{ "vercy": "1.0-draft", "publication": { "status": "research-draft", "adjudicationStatus": "unreviewed", "publishableCanonical": false, "generatedAt": "2026-09-12T11:29:38Z", "providers": [ "Codex" ], "breadth": "recalled by Codex without web access - no source was read", "missingProviders": [], "pass": 2, "cost": { "grok": { "seconds": 20.9, "error": "Reading additional input from stdin...\nOpenAI Codex v0.153.4\n--------\nworkdir: R:\\02_PROJECTS\\02_Meta_Models_Platforms\\Ver.cy\\current\\thing-registry-backlog\nmodel: gpt-6-astra\nprovider: openai\napproval: never\nsandbox: read-only\nreasoning effort: none\nreasoning summaries: none\nsession id: 01a09560-36f5-7af0-94ac-1b8aa6434e58\n--------\nuser\nDescribe what is already known about one registered thing. Answer as JSON only, no prose around it.\n\nThing: N-ribosylnicotinamide\nSense to describe: (none recorded)\nDomain code: PHY.MAT\nAlso known as: (none)\n\n\nContext for this batch of 1001 things:\n# Batch 044", "usd": 0.0, "recall": true }, "codex": { "seconds": 73.1, "error": "Reading additional input from stdin...\nOpenAI Codex v0.153.4\n--------\nworkdir: R:\\02_PROJECTS\\02_Meta_Models_Platforms\\Ver.cy\\current\\thing-registry-backlog\nmodel: gpt-6-astra\nprovider: openai\napproval: never\nsandbox: read-only\nreasoning effort: none\nreasoning summaries: none\nsession id: 01a09560-36ec-7122-b3c0-82660aef4733\n--------\nuser\nYou are drafting a Vercy meta-model for one registered thing. Answer as JSON only, no prose around it.\n\nThing: N-ribosylnicotinamide\nRegistry id: vr.tr.n-ribosylnicotinamide\nPlane / domain: PHY / PHY.MAT\nRegistry definition: (none recorded)\nNames folded into t" } }, "enrichment": { "pass": 3, "engine": "claude", "producedAt": "2026-10-06T12:00:00Z", "ingestedAt": "2026-10-06T08:56:07+00:00", "fields": [ "agent_conduct", "ethics", "failure_modes_and_hazards", "owners", "visual_identification" ] }, "gate": { "passed": true, "version": "1.0", "at": "2026-10-07T10:10:30+00:00", "evidence": [ "completeness 1.00", "sense: Wikidata description", "2 live sources", "review by codex: pass" ] } }, "metaModel": { "id": "THING-Q3334152", "registryId": "vr.tr.n-ribosylnicotinamide", "name": "N-ribosylnicotinamide", "version": "0.1.0-research.1", "entryKind": "thing", "family": "Thing Registry", "domain": [ "PHY.MAT" ], "status": "research-draft" }, "canonicalUrl": "https://ver.cy/models/thing/q3334152/", "model": { "registry_id": "vr.tr.n-ribosylnicotinamide", "name": "N-ribosylnicotinamide", "purpose": "Enable an agent to identify N-ribosylnicotinamide, assess the identity and condition of a material containing it, and determine which handling or research uses are supported by evidence.", "definition": "N-ribosylnicotinamide, commonly called nicotinamide riboside, is a pyridinium nucleoside formed by attaching ribose to the ring nitrogen of nicotinamide, whose β-D form is a precursor in nicotinamide adenine dinucleotide (NAD) biosynthesis.", "scope_statement": "This model owns the molecular identity registered as vr.tr.n-ribosylnicotinamide in PHY / PHY.MAT and the form-specific evidence needed to assess its samples; salts, formulations and biological processes are related entities.", "in_scope": [ "Molecular connectivity, ribose stereochemistry and pyridinium charge", "Identity mappings that distinguish the molecular species from its salts", "Sample composition, assay basis, impurities and analytical identity", "Physical state and stability under recorded conditions", "Evidence supporting biochemical use, handling and jurisdiction-specific eligibility" ], "out_of_scope": [ "Finished supplements, medicines and their formulation specifications", "Manufacturing processes and production equipment", "Complete NAD metabolism pathways", "Clinical treatment protocols and individual dosing decisions", "Independent models of counterions and related nicotinamide compounds" ], "distinguishing_features": [ "The reference identity has a β-D-ribofuranosyl group attached to nicotinamide's ring nitrogen at position 1; attachment and stereochemistry are identity tests. [ChEBI](https://www.ebi.ac.uk/chebi/CHEBI%3A15927)", "Confirm covalent ribosyl attachment rather than identifying a mixture of nicotinamide and ribose as this substance.", "Check for an unphosphorylated ribosyl moiety when distinguishing the target from nicotinamide mononucleotide.", "Confirm the pyridinium oxidation state when distinguishing the target from reduced nicotinamide riboside.", "Separate identification of the molecular cation from identification of a complete salt, including its counterion and stoichiometry." ], "characteristics": [ { "name": "Reference chemical identity", "kind": "category", "unit_or_values": "CHEBI:15927; formula C11H15N2O5+; net charge +1", "why_it_matters": "Anchors structure matching without silently including counterion mass. [ChEBI](https://www.ebi.ac.uk/chebi/CHEBI%3A15927)" }, { "name": "Ribosyl stereochemical identity", "kind": "category", "unit_or_values": "β-D-ribofuranosyl confirmed; alternative configuration; unresolved", "why_it_matters": "A matching nominal mass does not establish the required stereoisomer." }, { "name": "Material form", "kind": "relation", "unit_or_values": "Counterion identity and molar ratio; hydration or solvation; mixture composition", "why_it_matters": "Determines the relevant formula mass, specifications and applicable material evidence." }, { "name": "Registry identifier mapping", "kind": "relation", "unit_or_values": "CAS, PubChem CID and EC identifier, each with source and represented structure", "why_it_matters": "Prevents an identifier for a salt or ambiguous record from overriding structural identity." }, { "name": "Target content", "kind": "measurement", "unit_or_values": "% w/w or mmol/g; as received or dry basis; cation or salt basis; method and uncertainty", "why_it_matters": "Makes material quantities comparable and supports correct preparation calculations." }, { "name": "Related substances", "kind": "measurement", "unit_or_values": "Individual impurity concentrations in % w/w or mg/kg; unidentified chromatographic peaks separately reported", "why_it_matters": "Distinguishes target content from residual precursors, alternative species and degradation products." }, { "name": "Physical and solution state", "kind": "state", "unit_or_values": "Solid or dissolved; solid form; solvent; concentration in mmol/L; temperature in °C; solution pH", "why_it_matters": "Connects observations and permitted operations to the material actually present." }, { "name": "Condition-dependent stability", "kind": "measurement", "unit_or_values": "Target remaining in % versus time, with temperature, humidity or solution conditions", "why_it_matters": "Supports storage and use decisions from measured change rather than an assumed universal shelf life." }, { "name": "Thermal and dissolution behavior", "kind": "measurement", "unit_or_values": "Solubility in g/L or mol/L; thermal transitions or decomposition in °C; form and method required", "why_it_matters": "Supports preparation and processing without assigning salt-specific constants to the molecular cation." }, { "name": "Use and handling evidence status", "kind": "category", "unit_or_values": "Supported; conditional; unsupported; unresolved, with material form, use, jurisdiction, date and source", "why_it_matters": "Keeps biochemical observations, hazard records and permitted commercial uses from being treated as interchangeable." } ], "affordances": [ "Match a substance record to the reference structure and flag unresolved salt or stereochemical identity.", "Calculate target molar content using the declared assay basis and complete material composition.", "Assess a lot against an intended research specification using identity, impurity and stability evidence.", "Prepare a solution using form-specific dissolution and solution stability data.", "Link experimental biochemical observations to the tested material, biological system and analytical endpoint.", "Determine whether documented handling conditions and use restrictions apply to the exact material." ], "agent_conduct": { "may": [ "Explain nicotinamide riboside as a NAD precursor, citing research with its stage of evidence.", "Report the regulatory status of supplements containing it from official sources." ], "must_not": [ "Present nicotinamide riboside as proven to slow ageing or cure disease.", "Recommend doses for a specific person in place of a clinician.", "Advise replacing prescribed treatment with supplements.", "Hide commercial interests when summarizing supplement research." ], "requires_human": [ "Using it in a treatment plan for a patient with a medical condition." ] }, "ethics": { "considerations": [ "Anti-ageing supplement marketing can exploit hope and mislead buyers.", "Research must be reported without overstatement." ], "affected_parties": [ "Supplement buyers", "Patients", "Researchers" ] }, "owners": { "steward": "The supplement producer or seller; food and supplement regulators set rules for sale.", "master_systems": [] }, "visual_identification": [ "A white to off-white powder, usually sold as the chloride salt in capsules.", "Supplement labels list it as nicotinamide riboside." ], "failure_modes_and_hazards": [ "Unsupported health claims.", "Mislabelled supplement content.", "Interactions not yet well studied." ], "what_it_is_for": [ "N-ribosylnicotinamide is encountered in biochemical research on NAD biosynthesis and cellular metabolism.", "Its beta-D form is also encountered in ingredient research and products supplied as nicotinamide riboside salts.", "Interpreting a material requires identifying its stereochemical form and counterion because the general compound name does not fully specify the supplied substance." ], "standards_and_regulation": [ "The Globally Harmonized System of Classification and Labelling of Chemicals, published by the United Nations Economic Commission for Europe, provides a framework for communicating hazards of supplied research chemicals containing this compound." ] }, "sources": [ { "id": "wikidata", "title": "Wikidata item Q3334152: N-ribosylnicotinamide", "url": "https://www.wikidata.org/wiki/Q3334152", "url_status": "live", "what_it_supports": "identity and sense of the item", "checked_by": "wikidata-api" }, { "id": "wikipedia-en", "title": "Wikipedia: Nicotinamide riboside", "url": "https://en.wikipedia.org/wiki/Nicotinamide_riboside", "url_status": "live", "what_it_supports": "general description of the item", "checked_by": "wikidata-api sitelink" } ], "structure": { "bundles": [ { "id": "ribosylated-nicotinamide-identity", "name": "Ribosylated nicotinamide identity", "description": "Establishes which molecular structure the registry name denotes.", "rationale": "The name alone cannot resolve stereochemical, oxidation-state or salt ambiguity.", "layers": [ { "id": "connectivity-and-stereochemistry", "name": "Connectivity and stereochemistry", "description": "Resolves the ribose attachment and configuration.", "findings": [ { "id": "reference-structure-match", "name": "Reference structure match", "description": "Require structural evidence for the ring-nitrogen attachment and β-D-ribofuranosyl configuration.", "questions": [ { "text": "Does the proposed structure match CHEBI:15927 in connectivity, charge and stereochemistry?", "kind": "definition", "id": "reference-structure-match-q01" }, { "text": "Which analytical observations distinguish this structure from alternative anomers or attachment isomers?", "kind": "measurement", "id": "reference-structure-match-q02" } ] } ] }, { "id": "cation-and-material-identifiers", "name": "Cation and material identifiers", "description": "Separates molecular identity from identifiers for isolated material forms.", "findings": [ { "id": "identifier-form-alignment", "name": "Identifier and form alignment", "description": "Associate each external identifier with the structure and material form it actually represents.", "questions": [ { "text": "Which read source establishes each CAS, PubChem or EC mapping?", "kind": "provenance", "id": "identifier-form-alignment-q01" }, { "text": "Does each identifier represent the cation, a particular salt or an incompletely specified material?", "kind": "boundary", "id": "identifier-form-alignment-q02" } ] } ] } ] }, { "id": "nr-material-composition", "name": "NR material composition", "description": "Determines how much verified target a sample contains.", "rationale": "Counterions, water and impurities can make nominal material mass differ from target content.", "layers": [ { "id": "salt-and-assay-basis", "name": "Salt and assay basis", "description": "Connects the material formula to quantitative target content.", "findings": [ { "id": "target-equivalent-content", "name": "Target-equivalent content", "description": "Express assay results with counterion, hydration and reporting basis resolved.", "questions": [ { "text": "What counterion stoichiometry and water or solvent content were measured for this lot?", "kind": "measurement", "id": "target-equivalent-content-q01" }, { "text": "Is the reported assay a mass fraction, chromatographic area percentage or another quantity, and how is it converted to target mmol/g?", "kind": "measurement", "id": "target-equivalent-content-q02" } ] } ] }, { "id": "related-species-and-lot-evidence", "name": "Related species and lot evidence", "description": "Evaluates analytical specificity and sample provenance.", "findings": [ { "id": "resolved-impurity-profile", "name": "Resolved impurity profile", "description": "Assess whether the method separates the target from relevant related species without assuming their presence.", "questions": [ { "text": "Can the method resolve nicotinamide, alternative riboside species and other detected impurities from the target?", "kind": "measurement", "id": "resolved-impurity-profile-q01" }, { "text": "Which lot-linked chromatograms, spectra and reference standards support the reported identity and purity?", "kind": "provenance", "id": "resolved-impurity-profile-q02" } ] } ] } ] }, { "id": "nr-state-and-stability", "name": "NR state and stability", "description": "Relates physical behavior and chemical integrity to the exact material and environment.", "rationale": "A molecular identity does not supply universal storage limits or physical constants for every salt and solution.", "layers": [ { "id": "solid-and-dissolved-forms", "name": "Solid and dissolved forms", "description": "Records form-specific observations needed for preparation.", "findings": [ { "id": "conditioned-physical-properties", "name": "Conditioned physical properties", "description": "Use physical constants only when the tested form and measurement conditions are known.", "questions": [ { "text": "What solubility is measured for this form at the intended solvent composition, pH and temperature?", "kind": "measurement", "id": "conditioned-physical-properties-q01" }, { "text": "Does thermal evidence establish melting, desolvation or decomposition, and is a boiling point meaningful or unestablished?", "kind": "measurement", "id": "conditioned-physical-properties-q02" } ] } ] }, { "id": "integrity-over-time", "name": "Integrity over time", "description": "Tracks target loss and changes during storage or preparation.", "findings": [ { "id": "validated-use-window", "name": "Validated use window", "description": "Base storage and solution-use intervals on measured target integrity.", "questions": [ { "text": "How do target content and impurity signals change under the proposed temperature, humidity, light and solution conditions?", "kind": "measurement", "id": "validated-use-window-q01" }, { "text": "What evidence supports continued use, retesting or rejection after an excursion or elapsed storage interval?", "kind": "action", "id": "validated-use-window-q02" } ] } ] } ] }, { "id": "nr-biochemical-evidence", "name": "NR biochemical evidence", "description": "Organizes evidence about biological handling and experimental effects of the verified substance.", "rationale": "A biochemical role must remain tied to the tested system and must not become an unsupported product or clinical claim.", "layers": [ { "id": "conversion-and-fate", "name": "Conversion and fate", "description": "Links the substance to experimentally supported transformations.", "findings": [ { "id": "demonstrated-metabolic-connection", "name": "Demonstrated metabolic connection", "description": "Record evidence for conversion involving NMN or NAD with the experimental context preserved.", "questions": [ { "text": "Which primary experiments establish conversion of the target, and in which organism, tissue or enzyme system?", "kind": "provenance", "id": "demonstrated-metabolic-connection-q01" }, { "text": "Were target uptake and conversion measured directly, or inferred from downstream metabolite changes?", "kind": "measurement", "id": "demonstrated-metabolic-connection-q02" } ] } ] }, { "id": "experimental-interpretation", "name": "Experimental interpretation", "description": "Bounds conclusions drawn from biochemical observations.", "findings": [ { "id": "endpoint-specific-use", "name": "Endpoint-specific use", "description": "Connect a proposed research use to material quality, exposure conditions and supported endpoints.", "questions": [ { "text": "Which material form, concentration, exposure duration and controls support the proposed experiment?", "kind": "action", "id": "endpoint-specific-use-q01" }, { "text": "Which conclusions concern chemical conversion or biomarkers, and which require separate evidence about organism-level benefit?", "kind": "boundary", "id": "endpoint-specific-use-q02" } ] } ] } ] }, { "id": "nr-handling-and-use-status", "name": "NR handling and use status", "description": "Determines which safety records and permitted uses apply to the specified material.", "rationale": "Records for a named supplement ingredient or particular salt cannot automatically govern every NR-containing sample.", "layers": [ { "id": "form-specific-hazard-evidence", "name": "Form-specific hazard evidence", "description": "Associates handling requirements with an identified material and source.", "findings": [ { "id": "applicable-safety-record", "name": "Applicable safety record", "description": "Distinguish documented hazard classifications from missing information.", "questions": [ { "text": "Which current SDS or authoritative record matches this material form and supplies its GHS classification?", "kind": "provenance", "id": "applicable-safety-record-q01" }, { "text": "What handling controls and exposure limits are explicitly supported, and which remain unestablished?", "kind": "action", "id": "applicable-safety-record-q02" } ] } ] }, { "id": "use-specific-regulatory-boundary", "name": "Use-specific regulatory boundary", "description": "Checks the scope of any claimed permission or restriction.", "findings": [ { "id": "exact-material-use-eligibility", "name": "Exact material use eligibility", "description": "Tie eligibility to jurisdiction, material specification, intended use and effective date.", "questions": [ { "text": "Does the cited legal instrument cover this exact form, grade and intended use?", "kind": "boundary", "id": "exact-material-use-eligibility-q01" }, { "text": "Which current authoritative source establishes the applicable conditions or restrictions?", "kind": "provenance", "id": "exact-material-use-eligibility-q02" } ] } ] } ] }, { "id": "evidence-and-external-alignment", "name": "Evidence and external alignment", "description": "What the world already says about this thing, gathered so the model can be checked against it.", "rationale": "A model that cannot be lined up against existing standards, identifiers and practice cannot be adopted by anyone who already uses them.", "layers": [ { "id": "reported-evidence", "name": "Reported evidence", "description": "Findings from the breadth pass, kept separate from the structural claims.", "findings": [ { "id": "evidence-confidence-notes", "name": "Check these first", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "The registry name alone does not establish stereochemistry or counterion; verify whether the intended entry specifically denotes β-D-nicotinamide riboside.", "Exact registry identifiers, physical constants and hazard classifications require verification for the identified chemical form.", "Use as an NAD precursor does not by itself establish clinical benefit, anti-aging efficacy or long-term supplement safety." ], "questions": [ { "id": "evidence-confidence-notes-q01", "text": "Which of these check these first hold for the sense of N-ribosylnicotinamide this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-kinds", "name": "Kinds and varieties", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "β-D-nicotinamide riboside", "α-D-nicotinamide riboside" ], "questions": [ { "id": "evidence-kinds-q01", "text": "Which of these kinds and varieties hold for the sense of N-ribosylnicotinamide this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-identifiers", "name": "Identifiers and schemes", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ { "scheme": "Molecular formula", "value_or_pattern": "C11H15N2O5+", "note": "Describes the nicotinamide riboside cation; a salt additionally contains a counterion." }, { "scheme": "CAS Registry Number", "value_or_pattern": "Up to seven digits, hyphen, two digits, hyphen, one check digit", "note": "The exact identifier should be checked for the specified stereoisomer and salt." } ], "questions": [ { "id": "evidence-identifiers-q01", "text": "Which of these identifiers and schemes hold for the sense of N-ribosylnicotinamide this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-real-world-use", "name": "Real-world use", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "Research on NAD biosynthesis and metabolism.", "Ingredient in dietary supplements, commonly supplied as nicotinamide riboside chloride." ], "questions": [ { "id": "evidence-real-world-use-q01", "text": "Which of these real-world use hold for the sense of N-ribosylnicotinamide this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-measurements", "name": "Typical measurements", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ { "quantity": "Molar mass of the nicotinamide riboside cation", "typical_range": "255.25", "unit": "g/mol" } ], "questions": [ { "id": "evidence-measurements-q01", "text": "Which of these typical measurements hold for the sense of N-ribosylnicotinamide this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-failure-modes-and-hazards", "name": "Failure modes and hazards", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "Confusing the cation with its chloride salt gives incorrect formula masses and mass-based concentration calculations.", "Failure to specify anomeric configuration can obscure differences in biological recognition.", "Hydrolysis of the glycosidic bond can release nicotinamide; stability depends on formulation and storage conditions." ], "questions": [ { "id": "evidence-failure-modes-and-hazards-q01", "text": "Which of these failure modes and hazards hold for the sense of N-ribosylnicotinamide this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-neighbours", "name": "Neighbouring kinds and how to tell them apart", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ { "name": "Nicotinamide", "difference": "Lacks the ribose attached to the pyridine-ring nitrogen." }, { "name": "Nicotinamide mononucleotide", "difference": "Contains a phosphate group on the ribose, ordinarily at the 5′ position." }, { "name": "Nicotinamide riboside chloride", "difference": "Specifies chloride as the counterion of the nicotinamide riboside cation." }, { "name": "Nicotinic acid riboside", "difference": "Has a carboxyl group in place of nicotinamide riboside's carboxamide group." } ], "questions": [ { "id": "evidence-neighbours-q01", "text": "Which of these neighbouring kinds and how to tell them apart hold for the sense of N-ribosylnicotinamide this model covers, and on what evidence?", "kind": "provenance" } ] } ] } ] } ] }, "openQuestions": [ "Does the originating registry record unambiguously intend the β-D molecular cation represented by CHEBI:15927, or did its import conflate that identity with a salt?", "Which CAS, PubChem and EC identifiers are verified for the target and each relevant material form without merging distinct substances?", "Which form-specific physical constants, degradation products and storage intervals are supported by primary measurements?", "Which analytical methods adequately distinguish the target from alternative stereoisomers, reduced species and preparation-related impurities?", "Which current safety classifications, exposure limits and regulatory permissions apply to the exact forms and intended uses under consideration?" ], "statistics": { "bundles": 6, "layers": 11, "findings": 17, "questions": 27 } }