{ "vercy": "1.0-draft", "publication": { "status": "research-draft", "adjudicationStatus": "unreviewed", "publishableCanonical": false, "generatedAt": "2026-09-13T19:28:43Z", "providers": [ "Claude" ], "breadth": "written by Claude from model knowledge without web access - no source was read, every claim is a lead to verify", "pass": 2, "wave": 4, "engine": "claude", "enrichment": { "pass": 3, "engine": "claude", "producedAt": "2026-10-06T11:00:00Z", "ingestedAt": "2026-10-06T07:37:39+00:00", "fields": [ "agent_conduct", "ethics", "owners" ] }, "gate": { "passed": true, "version": "1.0", "at": "2026-10-06T19:51:59+00:00", "evidence": [ "completeness 1.00", "sense: Wikidata description", "2 live sources", "review by codex: pass" ] } }, "metaModel": { "id": "THING-Q420401", "registryId": "vr.tr.quaternary-ammonium-cation", "name": "quaternary ammonium cation", "version": "0.2.0-wave.4", "entryKind": "thing", "family": "Thing Registry", "domain": [ "PHY.MAT" ], "status": "research-draft" }, "canonicalUrl": "https://ver.cy/models/thing/q420401/", "model": { "registry_id": "vr.tr.quaternary-ammonium-cation", "name": "quaternary ammonium cation", "purpose": "Let an agent explain quaternary ammonium cations, relay structure, properties, uses and safety from chemistry and regulatory sources, describe the drugs and alkaloids the registry aliases name, and distinguish quaternary ammonium cations from primary to tertiary ammonium ions, amines and quaternary ammonium salts as whole compounds.", "definition": "A positively charged polyatomic ion with a nitrogen atom bonded to four organic groups, NR4+, permanently charged regardless of pH, found in quaternary ammonium compounds used as disinfectants, surfactants, fabric softeners and phase-transfer catalysts, in drugs such as the antimuscarinic propantheline and the older quaternary sulfanilamide derivatives, and in natural alkaloids such as tembetarine, N-methylated aporphines and hydroxy-N-methylcanadine; some quaternary ammonium disinfectants raise concerns about resistance and toxicity.", "what_it_is_for": "Disinfectants, surfactants, drugs and natural products.", "affordances": [ "explain structure and properties", "relay uses and safety", "describe named compounds", "distinguish related species" ], "distinguishing_features": [ "Four carbon substituents", "Permanent charge", "Surfactant and biocidal uses", "Natural and synthetic" ], "appearance": "Not a visible object; ions in salts that are often white solids.", "visual_identification": [ "NR4+ permanently charged cation", "Propanthelinium, quaternary ammonium sulfanilamide, tembetarine, N-methylated aporphine and canadine alkaloids, ethenyltrimethylazanium", "Primary to tertiary ammonium ions can lose protons; amines are neutral; salts include counterions" ], "physical_properties": [ { "quantity": "charge", "typical_range": "+1", "unit": "note", "note": "independent of pH" }, { "quantity": "benzalkonium chloride", "typical_range": "common disinfectant", "unit": "note", "note": "" }, { "quantity": "phase-transfer catalysis", "typical_range": "use of quats in synthesis", "unit": "note", "note": "" } ], "families_and_kinds": [ "disinfectant quats such as benzalkonium", "cationic surfactants and fabric softeners", "quaternary ammonium drugs", "natural quaternary alkaloids", "phase-transfer catalysts", "ionic liquids" ], "related_models": [ { "relation": "is a kind of", "target": "ammonium ion derivative", "why": "in registry terms" }, { "relation": "is used in", "target": "disinfectant", "why": "" }, { "relation": "includes", "target": "benzalkonium chloride", "why": "" }, { "relation": "is contrasted with", "target": "amine", "why": "" } ], "identifiers": [], "standards_and_regulation": [ "Biocidal products regulations such as EU BPR and US EPA registration", "Pharmaceutical regulations for quaternary drugs" ], "failure_modes_and_hazards": [ "Skin and respiratory irritation", "Antimicrobial resistance concerns", "Registry aliases naming very specific compounds" ], "in_scope": [], "out_of_scope": [], "characteristics": [], "agent_conduct": { "may": [ "Explain quaternary ammonium cations and their uses as disinfectants, surfactants and fabric softeners.", "Read product labels and safety data sheets and report hazards and contact times." ], "must_not": [ "Recommend mixing disinfectant products or using them beyond label directions.", "Present quaternary ammonium disinfectants as safe to ingest or apply to skin when not labelled for it.", "Overstate or dismiss concerns about antimicrobial resistance without evidence.", "Advise spraying disinfectants near people, food or animals without label guidance." ], "requires_human": [ "Choosing disinfectants for settings with vulnerable people such as hospitals and schools." ] }, "ethics": { "considerations": [ "Overuse of disinfectants irritates skin and lungs of cleaners and occupants.", "Antimicrobial resistance is a shared public health concern." ], "affected_parties": [ "Cleaning workers", "Patients and children", "Aquatic life" ] }, "owners": { "steward": "Nobody owns the chemical class; makers and users of each product answer for its use under chemical regulation.", "master_systems": [ "Chemical substance registers", "Biocide product registers" ] } }, "sources": [ { "id": "wikidata", "title": "Wikidata item Q420401: quaternary ammonium cation", "url": "https://www.wikidata.org/wiki/Q420401", "url_status": "live", "what_it_supports": "identity and sense of the item", "checked_by": "wikidata-api" }, { "id": "wikipedia-en", "title": "Wikipedia: Quaternary ammonium cation", "url": "https://en.wikipedia.org/wiki/Quaternary_ammonium_cation", "url_status": "live", "what_it_supports": "general description of the item", "checked_by": "wikidata-api sitelink" } ], "structure": { "bundles": [ { "id": "understand", "name": "Understand", "description": "What a quaternary ammonium cation is.", "rationale": "Science.", "layers": [ { "id": "definition", "name": "Definition", "description": "Definition.", "findings": [ { "id": "definition-finding", "name": "Definition", "description": "Definition.", "questions": [ { "text": "What is a quaternary ammonium cation, and how does it differ from other ammonium ions, amines and salts?", "kind": "definition" }, { "text": "Is the question about chemistry, disinfectants, drugs or safety?", "kind": "boundary" } ] } ] }, { "id": "compounds", "name": "Compounds", "description": "Named compounds.", "findings": [ { "id": "compounds-finding", "name": "Compounds", "description": "Compounds.", "questions": [ { "text": "What are propantheline, quaternary sulfanilamides, tembetarine and the other named alkaloids?", "kind": "definition" }, { "text": "Which entry fits the specific compound?", "kind": "action" } ] } ] } ] }, { "id": "chemistry", "name": "Chemistry", "description": "Chemistry.", "rationale": "Science.", "layers": [ { "id": "structure", "name": "Structure", "description": "Structure.", "findings": [ { "id": "structure-finding", "name": "Structure", "description": "Structure.", "questions": [ { "text": "How are quaternary ammonium ions formed and why is their charge permanent?", "kind": "provenance" }, { "text": "Which references are standard?", "kind": "provenance" } ] } ] }, { "id": "catalysis", "name": "Catalysis", "description": "Catalysis and materials.", "findings": [ { "id": "catalysis-finding", "name": "Catalysis", "description": "Catalysis.", "questions": [ { "text": "How are quats used as phase-transfer catalysts and in ionic liquids?", "kind": "provenance" }, { "text": "Which sources are cited?", "kind": "provenance" } ] } ] } ] }, { "id": "uses", "name": "Uses", "description": "Uses and safety.", "rationale": "Regulation.", "layers": [ { "id": "disinfectants", "name": "Disinfectants", "description": "Disinfectants.", "findings": [ { "id": "disinfectants-finding", "name": "Disinfectants", "description": "Disinfectants.", "questions": [ { "text": "How do quaternary ammonium disinfectants work, and how are they regulated?", "kind": "provenance" }, { "text": "Which entry fits quaternary ammonium compounds as disinfectants?", "kind": "action" } ] } ] }, { "id": "concerns", "name": "Concerns", "description": "Safety concerns.", "findings": [ { "id": "concerns-finding", "name": "Concerns", "description": "Concerns.", "questions": [ { "text": "What do studies report about irritation and resistance, with findings attributed?", "kind": "provenance" }, { "text": "Which entry fits antimicrobial resistance?", "kind": "action" } ] } ] } ] }, { "id": "context", "name": "Context", "description": "Drugs and nature.", "rationale": "Context.", "layers": [ { "id": "drugs", "name": "Drugs", "description": "Drugs.", "findings": [ { "id": "drugs-finding", "name": "Drugs", "description": "Drugs.", "questions": [ { "text": "Why do quaternary drugs such as propantheline act mainly outside the brain?", "kind": "provenance" }, { "text": "Which entry fits antimuscarinic?", "kind": "action" } ] } ] }, { "id": "nature", "name": "Nature", "description": "Natural products.", "findings": [ { "id": "nature-finding", "name": "Nature", "description": "Nature.", "questions": [ { "text": "Which plants produce quaternary alkaloids?", "kind": "provenance" }, { "text": "Which entry fits alkaloid?", "kind": "action" } ] } ] } ] } ] }, "openQuestions": [ "Should benzalkonium and natural quaternary alkaloids be separate primary entries?", "How should chemistry and regulatory sources be linked?", "The registry entry has merged aliases naming specific molecules; should they be split off?" ], "statistics": { "bundles": 4, "layers": 8, "findings": 8, "questions": 16 } }