{ "vercy": "1.0-draft", "publication": { "status": "research-draft", "adjudicationStatus": "unreviewed", "publishableCanonical": false, "generatedAt": "2026-09-12T11:08:27Z", "providers": [ "Codex" ], "breadth": "recalled by Codex without web access - no source was read", "missingProviders": [], "pass": 2, "cost": { "grok": { "seconds": 21.4, "error": "Reading additional input from stdin...\nOpenAI Codex v0.153.4\n--------\nworkdir: R:\\02_PROJECTS\\02_Meta_Models_Platforms\\Ver.cy\\current\\thing-registry-backlog\nmodel: gpt-6-astra\nprovider: openai\napproval: never\nsandbox: read-only\nreasoning effort: none\nreasoning summaries: none\nsession id: 01a0954c-b8e6-7ef2-9788-e36733e1b1cc\n--------\nuser\nDescribe what is already known about one registered thing. Answer as JSON only, no prose around it.\n\nThing: malaoxon\nSense to describe: (none recorded)\nDomain code: PHY.MAT\nAlso known as: (none)\n\n\nContext for this batch of 1001 things:\n# Batch 044: 1001 regist", "usd": 0.0, "recall": true }, "codex": { "seconds": 79.1, "error": "Reading additional input from stdin...\nOpenAI Codex v0.153.4\n--------\nworkdir: R:\\02_PROJECTS\\02_Meta_Models_Platforms\\Ver.cy\\current\\thing-registry-backlog\nmodel: gpt-6-astra\nprovider: openai\napproval: never\nsandbox: read-only\nreasoning effort: none\nreasoning summaries: none\nsession id: 01a0954c-b8ed-7fd3-8dc6-1018116b4494\n--------\nuser\nYou are drafting a Vercy meta-model for one registered thing. Answer as JSON only, no prose around it.\n\nThing: malaoxon\nRegistry id: vr.tr.malaoxon\nPlane / domain: PHY / PHY.MAT\nRegistry definition: (none recorded)\nNames folded into this entry: (none)\n\n\nContex" } }, "enrichment": { "pass": 3, "engine": "claude", "producedAt": "2026-10-06T12:00:00Z", "ingestedAt": "2026-10-06T08:42:12+00:00", "fields": [ "agent_conduct", "ethics", "failure_modes_and_hazards", "owners", "visual_identification" ] }, "gate": { "passed": true, "version": "1.0", "at": "2026-10-07T10:10:30+00:00", "evidence": [ "completeness 1.00", "sense: Wikidata description", "2 live sources", "review by codex: pass" ] } }, "metaModel": { "id": "THING-Q3270235", "registryId": "vr.tr.malaoxon", "name": "malaoxon", "version": "0.1.0-research.1", "entryKind": "thing", "family": "Thing Registry", "domain": [ "PHY.MAT" ], "status": "research-draft" }, "canonicalUrl": "https://ver.cy/models/thing/q3270235/", "model": { "registry_id": "vr.tr.malaoxon", "name": "malaoxon", "purpose": "Enable an agent to recognise malaoxon, assess the identity and condition of material containing it, and determine whether analytical or handling actions have adequate evidence.", "definition": "Malaoxon is the organophosphorus oxon analogue of malathion, formed by replacing its phosphorus-bound thione sulfur with oxygen, and is a potent acetylcholinesterase inhibitor.", "scope_statement": "This model owns malaoxon as the registered chemical substance vr.tr.malaoxon in PHY.MAT, including molecular identity, sample composition, condition-dependent properties, transformation relationships, analytical evidence, and applicable hazard constraints.", "in_scope": [ "Malaoxon identity and distinction from malathion and related transformation products", "Purity, stereochemical specification, impurities, and concentration in identified matrices", "Physical properties and stability under recorded conditions", "Evidence of malaoxon formation, persistence, and disappearance", "Analytical identification and quantification", "Malaoxon-specific toxicological evidence and jurisdiction-dependent handling constraints" ], "out_of_scope": [ "Malathion's complete substance model and pesticide application practices", "Commercial formulations, packaging, and product authorisations beyond their relation to malaoxon", "Complete models of environmental compartments or exposed organisms", "Clinical diagnosis and treatment of organophosphate poisoning", "Laboratory instrument design and general laboratory management", "Manufacturing process design or optimisation" ], "distinguishing_features": [ "Match the chemical structure and identifiers together: formula C10H19O7PS, CAS 1634-78-2, and PubChem CID 15415. [PubChem](https://pubchem.ncbi.nlm.nih.gov/compound/Malaoxon)", "Require the malathion-oxon connectivity, including P=O and the retained sulfur linkage to the succinate skeleton; an oxon label alone does not identify malaoxon. [PubChem](https://pubchem.ncbi.nlm.nih.gov/compound/Malaoxon)", "Distinguish the substance from a solution, environmental residue, or malathion formulation by recording its concentration and the identity of the surrounding matrix.", "Treat acetylcholinesterase inhibition as mechanistic evidence rather than a unique identification test: EPA identifies malaoxon as the active AChE-inhibiting form of malathion. [EPA](https://www.epa.gov/pesticides/epa-releases-updated-draft-risk-assessment-pesticide-malathion)", "Do not equate an unspecified stereochemical identity with a demonstrated racemate or a specified enantiomer; require evidence for the sample's stereochemical designation." ], "characteristics": [ { "name": "Chemical identity", "kind": "category", "unit_or_values": "Structure-linked identifiers; CAS 1634-78-2; PubChem CID 15415", "why_it_matters": "Prevents malathion or a similarly named transformation product from being recorded as malaoxon." }, { "name": "Stereochemical specification", "kind": "category", "unit_or_values": "Unspecified, racemic, enantiomer-enriched, or specified configuration with supporting evidence", "why_it_matters": "Makes the scope of reference materials and biological comparisons explicit." }, { "name": "Malaoxon purity", "kind": "measurement", "unit_or_values": "Mass fraction or mass percent, with analytical method and uncertainty", "why_it_matters": "Separates substance identity from the actual composition of a material batch." }, { "name": "Matrix concentration", "kind": "measurement", "unit_or_values": "mg/L, µg/L, mg/kg, or mol/L; record matrix and wet, dry, or other reporting basis", "why_it_matters": "Supports valid comparison of standards, residues, and exposure measurements." }, { "name": "Related-substance profile", "kind": "measurement", "unit_or_values": "Individually identified malathion and other impurities or transformation products, with concentrations and detection limits", "why_it_matters": "Distinguishes malaoxon content from mixed organophosphate content." }, { "name": "Physical state and thermal behaviour", "kind": "state", "unit_or_values": "Observed phase at temperature and pressure; melting, boiling, or decomposition observations in °C with pressure where applicable", "why_it_matters": "Avoids treating a solvent formulation or a decomposition event as an intrinsic substance property." }, { "name": "Partitioning and transport properties", "kind": "measurement", "unit_or_values": "Solubility in mg/L, vapour pressure in Pa, and dimensionless log Kow, with conditions and measured or estimated status", "why_it_matters": "Constrains interpretation of distribution between water, other phases, and air." }, { "name": "Stability under specified conditions", "kind": "measurement", "unit_or_values": "Recovery in percent, rate constant with units, or half-life in hours or days; include matrix, pH, temperature, light, and elapsed time", "why_it_matters": "Determines whether stored material or a collected sample still represents its earlier composition." }, { "name": "Acetylcholinesterase inhibition evidence", "kind": "measurement", "unit_or_values": "Percent inhibition, IC50 with concentration units, or kinetic parameter with units; include enzyme source and assay duration", "why_it_matters": "Preserves the conditions required to interpret malaoxon's biological activity." }, { "name": "Applicable regulatory identity and restrictions", "kind": "relation", "unit_or_values": "Verified registry records, jurisdiction, effective date, substance or mixture scope, hazard classifications, and any applicable exposure limits", "why_it_matters": "Prevents importing malathion requirements or another supplier's mixture classification without checking applicability." } ], "affordances": [ "Reconcile malaoxon names and identifiers against a structure-backed substance record.", "Assess whether a reference material or sample is adequately characterised for a proposed analysis.", "Quantify malaoxon separately from malathion using a method validated for the relevant matrix.", "Compare repeated measurements to flag changes in malaoxon content during storage or sample processing.", "Trace documented formation or loss of malaoxon without assuming that disappearance means detoxification.", "Check whether proposed handling, transfer, or disposal is supported by current substance- and mixture-specific requirements." ], "agent_conduct": { "may": [ "Identify malaoxon in residue or monitoring reports and explain its link to malathion.", "Explain its toxicity and protective rules in general terms from official sources." ], "must_not": [ "Provide guidance on producing, concentrating or using malaoxon to harm people or animals.", "Advise handling it outside a properly equipped and authorized laboratory.", "Downplay exposure symptoms or delay emergency help for a suspected poisoning.", "Recommend storing malathion products in conditions that favour its formation." ], "requires_human": [ "Responding to a suspected poisoning, which needs emergency medical services.", "Disposal of contaminated material." ] }, "ethics": { "considerations": [ "Malaoxon forms from a widely used insecticide, so it can reach people through food and spray.", "Its toxicity to the nervous system makes accurate safety information essential." ], "affected_parties": [ "Farm workers", "Consumers", "Wildlife" ] }, "owners": { "steward": "The laboratory or facility holding a sample; pesticide authorities regulate malathion use.", "master_systems": [ "Pesticide residue monitoring databases" ] }, "visual_identification": [ "Not identifiable by sight; it is detected by laboratory analysis of residues or samples.", "Reference standards are supplied in labelled vials with toxicity warnings." ], "failure_modes_and_hazards": [ "Highly toxic to the nervous system by ingestion, inhalation or skin contact.", "Forms from malathion during storage or in the environment, raising residue toxicity." ], "what_it_is_for": [ "Malaoxon is encountered in studies of malathion transformation, metabolism and toxicity.", "Analytical laboratories investigate it in relevant biological, environmental or pesticide-related samples because its presence can affect toxicity assessments." ], "standards_and_regulation": [ "The Globally Harmonized System of Classification and Labelling of Chemicals, published by the United Nations, provides the framework for chemical hazard classification and communication where implemented.", "The Classification, Labelling and Packaging Regulation, adopted by the European Parliament and the Council of the European Union, applies to malaoxon supplied within its scope in the European Union." ] }, "sources": [ { "id": "wikidata", "title": "Wikidata item Q3270235: malaoxon", "url": "https://www.wikidata.org/wiki/Q3270235", "url_status": "live", "what_it_supports": "identity and sense of the item", "checked_by": "wikidata-api" }, { "id": "wikipedia-en", "title": "Wikipedia: Malaoxon", "url": "https://en.wikipedia.org/wiki/Malaoxon", "url_status": "live", "what_it_supports": "general description of the item", "checked_by": "wikidata-api sitelink" } ], "structure": { "bundles": [ { "id": "malaoxon-identity", "name": "Malaoxon identity", "description": "Establish which molecular entity the malaoxon record represents.", "rationale": "Confusion with malathion or an unspecified oxon changes both analytical interpretation and hazard assessment.", "layers": [ { "id": "structure-and-identifiers", "name": "Structure and identifiers", "description": "Connect registry identity to molecular connectivity and authoritative identifier records.", "findings": [ { "id": "identity-concordance", "name": "Identity concordance", "description": "Require identifiers and structural evidence to refer to the same malaoxon entity.", "questions": [ { "text": "Which authoritative records connect the sample's name and CAS number to malaoxon's molecular structure?", "kind": "provenance", "id": "identity-concordance-q01" }, { "text": "Does the structure retain the malathion-derived skeleton while specifying the oxon phosphorus group?", "kind": "definition", "id": "identity-concordance-q02" } ] } ] }, { "id": "stereochemistry-and-boundaries", "name": "Stereochemistry and boundaries", "description": "Separate the registered substance from stereochemical specifications and materials containing it.", "findings": [ { "id": "entity-versus-material", "name": "Entity versus material", "description": "Keep one malaoxon substance identity while recording the actual stereochemical and mixture scope of each material.", "questions": [ { "text": "Is stereochemistry unspecified, measured as racemic, or supported as a specified or enriched enantiomer?", "kind": "measurement", "id": "entity-versus-material-q01" }, { "text": "Does the referenced record describe malaoxon itself, a reference solution, or a product containing malaoxon?", "kind": "boundary", "id": "entity-versus-material-q02" } ] } ] } ] }, { "id": "malaoxon-material-quality", "name": "Malaoxon material quality", "description": "Describe the composition and physical condition of the material being evaluated.", "rationale": "A nominal malaoxon label does not establish purity, solvent content, or suitability as an analytical standard.", "layers": [ { "id": "purity-and-related-substances", "name": "Purity and related substances", "description": "Account for malaoxon content, residual malathion, and other detected constituents.", "findings": [ { "id": "composition-basis", "name": "Composition basis", "description": "Separate independently measured malaoxon content from nominal purity or nonspecific detector response.", "questions": [ { "text": "What malaoxon mass fraction or solution concentration was established, by which method and with what uncertainty?", "kind": "measurement", "id": "composition-basis-q01" }, { "text": "Which related substances, solvents, or unidentified components could bias the stated purity or intended use?", "kind": "boundary", "id": "composition-basis-q02" } ] } ] }, { "id": "phase-and-property-evidence", "name": "Phase and property evidence", "description": "Attach physical-property values to the material form and experimental conditions they describe.", "findings": [ { "id": "conditioned-physical-properties", "name": "Conditioned physical properties", "description": "Distinguish properties of malaoxon from those of a carrier solvent or mixture.", "questions": [ { "text": "Which phase, thermal-transition, solubility, and vapour-pressure measurements are supported for characterised malaoxon?", "kind": "measurement", "id": "conditioned-physical-properties-q01" }, { "text": "For each value, what temperature, pressure, purity, and measured or estimated status were reported?", "kind": "provenance", "id": "conditioned-physical-properties-q02" } ] } ] } ] }, { "id": "malaoxon-formation-and-stability", "name": "Malaoxon formation and stability", "description": "Track malaoxon as a transformation product and as material whose concentration can change.", "rationale": "A concentration result needs a history that distinguishes initial content from subsequent formation or loss.", "layers": [ { "id": "malathion-transformation", "name": "Malathion transformation", "description": "Represent evidence linking malathion and malaoxon in a specified system.", "findings": [ { "id": "formation-attribution", "name": "Formation attribution", "description": "Require system-specific evidence before attributing measured malaoxon to transformation of malathion.", "questions": [ { "text": "What observations establish malaoxon formation from malathion in this biological, environmental, or stored-material context?", "kind": "provenance", "id": "formation-attribution-q01" }, { "text": "Can the evidence distinguish pre-existing malaoxon from malaoxon formed during collection, storage, or analysis?", "kind": "boundary", "id": "formation-attribution-q02" } ] } ] }, { "id": "persistence-and-sample-integrity", "name": "Persistence and sample integrity", "description": "Evaluate whether malaoxon remains representative over the relevant time interval.", "findings": [ { "id": "condition-specific-stability", "name": "Condition-specific stability", "description": "Tie changes in malaoxon concentration to recorded conditions and identified products where available.", "questions": [ { "text": "What recovery or degradation data apply to the actual matrix, pH, temperature, illumination, and storage duration?", "kind": "measurement", "id": "condition-specific-stability-q01" }, { "text": "Do stability data support using the material now, or is reanalysis required before its concentration can be relied upon?", "kind": "action", "id": "condition-specific-stability-q02" }, { "text": "Which products or unresolved mass-balance gaps prevent interpreting malaoxon loss as reduced hazard?", "kind": "boundary", "id": "condition-specific-stability-q03" } ] } ] } ] }, { "id": "malaoxon-analytical-evidence", "name": "Malaoxon analytical evidence", "description": "Establish whether malaoxon is identified and quantified reliably in the relevant matrix.", "rationale": "Coexisting malathion, related products, and sample-processing effects can make an apparent malaoxon result misleading.", "layers": [ { "id": "selective-identification", "name": "Selective identification", "description": "Demand evidence that distinguishes malaoxon from competing analytical explanations.", "findings": [ { "id": "malaoxon-signal-confirmation", "name": "Malaoxon signal confirmation", "description": "Connect the reported signal to a characterised reference material and method-specific identity criteria.", "questions": [ { "text": "Which chromatographic and spectrometric criteria confirm malaoxon against the reference material?", "kind": "measurement", "id": "malaoxon-signal-confirmation-q01" }, { "text": "How were interference from malathion, related substances, and analytical formation or loss of malaoxon evaluated?", "kind": "boundary", "id": "malaoxon-signal-confirmation-q02" } ] } ] }, { "id": "quantification-and-reporting", "name": "Quantification and reporting", "description": "Record the calibration and matrix validation behind a numerical result.", "findings": [ { "id": "defensible-malaoxon-concentration", "name": "Defensible malaoxon concentration", "description": "Require uncertainty, recovery, and reporting limits to accompany concentration claims.", "questions": [ { "text": "What calibration traceability, matrix recovery, precision, and quantification limit support this result?", "kind": "measurement", "id": "defensible-malaoxon-concentration-q01" }, { "text": "Is the result a measured concentration, a qualified estimate, or a nondetection at a stated limit?", "kind": "definition", "id": "defensible-malaoxon-concentration-q02" }, { "text": "Does the method's validated matrix and concentration range cover the decision being made?", "kind": "action", "id": "defensible-malaoxon-concentration-q03" } ] } ] } ] }, { "id": "malaoxon-hazard-and-action", "name": "Malaoxon hazard and action", "description": "Connect malaoxon-specific biological evidence and applicable requirements to material-use decisions.", "rationale": "Its relationship to malathion does not justify inheriting malathion's toxicological values or regulatory permissions.", "layers": [ { "id": "cholinesterase-effect-evidence", "name": "Cholinesterase effect evidence", "description": "Preserve the experimental scope of claims about malaoxon's biological activity.", "findings": [ { "id": "endpoint-and-exposure-context", "name": "Endpoint and exposure context", "description": "Keep enzyme inhibition results separate from organism-level toxicity and exposure conclusions.", "questions": [ { "text": "Which enzyme source, species, exposure route, duration, and endpoint support each malaoxon effect value?", "kind": "provenance", "id": "endpoint-and-exposure-context-q01" }, { "text": "If potency is compared with malathion, were the endpoints and experimental conditions sufficiently comparable?", "kind": "boundary", "id": "endpoint-and-exposure-context-q02" } ] } ] }, { "id": "classification-and-permitted-handling", "name": "Classification and permitted handling", "description": "Resolve the requirements applicable to the actual malaoxon material and proposed action.", "findings": [ { "id": "applicable-malaoxon-controls", "name": "Applicable malaoxon controls", "description": "Record verified hazard classifications and action constraints without treating missing limits as evidence of safety.", "questions": [ { "text": "Which current jurisdictional records and material-specific safety documentation establish the applicable hazard classification and handling requirements?", "kind": "provenance", "id": "applicable-malaoxon-controls-q01" }, { "text": "Is an exposure limit explicitly applicable to malaoxon, or has a value for malathion or a broader category been substituted?", "kind": "boundary", "id": "applicable-malaoxon-controls-q02" }, { "text": "What documented controls and waste acceptance criteria must be satisfied before handling, transferring, or disposing of this material?", "kind": "action", "id": "applicable-malaoxon-controls-q03" } ] } ] } ] }, { "id": "evidence-and-external-alignment", "name": "Evidence and external alignment", "description": "What the world already says about this thing, gathered so the model can be checked against it.", "rationale": "A model that cannot be lined up against existing standards, identifiers and practice cannot be adopted by anyone who already uses them.", "layers": [ { "id": "reported-evidence", "name": "Reported evidence", "description": "Findings from the breadth pass, kept separate from the structural claims.", "findings": [ { "id": "evidence-confidence-notes", "name": "Check these first", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "This account is based on recall, without consulted sources.", "Verify identifiers and purity-dependent physical properties before creating a publication or analytical specification.", "Current jurisdiction-specific hazard classifications, exposure limits, and residue definitions require research." ], "questions": [ { "id": "evidence-confidence-notes-q01", "text": "Which of these check these first hold for the sense of malaoxon this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-identifiers", "name": "Identifiers and schemes", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ { "scheme": "CAS Registry Number", "value_or_pattern": "1634-78-2", "note": "Identifies malaoxon as a chemical substance." }, { "scheme": "Molecular formula", "value_or_pattern": "C10H19O7PS", "note": "Describes elemental composition; does not uniquely identify molecular structure." } ], "questions": [ { "id": "evidence-identifiers-q01", "text": "Which of these identifiers and schemes hold for the sense of malaoxon this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-real-world-use", "name": "Real-world use", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "Reference analyte in analytical testing for malathion transformation products.", "Research on organophosphorus toxicity, metabolic activation, and acetylcholinesterase inhibition." ], "questions": [ { "id": "evidence-real-world-use-q01", "text": "Which of these real-world use hold for the sense of malaoxon this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-measurements", "name": "Typical measurements", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ { "quantity": "Molar mass", "typical_range": "Approximately 314.29", "unit": "g/mol" } ], "questions": [ { "id": "evidence-measurements-q01", "text": "Which of these typical measurements hold for the sense of malaoxon this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-failure-modes-and-hazards", "name": "Failure modes and hazards", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "Acetylcholinesterase inhibition can cause severe cholinergic poisoning, including respiratory failure.", "More potent as an acetylcholinesterase inhibitor than its parent compound, malathion.", "Oxidative conversion of malathion to malaoxon can increase the toxicological significance of residues." ], "questions": [ { "id": "evidence-failure-modes-and-hazards-q01", "text": "Which of these failure modes and hazards hold for the sense of malaoxon this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-neighbours", "name": "Neighbouring kinds and how to tell them apart", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ { "name": "malathion", "difference": "Malathion has a P=S group where malaoxon has P=O; malaoxon is its oxidative desulfuration product." }, { "name": "paraoxon", "difference": "Both are organophosphorus oxons, but paraoxon is derived from parathion and has a different molecular structure." }, { "name": "malathion formulation", "difference": "A formulation is a mixture containing malathion and other ingredients; malaoxon is a distinct chemical substance that may occur as a transformation product or impurity." } ], "questions": [ { "id": "evidence-neighbours-q01", "text": "Which of these neighbouring kinds and how to tell them apart hold for the sense of malaoxon this model covers, and on what evidence?", "kind": "provenance" } ] } ] } ] } ] }, "openQuestions": [ "Which primary measurements establish malaoxon's melting or freezing behaviour, boiling or decomposition behaviour, solubility, and vapour pressure with adequate purity and condition metadata?", "Which current authoritative records verify its EC identity, jurisdiction-specific GHS classifications, and any malaoxon-specific occupational exposure limits?", "How do stereochemical composition and related-substance impurities affect analytical response and biological activity in the intended use?", "What validated holding times and preservation conditions prevent consequential malaoxon formation or loss in the target matrices?", "Which transformation products and biological endpoints must be measured before a decrease in malaoxon concentration can support a reduced-hazard conclusion?" ], "statistics": { "bundles": 6, "layers": 11, "findings": 16, "questions": 29 } }