{ "vercy": "1.0-draft", "publication": { "status": "research-draft", "adjudicationStatus": "unreviewed", "publishableCanonical": false, "generatedAt": "2026-09-12T09:59:59Z", "providers": [ "Codex" ], "breadth": "recalled by Codex without web access - no source was read", "missingProviders": [], "pass": 2, "cost": { "grok": { "seconds": 21.0, "error": "Reading additional input from stdin...\nOpenAI Codex v0.153.4\n--------\nworkdir: R:\\02_PROJECTS\\02_Meta_Models_Platforms\\Ver.cy\\current\\thing-registry-backlog\nmodel: gpt-6-astra\nprovider: openai\napproval: never\nsandbox: read-only\nreasoning effort: none\nreasoning summaries: none\nsession id: 01a0950d-fe77-7f70-9ee8-8efbb88353bf\n--------\nuser\nDescribe what is already known about one registered thing. Answer as JSON only, no prose around it.\n\nThing: gestodene\nSense to describe: (none recorded)\nDomain code: PHY.MAT\nAlso known as: (none)\n\n\nContext for this batch of 1001 things:\n# Batch 043: 1001 regis", "usd": 0.0, "recall": true }, "codex": { "seconds": 82.8, "error": "Reading additional input from stdin...\nOpenAI Codex v0.153.4\n--------\nworkdir: R:\\02_PROJECTS\\02_Meta_Models_Platforms\\Ver.cy\\current\\thing-registry-backlog\nmodel: gpt-6-astra\nprovider: openai\napproval: never\nsandbox: read-only\nreasoning effort: none\nreasoning summaries: none\nsession id: 01a0950d-fe88-7182-b615-d80f91d74122\n--------\nuser\nYou are drafting a Vercy meta-model for one registered thing. Answer as JSON only, no prose around it.\n\nThing: gestodene\nRegistry id: vr.tr.gestodene\nPlane / domain: PHY / PHY.MAT\nRegistry definition: (none recorded)\nNames folded into this entry: (none)\n\n\nCont" } }, "enrichment": { "pass": 3, "engine": "claude", "producedAt": "2026-10-06T12:00:00Z", "ingestedAt": "2026-10-06T08:57:40+00:00", "fields": [ "agent_conduct", "ethics", "failure_modes_and_hazards", "owners", "standards_and_regulation", "visual_identification" ] }, "gate": { "passed": true, "version": "1.0", "at": "2026-10-07T10:10:30+00:00", "evidence": [ "completeness 1.00", "sense: Wikidata description", "2 live sources", "review by codex: pass" ] } }, "metaModel": { "id": "THING-Q408289", "registryId": "vr.tr.gestodene", "name": "gestodene", "version": "0.1.0-research.1", "entryKind": "thing", "family": "Thing Registry", "domain": [ "PHY.MAT" ], "status": "research-draft" }, "canonicalUrl": "https://ver.cy/models/thing/q408289/", "model": { "registry_id": "vr.tr.gestodene", "name": "gestodene", "purpose": "Enable an agent to recognise gestodene, assess the identity and quality of a material containing it, and determine which handling or use decisions its evidence supports.", "definition": "Gestodene is a synthetic steroidal progestogen of the gonane group, with molecular formula C21H26O2, used principally as the progestogen component of combined hormonal contraceptives.", "scope_statement": "This model owns gestodene as the stereochemically defined chemical substance registered as vr.tr.gestodene in PHY / PHY.MAT, including material quality, physical state, biological activity and substance-specific constraints.", "in_scope": [ "Molecular identity, stereochemistry and verified identifier mappings", "Gestodene content, related substances and suitability of individual material lots", "Solid form, solubility, thermal behaviour and storage stability", "Gestodene-specific pharmacological activity and disposition evidence", "Substance hazards, exposure controls and jurisdiction-specific identity records" ], "out_of_scope": [ "Finished contraceptive formulations, packaging and product authorisations", "Patient-specific prescribing, dosing and contraceptive counselling", "Manufacturing processes and production equipment", "Independent models of metabolites, other progestogens and co-formulated estrogens", "Clinical disease models and population-level contraceptive programmes" ], "distinguishing_features": [ "Require a stereochemical structure match to InChIKey SIGSPDASOTUPFS-XUDSTZEESA-N; a steroid name or molecular formula alone is insufficient. [ChEBI identity](https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI%3A135323)", "Check formula C21H26O2 and CAS 60282-87-3 together with structure, rather than accepting either identifier alone. [ChEBI identity](https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI%3A135323)", "Require analytical discrimination from related steroid impurities and stereoisomers through a qualified reference standard and a method with demonstrated specificity.", "Distinguish isolated gestodene from a medicine containing gestodene and ethinylestradiol; the latter has additional ingredients and product-level properties. [Femodene composition](https://www.medicines.org.uk/emc/product/1123/smpc)" ], "characteristics": [ { "name": "Stereochemical identity", "kind": "category", "unit_or_values": "Verified stereochemical structure and InChIKey; matched, conflicting or unresolved", "why_it_matters": "Prevents related steroids or incorrectly assigned stereoisomers from being treated as gestodene." }, { "name": "Gestodene assay", "kind": "measurement", "unit_or_values": "% mass fraction, with as-is or corrected basis, method and uncertainty", "why_it_matters": "Establishes actual gestodene content rather than relying on nominal grade." }, { "name": "Related-substance profile", "kind": "measurement", "unit_or_values": "Individual and total impurities in % or mg/kg; distinguish calibrated concentration from chromatographic area %", "why_it_matters": "Determines whether contamination or degradation prevents the proposed use." }, { "name": "Material grade and release state", "kind": "state", "unit_or_values": "Declared grade; quarantined, released, rejected or awaiting retest; governing specification", "why_it_matters": "A research reagent or reference standard does not automatically qualify as pharmaceutical starting material." }, { "name": "Physical form", "kind": "category", "unit_or_values": "Observed phase, crystalline or amorphous character, identified solid form and particle-size distribution", "why_it_matters": "Supports comparison of lots and assessment of dissolution, sampling and handling." }, { "name": "Thermal behaviour", "kind": "measurement", "unit_or_values": "Melting range and decomposition onset in °C; boiling point only with pressure and evidence of intact vaporisation", "why_it_matters": "Prevents a decomposition event or estimated value from being recorded as a usable phase-transition constant." }, { "name": "Solubility", "kind": "measurement", "unit_or_values": "mg/mL or mol/L, specifying solvent, temperature, pH where relevant and measurement method", "why_it_matters": "Supports preparation of analytical solutions and assessment of precipitation." }, { "name": "Biological activity", "kind": "measurement", "unit_or_values": "Assay-specific EC50, IC50 or binding affinity in nM, with receptor, system and comparator", "why_it_matters": "Keeps functional activity distinct from chemical purity and clinical efficacy." }, { "name": "Protein binding and disposition context", "kind": "relation", "unit_or_values": "Links to albumin and SHBG binding evidence, exposure studies and co-administered substances", "why_it_matters": "Gestodene pharmacokinetics depend on SHBG context, so study conditions must accompany reported values. [Femodene pharmacokinetics](https://www.medicines.org.uk/emc/product/1123/smpc)" }, { "name": "Hazard and exposure status", "kind": "category", "unit_or_values": "Verified classification, jurisdiction, source date and applicable exposure limit or documented absence of an established limit", "why_it_matters": "Supports handling decisions without confusing medicinal-product warnings with bulk-substance hazard classification." } ], "affordances": [ "Reconcile a supplier's gestodene identity against a verified stereochemical reference.", "Compare a gestodene lot with an explicitly selected analytical or pharmaceutical specification.", "Select a supported sampling and analytical approach that distinguishes gestodene from related substances.", "Assess whether recorded storage conditions and stability evidence support continued use or require retesting.", "Link gestodene to containing products and biological studies while preserving their formulation and exposure context.", "Identify missing hazard or quality evidence that prevents a proposed handling or use decision." ], "agent_conduct": { "may": [ "Identify gestodene by name, identifiers and documented properties, citing sources.", "Report approved contraceptive products and their warnings from official product information.", "Check a material lot's certificate of analysis against its specification." ], "must_not": [ "Recommend a contraceptive or dose for a particular person.", "Downplay blood clot risks when describing products containing it.", "Disclose or infer a person's contraceptive use without consent.", "Supply it outside lawful pharmaceutical channels." ], "requires_human": [ "Any decision to start, stop or switch a person's contraception.", "Releasing or destroying a material lot." ] }, "ethics": { "considerations": [ "Contraception is a private choice tied to bodily autonomy.", "Women deserve honest information about clot risks that differ between progestogens." ], "affected_parties": [ "People using hormonal contraception", "Prescribers and pharmacists", "Manufacturing staff" ] }, "owners": { "steward": "The marketing authorization holder for each medicine; the national medicines regulator oversees it.", "master_systems": [ "National medicines registers" ] }, "visual_identification": [ "Identity rests on the label, batch record and certificate of analysis, not appearance.", "Usually found in combined products with an estrogen, named on the pack." ], "failure_modes_and_hazards": [ "Raised risk of venous blood clots with combined products.", "Missed pills reducing contraceptive protection.", "Hormonal exposure of manufacturing staff." ], "standards_and_regulation": [ "ICH Q7 Good Manufacturing Practice Guide for Active Pharmaceutical Ingredients, International Council for Harmonisation." ], "what_it_is_for": [ "Gestodene is used principally with an estrogen in combined hormonal contraceptive medicines.", "It is encountered in pharmaceutical manufacturing, finished contraceptive products and laboratories assessing ingredient identity, purity and content." ] }, "sources": [ { "id": "wikidata", "title": "Wikidata item Q408289: gestodene", "url": "https://www.wikidata.org/wiki/Q408289", "url_status": "live", "what_it_supports": "identity and sense of the item", "checked_by": "wikidata-api" }, { "id": "wikipedia-en", "title": "Wikipedia: Gestodene", "url": "https://en.wikipedia.org/wiki/Gestodene", "url_status": "live", "what_it_supports": "general description of the item", "checked_by": "wikidata-api sitelink" } ], "structure": { "bundles": [ { "id": "gestodene-identity", "name": "Gestodene identity", "description": "Establish the exact molecule and its boundary against related steroids and containing products.", "rationale": "Steroid similarity and product naming can conceal materially different identities.", "layers": [ { "id": "molecular-reference", "name": "Molecular reference", "description": "Anchor recognition to a stereochemically explicit structure.", "findings": [ { "id": "structure-identifier-agreement", "name": "Structure and identifier agreement", "description": "ChEBI supplies a stereochemical structure, formula and CAS mapping for gestodene; the model should record agreement or conflict between these and the material documentation. [ChEBI](https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI%3A135323)", "questions": [ { "text": "Does the declared structure match the gestodene reference including every specified stereocentre and double bond?", "kind": "definition", "id": "structure-identifier-agreement-q01" }, { "text": "Which read source establishes each CAS, PubChem or EC identifier mapping, and do any mappings conflict?", "kind": "provenance", "id": "structure-identifier-agreement-q02" } ] } ] }, { "id": "substance-product-boundary", "name": "Substance and product boundary", "description": "Separate molecular identity from mixtures, standards and medicines.", "findings": [ { "id": "gestodene-bearing-material", "name": "Gestodene-bearing material", "description": "Classify the observed material as isolated substance, reference preparation or mixture, and link containing products separately.", "questions": [ { "text": "Is this material isolated gestodene, a reference solution or a formulation containing other active ingredients?", "kind": "boundary", "id": "gestodene-bearing-material-q01" }, { "text": "Which reported properties belong to gestodene itself and which depend on the containing preparation?", "kind": "boundary", "id": "gestodene-bearing-material-q02" } ] } ] } ] }, { "id": "gestodene-quality", "name": "Gestodene content and quality", "description": "Determine whether an identified lot meets the requirements of its intended use.", "rationale": "Identity alone cannot establish content, impurity acceptability or pharmaceutical suitability.", "layers": [ { "id": "assay-specificity", "name": "Assay and specificity", "description": "Connect content measurements to methods capable of resolving relevant steroid species.", "findings": [ { "id": "qualified-content-result", "name": "Qualified content result", "description": "Record the gestodene assay basis, reference-standard qualification and demonstrated analytical selectivity.", "questions": [ { "text": "What gestodene content was measured, on what correction basis and with what uncertainty?", "kind": "measurement", "id": "qualified-content-result-q01" }, { "text": "What evidence shows the method distinguishes gestodene from relevant related steroids and stereoisomers?", "kind": "provenance", "id": "qualified-content-result-q02" } ] } ] }, { "id": "impurities-release", "name": "Impurities and release", "description": "Evaluate individual contaminants against a named specification.", "findings": [ { "id": "use-specific-acceptability", "name": "Use-specific acceptability", "description": "Tie impurity, solvent and water results to documented limits and a lot-level disposition.", "questions": [ { "text": "Which related substances, residual solvents and water levels were measured, and which remain unidentified or unmeasured?", "kind": "measurement", "id": "use-specific-acceptability-q01" }, { "text": "Does this lot meet the applicable specification for its proposed use, or must it remain quarantined?", "kind": "action", "id": "use-specific-acceptability-q02" } ] } ] } ] }, { "id": "gestodene-physical-state", "name": "Gestodene physical state and stability", "description": "Capture the material conditions that govern preparation, storage and reliable measurement.", "rationale": "Physical constants and stability claims need conditions and evidence before they can guide handling.", "layers": [ { "id": "solid-thermal-properties", "name": "Solid and thermal properties", "description": "Describe the observed solid and distinguish phase changes from decomposition.", "findings": [ { "id": "conditioned-solid-description", "name": "Conditioned solid description", "description": "Record solid-form evidence, particle characteristics and measured thermal events without assuming a universal polymorph or boiling point.", "questions": [ { "text": "What diffraction, thermal or other evidence identifies the solid form of this gestodene lot?", "kind": "measurement", "id": "conditioned-solid-description-q01" }, { "text": "Do reported melting or boiling values specify conditions and distinguish intact phase change from decomposition?", "kind": "provenance", "id": "conditioned-solid-description-q02" } ] } ] }, { "id": "solution-storage-behaviour", "name": "Solution and storage behaviour", "description": "Assess solution preparation and retention of quality over time.", "findings": [ { "id": "supported-preparation-lifetime", "name": "Supported preparation lifetime", "description": "Connect solvent choice, concentration, packaging and environmental exposure to measured solubility and stability.", "questions": [ { "text": "At the intended concentration and temperature, what evidence supports complete dissolution and absence of precipitation?", "kind": "measurement", "id": "supported-preparation-lifetime-q01" }, { "text": "Which stability results justify the storage conditions and retest or expiry interval for this solid or solution?", "kind": "action", "id": "supported-preparation-lifetime-q02" } ] } ] } ] }, { "id": "gestodene-biological-behaviour", "name": "Gestodene biological behaviour", "description": "Represent activity and disposition with enough context to prevent unsupported extrapolation.", "rationale": "An ingredient's assay activity and exposure properties do not independently establish a finished medicine's effects.", "layers": [ { "id": "activity-attribution", "name": "Activity attribution", "description": "Distinguish gestodene-specific pharmacology from combination-product outcomes.", "findings": [ { "id": "activity-evidence-boundary", "name": "Activity evidence boundary", "description": "Record receptor-level and functional evidence separately from outcomes observed with gestodene-containing contraceptives.", "questions": [ { "text": "Which experiments establish gestodene's progestogenic activity, and what receptor system and comparator did they use?", "kind": "provenance", "id": "activity-evidence-boundary-q01" }, { "text": "Was the reported effect measured for gestodene alone or for an estrogen-progestogen combination?", "kind": "boundary", "id": "activity-evidence-boundary-q02" } ] } ] }, { "id": "binding-exposure", "name": "Binding and exposure", "description": "Preserve the biological conditions behind disposition measurements.", "findings": [ { "id": "shbg-dependent-context", "name": "SHBG-dependent context", "description": "The Femodene label describes gestodene binding to albumin and SHBG and SHBG-dependent pharmacokinetics; retain these conditions when reusing measurements. [Femodene SmPC](https://www.medicines.org.uk/emc/product/1123/smpc)", "questions": [ { "text": "Do reported concentrations represent total or unbound gestodene, and what binding conditions were measured?", "kind": "measurement", "id": "shbg-dependent-context-q01" }, { "text": "What route, dosing history, co-administered estrogen and population qualify each exposure or elimination estimate?", "kind": "boundary", "id": "shbg-dependent-context-q02" } ] } ] } ] }, { "id": "gestodene-handling-constraints", "name": "Gestodene hazards and permitted uses", "description": "Connect bulk-substance handling and use decisions to applicable evidence.", "rationale": "Neither a medicinal-product label nor an unverified supplier classification establishes every constraint on bulk gestodene.", "layers": [ { "id": "occupational-environmental-evidence", "name": "Occupational and environmental evidence", "description": "Assess the evidence relevant to exposure during weighing, transfer and disposal.", "findings": [ { "id": "substance-hazard-basis", "name": "Substance hazard basis", "description": "Record verified bulk-substance classifications and exposure-control evidence, marking missing limits explicitly.", "questions": [ { "text": "Which current safety data sheet or authoritative classification applies to this gestodene material and jurisdiction?", "kind": "provenance", "id": "substance-hazard-basis-q01" }, { "text": "What evidence supports containment, protective measures and waste handling for the proposed quantity and physical form?", "kind": "action", "id": "substance-hazard-basis-q02" } ] } ] }, { "id": "regulatory-use-boundaries", "name": "Regulatory use boundaries", "description": "Separate substance records, material qualification and finished-product permissions.", "findings": [ { "id": "qualified-use-link", "name": "Qualified use link", "description": "Associate intended use with dated jurisdictional records and quality requirements without treating ingredient identity as permission to manufacture or administer a medicine.", "questions": [ { "text": "Which jurisdictional record and quality standard govern the proposed research or pharmaceutical use of this gestodene lot?", "kind": "provenance", "id": "qualified-use-link-q01" }, { "text": "Which remaining decision belongs to the containing medicine's authorisation or a clinical model?", "kind": "boundary", "id": "qualified-use-link-q02" } ] } ] } ] }, { "id": "evidence-and-external-alignment", "name": "Evidence and external alignment", "description": "What the world already says about this thing, gathered so the model can be checked against it.", "rationale": "A model that cannot be lined up against existing standards, identifiers and practice cannot be adopted by anyone who already uses them.", "layers": [ { "id": "reported-evidence", "name": "Reported evidence", "description": "Findings from the breadth pass, kept separate from the structural claims.", "findings": [ { "id": "evidence-confidence-notes", "name": "Check these first", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "This account is recalled knowledge; no sources were consulted.", "Verify current product authorizations, contraindications and comparative thromboembolic risks against jurisdiction-specific labeling.", "Confirm pharmacopoeial specifications, purity grades, physical constants and bulk-substance hazard classification before adding them." ], "questions": [ { "id": "evidence-confidence-notes-q01", "text": "Which of these check these first hold for the sense of gestodene this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-identifiers", "name": "Identifiers and schemes", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ { "scheme": "International Nonproprietary Name (INN)", "value_or_pattern": "gestodene", "note": "Names the active substance rather than a finished contraceptive product." }, { "scheme": "CAS Registry Number", "value_or_pattern": "60282-87-3", "note": "Identifies gestodene with its specified steroid stereochemistry." }, { "scheme": "Molecular formula", "value_or_pattern": "C21H26O2", "note": "Describes elemental composition but does not uniquely establish structure or stereochemistry." } ], "questions": [ { "id": "evidence-identifiers-q01", "text": "Which of these identifiers and schemes hold for the sense of gestodene this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-standards-and-regulation", "name": "Standards and regulation", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "ICH Q7, issued by the International Council for Harmonisation, provides good manufacturing practice guidance for active pharmaceutical ingredients.", "Marketing authorization and approved labeling are determined by medicines regulators for individual gestodene-containing products." ], "questions": [ { "id": "evidence-standards-and-regulation-q01", "text": "Which of these standards and regulation hold for the sense of gestodene this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-real-world-use", "name": "Real-world use", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "Active ingredient in combined oral contraceptives, commonly paired with ethinylestradiol.", "Reference substance for pharmaceutical identity, assay and impurity testing." ], "questions": [ { "id": "evidence-real-world-use-q01", "text": "Which of these real-world use hold for the sense of gestodene this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-measurements", "name": "Typical measurements", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ { "quantity": "Molar mass", "typical_range": "310.43", "unit": "g/mol" } ], "questions": [ { "id": "evidence-measurements-q01", "text": "Which of these typical measurements hold for the sense of gestodene this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-failure-modes-and-hazards", "name": "Failure modes and hazards", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "Gestodene-containing combined hormonal contraceptives carry a risk of venous thromboembolism; this is a product-level clinical risk, not a bulk-substance GHS classification.", "Enzyme-inducing medicines can reduce the effectiveness of gestodene-containing hormonal contraceptives.", "Incorrect active ingredient content, impurities or incorrect stereochemical identity can compromise pharmaceutical quality." ], "questions": [ { "id": "evidence-failure-modes-and-hazards-q01", "text": "Which of these failure modes and hazards hold for the sense of gestodene this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-regional-variation", "name": "Regional variation", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "Availability, prescription status and authorized formulations vary by jurisdiction." ], "questions": [ { "id": "evidence-regional-variation-q01", "text": "Which of these regional variation hold for the sense of gestodene this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-neighbours", "name": "Neighbouring kinds and how to tell them apart", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ { "name": "Levonorgestrel", "difference": "A related gonane progestogen; gestodene has an additional carbon-carbon double bond at positions 15-16." }, { "name": "Desogestrel", "difference": "A distinct progestogen that is converted to the active metabolite etonogestrel; gestodene is itself pharmacologically active." }, { "name": "Ethinylestradiol", "difference": "An estrogen often combined with gestodene, whereas gestodene supplies progestogenic activity." }, { "name": "Gestodene-containing contraceptive", "difference": "A finished medicinal product with a specified formulation and dose, rather than the gestodene substance alone." } ], "questions": [ { "id": "evidence-neighbours-q01", "text": "Which of these neighbouring kinds and how to tell them apart hold for the sense of gestodene this model covers, and on what evidence?", "kind": "provenance" } ] } ] } ] } ] }, "openQuestions": [ "Which authoritative source verifies gestodene's EC identifier and the bulk-substance hazard classifications applicable in the target jurisdictions?", "Which current pharmacopoeial or validated specifications define gestodene assay, stereochemical identity and acceptable related-substance limits?", "What experimentally supported solid forms, melting behaviour, decomposition behaviour and condition-specific solubilities should be recognised?", "What substance-specific occupational exposure limits, environmental evidence and stability studies support handling and storage decisions?", "How should ChEBI's estrogen role annotation be reconciled with gestodene's progestogenic role using primary pharmacology evidence? [ChEBI role annotation](https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI%3A135323)" ], "statistics": { "bundles": 6, "layers": 11, "findings": 18, "questions": 28 } }