{
  "vercy": "1.0-draft",
  "publication": {
    "status": "research-draft",
    "adjudicationStatus": "unreviewed",
    "publishableCanonical": false,
    "generatedAt": "2026-09-14T00:54:02Z",
    "providers": [
      "Claude"
    ],
    "breadth": "written by Claude from model knowledge without web access - no source was read, every claim is a lead to verify",
    "pass": 2,
    "wave": 4,
    "engine": "claude"
  },
  "metaModel": {
    "id": "THING-Q419639",
    "registryId": "vr.tr.azole",
    "name": "azole",
    "version": "0.2.0-wave.4",
    "entryKind": "thing",
    "family": "Thing Registry",
    "domain": [
      "PHY.MAT"
    ],
    "status": "research-draft"
  },
  "canonicalUrl": "https://ver.cy/models/thing/q419639/",
  "model": {
    "registry_id": "vr.tr.azole",
    "name": "azole",
    "purpose": "Let an agent explain azoles, relay structure, classes, uses in medicine and agriculture, drug interactions and resistance debates from chemistry and pharmacology sources, describe the named compounds and flag instance aliases, and distinguish azoles from azines, pyrroles without additional heteroatoms, echinocandins and polyene antifungals, without giving individual dosing advice.",
    "definition": "A five-membered aromatic heterocyclic compound containing at least one nitrogen atom and possibly other heteroatoms such as oxygen or sulfur, a class including imidazole, pyrazole, triazoles, tetrazole, oxazole and thiazole, and the basis of azole antifungal drugs that inhibit fungal ergosterol synthesis, such as fluconazole, and posaconazole and sertaconazole named in registry aliases; the aliases also list stereoisomer and ion forms of sertaconazole, which are specific compound instances, and pyrazolopyrimidine, a fused ring system that contains a pyrazole but is a broader scaffold. Azole antifungals interact with many medicines through cytochrome P450 enzymes, and people should check with pharmacists, while agricultural azole fungicides are linked to antifungal resistance concerns, with positions attributed.",
    "what_it_is_for": "Chemical scaffolds for drugs, fungicides and materials.",
    "affordances": [
      "explain structure and classes",
      "relay antifungal uses",
      "describe named compounds",
      "relay interactions and resistance debates"
    ],
    "distinguishing_features": [
      "Nitrogen heteroaromatic ring",
      "Antifungal drug class",
      "CYP450 interactions",
      "Agricultural fungicides"
    ],
    "appearance": "Mostly colourless or white crystalline compounds; drugs as tablets, creams or infusions.",
    "visual_identification": [
      "Five-membered nitrogen heteroaromatic ring",
      "(RS)-sertaconazole, posaconazole, (S)-sertaconazole, arasertaconazole, sertaconazole cation, pyrazolopyrimidine",
      "Azines are six-membered; pyrrole has one nitrogen and is usually classed separately; echinocandins target cell walls; polyenes bind ergosterol"
    ],
    "physical_properties": [
      {
        "quantity": "ring size",
        "typical_range": "5",
        "unit": "atoms",
        "note": ""
      },
      {
        "quantity": "antifungal target",
        "typical_range": "lanosterol 14-alpha-demethylase",
        "unit": "enzyme",
        "note": "CYP51"
      },
      {
        "quantity": "fluconazole approval",
        "typical_range": "1990",
        "unit": "year",
        "note": "US, as reported"
      }
    ],
    "families_and_kinds": [
      "imidazoles",
      "triazoles",
      "tetrazoles",
      "oxazoles and thiazoles",
      "azole antifungals"
    ],
    "related_models": [
      {
        "relation": "is a kind of",
        "target": "heteroarene",
        "why": "in registry terms"
      },
      {
        "relation": "includes",
        "target": "imidazole",
        "why": ""
      },
      {
        "relation": "is used as",
        "target": "antifungal",
        "why": ""
      },
      {
        "relation": "is contrasted with",
        "target": "echinocandin",
        "why": ""
      }
    ],
    "identifiers": [],
    "standards_and_regulation": [
      "Medicines regulation and prescribing information",
      "Pesticide regulation of azole fungicides",
      "WHO fungal priority pathogens list"
    ],
    "failure_modes_and_hazards": [
      "Drug interactions",
      "Liver toxicity with some azoles",
      "Antifungal resistance"
    ],
    "in_scope": [],
    "out_of_scope": [],
    "characteristics": []
  },
  "sources": [],
  "structure": {
    "bundles": [
      {
        "id": "understand",
        "name": "Understand",
        "description": "What an azole is.",
        "rationale": "Science.",
        "layers": [
          {
            "id": "definition",
            "name": "Definition",
            "description": "Definition.",
            "findings": [
              {
                "id": "definition-finding",
                "name": "Definition",
                "description": "Definition.",
                "questions": [
                  {
                    "text": "What is an azole, and how does it differ from azines, pyrroles, echinocandins and polyenes?",
                    "kind": "definition"
                  },
                  {
                    "text": "Is someone taking an azole antifungal with other medicines, in which case a pharmacist should check interactions?",
                    "kind": "boundary"
                  }
                ]
              }
            ]
          },
          {
            "id": "compounds",
            "name": "Compounds",
            "description": "Named compounds.",
            "findings": [
              {
                "id": "compounds-finding",
                "name": "Compounds",
                "description": "Compounds.",
                "questions": [
                  {
                    "text": "What are posaconazole, sertaconazole and its forms, and pyrazolopyrimidine?",
                    "kind": "definition"
                  },
                  {
                    "text": "Which entry fits the specific compound?",
                    "kind": "action"
                  }
                ]
              }
            ]
          }
        ]
      },
      {
        "id": "chemistry",
        "name": "Chemistry",
        "description": "Chemistry.",
        "rationale": "Science.",
        "layers": [
          {
            "id": "structure",
            "name": "Structure",
            "description": "Ring structure.",
            "findings": [
              {
                "id": "structure-finding",
                "name": "Structure",
                "description": "Structure.",
                "questions": [
                  {
                    "text": "How are azoles named by heteroatom number and position?",
                    "kind": "provenance"
                  },
                  {
                    "text": "Which references are standard?",
                    "kind": "provenance"
                  }
                ]
              }
            ]
          },
          {
            "id": "click",
            "name": "Click chemistry",
            "description": "Triazole synthesis.",
            "findings": [
              {
                "id": "click-finding",
                "name": "Click chemistry",
                "description": "Click chemistry.",
                "questions": [
                  {
                    "text": "Why are triazoles important in click chemistry, as described in the literature?",
                    "kind": "provenance"
                  },
                  {
                    "text": "Which sources are cited?",
                    "kind": "provenance"
                  }
                ]
              }
            ]
          }
        ]
      },
      {
        "id": "medicine",
        "name": "Medicine",
        "description": "Antifungal use.",
        "rationale": "Regulation.",
        "layers": [
          {
            "id": "mechanism",
            "name": "Mechanism",
            "description": "Mechanism.",
            "findings": [
              {
                "id": "mechanism-finding",
                "name": "Mechanism",
                "description": "Mechanism.",
                "questions": [
                  {
                    "text": "How do azole antifungals block ergosterol synthesis?",
                    "kind": "provenance"
                  },
                  {
                    "text": "Which entry fits ergosterol?",
                    "kind": "action"
                  }
                ]
              }
            ]
          },
          {
            "id": "interactions",
            "name": "Interactions",
            "description": "Drug interactions.",
            "findings": [
              {
                "id": "interactions-finding",
                "name": "Interactions",
                "description": "Interactions.",
                "questions": [
                  {
                    "text": "Why do azoles interact with many drugs through CYP450 enzymes, in general terms?",
                    "kind": "provenance"
                  },
                  {
                    "text": "Is the information current?",
                    "kind": "boundary"
                  }
                ]
              }
            ]
          }
        ]
      },
      {
        "id": "context",
        "name": "Context",
        "description": "Resistance.",
        "rationale": "Attribution.",
        "layers": [
          {
            "id": "agriculture",
            "name": "Agriculture",
            "description": "Agricultural fungicides.",
            "findings": [
              {
                "id": "agriculture-finding",
                "name": "Agriculture",
                "description": "Agriculture.",
                "questions": [
                  {
                    "text": "What do researchers, regulators and farm groups say about agricultural azoles and resistant Aspergillus, with positions attributed?",
                    "kind": "provenance"
                  },
                  {
                    "text": "Is the presentation neutral and attributed?",
                    "kind": "boundary"
                  }
                ]
              }
            ]
          },
          {
            "id": "auris",
            "name": "Candida auris",
            "description": "Resistant fungi.",
            "findings": [
              {
                "id": "auris-finding",
                "name": "Candida auris",
                "description": "Candida auris.",
                "questions": [
                  {
                    "text": "Why is azole resistance in Candida auris a public health concern?",
                    "kind": "provenance"
                  },
                  {
                    "text": "Which entry fits Candida auris?",
                    "kind": "action"
                  }
                ]
              }
            ]
          }
        ]
      }
    ]
  },
  "openQuestions": [
    "The registry aliases for sertaconazole forms should be split off as instances",
    "Should pyrazolopyrimidine be moved to fused heterocycle entries?",
    "How should resistance surveillance be linked?"
  ],
  "statistics": {
    "bundles": 4,
    "layers": 8,
    "findings": 8,
    "questions": 16
  }
}