "steward": "The laboratory or business that holds it; chemical safety authorities regulate supply and use.", "master_systems": [] }, "visual_identification": [ "Identified by container label, chemical name and identifier, and certificate of analysis rather than by appearance alone." ], "failure_modes_and_hazards": [ "Sedation and impaired driving.", "Possible liver injury reported with some kava products.", "Interactions with alcohol and sedatives." ], "what_it_is_for": [ "Kavain is encountered in chemical studies of kava, analytical reference materials and laboratory investigations of kavalactones.", "It is used to investigate chemical composition and biological activity, with sample identity and purity affecting interpretation." ], "standards_and_regulation": [ "The Globally Harmonized System of Classification and Labelling of Chemicals, issued by the United Nations, provides the framework for assessing and communicating hazards of kavain supplied as a chemical." ] }, "sources": [ { "id": "wikidata", "title": "Wikidata item Q3194310: kavain", "url": "https://www.wikidata.org/wiki/Q3194310", "url_status": "live", "what_it_supports": "identity and sense of the item", "checked_by": "wikidata-api" }, { "id": "wikipedia-en", "title": "Wikipedia: Kavain", "url": "https://en.wikipedia.org/wiki/Kavain", "url_status": "live", "what_it_supports": "general description of the item", "checked_by": "wikidata-api sitelink" } ], "structure": { "bundles": [ { "id": "kavain-identity", "name": "Kavain identity and registry boundary", "description": "Defines which molecular and stereochemical material a kavain record represents.", "rationale": "The registry lacks a definition, and the substance name alone is insufficient to resolve stereochemical identity.", "layers": [ { "id": "molecular-recognition", "name": "Molecular recognition", "description": "Connects the registered name to a verifiable chemical structure.", "findings": [ { "id": "structure-backed-identifiers", "name": "Structure-backed identifiers", "description": "PubChem associates (+)-kavain with CID 5281565, CAS 500-64-1 and EC 207-907-2; use these as sourced mappings for that represented form, subject to registry boundary review. [PubChem](https://pubchem.ncbi.nlm.nih.gov/compound/Kavain)", "questions": [ { "text": "Which structure and stereochemical specification does vr.tr.kavain intend to cover?", "kind": "definition", "id": "structure-backed-identifiers-q01" }, { "text": "Does each proposed external identifier resolve to that same represented form?", "kind": "provenance", "id": "structure-backed-identifiers-q02" } ] } ] }, { "id": "stereochemical-boundary", "name": "Stereochemical boundary", "description": "Preserves differences between a specified enantiomer, racemic material and unresolved samples within the registered entry.", "findings": [ { "id": "form-is-not-established-by-name", "name": "Form requires independent evidence", "description": "Represent stereochemical form explicitly without creating additional registry entries or inferring configuration from a supplier's use of kavain or kawain.", "questions": [ { "text": "Is this sample a specified enantiomer, a racemate or material with unmeasured enantiomeric composition?", "kind": "boundary", "id": "form-is-not-established-by-name-q01" }, { "text": "What chiral analysis or traceable reference establishes its stereochemical assignment?", "kind": "measurement", "id": "form-is-not-established-by-name-q02" } ] } ] } ] }, { "id": "kavain-composition-and-authentication", "name": "Kavain composition and authentication", "description": "Establishes what a sample contains and how its kavain identity was demonstrated.", "rationale": "A kavain label, a total-kavalactone assay and an authenticated kavain sample provide different levels of evidence.", "layers": [ { "id": "sample-composition", "name": "Sample composition", "description": "Separates kavain content from matrix components and impurities.", "findings": [ { "id": "kavain-specific-content", "name": "Kavain-specific content", "description": "Record a kavain-specific assay with its calculation basis and separately quantify relevant related compounds, water and residual solvents.", "questions": [ { "text": "What is the kavain mass fraction, and is the result an absolute assay or chromatographic area percentage?", "kind": "measurement", "id": "kavain-specific-content-q01" }, { "text": "Which accompanying kavalactones or other impurities were measured, and with what detection limits?", "kind": "measurement", "id": "kavain-specific-content-q02" } ] } ] }, { "id": "authentication-evidence", "name": "Authentication evidence", "description": "Links analytical conclusions to methods, standards and the actual sample tested.", "findings": [ { "id": "discriminating-analytical-confirmation", "name": "Discriminating analytical confirmation", "description": "Use complementary evidence appropriate to the claim, such as structure-sensitive spectra, selective chromatography and chiral analysis; retention time alone needs supporting specificity evidence.", "questions": [ { "text": "How does the method distinguish kavain from dihydrokavain and other compounds expected in this sample?", "kind": "measurement", "id": "discriminating-analytical-confirmation-q01" }, { "text": "Which reference material, lot and raw analytical records support the reported identity and assay?", "kind": "provenance", "id": "discriminating-analytical-confirmation-q02" } ] } ] } ] }, { "id": "kavain-physical-state-and-stability", "name": "Kavain physical state and stability", "description": "Connects measured material properties to preparation, storage and current sample condition.", "rationale": "Property values and holding conditions must apply to the actual kavain form and presentation being used.", "layers": [ { "id": "phase-and-solution-behaviour", "name": "Phase and solution behaviour", "description": "Records solid-state observations and solvent-dependent preparation limits.", "findings": [ { "id": "condition-qualified-properties", "name": "Condition-qualified properties", "description": "Capture measured melting behaviour, solubility and thermal observations with form, purity and experimental conditions; leave unverified constants unresolved.", "questions": [ { "text": "What melting range or thermal transition was measured for this kavain form and purity?", "kind": "measurement", "id": "condition-qualified-properties-q01" }, { "text": "At the proposed solvent composition and temperature, what dissolved kavain concentration is experimentally supported?", "kind": "measurement", "id": "condition-qualified-properties-q02" } ] } ] }, { "id": "sample-aging", "name": "Sample aging", "description": "Evaluates whether stored solids or prepared solutions retain their specified composition.", "findings": [ { "id": "supported-holding-conditions", "name": "Supported holding conditions", "description": "Treat storage recommendations and solution holding times as evidence-dependent limits, with sample history and retest results available for assessment.", "questions": [ { "text": "What data support the stated container, temperature, light exposure and holding time for this presentation?", "kind": "provenance", "id": "supported-holding-conditions-q01" }, { "text": "After a storage excursion or observed change, which kavain assay and impurity checks are required before reuse?", "kind": "action", "id": "supported-holding-conditions-q02" } ] } ] } ] }, { "id": "kavain-evidence-and-use-constraints", "name": "Kavain evidence and use constraints", "description": "Bounds the conclusions and actions supported for a particular kavain material.", "rationale": "Evidence concerning a plant extract, another stereochemical form or a specific experimental system cannot automatically establish the suitability of this sample.", "layers": [ { "id": "biological-evidence-boundary", "name": "Biological evidence boundary", "description": "Keeps substance-level experimental observations tied to their tested material and conditions.", "findings": [ { "id": "tested-material-attribution", "name": "Tested-material attribution", "description": "Any biological claim attached to kavain should identify the tested form, purity, concentration, vehicle and experimental system, and distinguish purified substance evidence from mixture evidence.", "questions": [ { "text": "Was the reported result obtained with authenticated kavain, a stereochemically specified sample or a kava mixture?", "kind": "boundary", "id": "tested-material-attribution-q01" }, { "text": "Which experimental conditions and material records limit transfer of that result to this sample?", "kind": "provenance", "id": "tested-material-attribution-q02" } ] } ] }, { "id": "handling-and-use-eligibility", "name": "Handling and use eligibility", "description": "Relates the identified material to applicable safety documentation and intended-use requirements.", "findings": [ { "id": "documented-use-decision", "name": "Documented use decision", "description": "Assess handling and use against current documents for the relevant chemical form, composition and jurisdiction; record unresolved classifications and exposure limits explicitly.", "questions": [ { "text": "Which current safety data sheet and authoritative classifications apply to this kavain form or solution?", "kind": "provenance", "id": "documented-use-decision-q01" }, { "text": "Do this lot's identity, grade and documentation satisfy the requirements of the proposed use?", "kind": "action", "id": "documented-use-decision-q02" } ] } ] } ] }, { "id": "evidence-and-external-alignment", "name": "Evidence and external alignment", "description": "What the world already says about this thing, gathered so the model can be checked against it.", "rationale": "A model that cannot be lined up against existing standards, identifiers and practice cannot be adopted by anyone who already uses them.", "layers": [ { "id": "reported-evidence", "name": "Reported evidence", "description": "Findings from the breadth pass, kept separate from the structural claims.", "findings": [ { "id": "evidence-confidence-notes", "name": "Check these first", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "This is recall only; no sources were consulted.", "Verify the CAS record's stereochemical scope and the identity, enantiomeric composition and purity of any specific sample.", "Physical constants, hazard classifications, exposure limits and jurisdiction-specific rules require verification and are omitted." ], "questions": [ { "id": "evidence-confidence-notes-q01", "text": "Which of these check these first hold for the sense of kavain this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-kinds", "name": "Kinds and varieties", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "Naturally occurring (+)-kavain", "Synthetic racemic kavain" ], "questions": [ { "id": "evidence-kinds-q01", "text": "Which of these kinds and varieties hold for the sense of kavain this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-identifiers", "name": "Identifiers and schemes", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ { "scheme": "CAS Registry Number", "value_or_pattern": "500-64-1", "note": "Recalled identifier for kavain; verify the stereochemical scope before assigning it to an enantiomer-specific material." }, { "scheme": "Molecular formula", "value_or_pattern": "C14H14O3", "note": "Describes composition but does not distinguish stereoisomers." } ], "questions": [ { "id": "evidence-identifiers-q01", "text": "Which of these identifiers and schemes hold for the sense of kavain this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-real-world-use", "name": "Real-world use", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "Analytical reference material for identifying and quantifying kavalactones in kava preparations.", "Research compound for investigating kavalactone pharmacology.", "Constituent measured in the chemical characterization and quality assessment of kava extracts." ], "questions": [ { "id": "evidence-real-world-use-q01", "text": "Which of these real-world use hold for the sense of kavain this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-measurements", "name": "Typical measurements", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ { "quantity": "Molar mass", "typical_range": "230.26", "unit": "g/mol" } ], "questions": [ { "id": "evidence-measurements-q01", "text": "Which of these typical measurements hold for the sense of kavain this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-failure-modes-and-hazards", "name": "Failure modes and hazards", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "Failure to distinguish natural kavain from racemic material can confound pharmacological comparisons.", "Other kavalactones and impurities can confound measurements or biological results unless composition and purity are established.", "Safety findings for whole kava preparations cannot automatically be attributed to isolated kavain." ], "questions": [ { "id": "evidence-failure-modes-and-hazards-q01", "text": "Which of these failure modes and hazards hold for the sense of kavain this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-neighbours", "name": "Neighbouring kinds and how to tell them apart", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ { "name": "Kava", "difference": "Kava denotes the plant or preparations made from it; kavain is an individual chemical constituent." }, { "name": "Kavalactones", "difference": "Kavalactones are a family of compounds; kavain is one member." }, { "name": "Dihydrokavain", "difference": "Dihydrokavain has a saturated side-chain linkage where kavain has a carbon-carbon double bond." } ], "questions": [ { "id": "evidence-neighbours-q01", "text": "Which of these neighbouring kinds and how to tell them apart hold for the sense of kavain this model covers, and on what evidence?", "kind": "provenance" } ] } ] } ] } ] }, "openQuestions": [ "Does vr.tr.kavain encompass all stereochemical forms, or is its intended referent specifically (+)-kavain?", "Which experimentally measured melting, solubility and thermal data are reliable for each relevant stereochemical form and purity?", "Which validated methods adequately resolve kavain from likely co-occurring kavalactones, stereochemical variants and degradation products?", "What stability studies justify solid storage conditions, solution holding times and retest intervals?", "Which current hazard classifications, exposure limits if any, and intended-use restrictions apply to the exact kavain material in each relevant jurisdiction?" ], "statistics": { "bundles": 5, "layers": 9, "findings": 15, "questions": 23 } }