{ "vercy": "1.0-draft", "publication": { "status": "research-draft", "adjudicationStatus": "unreviewed", "publishableCanonical": false, "generatedAt": "2026-09-12T11:10:18Z", "providers": [ "Codex" ], "breadth": "recalled by Codex without web access - no source was read", "missingProviders": [], "pass": 2, "cost": { "grok": { "seconds": 18.9, "error": "Reading additional input from stdin...\nOpenAI Codex v0.153.4\n--------\nworkdir: R:\\02_PROJECTS\\02_Meta_Models_Platforms\\Ver.cy\\current\\thing-registry-backlog\nmodel: gpt-6-astra\nprovider: openai\napproval: never\nsandbox: read-only\nreasoning effort: none\nreasoning summaries: none\nsession id: 01a0954e-6c62-7010-af89-7fb1798896db\n--------\nuser\nDescribe what is already known about one registered thing. Answer as JSON only, no prose around it.\n\nThing: maropitant\nSense to describe: (none recorded)\nDomain code: PHY.MAT\nAlso known as: (none)\n\n\nContext for this batch of 1001 things:\n# Batch 044: 1001 regi", "usd": 0.0, "recall": true }, "codex": { "seconds": 78.6, "error": "Reading additional input from stdin...\nOpenAI Codex v0.153.4\n--------\nworkdir: R:\\02_PROJECTS\\02_Meta_Models_Platforms\\Ver.cy\\current\\thing-registry-backlog\nmodel: gpt-6-astra\nprovider: openai\napproval: never\nsandbox: read-only\nreasoning effort: none\nreasoning summaries: none\nsession id: 01a0954e-6c70-7122-a88b-ec3256b5d216\n--------\nuser\nYou are drafting a Vercy meta-model for one registered thing. Answer as JSON only, no prose around it.\n\nThing: maropitant\nRegistry id: vr.tr.maropitant\nPlane / domain: PHY / PHY.MAT\nRegistry definition: (none recorded)\nNames folded into this entry: (none)\n\n\nCo" } }, "enrichment": { "pass": 3, "engine": "claude", "producedAt": "2026-10-06T12:00:00Z", "ingestedAt": "2026-10-06T08:48:58+00:00", "fields": [ "agent_conduct", "ethics", "failure_modes_and_hazards", "owners", "visual_identification" ] }, "gate": { "passed": true, "version": "1.0", "at": "2026-10-07T10:10:30+00:00", "evidence": [ "completeness 1.00", "sense: Wikidata description", "2 live sources", "review by codex: pass" ] } }, "metaModel": { "id": "THING-Q3849795", "registryId": "vr.tr.maropitant", "name": "maropitant", "version": "0.1.0-research.1", "entryKind": "thing", "family": "Thing Registry", "domain": [ "PHY.MAT" ], "status": "research-draft" }, "canonicalUrl": "https://ver.cy/models/thing/q3849795/", "model": { "registry_id": "vr.tr.maropitant", "name": "maropitant", "purpose": "Enable an agent to identify maropitant, evaluate the identity and condition of its material forms, and determine which handling or use decisions require further evidence.", "definition": "Maropitant is a small-molecule neurokinin-1 receptor antagonist used in veterinary medicine to inhibit substance P-mediated emetic signalling and prevent or treat vomiting.", "scope_statement": "This model owns vr.tr.maropitant as a chemical substance in PHY.MAT, including molecular identity, material quality, physicochemical state, pharmacological relationships, and evidence governing handling; salts and medicinal products are explicitly linked forms or neighbouring entities.", "in_scope": [ "Maropitant molecular structure, stereochemistry, and substance identifiers", "Relationships between maropitant, its citrate salt, and hydrated material forms", "Material grade, assay basis, stereochemical purity, and impurities", "Form-specific physical properties, stability, and storage conditions", "Pharmacological target relationships and boundaries of supporting evidence", "Substance handling hazards and links to jurisdiction-specific product authorizations" ], "out_of_scope": [ "Finished tablet and injectable product composition, packaging, and release specifications", "Individual animal diagnosis, prescribing, dosing, and treatment monitoring", "Manufacturing routes and production equipment", "Vomiting disorders and their underlying causes", "Independent models of citrate, substance P, and the NK1 receptor" ], "distinguishing_features": [ "Match molecular structure to maropitant rather than relying on an antiemetic class name: PubChem identifies the parent substance as C32H40N2O, CID 204108. [PubChem](https://pubchem.ncbi.nlm.nih.gov/compound/Maropitant)", "Verify stereochemistry against the named (2S,3S) active structure rather than accepting any material with the same molecular formula. [Cerenia label](https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=3bc065ce-09d6-4131-a5a0-dca3909e0bc8)", "Distinguish parent maropitant from citrate monohydrate; the label's molecular weight of 678.81 belongs to the latter form. [Cerenia label](https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=3bc065ce-09d6-4131-a5a0-dca3909e0bc8)", "Distinguish the active substance from Cerenia tablets, whose stated strengths represent maropitant supplied as citrate. [Cerenia label](https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=3bc065ce-09d6-4131-a5a0-dca3909e0bc8)", "Record NK1 receptor antagonism and substance P blockade as its mechanism, while requiring chemical identity evidence to distinguish it from other NK1 antagonists. [Cerenia label](https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=3bc065ce-09d6-4131-a5a0-dca3909e0bc8)" ], "characteristics": [ { "name": "Structure and identifier agreement", "kind": "relation", "unit_or_values": "Stereochemical structure linked to PubChem CID, CAS number, and applicable EC identifier, each with source and form", "why_it_matters": "Prevents parent, salt, hydrate, and stereoisomer records from being treated as interchangeable." }, { "name": "Material form", "kind": "category", "unit_or_values": "Parent base; citrate with specified stoichiometry and hydration; other evidenced form; unresolved", "why_it_matters": "Determines which molecular mass, assay conversion, and physical-property measurements apply." }, { "name": "Maropitant content", "kind": "measurement", "unit_or_values": "% w/w or mg/g, explicitly as parent equivalent or specified salt, on an as-is or dry basis", "why_it_matters": "Separates active-moiety quantity from counterion and water mass." }, { "name": "Stereochemical purity", "kind": "measurement", "unit_or_values": "% specified stereoisomer, with method and reporting basis", "why_it_matters": "A matching molecular formula does not establish the required stereochemical composition." }, { "name": "Impurity profile and grade", "kind": "state", "unit_or_values": "Measured impurity concentrations and limits; research, reference-standard, or pharmaceutical grade; qualified or unresolved", "why_it_matters": "Determines whether a batch meets the requirements of its intended activity." }, { "name": "Water content and solid form", "kind": "measurement", "unit_or_values": "% w/w water; hydrate stoichiometry; crystalline or amorphous assignment with method", "why_it_matters": "Supports correct mass accounting and interpretation of form-dependent properties." }, { "name": "Solubility and ionization", "kind": "measurement", "unit_or_values": "mg/mL or mol/L with solvent, pH, temperature, material form, and method; pKa where established", "why_it_matters": "Supports justified dissolution and compatibility decisions." }, { "name": "Thermal behaviour", "kind": "measurement", "unit_or_values": "Melting, dehydration, and decomposition temperatures in °C; boiling point only where experimentally meaningful", "why_it_matters": "Prevents a thermal event for one form from being assigned to all maropitant materials." }, { "name": "Stability status", "kind": "state", "unit_or_values": "Within supported conditions; excursion awaiting assessment; degraded; uncharacterized", "why_it_matters": "Connects storage history and analytical evidence to continued usability." }, { "name": "Handling classification", "kind": "category", "unit_or_values": "Form-specific GHS classification and exposure limits, with jurisdiction, supplier, document date, or explicit unknown", "why_it_matters": "Provides handling constraints without substituting medicinal-product warnings for a substance assessment." } ], "affordances": [ "Reconcile a supplier's maropitant identity against structural and form-specific reference records.", "Calculate parent-equivalent content when salt stoichiometry, hydration, and assay basis are established.", "Assess whether a batch's assay, impurities, and grade support a proposed laboratory or manufacturing activity.", "Select supported storage and handling conditions for the identified material form.", "Link pharmacological claims to the species, route, formulation, and endpoint actually studied.", "Flag unsupported substitutions between maropitant material forms or medicinal products." ], "agent_conduct": { "may": [ "Explain that maropitant is a veterinary antiemetic used in dogs and cats under a veterinarian's direction.", "Remind an animal's keeper to follow the veterinary prescription and label." ], "must_not": [ "Recommend a dose or give it to an animal without a veterinarian's decision.", "Advise using it to suppress vomiting when the animal may have swallowed a toxin or have an obstruction.", "Suggest giving it to people or to species it is not authorised for.", "Present it as treating the cause of vomiting rather than the symptom." ], "requires_human": [ "Any treatment decision for an animal in its care." ] }, "ethics": { "considerations": [ "Masking vomiting can delay diagnosis of a serious illness and prolong suffering.", "Animals cannot consent, so their keepers and vets carry the duty of care." ], "affected_parties": [ "Treated dogs and cats", "Their keepers", "Veterinary staff" ] }, "owners": { "steward": "The marketing authorisation holder; the prescribing veterinarian answers for each use.", "master_systems": [ "National veterinary medicines registers" ] }, "visual_identification": [ "Supplied as tablets or an injectable solution for veterinary use; identity is confirmed by label and dispensing records." ], "failure_modes_and_hazards": [ "Suppressing vomiting can hide an obstruction or poisoning.", "Injection can be painful for the animal.", "Accidental human exposure should be avoided." ], "what_it_is_for": [ "Maropitant is encountered in veterinary medicines used to prevent or treat vomiting in animals.", "Its suitability depends on the animal species, clinical condition, formulation and locally authorised product information." ], "standards_and_regulation": [ "Regulation (EU) 2019/6 on veterinary medicinal products, issued by the European Parliament and the Council of the European Union, governs veterinary medicines containing maropitant in the European Union." ] }, "sources": [ { "id": "wikidata", "title": "Wikidata item Q3849795: maropitant", "url": "https://www.wikidata.org/wiki/Q3849795", "url_status": "live", "what_it_supports": "identity and sense of the item", "checked_by": "wikidata-api" }, { "id": "wikipedia-en", "title": "Wikipedia: Maropitant", "url": "https://en.wikipedia.org/wiki/Maropitant", "url_status": "live", "what_it_supports": "general description of the item", "checked_by": "wikidata-api sitelink" } ], "structure": { "bundles": [ { "id": "chemical-identity", "name": "Chemical identity", "description": "Resolve what counts as maropitant and which related forms a record describes.", "rationale": "The parent name is used alongside citrate-containing materials, creating consequential identity ambiguity.", "layers": [ { "id": "molecular-recognition", "name": "Molecular recognition", "description": "Establish connectivity and stereochemical identity.", "findings": [ { "id": "structure-before-name", "name": "Structure before name", "description": "Require a stereochemically explicit reference structure and an identifier trail for the supplied material.", "questions": [ { "text": "Which reference structure defines maropitant, including its stereocentres?", "kind": "definition", "id": "structure-before-name-q01" }, { "text": "Do the supplier's identifiers resolve to that structure or to a salt, hydrate, or unspecified stereoisomer?", "kind": "provenance", "id": "structure-before-name-q02" } ] } ] }, { "id": "parent-and-associated-forms", "name": "Parent and associated forms", "description": "Keep parent identity distinct from counterions, water, and finished products.", "findings": [ { "id": "form-specific-identity", "name": "Form-specific identity", "description": "Represent citrate stoichiometry and hydration explicitly, retaining their relationship to the registered parent substance.", "questions": [ { "text": "Does this sample contain parent maropitant or a specified citrate and hydration form?", "kind": "boundary", "id": "form-specific-identity-q01" }, { "text": "What evidence establishes counterion ratio and water content?", "kind": "measurement", "id": "form-specific-identity-q02" }, { "text": "Does a brand name refer to a finished product requiring a separate linked record?", "kind": "boundary", "id": "form-specific-identity-q03" } ] } ] } ] }, { "id": "content-and-material-quality", "name": "Content and material quality", "description": "Determine how much maropitant a material contains and whether its quality supports an intended activity.", "rationale": "Salt mass, water, stereoisomers, and other impurities can change the interpretation of a nominal maropitant quantity.", "layers": [ { "id": "assay-and-equivalence", "name": "Assay and equivalence", "description": "Make analytical content and mass-conversion assumptions explicit.", "findings": [ { "id": "parent-equivalent-assay", "name": "Parent-equivalent assay", "description": "Record whether content is expressed as maropitant or a specified salt, including moisture correction and analytical uncertainty.", "questions": [ { "text": "Is the reported assay parent-equivalent content, salt content, or chromatographic area percentage?", "kind": "measurement", "id": "parent-equivalent-assay-q01" }, { "text": "Which verified stoichiometry, hydration, and assay basis support conversion to maropitant mass?", "kind": "action", "id": "parent-equivalent-assay-q02" } ] } ] }, { "id": "purity-and-qualification", "name": "Purity and qualification", "description": "Evaluate stereochemical composition and the batch's documented impurity controls.", "findings": [ { "id": "qualified-maropitant-material", "name": "Qualified maropitant material", "description": "Separate a chemical identity match from evidence that the batch meets an activity-specific quality specification.", "questions": [ { "text": "Which methods quantify unwanted stereoisomers, related substances, residual solvents, and relevant degradants?", "kind": "measurement", "id": "qualified-maropitant-material-q01" }, { "text": "Which certificate and specification justify the claimed grade for this batch?", "kind": "provenance", "id": "qualified-maropitant-material-q02" }, { "text": "Do unresolved impurities or missing tests prevent the proposed use?", "kind": "action", "id": "qualified-maropitant-material-q03" } ] } ] } ] }, { "id": "physical-state-and-stability", "name": "Physical state and stability", "description": "Describe maropitant properties under identified material and environmental conditions.", "rationale": "Properties measured for a citrate hydrate or formulation cannot automatically characterize parent maropitant.", "layers": [ { "id": "conditioned-properties", "name": "Conditioned properties", "description": "Tie physical measurements to form, medium, and method.", "findings": [ { "id": "interpretable-property-values", "name": "Interpretable property values", "description": "Require form-specific evidence for solubility, ionization, and thermal behaviour.", "questions": [ { "text": "For which maropitant form, solvent, pH, and temperature was solubility measured?", "kind": "measurement", "id": "interpretable-property-values-q01" }, { "text": "Does a reported thermal transition represent melting, dehydration, or decomposition?", "kind": "measurement", "id": "interpretable-property-values-q02" } ] } ] }, { "id": "storage-and-change", "name": "Storage and change", "description": "Connect environmental history to chemical and solid-state integrity.", "findings": [ { "id": "supported-material-lifetime", "name": "Supported material lifetime", "description": "Base storage and retest decisions on evidence for the identified substance form and container.", "questions": [ { "text": "Which stability study supports temperature, light, humidity, and container requirements for this material?", "kind": "provenance", "id": "supported-material-lifetime-q01" }, { "text": "After an excursion, which assay, degradant, or water-content results are needed before reuse?", "kind": "action", "id": "supported-material-lifetime-q02" } ] } ] } ] }, { "id": "pharmacological-evidence-boundaries", "name": "Pharmacological evidence boundaries", "description": "Connect maropitant's biological activity to evidence without embedding a prescribing protocol.", "rationale": "A target mechanism does not by itself establish effectiveness or safe use across species, routes, and formulations.", "layers": [ { "id": "target-and-response", "name": "Target and response", "description": "Distinguish receptor activity from demonstrated clinical outcomes.", "findings": [ { "id": "mechanism-to-endpoint", "name": "Mechanism to endpoint", "description": "Keep receptor interaction evidence separate from evidence for suppression of vomiting or other proposed outcomes.", "questions": [ { "text": "Which experimental system establishes maropitant's NK1 antagonist activity?", "kind": "provenance", "id": "mechanism-to-endpoint-q01" }, { "text": "Does the cited study measure receptor binding, vomiting, nausea-related behaviour, or another endpoint?", "kind": "boundary", "id": "mechanism-to-endpoint-q02" } ] } ] }, { "id": "exposure-context", "name": "Exposure context", "description": "Attach biological measurements to species and administration conditions.", "findings": [ { "id": "bounded-pharmacokinetics", "name": "Bounded pharmacokinetics", "description": "Treat exposure and elimination measurements as conditional evidence rather than universal substance constants.", "questions": [ { "text": "Which species, route, formulation, dose range, and sampling method produced the reported exposure data?", "kind": "measurement", "id": "bounded-pharmacokinetics-q01" }, { "text": "What evidence supports transferring those results to the proposed biological context?", "kind": "boundary", "id": "bounded-pharmacokinetics-q02" } ] } ] } ] }, { "id": "handling-and-use-constraints", "name": "Handling and use constraints", "description": "Identify evidence governing substance handling and links governing medicinal use.", "rationale": "Chemical handling assessments and product authorizations answer different questions about maropitant.", "layers": [ { "id": "substance-exposure", "name": "Substance exposure", "description": "Establish handling controls for the actual maropitant material.", "findings": [ { "id": "form-specific-hazard-evidence", "name": "Form-specific hazard evidence", "description": "Require an applicable safety data sheet and distinguish missing hazard data from an assessed absence of hazard.", "questions": [ { "text": "Which current safety data sheet covers this exact maropitant form, concentration, and supplier?", "kind": "provenance", "id": "form-specific-hazard-evidence-q01" }, { "text": "Which GHS classifications and occupational exposure limits are established, and which remain unavailable?", "kind": "definition", "id": "form-specific-hazard-evidence-q02" }, { "text": "What containment, protective equipment, and disposal controls follow for the intended operation?", "kind": "action", "id": "form-specific-hazard-evidence-q03" } ] } ] }, { "id": "authorized-product-links", "name": "Authorized product links", "description": "Locate medicinal permissions in their applicable product and jurisdiction records.", "findings": [ { "id": "context-specific-permissions", "name": "Context-specific permissions", "description": "Link maropitant to dated product authorization evidence rather than assigning unrestricted therapeutic permissions to the substance.", "questions": [ { "text": "Which current product authorization supports the proposed species, indication, route, and jurisdiction?", "kind": "provenance", "id": "context-specific-permissions-q01" }, { "text": "Does the proposed action require a veterinarian's decision or a separate product-equivalence assessment?", "kind": "action", "id": "context-specific-permissions-q02" } ] } ] } ] }, { "id": "evidence-and-external-alignment", "name": "Evidence and external alignment", "description": "What the world already says about this thing, gathered so the model can be checked against it.", "rationale": "A model that cannot be lined up against existing standards, identifiers and practice cannot be adopted by anyone who already uses them.", "layers": [ { "id": "reported-evidence", "name": "Reported evidence", "description": "Findings from the breadth pass, kept separate from the structural claims.", "findings": [ { "id": "evidence-confidence-notes", "name": "Check these first", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "This is recalled knowledge; no sources were consulted.", "Verify CAS and other database identifiers separately for the free base, citrate salt and hydrated salt.", "Check current jurisdiction-specific product information before asserting exact indications or safety restrictions; physical constants and hazard classifications are not supplied here." ], "questions": [ { "id": "evidence-confidence-notes-q01", "text": "Which of these check these first hold for the sense of maropitant this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-kinds", "name": "Kinds and varieties", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "Maropitant free base", "Maropitant citrate", "Maropitant citrate monohydrate" ], "questions": [ { "id": "evidence-kinds-q01", "text": "Which of these kinds and varieties hold for the sense of maropitant this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-identifiers", "name": "Identifiers and schemes", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ { "scheme": "International Nonproprietary Name (INN)", "value_or_pattern": "maropitant", "note": "Names the active substance; salt and hydration state require additional specification." }, { "scheme": "Molecular formula", "value_or_pattern": "C32H40N2O", "note": "Formula of the free base, excluding citrate and water of crystallisation." } ], "questions": [ { "id": "evidence-identifiers-q01", "text": "Which of these identifiers and schemes hold for the sense of maropitant this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-standards-and-regulation", "name": "Standards and regulation", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "US Food and Drug Administration veterinary drug approvals and approved prescribing information govern authorised maropitant products.", "European Union veterinary medicinal-product authorisations and associated product information govern authorised species, indications and formulations." ], "questions": [ { "id": "evidence-standards-and-regulation-q01", "text": "Which of these standards and regulation hold for the sense of maropitant this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-real-world-use", "name": "Real-world use", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "Prevention and treatment of vomiting in dogs.", "Prevention of vomiting associated with motion sickness in dogs.", "Treatment of vomiting in cats using authorised formulations." ], "questions": [ { "id": "evidence-real-world-use-q01", "text": "Which of these real-world use hold for the sense of maropitant this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-measurements", "name": "Typical measurements", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ { "quantity": "Molar mass of free base", "typical_range": "468.67", "unit": "g/mol" } ], "questions": [ { "id": "evidence-measurements-q01", "text": "Which of these typical measurements hold for the sense of maropitant this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-failure-modes-and-hazards", "name": "Failure modes and hazards", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "Injection can cause pain and local reactions.", "Hepatic impairment can alter exposure because maropitant undergoes hepatic metabolism.", "Suppression of vomiting does not resolve its underlying cause, including gastrointestinal obstruction or poisoning.", "Safety restrictions depend on species, age, reproductive status and formulation.", "Confusing free-base content with citrate or hydrated-salt mass can cause formulation and concentration errors." ], "questions": [ { "id": "evidence-failure-modes-and-hazards-q01", "text": "Which of these failure modes and hazards hold for the sense of maropitant this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-regional-variation", "name": "Regional variation", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "Approved species, indications, age restrictions and available formulations vary between jurisdictions." ], "questions": [ { "id": "evidence-regional-variation-q01", "text": "Which of these regional variation hold for the sense of maropitant this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-neighbours", "name": "Neighbouring kinds and how to tell them apart", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ { "name": "Cerenia", "difference": "Cerenia is a veterinary medicinal-product brand containing maropitant; maropitant is the active chemical substance." }, { "name": "Aprepitant", "difference": "Aprepitant is a chemically distinct neurokinin-1 antagonist used principally in human medicine." }, { "name": "Ondansetron", "difference": "Ondansetron acts primarily through serotonin 5-HT3 receptor antagonism rather than neurokinin-1 receptor antagonism." } ], "questions": [ { "id": "evidence-neighbours-q01", "text": "Which of these neighbouring kinds and how to tell them apart hold for the sense of maropitant this model covers, and on what evidence?", "kind": "provenance" } ] } ] } ] } ] }, "openQuestions": [ "Which authoritative CAS and EC identifiers apply separately to parent maropitant, citrate, and citrate monohydrate, and where do supplier records conflate them?", "Which experimentally supported solubility, pKa, solid-form, and thermal values are available for each relevant form?", "Which validated impurity and stereochemical-purity specifications establish suitability for the intended material grade?", "Which form-specific safety data sheets, exposure limits, and stability studies support handling and storage decisions?", "Which current jurisdiction-specific authorizations and primary studies support each proposed species, route, formulation, and therapeutic claim?" ], "statistics": { "bundles": 6, "layers": 11, "findings": 19, "questions": 32 } }