{ "vercy": "1.0-draft", "publication": { "status": "research-draft", "adjudicationStatus": "unreviewed", "publishableCanonical": false, "generatedAt": "2026-09-13T12:48:09Z", "providers": [ "Claude" ], "breadth": "written by Claude from model knowledge without web access - no source was read, every claim is a lead to verify", "pass": 2, "wave": 4, "engine": "claude", "enrichment": { "pass": 3, "engine": "claude", "producedAt": "2026-10-06T10:00:00Z", "ingestedAt": "2026-10-06T07:11:44+00:00", "fields": [ "agent_conduct", "ethics", "owners" ] }, "gate": { "passed": true, "version": "1.0", "at": "2026-10-06T19:51:59+00:00", "evidence": [ "completeness 1.00", "sense: Wikidata description", "2 live sources", "review by codex: pass" ] } }, "metaModel": { "id": "THING-Q35970", "registryId": "vr.tr.mesothelium", "name": "mesothelium", "version": "0.2.0-wave.4", "entryKind": "thing", "family": "Thing Registry", "domain": [ "PHY.LIV" ], "status": "research-draft" }, "canonicalUrl": "https://ver.cy/models/thing/q35970/", "model": { "registry_id": "vr.tr.mesothelium", "name": "mesothelium", "purpose": "Let an agent explain the mesothelium and its locations, relay structure, function and development from histology references, describe its clinical significance in general terms, and distinguish mesothelium from other epithelia, from endothelium and from the serous membranes as a whole.", "definition": "A simple squamous epithelium derived from mesoderm that lines the serous cavities of the body and covers their organs, forming the mesothelium of the pleura, the serous pericardium and the parietal and visceral peritoneum, and also the epithelium of the tunica vaginalis, with related mesothelial-type epithelium in regions of the epididymis; mesothelial cells secrete lubricating fluid, and their malignant transformation, usually after asbestos exposure, causes mesothelioma.", "what_it_is_for": "Not applicable; a tissue.", "affordances": [ "explain structure and locations", "relay function and development", "describe clinical significance", "distinguish related tissues" ], "distinguishing_features": [ "Mesodermal epithelium", "Serous lining", "Fluid secretion", "Mesothelioma origin" ], "appearance": "Not a visible object; a single flat cell layer on serous surfaces.", "visual_identification": [ "Simple squamous lining of serous cavities", "Mesothelium of pleura, pericardium, parietal and visceral peritoneum", "Endothelium lines vessels; other epithelia derive from ectoderm or endoderm; the serous membrane includes connective tissue" ], "physical_properties": [ { "quantity": "cell type", "typical_range": "simple squamous", "unit": "note", "note": "" }, { "quantity": "origin", "typical_range": "mesoderm", "unit": "note", "note": "" }, { "quantity": "serous cavities lined", "typical_range": "pleural, pericardial, peritoneal", "unit": "list", "note": "" } ], "families_and_kinds": [ "pleural mesothelium", "pericardial mesothelium", "parietal and visceral peritoneal mesothelium", "mesothelium of the tunica vaginalis", "mesothelial-type epithelium of the epididymis region" ], "related_models": [ { "relation": "is a kind of", "target": "tissue", "why": "in registry terms" }, { "relation": "is a kind of", "target": "meso-epithelium", "why": "in registry terms" }, { "relation": "is a kind of", "target": "particular anatomical entity", "why": "in registry terms" }, { "relation": "is contrasted with", "target": "endothelium", "why": "which lines vessels" } ], "identifiers": [ { "scheme": "UBERON", "value_or_pattern": "UBERON:0001136", "note": "mesothelium" }, { "scheme": "FMA", "value_or_pattern": "FMA:14074", "note": "mesothelium" } ], "standards_and_regulation": [ "Terminologia Histologica", "Asbestos regulations relevant to mesothelioma prevention" ], "failure_modes_and_hazards": [ "Confusing mesothelium with endothelium", "Agents giving personal medical advice about mesothelioma", "Registry aliases naming each regional part" ], "in_scope": [], "out_of_scope": [], "characteristics": [], "agent_conduct": { "may": [ "Describe the mesothelium and the cavities it lines for teaching.", "Explain how mesothelium differs from endothelium.", "Point people worried about asbestos exposure to a clinician." ], "must_not": [ "Tell a person whether they have mesothelioma from symptoms or history.", "Give advice on treatment of pleural or peritoneal disease for a person.", "Minimise the link between asbestos and mesothelial cancer.", "Disclose a person's diagnosis or exposure history without consent." ], "requires_human": [ "Any clinical decision about pleural, pericardial or peritoneal disease." ] }, "ethics": { "considerations": [ "Mesothelioma follows workplace asbestos exposure; accuracy matters for patients and their claims.", "Anatomical errors carry into clinical training." ], "affected_parties": [ "Patients", "Workers exposed to asbestos", "Students" ] }, "owners": { "steward": "Nobody owns anatomy; anatomical terminology is maintained by international anatomists' bodies.", "master_systems": [] } }, "sources": [ { "id": "wikidata", "title": "Wikidata item Q35970: mesothelium", "url": "https://www.wikidata.org/wiki/Q35970", "url_status": "live", "what_it_supports": "identity and sense of the item", "checked_by": "wikidata-api" }, { "id": "wikipedia-en", "title": "Wikipedia: Mesothelium", "url": "https://en.wikipedia.org/wiki/Mesothelium", "url_status": "live", "what_it_supports": "general description of the item", "checked_by": "wikidata-api sitelink" } ], "structure": { "bundles": [ { "id": "understand", "name": "Understand", "description": "What the mesothelium is.", "rationale": "Science.", "layers": [ { "id": "definition", "name": "Definition", "description": "Definition and structure.", "findings": [ { "id": "definition-finding", "name": "Definition", "description": "Definition.", "questions": [ { "text": "What is the mesothelium, and how does it differ from endothelium and other epithelia?", "kind": "definition" }, { "text": "Is the question about histology, a location or a clinical matter?", "kind": "boundary" } ] } ] }, { "id": "locations", "name": "Locations", "description": "Locations.", "findings": [ { "id": "locations-finding", "name": "Locations", "description": "Locations.", "questions": [ { "text": "Where is mesothelium found, from pleura and pericardium to peritoneum and tunica vaginalis?", "kind": "definition" }, { "text": "Which entry fits the specific serous membrane?", "kind": "action" } ] } ] } ] }, { "id": "function", "name": "Function", "description": "Function and development.", "rationale": "Science.", "layers": [ { "id": "function", "name": "Function", "description": "Function.", "findings": [ { "id": "function-finding", "name": "Function", "description": "Function.", "questions": [ { "text": "How does mesothelium lubricate, transport fluid and respond to injury?", "kind": "provenance" }, { "text": "Which references are standard?", "kind": "provenance" } ] } ] }, { "id": "development", "name": "Development", "description": "Development.", "findings": [ { "id": "development-finding", "name": "Development", "description": "Development.", "questions": [ { "text": "How does mesothelium develop from the mesoderm and coelom?", "kind": "provenance" }, { "text": "Which sources are cited?", "kind": "provenance" } ] } ] } ] }, { "id": "clinical", "name": "Clinical", "description": "Clinical significance.", "rationale": "Clinical.", "layers": [ { "id": "disease", "name": "Disease", "description": "Mesothelioma and other conditions.", "findings": [ { "id": "disease-finding", "name": "Disease", "description": "Disease.", "questions": [ { "text": "What are mesothelioma, adhesions and serositis, in general terms?", "kind": "provenance" }, { "text": "Is the user asking about their own diagnosis, which needs a clinician?", "kind": "boundary" } ] } ] }, { "id": "pathology", "name": "Pathology", "description": "Pathology.", "findings": [ { "id": "pathology-finding", "name": "Pathology", "description": "Pathology.", "questions": [ { "text": "How do pathologists identify mesothelial cells and distinguish reactive from malignant ones?", "kind": "provenance" }, { "text": "Which entry fits mesothelioma?", "kind": "action" } ] } ] } ] }, { "id": "context", "name": "Context", "description": "Research and history.", "rationale": "Context.", "layers": [ { "id": "research", "name": "Research", "description": "Research.", "findings": [ { "id": "research-finding", "name": "Research", "description": "Research.", "questions": [ { "text": "What research addresses mesothelial regeneration and repair?", "kind": "provenance" }, { "text": "Which entry fits regenerative medicine?", "kind": "action" } ] } ] }, { "id": "history", "name": "History", "description": "History.", "findings": [ { "id": "history-finding", "name": "History", "description": "History.", "questions": [ { "text": "How was the mesothelium described, and how was its link to asbestos established?", "kind": "provenance" }, { "text": "Which entry fits the history of histology?", "kind": "action" } ] } ] } ] } ] }, "openQuestions": [ "Should the pleural, pericardial and peritoneal parts be separate entries?", "How should histology references be linked?", "The registry entry has merged aliases naming regional parts and an epididymal epithelium; should they be split off?" ], "statistics": { "bundles": 4, "layers": 8, "findings": 8, "questions": 16 } }