{ "vercy": "1.0-draft", "publication": { "status": "research-draft", "adjudicationStatus": "unreviewed", "publishableCanonical": false, "generatedAt": "2026-09-12T10:25:41Z", "providers": [ "Codex" ], "breadth": "recalled by Codex without web access - no source was read", "missingProviders": [], "pass": 2, "cost": { "grok": { "seconds": 23.5, "error": "Reading additional input from stdin...\nOpenAI Codex v0.153.4\n--------\nworkdir: R:\\02_PROJECTS\\02_Meta_Models_Platforms\\Ver.cy\\current\\thing-registry-backlog\nmodel: gpt-6-astra\nprovider: openai\napproval: never\nsandbox: read-only\nreasoning effort: none\nreasoning summaries: none\nsession id: 01a09525-b3c6-7020-a9a0-7445f8ba43da\n--------\nuser\nDescribe what is already known about one registered thing. Answer as JSON only, no prose around it.\n\nThing: immune disorder\nSense to describe: (none recorded)\nDomain code: XCT.STA\nAlso known as: (none)\n\n\nContext for this batch of 1001 things:\n# Batch 043: 1001", "usd": 0.0, "recall": true }, "codex": { "seconds": 70.9, "error": "Reading additional input from stdin...\nOpenAI Codex v0.153.4\n--------\nworkdir: R:\\02_PROJECTS\\02_Meta_Models_Platforms\\Ver.cy\\current\\thing-registry-backlog\nmodel: gpt-6-astra\nprovider: openai\napproval: never\nsandbox: read-only\nreasoning effort: none\nreasoning summaries: none\nsession id: 01a09525-b3b8-70c3-a7e2-e88cf3026969\n--------\nuser\nYou are drafting a Vercy meta-model for one registered thing. Answer as JSON only, no prose around it.\n\nThing: immune disorder\nRegistry id: vr.tr.immune-disorder\nPlane / domain: XCT / XCT.STA\nRegistry definition: (none recorded)\nNames folded into this entry: (" } }, "enrichment": { "pass": 3, "engine": "claude", "producedAt": "2026-10-05T23:50:00Z", "ingestedAt": "2026-10-05T20:45:09+00:00", "fields": [ "agent_conduct", "ethics", "failure_modes_and_hazards", "owners", "standards_and_regulation", "visual_identification" ] }, "gate": { "passed": true, "version": "1.0", "at": "2026-10-07T10:10:30+00:00", "evidence": [ "completeness 1.00", "sense: Wikidata description", "2 live sources", "review by codex: pass" ] } }, "metaModel": { "id": "THING-Q3843811", "registryId": "vr.tr.immune-disorder", "name": "immune disorder", "version": "0.1.0-research.1", "entryKind": "thing", "family": "Thing Registry", "domain": [ "XCT.STA" ], "status": "research-draft" }, "canonicalUrl": "https://ver.cy/models/thing/q3843811/", "model": { "registry_id": "vr.tr.immune-disorder", "name": "immune disorder", "purpose": "Enable an AI agent to recognise an immune disorder, represent evidence about its immune dysfunction and current state, and identify which assessments or actions require condition-specific clinical authority.", "definition": "An immune disorder is a pathological condition involving deficient, excessive, misdirected or otherwise dysregulated immune function, encompassing multiple diseases rather than a single diagnosis.", "scope_statement": "This model owns immune disorder as a broad condition category and the information needed to distinguish its subtypes and manifestations, while keeping the condition separate from diagnostic assertions, patients and episodes of care.", "in_scope": [ "The defining immune dysfunction and boundaries of the immune disorder category", "Subtype, affected immune components and supported mechanisms", "Aetiology, predisposition and acquired contributors, with uncertainty recorded", "Evidence requirements, diagnostic criteria and versioned classification mappings", "Immune manifestations, disease activity, functional impairment and longitudinal course", "Condition-specific assessment, monitoring and intervention constraints" ], "out_of_scope": [ "The patient's complete identity, history and overall health record", "Visits, admissions, referrals and other episodes of care", "Laboratory assays as technical procedures and specimens as physical objects", "Medicines, vaccines and therapeutic products as independently modelled things", "Infections, malignancies and organ diseases except for their documented relationship to immune dysfunction", "Normal immune responses without evidence of a disorder" ], "distinguishing_features": [ "Require evidence or an explicit hypothesis of pathological immune function; an immune response to an ordinary challenge alone does not establish an immune disorder.", "Distinguish the underlying disorder from an isolated abnormal immune test by recording clinical relevance, persistence and alternative explanations.", "Distinguish immune deficiency, immune-mediated tissue injury, hypersensitivity and dysregulated inflammation without assuming these categories are mutually exclusive.", "Distinguish an immune disorder from an infection or organ manifestation by recording whether each is a cause, consequence, associated condition or unresolved alternative.", "Treat 'immune disorder' as a broad category unless evidence supports a named subtype; do not equate the entire category with autoimmune disease." ], "characteristics": [ { "name": "Diagnostic specificity", "kind": "category", "unit_or_values": "Broad immune disorder category; named disorder family; named subtype; unresolved", "why_it_matters": "Prevents broad or incomplete evidence from being represented as a specific diagnosis." }, { "name": "Immune dysfunction pattern", "kind": "category", "unit_or_values": "Deficiency; autoimmunity; hypersensitivity; autoinflammatory dysfunction; other dysregulation; mixed; undetermined; terminology subject to research", "why_it_matters": "Identifies which condition-specific distinctions and assessments the model must support." }, { "name": "Affected immune component", "kind": "relation", "unit_or_values": "Links to implicated immune cells, antibodies, complement components, tissues or pathways, with evidence status", "why_it_matters": "Connects the disorder to a supported functional mechanism without treating all immune abnormalities as equivalent." }, { "name": "Aetiological attribution", "kind": "category", "unit_or_values": "Inherited; acquired; multifactorial; unexplained; disputed, with supporting evidence", "why_it_matters": "Separates causal explanation from observed immune phenotype." }, { "name": "Diagnostic assertion status", "kind": "state", "unit_or_values": "Suspected; supported; confirmed under named criteria; disputed; excluded; historical", "why_it_matters": "Keeps confidence in a diagnosis separate from the existence and activity of the condition." }, { "name": "Diagnostic framework", "kind": "relation", "unit_or_values": "Issuing body, criteria title, version, intended population and assessment date", "why_it_matters": "Makes diagnostic claims interpretable when criteria change or apply only to particular populations." }, { "name": "Classification mapping", "kind": "relation", "unit_or_values": "Verified ICD or SNOMED CT concept, system release, jurisdiction or edition, and mapping relationship", "why_it_matters": "Prevents an administrative code or broader concept from silently substituting for a clinical definition." }, { "name": "Immune assessment result", "kind": "measurement", "unit_or_values": "Assay-specific result and unit, method, reference interval, specimen, date and relevant clinical context", "why_it_matters": "Allows immune measurements to be interpreted in context rather than as universal diagnostic thresholds." }, { "name": "Disease activity", "kind": "state", "unit_or_values": "Condition-specific activity state or validated score; unknown when not established", "why_it_matters": "Separates current immune activity from diagnostic certainty and accumulated damage." }, { "name": "Clinical consequence", "kind": "relation", "unit_or_values": "Linked manifestations, infections, organ injury or functional limitations, each with attribution confidence", "why_it_matters": "Records impact without assuming every coexisting illness is caused by the immune disorder." }, { "name": "Population frequency", "kind": "measurement", "unit_or_values": "Prevalence or incidence with denominator, population, geography, observation period, case definition and uncertainty", "why_it_matters": "Prevents estimates for one subtype or population from being applied to the entire category." } ], "affordances": [ "Determine whether a record supports only the broad immune disorder category or a more specific subtype.", "Identify missing immune evidence and the condition-specific criteria needed to interpret it.", "Compare diagnostic assertions across criteria versions and terminology releases.", "Track immune activity, manifestations and lasting impairment as separate aspects of course.", "Surface documented monitoring needs and intervention constraints for qualified clinical review.", "Flag unsupported causal attributions, incompatible classifications and unresolved alternatives." ], "agent_conduct": { "may": [ "Explain what immune disorders are and how the main groups differ, citing medical sources.", "Direct people with symptoms or concerns to qualified clinicians." ], "must_not": [ "Diagnose an immune disorder or rule one out for a specific person.", "Advise starting, stopping or changing immunosuppressive or immune treatments.", "Disclose a person's immune status or diagnosis without consent.", "Promote unproven remedies that claim to boost or cure the immune system." ], "requires_human": [ "Any treatment or vaccination decision for a person with an immune disorder.", "Sharing health data about a person's immune condition." ] }, "ethics": { "considerations": [ "People with immune disorders face infection risks and stigma that misinformation makes worse.", "Health data about immunity is sensitive and can lead to discrimination." ], "affected_parties": [ "Patients", "Families and carers", "Close contacts of immunocompromised people" ] }, "owners": { "steward": "The patient, with the treating clinician; health authorities set clinical guidance.", "master_systems": [ "Patient health records" ] }, "visual_identification": [ "Diagnosis rests on laboratory tests of immune function rather than appearance.", "Recurrent, severe or unusual infections can be a sign that prompts testing.", "Some autoimmune and allergic disorders show visible rashes or swelling." ], "failure_modes_and_hazards": [ "Serious or opportunistic infections in people with weakened immunity.", "Immune attack on the body's own tissues and organs.", "Severe allergic reactions such as anaphylaxis.", "Delayed diagnosis because symptoms resemble common illnesses." ], "standards_and_regulation": [ "International Classification of Diseases (ICD-11), World Health Organization." ], "what_it_is_for": [ "Immune disorders are encountered in clinical care when immune dysfunction contributes to recurrent infections, inflammation, allergic reactions or damage to the body's own tissues.", "The term groups diverse conditions for assessment and communication, while diagnosis and management depend on the specific disorder and clinical evidence." ] }, "sources": [ { "id": "wikidata", "title": "Wikidata item Q3843811: immune disorder", "url": "https://www.wikidata.org/wiki/Q3843811", "url_status": "live", "what_it_supports": "identity and sense of the item", "checked_by": "wikidata-api" }, { "id": "wikipedia-en", "title": "Wikipedia: Immune disorder", "url": "https://en.wikipedia.org/wiki/Immune_disorder", "url_status": "live", "what_it_supports": "general description of the item", "checked_by": "wikidata-api sitelink" } ], "structure": { "bundles": [ { "id": "immune-disorder-boundaries", "name": "Immune disorder boundaries", "description": "Establish what constitutes the disorder and how specifically it can be named.", "rationale": "The registry label is broad and must not collapse all immune-related findings into one diagnosis.", "layers": [ { "id": "pathological-immune-function", "name": "Pathological immune function", "description": "Separate immune dysfunction from normal responses and incidental abnormalities.", "findings": [ { "id": "immune-dysfunction-boundary", "name": "Immune dysfunction boundary", "description": "Record the basis for treating an immune phenomenon as a disorder rather than a physiological response or isolated result.", "questions": [ { "text": "What pathological change in immune function defines the proposed disorder?", "kind": "definition", "id": "immune-dysfunction-boundary-q01" }, { "text": "What evidence distinguishes it from a normal response, transient variation or incidental laboratory abnormality?", "kind": "boundary", "id": "immune-dysfunction-boundary-q02" } ] } ] }, { "id": "subtype-and-overlap", "name": "Subtype and overlap", "description": "Locate the disorder within researched immune disease categories while allowing overlap.", "findings": [ { "id": "supported-subtype", "name": "Supported subtype", "description": "Record the narrowest justified classification and its relationship to neighbouring immune disorders.", "questions": [ { "text": "Which named disorder or family is supported, and which defining features justify that specificity?", "kind": "definition", "id": "supported-subtype-q01" }, { "text": "Does the presentation combine deficiency, autoimmunity, hypersensitivity or other dysregulation, and how does the chosen classification represent that overlap?", "kind": "boundary", "id": "supported-subtype-q02" } ] } ] } ] }, { "id": "immune-mechanism-and-origin", "name": "Immune mechanism and origin", "description": "Represent the affected immune functions and the evidence for why they are abnormal.", "rationale": "Similar manifestations can arise from different immune mechanisms, and observed abnormalities do not by themselves establish causation.", "layers": [ { "id": "affected-immune-functions", "name": "Affected immune functions", "description": "Identify implicated components and distinguish functional evidence from proposed mechanisms.", "findings": [ { "id": "component-function-evidence", "name": "Component and function evidence", "description": "Connect implicated immune components to demonstrable functional changes.", "questions": [ { "text": "Which immune cells, molecules or pathways are implicated, and what function is deficient, excessive or misdirected?", "kind": "definition", "id": "component-function-evidence-q01" }, { "text": "Which functional tests or other observations support that mechanism, and which parts remain hypothetical?", "kind": "provenance", "id": "component-function-evidence-q02" } ] } ] }, { "id": "causes-and-contributors", "name": "Causes and contributors", "description": "Distinguish underlying causes, susceptibility factors, triggers and secondary effects.", "findings": [ { "id": "aetiological-evidence", "name": "Aetiological evidence", "description": "Represent inherited and acquired explanations without inferring origin from age at presentation alone.", "questions": [ { "text": "What evidence supports an inherited, acquired or multifactorial origin, and who made that attribution?", "kind": "provenance", "id": "aetiological-evidence-q01" }, { "text": "Are linked exposures, medicines, infections or genetic findings established causes, predispositions, triggers or unresolved associations?", "kind": "boundary", "id": "aetiological-evidence-q02" } ] } ] } ] }, { "id": "immune-diagnostic-evidence", "name": "Immune diagnostic evidence", "description": "Define how diagnostic assertions and immune investigations should be interpreted.", "rationale": "Immune diagnoses require subtype-specific interpretation, and neither a code nor an abnormal assay alone establishes the condition.", "layers": [ { "id": "criteria-and-terminology", "name": "Criteria and terminology", "description": "Anchor diagnostic and coding claims to identifiable authorities and releases.", "findings": [ { "id": "versioned-diagnostic-basis", "name": "Versioned diagnostic basis", "description": "Record the applicable criteria, their intended use and the precision of terminology mappings.", "questions": [ { "text": "Which issuing body's criteria and version support the assertion, and are they diagnostic criteria or classification criteria for another purpose?", "kind": "provenance", "id": "versioned-diagnostic-basis-q01" }, { "text": "Which verified ICD and SNOMED CT concepts map to this category or subtype, in which releases, and with what degree of equivalence?", "kind": "boundary", "id": "versioned-diagnostic-basis-q02" } ] } ] }, { "id": "immune-test-interpretation", "name": "Immune test interpretation", "description": "Capture the context and limitations of evidence used to assess immune function.", "findings": [ { "id": "interpretable-immune-results", "name": "Interpretable immune results", "description": "Require sufficient measurement context to judge immune abnormalities and discordant results.", "questions": [ { "text": "What assay, units, reference interval, specimen and collection date accompany each result, and are age or treatment relevant to interpretation?", "kind": "measurement", "id": "interpretable-immune-results-q01" }, { "text": "What condition-specific evidence is needed to resolve transient, conflicting or clinically unexplained results?", "kind": "action", "id": "interpretable-immune-results-q02" } ] } ] } ] }, { "id": "immune-course-and-impact", "name": "Immune course and impact", "description": "Describe how the disorder develops and how it affects health over time.", "rationale": "Immune activity, infection burden and lasting organ impairment are different dimensions and may change independently.", "layers": [ { "id": "activity-and-persistence", "name": "Activity and persistence", "description": "Represent onset, persistence and changes in immune disease activity.", "findings": [ { "id": "longitudinal-immune-state", "name": "Longitudinal immune state", "description": "Use condition-appropriate definitions for active disease, stable dysfunction, relapse and remission.", "questions": [ { "text": "What evidence establishes onset and a persistent, episodic or resolving course?", "kind": "measurement", "id": "longitudinal-immune-state-q01" }, { "text": "Which activity or remission definitions apply to this subtype, and how do they distinguish improvement from lasting immune impairment?", "kind": "definition", "id": "longitudinal-immune-state-q02" } ] } ] }, { "id": "manifestations-and-populations", "name": "Manifestations and populations", "description": "Connect clinical consequences and population patterns to the correct disorder definition.", "findings": [ { "id": "attributable-burden", "name": "Attributable burden", "description": "Record manifestation burden and epidemiological evidence without conflating association with causation.", "questions": [ { "text": "Which infections, inflammatory manifestations or organ impairments are attributed to the disorder, and what supports each attribution?", "kind": "provenance", "id": "attributable-burden-q01" }, { "text": "For each frequency estimate, what subtype, case definition, population, geography and observation year were studied?", "kind": "measurement", "id": "attributable-burden-q02" } ] } ] } ] }, { "id": "immune-management-constraints", "name": "Immune management constraints", "description": "Represent the clinical authority and evidence needed to assess management options.", "rationale": "Different immune dysfunctions can require different approaches, so management cannot be inferred from the broad registry label.", "layers": [ { "id": "assessment-and-monitoring", "name": "Assessment and monitoring", "description": "Identify condition-specific follow-up needs and escalation criteria.", "findings": [ { "id": "monitoring-and-escalation-basis", "name": "Monitoring and escalation basis", "description": "Connect monitoring and escalation decisions to documented guidance and the relevant immune phenotype.", "questions": [ { "text": "Which changes in infection pattern, immune measurements or organ manifestations require reassessment under the applicable guidance?", "kind": "action", "id": "monitoring-and-escalation-basis-q01" }, { "text": "Which authority specifies monitoring intervals and escalation criteria, and for which subtype and population?", "kind": "provenance", "id": "monitoring-and-escalation-basis-q02" } ] } ] }, { "id": "intervention-eligibility", "name": "Intervention eligibility", "description": "Capture prerequisites and constraints for clinician-directed interventions.", "findings": [ { "id": "immune-specific-action-constraints", "name": "Immune-specific action constraints", "description": "Record how the established immune phenotype affects consideration of treatment, vaccination or preventive measures.", "questions": [ { "text": "What subtype-specific evidence and clinical review are required before considering immune-directed treatment, vaccination or infection prevention?", "kind": "action", "id": "immune-specific-action-constraints-q01" }, { "text": "Which documented immune deficits, current infections or treatment effects alter eligibility or require specialist review?", "kind": "boundary", "id": "immune-specific-action-constraints-q02" } ] } ] } ] }, { "id": "evidence-and-external-alignment", "name": "Evidence and external alignment", "description": "What the world already says about this thing, gathered so the model can be checked against it.", "rationale": "A model that cannot be lined up against existing standards, identifiers and practice cannot be adopted by anyone who already uses them.", "layers": [ { "id": "reported-evidence", "name": "Reported evidence", "description": "Findings from the breadth pass, kept separate from the structural claims.", "findings": [ { "id": "evidence-confidence-notes", "name": "Check these first", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "No sense is recorded, so this treats immune disorder as a broad umbrella term; verify the registry's intended scope before assigning a terminology concept.", "There is no single diagnostic criterion set, stage sequence or prevalence estimate for this umbrella category; those require a specific disorder, population and date.", "This is recall-based information, not source-verified research; classification editions and exact codes require checking." ], "questions": [ { "id": "evidence-confidence-notes-q01", "text": "Which of these check these first hold for the sense of immune disorder this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-kinds", "name": "Kinds and varieties", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "Inborn errors of immunity, including primary immunodeficiencies", "Secondary or acquired immunodeficiencies", "Autoimmune disorders", "Allergic and other hypersensitivity disorders", "Autoinflammatory disorders" ], "questions": [ { "id": "evidence-kinds-q01", "text": "Which of these kinds and varieties hold for the sense of immune disorder this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-identifiers", "name": "Identifiers and schemes", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ { "scheme": "ICD-10 and ICD-11", "value_or_pattern": "Condition-specific category or subcategory codes", "note": "WHO classifications distribute immune disorders across multiple categories; the specific diagnosis, revision and applicable national modification must accompany a code." }, { "scheme": "SNOMED CT", "value_or_pattern": "Numeric concept identifier", "note": "Select the concept matching the documented disorder and record the terminology edition and release; no identifier is asserted here." } ], "questions": [ { "id": "evidence-identifiers-q01", "text": "Which of these identifiers and schemes hold for the sense of immune disorder this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-standards-and-regulation", "name": "Standards and regulation", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "World Health Organization ICD-10 and ICD-11 classify diseases for recording and reporting.", "International Union of Immunological Societies expert classifications organise inborn errors of immunity." ], "questions": [ { "id": "evidence-standards-and-regulation-q01", "text": "Which of these standards and regulation hold for the sense of immune disorder this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-real-world-use", "name": "Real-world use", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "Organising clinical evaluation of suspected immune dysfunction.", "Classifying diagnoses in health records and disease registries.", "Distinguishing inherited immune defects from acquired dysfunction.", "Defining disease-specific research cohorts and clinical trial eligibility." ], "questions": [ { "id": "evidence-real-world-use-q01", "text": "Which of these real-world use hold for the sense of immune disorder this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-measurements", "name": "Typical measurements", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ { "quantity": "Serum immunoglobulin concentrations", "typical_range": "Age-, immunoglobulin-class- and laboratory-dependent; no universal range defines an immune disorder.", "unit": "g/L" }, { "quantity": "Absolute lymphocyte subset counts", "typical_range": "Age-, subset- and laboratory-dependent; interpretation requires the clinical context.", "unit": "cells/µL" } ], "questions": [ { "id": "evidence-measurements-q01", "text": "Which of these typical measurements hold for the sense of immune disorder this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-failure-modes-and-hazards", "name": "Failure modes and hazards", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "Deficient immune defence can cause recurrent, severe or opportunistic infections.", "Misdirected immune responses can damage the body's own tissues.", "Severe allergic responses can produce anaphylaxis.", "Uncontrolled inflammation can cause organ damage.", "Treatments that suppress immunity can increase susceptibility to infection." ], "questions": [ { "id": "evidence-failure-modes-and-hazards-q01", "text": "Which of these failure modes and hazards hold for the sense of immune disorder this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-regional-variation", "name": "Regional variation", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "ICD implementation, national coding modifications and adoption dates differ between jurisdictions.", "Access to specialist assessment, immune testing and genetic diagnosis varies between health systems." ], "questions": [ { "id": "evidence-regional-variation-q01", "text": "Which of these regional variation hold for the sense of immune disorder this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-neighbours", "name": "Neighbouring kinds and how to tell them apart", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ { "name": "Immunodeficiency", "difference": "Specifically denotes inadequate immune defence; immune disorder also includes excessive or misdirected responses." }, { "name": "Autoimmune disease", "difference": "Involves immune responses directed against self components; not every immune disorder involves autoimmunity." }, { "name": "Autoinflammatory disease", "difference": "Primarily involves dysregulated innate immunity; the distinction from adaptive autoimmunity can overlap." }, { "name": "Infection", "difference": "Involves an infectious agent; it can cause or result from immune dysfunction but does not itself establish an immune disorder." }, { "name": "Immune-mediated disease", "difference": "Describes disease caused through immune mechanisms; its extension overlaps with, but is not necessarily identical to, immune disorder." } ], "questions": [ { "id": "evidence-neighbours-q01", "text": "Which of these neighbouring kinds and how to tell them apart hold for the sense of immune disorder this model covers, and on what evidence?", "kind": "provenance" } ] } ] } ] } ] }, "openQuestions": [ "Which authoritative definition should anchor this undefined registry entry, and exactly which immune disorder families does that definition include?", "Does an existing Vercy world model already own this concept or any proposed subtype boundary, requiring a link instead of another publication?", "Which current ICD and SNOMED CT concepts represent the broad category, and where are mappings broader, narrower or absent?", "Which diagnostic frameworks and validated activity measures apply to specific subtypes, and where is there no accepted common framework?", "Which population-specific epidemiological sources and management authorities are suitable for this category without generalising evidence from individual disorders?" ], "statistics": { "bundles": 6, "layers": 11, "findings": 19, "questions": 29 } }