{ "vercy": "1.0-draft", "publication": { "status": "research-draft", "adjudicationStatus": "unreviewed", "publishableCanonical": false, "generatedAt": "2026-09-12T08:25:08Z", "providers": [ "Codex" ], "breadth": "recalled by Codex without web access - no source was read", "missingProviders": [], "pass": 2, "cost": { "grok": { "seconds": 23.2, "error": "Reading additional input from stdin...\nOpenAI Codex v0.153.4\n--------\nworkdir: R:\\02_PROJECTS\\02_Meta_Models_Platforms\\Ver.cy\\current\\thing-registry-backlog\nmodel: gpt-6-astra\nprovider: openai\napproval: never\nsandbox: read-only\nreasoning effort: none\nreasoning summaries: none\nsession id: 01a094b7-2da0-7e32-ae6e-48220db339bb\n--------\nuser\nDescribe what is already known about one registered thing. Answer as JSON only, no prose around it.\n\nThing: casomorphin\nSense to describe: (none recorded)\nDomain code: PHY.MAT\nAlso known as: (none)\n\n\nContext for this batch of 1001 things:\n# Batch 043: 1001 reg", "usd": 0.0, "recall": true }, "codex": { "seconds": 80.7, "error": "Reading additional input from stdin...\nOpenAI Codex v0.153.4\n--------\nworkdir: R:\\02_PROJECTS\\02_Meta_Models_Platforms\\Ver.cy\\current\\thing-registry-backlog\nmodel: gpt-6-astra\nprovider: openai\napproval: never\nsandbox: read-only\nreasoning effort: none\nreasoning summaries: none\nsession id: 01a094b7-2daf-74e2-bc01-971c284ebaea\n--------\nuser\nYou are drafting a Vercy meta-model for one registered thing. Answer as JSON only, no prose around it.\n\nThing: casomorphin\nRegistry id: vr.tr.casomorphin\nPlane / domain: PHY / PHY.MAT\nRegistry definition: (none recorded)\nNames folded into this entry: (none)\n\n\n" } }, "enrichment": { "pass": 3, "engine": "claude", "producedAt": "2026-10-06T12:00:00Z", "ingestedAt": "2026-10-06T08:52:34+00:00", "fields": [ "agent_conduct", "ethics", "failure_modes_and_hazards", "owners", "visual_identification" ] }, "gate": { "passed": true, "version": "1.0", "at": "2026-10-07T10:10:30+00:00", "evidence": [ "completeness 1.00", "sense: Wikidata description", "2 live sources", "review by codex: pass" ] } }, "metaModel": { "id": "THING-Q425309", "registryId": "vr.tr.casomorphin", "name": "casomorphin", "version": "0.1.0-research.1", "entryKind": "thing", "family": "Thing Registry", "domain": [ "PHY.MAT" ], "status": "research-draft" }, "canonicalUrl": "https://ver.cy/models/thing/q425309/", "model": { "registry_id": "vr.tr.casomorphin", "name": "casomorphin", "purpose": "Enable an agent to identify casomorphin peptides, assess their measured condition and opioid activity, and decide whether evidence supports a proposed analytical or experimental use.", "definition": "Casomorphins are casein-derived peptides with opioid activity, best characterized among fragments of beta-casein, whose properties depend on their amino-acid sequence and length.", "scope_statement": "This model owns vr.tr.casomorphin as a peptide-family entry, provisionally covering casein-derived casomorphins and their sequence-defined specimens without treating the family as one chemically uniform substance.", "in_scope": [ "Casomorphin family membership and sequence-defined members", "Parent casein, species, protein variant and fragment mapping", "Peptide release, synthesis, isolation and degradation history", "Specimen composition, purity, concentration and stability", "Opioid activity, exposure measurements and limits of interpretation" ], "out_of_scope": [ "Whole casein proteins and their complete nutritional properties", "Milk, cheese and other products containing or potentially releasing the peptides", "Digestion and food-processing systems beyond their relationship to peptide formation", "Endogenous opioid peptides and unrelated opioid substances", "Clinical diagnoses, dietary recommendations and treatment protocols", "Synthetic opioid analogues as independently characterised drug substances" ], "distinguishing_features": [ "Require a defined peptide sequence and a documented relationship to casein; opioid activity alone does not establish casomorphin identity.", "Distinguish a released peptide from the same sequence embedded within intact casein.", "Resolve species, fragment length and terminal chemistry before equating two specimens carrying a casomorphin name.", "Treat beta-casomorphin-7 as a particular member designation, not an automatic synonym for the entire registry entry.", "Separate sequence-preserving synthetic preparations from modified analogues and distinguish chemical identification from demonstrated biological activity." ], "characteristics": [ { "name": "Peptide identity", "kind": "category", "unit_or_values": "Amino-acid sequence, residue stereochemistry, terminal groups and modifications", "why_it_matters": "Names and fragment lengths alone cannot establish chemical equivalence." }, { "name": "Casein precursor mapping", "kind": "relation", "unit_or_values": "Species, casein type, protein accession and version, variant, residue interval and numbering convention", "why_it_matters": "Connects each peptide to its precursor without confusing protein variants or sequence numbering." }, { "name": "Preparation origin", "kind": "category", "unit_or_values": "Isolated from biological material; experimentally hydrolysed; chemically synthesised; unknown", "why_it_matters": "Distinguishes evidence of occurrence from manufacture of an equivalent sequence." }, { "name": "Chemical identifier assignment", "kind": "relation", "unit_or_values": "Verified CAS, PubChem or other identifier for the exact member and chemical form; unresolved", "why_it_matters": "Prevents transferring a member-specific identifier to the whole family." }, { "name": "Molecular mass", "kind": "measurement", "unit_or_values": "Da, specifying monoisotopic or average mass; measured m/z with charge state", "why_it_matters": "Supports identification when interpreted with sequence and mass-spectrometric evidence." }, { "name": "Peptide content and purity", "kind": "measurement", "unit_or_values": "Mass fraction, chromatographic area percentage and net peptide content, each with method", "why_it_matters": "Counterions, water and coexisting peptides can make weighed material differ from active peptide quantity." }, { "name": "Matrix-specific concentration", "kind": "measurement", "unit_or_values": "nmol/L, mol/L or ng/g with matrix, recovery, uncertainty and quantification limit", "why_it_matters": "Makes exposure and experimental doses interpretable." }, { "name": "Specimen condition", "kind": "state", "unit_or_values": "Dry or dissolved; solvent, pH, temperature, storage duration and measured intact fraction", "why_it_matters": "Tracks whether handling has changed the peptide available for measurement or use." }, { "name": "Opioid assay response", "kind": "measurement", "unit_or_values": "Ki, IC50 or EC50 in mol/L where appropriate, plus maximal response, receptor subtype and assay conditions", "why_it_matters": "Separates binding affinity from functional activity and prevents unsupported cross-assay comparisons." }, { "name": "Exposure evidence", "kind": "category", "unit_or_values": "Precursor presence; measured release; luminal detection; tissue or plasma detection; controlled organism-level response", "why_it_matters": "These observations support different conclusions and must remain distinguishable." } ], "affordances": [ "Resolve an ambiguous casomorphin label to a sequence-defined member or flag unresolved identity.", "Compare specimens for sequence, chemical-form and assay compatibility.", "Select analytical confirmation and quantification procedures appropriate to the peptide and matrix.", "Evaluate documented processing or digestion conditions for evidence of peptide release and persistence.", "Assess whether a preparation meets the purity, stability and handling requirements of a proposed experiment.", "Trace biological claims to the measured peptide, dose, route and experimental system." ], "agent_conduct": { "may": [ "Describe casomorphins as opioid-active peptides released when casein is digested.", "Summarise research while separating established findings from hypotheses." ], "must_not": [ "Claim that casomorphins cause autism, sudden infant death or other diseases without solid evidence.", "Use the topic to sell milk products with unproven health claims.", "Advise parents to change an infant's diet without a health professional." ], "requires_human": [ "Any change to the diet of an infant or a person with a medical condition." ] }, "ethics": { "considerations": [ "Unproven health scares about milk can frighten parents and stigmatise families.", "Marketing claims built on preliminary science mislead consumers." ], "affected_parties": [ "Parents and infants", "Consumers", "Dairy farmers" ] }, "owners": { "steward": "Nobody owns the peptides; food regulators control health claims made about products.", "master_systems": [] }, "visual_identification": [ "They cannot be seen; they are detected in digests or body fluids by laboratory analysis." ], "failure_modes_and_hazards": [ "Overstated claims spread misinformation about diet and health.", "Different peptide fragments are often conflated in popular sources." ], "what_it_is_for": [ "Casomorphins are studied in research on casein digestion, milk-derived peptides and opioid receptor activity.", "They may be encountered in protein hydrolysates, digestion experiments and analytical peptide preparations.", "Their interpretation requires a specified peptide sequence because different casein fragments do not have interchangeable properties." ], "facets_not_applicable": { "interfaces": "No dedicated standard, law or official classification is identified here for casomorphins as a peptide family independently of their intended use." } }, "sources": [ { "id": "wikidata", "title": "Wikidata item Q425309: casomorphin", "url": "https://www.wikidata.org/wiki/Q425309", "url_status": "live", "what_it_supports": "identity and sense of the item", "checked_by": "wikidata-api" }, { "id": "wikipedia-en", "title": "Wikipedia: Casomorphin", "url": "https://en.wikipedia.org/wiki/Casomorphin", "url_status": "live", "what_it_supports": "general description of the item", "checked_by": "wikidata-api sitelink" } ], "structure": { "bundles": [ { "id": "family-and-sequence-identity", "name": "Family and sequence identity", "description": "Resolve what the casomorphin name denotes before assigning chemical properties.", "rationale": "The registry label does not specify a single sequence, precursor species or chemical form.", "layers": [ { "id": "family-membership", "name": "Family membership", "description": "Establish the naming boundary and relationships among peptide members.", "findings": [ { "id": "member-specific-names", "name": "Member-specific names", "description": "Record a family interpretation while preserving species-specific member identities; human beta-casomorphins have been separately reported in [primary research](https://pubmed.ncbi.nlm.nih.gov/6529969/).", "questions": [ { "text": "Does this record denote the casomorphin family, a specified beta-casomorphin or an unresolved commercial label?", "kind": "definition", "id": "member-specific-names-q01" }, { "text": "Which naming authority establishes whether a proposed member or modified analogue belongs within this entry?", "kind": "boundary", "id": "member-specific-names-q02" } ] } ] }, { "id": "molecular-resolution", "name": "Molecular resolution", "description": "Identify the exact peptide independently of its abbreviated name.", "findings": [ { "id": "sequence-and-chemical-form", "name": "Sequence and chemical form", "description": "Require sequence, termini and modifications before attaching identifiers or calculated properties.", "questions": [ { "text": "What are the complete sequence, stereochemistry, terminal groups and any chemical modifications?", "kind": "definition", "id": "sequence-and-chemical-form-q01" }, { "text": "Which verified identifiers describe this exact peptide, and do they distinguish the free peptide from a salt or modified form?", "kind": "provenance", "id": "sequence-and-chemical-form-q02" } ] } ] } ] }, { "id": "casein-origin-and-release", "name": "Casein origin and release", "description": "Connect a peptide to its precursor and the conditions under which it was obtained.", "rationale": "A sequence embedded in casein is not evidence that the free peptide was present or released.", "layers": [ { "id": "precursor-mapping", "name": "Precursor mapping", "description": "Locate the peptide within a versioned casein sequence.", "findings": [ { "id": "species-variant-and-position", "name": "Species, variant and position", "description": "Record precursor species, casein type, variant and residue numbering as linked evidence.", "questions": [ { "text": "Which casein accession, species and protein variant contain the assigned peptide sequence?", "kind": "provenance", "id": "species-variant-and-position-q01" }, { "text": "What residue interval matches the peptide, and does numbering refer to the precursor or mature protein?", "kind": "definition", "id": "species-variant-and-position-q02" } ] } ] }, { "id": "formation-evidence", "name": "Formation evidence", "description": "Describe release or synthesis without extrapolating beyond the preparation conditions.", "findings": [ { "id": "conditional-peptide-release", "name": "Conditional peptide release", "description": "Treat precursor-variant effects as condition-specific observations: [an enzymatic release study](https://pubmed.ncbi.nlm.nih.gov/10503774/) reported variant-dependent beta-casomorphin-7 release under its tested conditions.", "questions": [ { "text": "Was this peptide isolated, released experimentally or synthesised, and what records establish that history?", "kind": "provenance", "id": "conditional-peptide-release-q01" }, { "text": "Which enzymes, processing conditions, pH, temperature and duration produced a measured yield of intact peptide?", "kind": "measurement", "id": "conditional-peptide-release-q02" } ] } ] } ] }, { "id": "analytical-identity-and-content", "name": "Analytical identity and content", "description": "Determine whether the assigned peptide is present and how much is present.", "rationale": "Complex casein digests require discrimination between related fragments and reliable matrix-specific quantification.", "layers": [ { "id": "identity-confirmation", "name": "Identity confirmation", "description": "Assess evidence that distinguishes the target sequence from related peptides.", "findings": [ { "id": "sequence-specific-detection", "name": "Sequence-specific detection", "description": "Capture orthogonal identification evidence and method-specific ambiguity.", "questions": [ { "text": "Which retention-time, accurate-mass and fragment-ion observations support the assigned sequence against an authenticated standard?", "kind": "measurement", "id": "sequence-specific-detection-q01" }, { "text": "Could antibody cross-reactivity, coeluting fragments or unresolved isomers explain the reported signal?", "kind": "boundary", "id": "sequence-specific-detection-q02" } ] } ] }, { "id": "quantitative-composition", "name": "Quantitative composition", "description": "Separate target peptide quantity from total preparation mass and analytical response.", "findings": [ { "id": "content-purity-and-recovery", "name": "Content, purity and recovery", "description": "Record calibration, extraction recovery, matrix effects and the basis of purity claims.", "questions": [ { "text": "What target concentration was measured, with which calibration standard, recovery correction and quantification limit?", "kind": "measurement", "id": "content-purity-and-recovery-q01" }, { "text": "How much of the preparation is target peptide, related peptides, counterions, residual solvent or water?", "kind": "measurement", "id": "content-purity-and-recovery-q02" } ] } ] } ] }, { "id": "peptide-state-and-handling", "name": "Peptide state and handling", "description": "Track the chemical form and preservation of a usable casomorphin specimen.", "rationale": "Nominal peptide mass and initial purity do not establish the intact dose after dissolution, storage or incubation.", "layers": [ { "id": "form-and-solution-behaviour", "name": "Form and solution behaviour", "description": "Specify the supplied material and conditions for preparing a measurable solution.", "findings": [ { "id": "usable-peptide-preparation", "name": "Usable peptide preparation", "description": "Relate counterion content, dissolution and recovery to the intended assay concentration.", "questions": [ { "text": "What salt form, water content and net peptide content must be considered when preparing a molar dose?", "kind": "measurement", "id": "usable-peptide-preparation-q01" }, { "text": "Under which solvent, pH and concentration conditions has complete dissolution and acceptable recovery been demonstrated?", "kind": "action", "id": "usable-peptide-preparation-q02" } ] } ] }, { "id": "integrity-and-use-conditions", "name": "Integrity and use conditions", "description": "Establish whether the specimen remains suitable through storage and experimental handling.", "findings": [ { "id": "stability-and-handling-evidence", "name": "Stability and handling evidence", "description": "Tie storage limits and handling controls to the exact preparation and intended exposure.", "questions": [ { "text": "What intact fraction remains after the proposed storage, freeze-thaw history and incubation in the relevant matrix?", "kind": "measurement", "id": "stability-and-handling-evidence-q01" }, { "text": "Which supplier safety information and experimentally established handling limits apply to this member and preparation?", "kind": "action", "id": "stability-and-handling-evidence-q02" } ] } ] } ] }, { "id": "opioid-activity-and-exposure", "name": "Opioid activity and exposure", "description": "Connect sequence-specific activity with measured exposure and bounded biological interpretations.", "rationale": "An opioid assay result cannot alone establish absorption, organism-level effects or the effects of a casein-containing food.", "layers": [ { "id": "receptor-pharmacology", "name": "Receptor pharmacology", "description": "Characterise binding and functional response in a defined experimental system.", "findings": [ { "id": "assay-specific-opioid-response", "name": "Assay-specific opioid response", "description": "Keep receptor binding, agonist response and antagonist-sensitive effects as distinct observations.", "questions": [ { "text": "Which receptor subtype, species and assay system were tested, and was binding or functional activation measured?", "kind": "measurement", "id": "assay-specific-opioid-response-q01" }, { "text": "What concentration-response data and antagonist or receptor controls support attributing the response to the identified peptide?", "kind": "measurement", "id": "assay-specific-opioid-response-q02" } ] } ] }, { "id": "exposure-and-inference", "name": "Exposure and inference", "description": "Determine whether intact peptide reaches the compartment relevant to a claimed effect.", "findings": [ { "id": "compartment-specific-evidence", "name": "Compartment-specific evidence", "description": "Separate peptide release, survival, absorption and biological response while recording the limits of each study.", "questions": [ { "text": "After which administration route was intact peptide measured, in which compartment and over what time course?", "kind": "measurement", "id": "compartment-specific-evidence-q01" }, { "text": "Does the proposed interpretation require unmeasured absorption, tissue access or extrapolation from experimental doses to food consumption?", "kind": "boundary", "id": "compartment-specific-evidence-q02" } ] } ] } ] }, { "id": "evidence-and-external-alignment", "name": "Evidence and external alignment", "description": "What the world already says about this thing, gathered so the model can be checked against it.", "rationale": "A model that cannot be lined up against existing standards, identifiers and practice cannot be adopted by anyone who already uses them.", "layers": [ { "id": "reported-evidence", "name": "Reported evidence", "description": "Findings from the breadth pass, kept separate from the structural claims.", "findings": [ { "id": "evidence-confidence-notes", "name": "Check these first", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "The entry is interpreted as a peptide family, not a single chemically defined substance.", "Verify each member's sequence, source species, chemical form and registry identifiers before assigning molecular constants.", "Human absorption, physiological significance and proposed disease associations require research; no causal health claim is asserted here." ], "questions": [ { "id": "evidence-confidence-notes-q01", "text": "Which of these check these first hold for the sense of casomorphin this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-kinds", "name": "Kinds and varieties", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "Beta-casomorphin-5", "Beta-casomorphin-7", "Beta-casomorphin-9" ], "questions": [ { "id": "evidence-kinds-q01", "text": "Which of these kinds and varieties hold for the sense of casomorphin this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-identifiers", "name": "Identifiers and schemes", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ { "scheme": "Peptide nomenclature", "value_or_pattern": "Beta-casomorphin-n, where n denotes peptide length in amino-acid residues", "note": "The source species and sequence are needed to identify a particular peptide unambiguously." }, { "scheme": "IUPAC-IUB amino-acid one-letter notation", "value_or_pattern": "YPFPGPI", "note": "Sequence of bovine beta-casomorphin-7; this identifies one member, not the whole family." }, { "scheme": "CAS Registry Number", "value_or_pattern": "Digits in three hyphen-separated groups, with a final check digit", "note": "Any registry number must be checked against the specific peptide and chemical form; none is asserted for the family." } ], "questions": [ { "id": "evidence-identifiers-q01", "text": "Which of these identifiers and schemes hold for the sense of casomorphin this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-real-world-use", "name": "Real-world use", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "Research on food-derived opioid peptides and opioid-receptor activity.", "Investigation of casein digestion and peptide release during dairy processing.", "Analytical measurement of casein-derived peptides in food and digestion experiments." ], "questions": [ { "id": "evidence-real-world-use-q01", "text": "Which of these real-world use hold for the sense of casomorphin this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-measurements", "name": "Typical measurements", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ { "quantity": "Peptide length of beta-casomorphin-7", "typical_range": "7", "unit": "amino-acid residues" } ], "questions": [ { "id": "evidence-measurements-q01", "text": "Which of these typical measurements hold for the sense of casomorphin this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-failure-modes-and-hazards", "name": "Failure modes and hazards", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "Peptide degradation during digestion or sample handling can change measured concentration and biological activity.", "Opioid activity in an experimental assay does not establish systemic exposure or harmful effects from ordinary dairy consumption.", "Confusing different casomorphin sequences or source species can invalidate analytical and biological comparisons." ], "questions": [ { "id": "evidence-failure-modes-and-hazards-q01", "text": "Which of these failure modes and hazards hold for the sense of casomorphin this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-neighbours", "name": "Neighbouring kinds and how to tell them apart", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ { "name": "Casein", "difference": "Casein denotes the parent milk proteins; casomorphins are particular peptide fragments released from them." }, { "name": "Beta-casomorphin-7", "difference": "This is a seven-residue member of the casomorphin family, rather than a synonym for all casomorphins." }, { "name": "A1 and A2 beta-casein", "difference": "These are parent-protein variants whose sequences affect potential peptide release; they are not casomorphins themselves." }, { "name": "Morphine", "difference": "Morphine is an alkaloid opioid; casomorphins are peptides despite the related name and receptor activity." }, { "name": "Exorphins", "difference": "Exorphins are the broader category of externally derived opioid peptides; casomorphins specifically originate from casein." } ], "questions": [ { "id": "evidence-neighbours-q01", "text": "Which of these neighbouring kinds and how to tell them apart hold for the sense of casomorphin this model covers, and on what evidence?", "kind": "provenance" } ] } ] } ] } ] }, "openQuestions": [ "Does the registry intend casomorphin to cover only beta-casomorphins, and where should other casein-derived opioid peptides and modified analogues sit?", "Which sequence-defined members have authoritative chemical identifiers and experimentally verified reference materials?", "Under which digestion and food-processing conditions do particular precursor variants release quantifiable intact members?", "What validated stability and analytical methods distinguish individual casomorphins in food, digestive contents and biological fluids?", "For each member, what measured human exposure and controlled evidence support effects beyond receptor or isolated-tissue assays?" ], "statistics": { "bundles": 6, "layers": 11, "findings": 17, "questions": 27 } }