{ "vercy": "1.0-draft", "publication": { "status": "research-draft", "adjudicationStatus": "unreviewed", "publishableCanonical": false, "generatedAt": "2026-09-12T09:07:25Z", "providers": [ "Codex" ], "breadth": "recalled by Codex without web access - no source was read", "missingProviders": [], "pass": 2, "cost": { "grok": { "seconds": 21.6, "error": "Reading additional input from stdin...\nOpenAI Codex v0.153.4\n--------\nworkdir: R:\\02_PROJECTS\\02_Meta_Models_Platforms\\Ver.cy\\current\\thing-registry-backlog\nmodel: gpt-6-astra\nprovider: openai\napproval: never\nsandbox: read-only\nreasoning effort: none\nreasoning summaries: none\nsession id: 01a094dd-efad-7d83-b443-5e06f7433892\n--------\nuser\nDescribe what is already known about one registered thing. Answer as JSON only, no prose around it.\n\nThing: desmethylprodine\nSense to describe: (none recorded)\nDomain code: PHY.MAT\nAlso known as: (none)\n\n\nContext for this batch of 1001 things:\n# Batch 043: 100", "usd": 0.0, "recall": true }, "codex": { "seconds": 78.2, "error": "Reading additional input from stdin...\nOpenAI Codex v0.153.4\n--------\nworkdir: R:\\02_PROJECTS\\02_Meta_Models_Platforms\\Ver.cy\\current\\thing-registry-backlog\nmodel: gpt-6-astra\nprovider: openai\napproval: never\nsandbox: read-only\nreasoning effort: none\nreasoning summaries: none\nsession id: 01a094dd-efb6-7a10-8db2-942f47edd5ea\n--------\nuser\nYou are drafting a Vercy meta-model for one registered thing. Answer as JSON only, no prose around it.\n\nThing: desmethylprodine\nRegistry id: vr.tr.desmethylprodine\nPlane / domain: PHY / PHY.MAT\nRegistry definition: (none recorded)\nNames folded into this entry:" } }, "enrichment": { "pass": 3, "engine": "claude", "producedAt": "2026-10-06T12:00:00Z", "ingestedAt": "2026-10-06T08:48:58+00:00", "fields": [ "agent_conduct", "ethics", "failure_modes_and_hazards", "owners", "standards_and_regulation", "visual_identification" ] }, "revisions": [ { "at": "2026-10-07T11:32:17+00:00", "engine": "codex", "fields": [ "owners" ], "answering_review": "3d8c416e1fd4d115a20545061b2c3f44154779cf7e7d9633cf43200227741295" } ], "gate": { "passed": true, "version": "1.0", "at": "2026-10-07T12:16:32+00:00", "evidence": [ "completeness 1.00", "sense: Wikidata description", "2 live sources", "review by codex: pass" ] } }, "metaModel": { "id": "THING-Q408952", "registryId": "vr.tr.desmethylprodine", "name": "desmethylprodine", "version": "0.1.0-research.1", "entryKind": "thing", "family": "Thing Registry", "domain": [ "PHY.MAT" ], "status": "research-draft" }, "canonicalUrl": "https://ver.cy/models/thing/q408952/", "model": { "registry_id": "vr.tr.desmethylprodine", "name": "desmethylprodine", "purpose": "Enable an agent to identify desmethylprodine, assess the identity and condition of material attributed to it, and determine whether a proposed activity has adequate analytical, safety and regulatory support.", "definition": "Desmethylprodine, commonly called MPPP, is a synthetic phenylpiperidine opioid with analgesic activity, chemically the propionate ester of 1-methyl-4-phenylpiperidin-4-ol.", "scope_statement": "This model owns the substance identity of desmethylprodine under vr.tr.desmethylprodine in PHY / PHY.MAT, including form-specific properties, specimen composition, impurity evidence and constraints on permitted handling.", "in_scope": [ "Molecular identity and reconciliation of desmethylprodine and MPPP names", "Free-base identity and relationships to explicitly identified salts", "Specimen assay, purity and targeted MPTP impurity assessment", "Physical state, measured properties and stability under recorded conditions", "Substance-specific hazard evidence and jurisdiction-dependent activity restrictions" ], "out_of_scope": [ "Synthesis recipes, process optimization and precursor procurement", "Formulated products and mixtures as independently identified things", "MPTP and MPP+ as independently modeled substances", "Patient diagnosis, treatment and administration regimens", "Laboratory facilities and organization-wide compliance systems" ], "distinguishing_features": [ "Resolve the name to 1-methyl-4-phenylpiperidin-4-yl propanoate, rather than accepting the abbreviation MPPP alone; PubChem associates desmethylprodine with CID 61583. [PubChem identity record](https://pubchem.ncbi.nlm.nih.gov/compound/4-propionyloxy-4-phenyl-N-methylpiperidine)", "Check methyl-group location: the specified structure retains the nitrogen methyl group and has no additional carbon-3 methyl group; interpret 'desmethyl' against the actual structure.", "Check ester connectivity when distinguishing it from meperidine: desmethylprodine has a propanoyloxy substituent at piperidine carbon 4; a related name or matching elemental composition alone does not establish identity.", "Distinguish MPPP from MPTP analytically and semantically; primary case research identified both in implicated material, so neither abbreviation nor a historical association makes them the same substance. [Primary case study](https://pubmed.ncbi.nlm.nih.gov/6823561/)", "Distinguish parent-compound identity from salt or solution identity before comparing assay values or physical constants." ], "characteristics": [ { "name": "Identity assignment", "kind": "relation", "unit_or_values": "vr.tr.desmethylprodine linked to a verified structure and external identifiers", "why_it_matters": "Prevents ambiguous names and structurally related compounds from being merged." }, { "name": "Chemical form", "kind": "category", "unit_or_values": "Free base; specified salt; specified solvate; unresolved", "why_it_matters": "Determines which composition, assay basis and physical-property records apply." }, { "name": "Desmethylprodine content", "kind": "measurement", "unit_or_values": "Mass fraction or concentration with units, analytical method, uncertainty and parent-equivalent or salt basis", "why_it_matters": "Separates an identity claim from a quantitative statement about a specimen." }, { "name": "MPTP assessment", "kind": "state", "unit_or_values": "Not tested; detected; quantified; not detected at a stated detection limit; inconclusive", "why_it_matters": "Makes targeted impurity evidence explicit without treating an untested specimen as impurity-free." }, { "name": "MPTP content", "kind": "measurement", "unit_or_values": "Mass fraction or concentration with units, detection limit, quantification limit and uncertainty", "why_it_matters": "Supports specimen-specific assessment of this distinct contaminant." }, { "name": "Physical state and property conditions", "kind": "state", "unit_or_values": "Observed phase, temperature in °C, pressure in kPa, and solvent composition where applicable", "why_it_matters": "Prevents properties measured for different forms or conditions from being treated as interchangeable." }, { "name": "Thermal and solution properties", "kind": "measurement", "unit_or_values": "Melting or decomposition temperature in °C; boiling temperature in °C at stated pressure; solubility in g/L at stated temperature and solvent", "why_it_matters": "Provides usable property evidence while allowing genuinely unknown constants to remain unset." }, { "name": "Activity authorization", "kind": "state", "unit_or_values": "Verified permitted; prohibited; conditional; unresolved, for a named jurisdiction, date, actor and activity", "why_it_matters": "A substance name or research purpose alone does not establish permission to possess, transfer or use it." } ], "affordances": [ "Reconcile a specimen label against structure-based desmethylprodine identity.", "Compare assay results only after aligning chemical form, units and reporting basis.", "Flag missing or inconclusive MPTP testing for specialist review.", "Assess whether storage history leaves existing analytical evidence applicable.", "Check a proposed handling or transfer activity against documented authorization.", "Route unresolved identity, impurity or condition findings to an authorized analytical or safety specialist." ], "agent_conduct": { "may": [ "Describe MPPP's place in the history of opioid pharmacology and drug policy.", "Explain the public health lesson of contaminated illicit batches that caused permanent parkinsonism." ], "must_not": [ "Provide any guidance on making, purifying, obtaining or dosing it.", "Help anyone buy, sell, ship or conceal it.", "Present it as safe, legal or a substitute for prescribed pain relief.", "Identify individuals as users without evidence." ], "requires_human": [ "Handling suspected samples, which belongs to licensed forensic laboratories and authorities." ] }, "ethics": { "considerations": [ "Illicit opioids cause overdose deaths and lasting brain injury.", "People who use drugs deserve harm-reduction information without stigma." ], "affected_parties": [ "People who use drugs", "Families", "Emergency responders" ] }, "owners": { "steward": "Authorized research institutions, forensic laboratories and competent authorities may hold samples where permitted by applicable jurisdictional law; national drug control authorities regulate possession and handling.", "master_systems": [ "National controlled substance schedules record applicable substance classifications." ] }, "visual_identification": [ "It cannot be identified by sight; suspected material needs forensic laboratory testing." ], "failure_modes_and_hazards": [ "Opioid overdose can stop breathing.", "Illicit batches have contained a neurotoxic by-product that caused permanent parkinsonism." ], "standards_and_regulation": [ "Controlled Substances Act, Schedule I, United States Drug Enforcement Administration." ], "what_it_is_for": [ "Desmethylprodine is encountered in opioid research, forensic drug identification and toxicological investigation.", "Analytical work distinguishes it from related compounds and from MPTP, a neurotoxic impurity associated with some illicit preparations.", "Reference materials may support laboratory identification, but an attributed name alone does not establish a sample's composition or suitability." ] }, "sources": [ { "id": "wikidata", "title": "Wikidata item Q408952: desmethylprodine", "url": "https://www.wikidata.org/wiki/Q408952", "url_status": "live", "what_it_supports": "identity and sense of the item", "checked_by": "wikidata-api" }, { "id": "wikipedia-en", "title": "Wikipedia: Desmethylprodine", "url": "https://en.wikipedia.org/wiki/Desmethylprodine", "url_status": "live", "what_it_supports": "general description of the item", "checked_by": "wikidata-api sitelink" } ], "structure": { "bundles": [ { "id": "mppp-identity-and-boundaries", "name": "MPPP identity and boundaries", "description": "Establish what the registry name denotes and distinguish related substances and material forms.", "rationale": "Desmethylprodine has abbreviation, demethylation and structural-analogue ambiguities that can corrupt later decisions.", "layers": [ { "id": "structure-and-names", "name": "Structure and names", "description": "Anchor names to molecular connectivity.", "findings": [ { "id": "structure-anchored-identity", "name": "Structure-anchored identity", "description": "Record the accepted structure behind desmethylprodine and MPPP, and reconcile external records before accepting identifier equivalence.", "questions": [ { "text": "Which verified structure defines desmethylprodine, including the nitrogen methyl group and carbon-4 propanoate ester?", "kind": "definition", "id": "structure-anchored-identity-q01" }, { "text": "Which authoritative records establish its CAS number, PubChem CID and any EC identifier, and do those records describe the same chemical form?", "kind": "provenance", "id": "structure-anchored-identity-q02" } ] } ] }, { "id": "related-compounds-and-forms", "name": "Related compounds and forms", "description": "Separate the parent substance from analogues, salts and mixtures.", "findings": [ { "id": "identity-boundary-tests", "name": "Identity boundary tests", "description": "Require explicit structural and compositional distinctions from prodine, meperidine, MPTP and any specimen containing multiple substances.", "questions": [ { "text": "What evidence distinguishes this material from prodine, meperidine and MPTP rather than merely assigning a related name?", "kind": "boundary", "id": "identity-boundary-tests-q01" }, { "text": "Is the specimen the free base, an identified salt or a mixture, and which properties belong to that form rather than the parent compound?", "kind": "boundary", "id": "identity-boundary-tests-q02" } ] } ] } ] }, { "id": "assay-and-mptp-evidence", "name": "Assay and MPTP evidence", "description": "Characterize actual specimens through identity confirmation, quantitative assay and distinct impurity findings.", "rationale": "Historical toxic mixtures make an MPPP label insufficient evidence of composition or hazard attribution.", "layers": [ { "id": "specimen-confirmation", "name": "Specimen confirmation", "description": "Connect analytical conclusions to the material actually examined.", "findings": [ { "id": "traceable-mppp-assay", "name": "Traceable MPPP assay", "description": "Retain sample identity, method selectivity, reference-material identity and the reporting basis of each assay.", "questions": [ { "text": "Which analytical evidence confirms desmethylprodine in this specimen, and what relevant analogues or interferents can the method distinguish?", "kind": "measurement", "id": "traceable-mppp-assay-q01" }, { "text": "What fraction or concentration was measured, on what chemical-form basis, and with what uncertainty and sample provenance?", "kind": "provenance", "id": "traceable-mppp-assay-q02" } ] } ] }, { "id": "targeted-mptp-assessment", "name": "Targeted MPTP assessment", "description": "Represent MPTP results separately from overall purity.", "findings": [ { "id": "mptp-specific-result", "name": "MPTP-specific result", "description": "Record targeted MPTP evidence because affected historical material contained MPTP alongside MPPP; the observation does not establish the composition of every desmethylprodine specimen. [Primary analytical case evidence](https://pubmed.ncbi.nlm.nih.gov/6823561/)", "questions": [ { "text": "Was MPTP specifically assessed using a method with documented selectivity, recovery and detection capability in this matrix?", "kind": "measurement", "id": "mptp-specific-result-q01" }, { "text": "Does the report establish a quantity, a bounded non-detection, an inconclusive result or simply an absence of testing?", "kind": "measurement", "id": "mptp-specific-result-q02" }, { "text": "What review or restriction is required while the specimen's MPTP status remains unresolved?", "kind": "action", "id": "mptp-specific-result-q03" } ] } ] } ] }, { "id": "form-condition-and-stability", "name": "Form, condition and stability", "description": "Assess whether property and composition evidence applies to the present material.", "rationale": "Form-dependent properties and an uncertain storage history can invalidate otherwise plausible comparisons.", "layers": [ { "id": "form-specific-properties", "name": "Form-specific properties", "description": "Keep measured physical constants attached to a characterized form.", "findings": [ { "id": "conditional-property-record", "name": "Conditional property record", "description": "Record phase, thermal behavior and solubility only with source, chemical form and measurement conditions; distinguish decomposition from a true phase transition.", "questions": [ { "text": "Which phase and thermal or solubility measurements are supported for the identified desmethylprodine form?", "kind": "measurement", "id": "conditional-property-record-q01" }, { "text": "Do the cited constants describe the free base, a salt or a solution, and were pressure, temperature and decomposition observations reported?", "kind": "boundary", "id": "conditional-property-record-q02" } ] } ] }, { "id": "condition-over-time", "name": "Condition over time", "description": "Relate storage and observed change to continued fitness for the intended authorized activity.", "findings": [ { "id": "stability-evidence-applicability", "name": "Stability evidence applicability", "description": "Track storage conditions, analytical dates and observed composition changes without assuming an unverified degradation pathway or shelf life.", "questions": [ { "text": "What form-specific evidence supports stability under the specimen's recorded storage conditions and elapsed time?", "kind": "provenance", "id": "stability-evidence-applicability-q01" }, { "text": "Which changes or gaps in storage history require renewed identity, assay or impurity assessment before the proposed activity?", "kind": "action", "id": "stability-evidence-applicability-q02" } ] } ] } ] }, { "id": "hazard-attribution-and-permitted-activity", "name": "Hazard attribution and permitted activity", "description": "Keep pharmacological evidence, contaminant hazards and legal authorization distinct but jointly actionable.", "rationale": "Decisions require both substance-specific hazard attribution and current evidence that the intended activity is permitted.", "layers": [ { "id": "pharmacology-and-hazard-evidence", "name": "Pharmacology and hazard evidence", "description": "Distinguish evidence about MPPP from evidence about toxic mixtures.", "findings": [ { "id": "compound-specific-hazard-attribution", "name": "Compound-specific hazard attribution", "description": "MPPP and MPTP have been studied as separate constituents of a toxic mixture; preserve that distinction when interpreting opioid activity and neurological outcomes. [Primary pharmacology study](https://pubmed.ncbi.nlm.nih.gov/6148225/)", "questions": [ { "text": "Which effects are supported for analytically characterized desmethylprodine, and which are supported only for MPTP or mixed material?", "kind": "boundary", "id": "compound-specific-hazard-attribution-q01" }, { "text": "What substance- and form-specific hazard classification or exposure-limit evidence exists, with which authority and applicability limits?", "kind": "provenance", "id": "compound-specific-hazard-attribution-q02" } ] } ] }, { "id": "jurisdiction-and-activity", "name": "Jurisdiction and activity", "description": "Determine authorization for the actual substance form and proposed operation.", "findings": [ { "id": "documented-activity-permission", "name": "Documented activity permission", "description": "Record applicable controlled-substance provisions, their treatment of salts and mixtures, and the permissions held by the actor instead of assigning one timeless global legal status.", "questions": [ { "text": "Which current official provisions cover desmethylprodine or MPPP in the relevant jurisdiction, including the specimen's salt or mixture status?", "kind": "provenance", "id": "documented-activity-permission-q01" }, { "text": "Do the actor's documented permissions cover the proposed possession, analysis, transfer or disposal activity at the relevant place and date?", "kind": "action", "id": "documented-activity-permission-q02" } ] } ] } ] }, { "id": "evidence-and-external-alignment", "name": "Evidence and external alignment", "description": "What the world already says about this thing, gathered so the model can be checked against it.", "rationale": "A model that cannot be lined up against existing standards, identifiers and practice cannot be adopted by anyone who already uses them.", "layers": [ { "id": "reported-evidence", "name": "Reported evidence", "description": "Findings from the breadth pass, kept separate from the structural claims.", "findings": [ { "id": "evidence-confidence-notes", "name": "Check these first", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "This is recalled knowledge; no sources were consulted.", "Verify the CAS identifier and current jurisdiction-specific scheduling before operational use.", "Physical constants, exposure limits and GHS classifications are omitted because they are not confidently recalled; distinguish free-base data from salt data when researching them." ], "questions": [ { "id": "evidence-confidence-notes-q01", "text": "Which of these check these first hold for the sense of desmethylprodine this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-identifiers", "name": "Identifiers and schemes", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ { "scheme": "CAS Registry Number", "value_or_pattern": "13147-09-6", "note": "Identifier for desmethylprodine." }, { "scheme": "Chemical abbreviation", "value_or_pattern": "MPPP", "note": "Must be distinguished from MPTP and MPP+, which are different compounds." }, { "scheme": "Molecular formula", "value_or_pattern": "C15H21NO2", "note": "Formula of the neutral free base." } ], "questions": [ { "id": "evidence-identifiers-q01", "text": "Which of these identifiers and schemes hold for the sense of desmethylprodine this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-standards-and-regulation", "name": "Standards and regulation", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "United States Controlled Substances Act: desmethylprodine is listed in Schedule I, administered by the Drug Enforcement Administration." ], "questions": [ { "id": "evidence-standards-and-regulation-q01", "text": "Which of these standards and regulation hold for the sense of desmethylprodine this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-real-world-use", "name": "Real-world use", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "Historically investigated as a synthetic opioid analgesic.", "Encountered as an illicit opioid.", "Relevant to research on drug contamination and toxin-induced parkinsonism because illicit preparations have contained MPTP." ], "questions": [ { "id": "evidence-real-world-use-q01", "text": "Which of these real-world use hold for the sense of desmethylprodine this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-measurements", "name": "Typical measurements", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ { "quantity": "Molar mass of the neutral free base", "typical_range": "247.33", "unit": "g/mol" } ], "questions": [ { "id": "evidence-measurements-q01", "text": "Which of these typical measurements hold for the sense of desmethylprodine this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-failure-modes-and-hazards", "name": "Failure modes and hazards", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "Opioid toxicity can cause respiratory depression and fatal overdose.", "Repeated exposure can produce dependence.", "Illicit preparations contaminated with MPTP can cause severe, persistent parkinsonism through damage to dopaminergic neurons.", "Unknown purity and variable composition make illicit material especially hazardous." ], "questions": [ { "id": "evidence-failure-modes-and-hazards-q01", "text": "Which of these failure modes and hazards hold for the sense of desmethylprodine this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-neighbours", "name": "Neighbouring kinds and how to tell them apart", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ { "name": "MPTP", "difference": "A distinct tetrahydropyridine neurotoxin associated with contaminated MPPP preparations; it is not desmethylprodine itself." }, { "name": "MPP+", "difference": "A pyridinium ion formed metabolically from MPTP that mediates neurotoxicity; it is not the opioid MPPP." }, { "name": "Pethidine (meperidine)", "difference": "A related phenylpiperidine opioid with an ethyl carboxylate group at the piperidine 4-position, whereas desmethylprodine has an oxygen-linked propionate ester there." } ], "questions": [ { "id": "evidence-neighbours-q01", "text": "Which of these neighbouring kinds and how to tell them apart hold for the sense of desmethylprodine this model covers, and on what evidence?", "kind": "provenance" } ] } ] } ] } ] }, "openQuestions": [ "Which CAS and EC identifiers can be confirmed for the parent compound and separately for relevant salts without conflating their identities?", "Which reliable experimental measurements establish melting, boiling or decomposition behavior and solubility for each relevant form?", "What validated analytical methods and reporting limits adequately distinguish and quantify MPPP and MPTP in the intended specimen matrices?", "Which toxicological conclusions apply to characterized desmethylprodine itself, and what authoritative GHS classifications or occupational exposure limits are available?", "What evidence supports storage stability and reassessment intervals, and which current local permissions govern the intended activity?" ], "statistics": { "bundles": 5, "layers": 9, "findings": 15, "questions": 24 } }