{ "vercy": "1.0-draft", "publication": { "status": "research-draft", "adjudicationStatus": "unreviewed", "publishableCanonical": false, "generatedAt": "2026-09-12T09:30:37Z", "providers": [ "Codex" ], "breadth": "recalled by Codex without web access - no source was read", "missingProviders": [], "pass": 2, "cost": { "grok": { "seconds": 20.7, "error": "Reading additional input from stdin...\nOpenAI Codex v0.153.4\n--------\nworkdir: R:\\02_PROJECTS\\02_Meta_Models_Platforms\\Ver.cy\\current\\thing-registry-backlog\nmodel: gpt-6-astra\nprovider: openai\napproval: never\nsandbox: read-only\nreasoning effort: none\nreasoning summaries: none\nsession id: 01a094f3-576b-7d93-84f8-8b00b1309dd4\n--------\nuser\nDescribe what is already known about one registered thing. Answer as JSON only, no prose around it.\n\nThing: eosinopenia\nSense to describe: (none recorded)\nDomain code: XCT.STA\nAlso known as: (none)\n\n\nContext for this batch of 1001 things:\n# Batch 043: 1001 reg", "usd": 0.0, "recall": true }, "codex": { "seconds": 67.7, "error": "Reading additional input from stdin...\nOpenAI Codex v0.153.4\n--------\nworkdir: R:\\02_PROJECTS\\02_Meta_Models_Platforms\\Ver.cy\\current\\thing-registry-backlog\nmodel: gpt-6-astra\nprovider: openai\napproval: never\nsandbox: read-only\nreasoning effort: none\nreasoning summaries: none\nsession id: 01a094f3-5761-7062-94f3-1287dadbb833\n--------\nuser\nYou are drafting a Vercy meta-model for one registered thing. Answer as JSON only, no prose around it.\n\nThing: eosinopenia\nRegistry id: vr.tr.eosinopenia\nPlane / domain: XCT / XCT.STA\nRegistry definition: (none recorded)\nNames folded into this entry: (none)\n\n\n" } }, "enrichment": { "pass": 3, "engine": "claude", "producedAt": "2026-10-06T12:00:00Z", "ingestedAt": "2026-10-06T08:39:52+00:00", "fields": [ "agent_conduct", "ethics", "owners" ] }, "gate": { "passed": true, "version": "1.0", "at": "2026-10-07T10:10:31+00:00", "evidence": [ "completeness 1.00", "sense: Wikidata description", "2 live sources", "review by codex: pass" ] } }, "metaModel": { "id": "THING-Q490539", "registryId": "vr.tr.eosinopenia", "name": "eosinopenia", "version": "0.1.0-research.1", "entryKind": "thing", "family": "Thing Registry", "domain": [ "XCT.STA" ], "status": "research-draft" }, "canonicalUrl": "https://ver.cy/models/thing/q490539/", "model": { "registry_id": "vr.tr.eosinopenia", "name": "eosinopenia", "purpose": "Enable an agent to recognise eosinopenia, assess the reliability and context of a low circulating eosinophil count, and identify appropriate review or monitoring needs.", "definition": "Eosinopenia is a reduction in circulating blood eosinophils below the applicable reference interval or specified threshold, usually described as a laboratory finding rather than a distinct disease.", "scope_statement": "This model owns eosinopenia as a measured peripheral-blood state for registry entry vr.tr.eosinopenia in XCT / XCT.STA, including its operational definition, measurement confidence, temporal course and contextual interpretation.", "in_scope": [ "Absolute circulating eosinophil counts assessed against an explicitly recorded reference interval or decision threshold", "Distinction between absolute eosinopenia and a reduced eosinophil percentage", "Measurement limitations affecting very low or reported-zero counts", "Transient, recurrent and persistent low-count observations", "Evidence linking the observation to medication exposure or concurrent illness", "Limits on diagnostic inference and grounds for clinical review" ], "out_of_scope": [ "Complete models of sepsis, endocrine disorders or other possible underlying conditions", "Eosinophilia and hypereosinophilic syndromes", "Eosinophil biology outside what is needed to interpret the low-count state", "Diagnosis of tissue eosinophil depletion from blood measurements alone", "General leukopenia, neutropenia and bone-marrow failure models", "Prescribing or changing treatment for an underlying condition" ], "distinguishing_features": [ "An instance requires a circulating eosinophil result that meets an identified low-count criterion; an unspecified 'abnormal differential' is insufficient.", "A low eosinophil percentage must be checked against the absolute count because the proportion also depends on other leukocyte populations.", "A decline from an individual's baseline is distinct from crossing a low-count threshold and should be recorded separately.", "A reported zero requires interpretation through the assay's reporting precision and detection capability before being treated as absence of circulating eosinophils.", "The blood-count state is distinct from its cause: corticosteroid exposure or an infection diagnosis does not itself establish measured eosinopenia." ], "characteristics": [ { "name": "Absolute eosinophil count", "kind": "measurement", "unit_or_values": "cells/µL or ×10^9/L; 1 ×10^9/L = 1000 cells/µL", "why_it_matters": "Provides the principal quantitative observation for assessing absolute eosinopenia." }, { "name": "Eosinophil proportion", "kind": "measurement", "unit_or_values": "% of leukocytes", "why_it_matters": "Preserves the reported differential while allowing relative reduction to be distinguished from an absolute deficit." }, { "name": "Concurrent total leukocyte count", "kind": "measurement", "unit_or_values": "cells/µL or ×10^9/L from the same specimen", "why_it_matters": "Supports calculation or cross-checking of the absolute eosinophil count and interpretation of percentage changes." }, { "name": "Low-count criterion", "kind": "category", "unit_or_values": "Threshold, units, comparison operator, laboratory or study source, and applicable population", "why_it_matters": "Makes classification reproducible without assuming a universal cutoff." }, { "name": "Measurement qualification", "kind": "state", "unit_or_values": "Quantified low; reported zero; below quantification limit; flagged; unresolved", "why_it_matters": "Separates biological interpretation from the limits of the reported measurement." }, { "name": "Episode course", "kind": "state", "unit_or_values": "Single observation; transient; recurrent; persistent; resolved; indeterminate, with supporting dates", "why_it_matters": "Prevents one measurement from being treated as an established long-term state." }, { "name": "Medication timing", "kind": "relation", "unit_or_values": "Links to relevant medication administrations, including agent, dose, route and interval before sampling", "why_it_matters": "Allows treatment-associated changes to be evaluated against the sampling timeline." }, { "name": "Clinical-context attribution", "kind": "relation", "unit_or_values": "Linked condition or exposure; suspected, supported, contradicted or unresolved attribution", "why_it_matters": "Keeps an observed low count separate from claims about why it occurred." } ], "affordances": [ "Classify a result against a documented low-count criterion while preserving uncertainty.", "Calculate or cross-check the absolute count using the concurrent leukocyte count and eosinophil percentage.", "Identify low or zero results that require clarification of laboratory reporting limits.", "Compare serial counts with medication administrations and clinical events.", "Summarise supported explanations, competing explanations and missing evidence for clinical review.", "Track resolution or persistence without treating count recovery as proof that an underlying illness has resolved." ], "agent_conduct": { "may": [ "Explain what a low eosinophil count means as a laboratory finding, citing reference sources.", "Note that reference intervals vary by laboratory and population." ], "must_not": [ "Interpret a person's blood result as a diagnosis.", "Treat eosinopenia alone as proof of infection, stress or steroid use.", "Advise stopping prescribed steroids based on a blood count.", "Share a person's laboratory results without consent." ], "requires_human": [ "Any clinical decision based on a person's blood count." ] }, "ethics": { "considerations": [ "A lab value out of context can cause needless fear or false reassurance.", "Laboratory results are personal health data." ], "affected_parties": [ "Patients", "Clinicians interpreting results" ] }, "owners": { "steward": "Nobody owns the finding; the laboratory and treating clinician answer for each result.", "master_systems": [] }, "what_it_is_for": [ "Eosinopenia is encountered when reviewing a blood count with a white blood cell differential.", "It describes a laboratory finding interpreted alongside the laboratory reference interval, other results and the person's clinical context." ], "standards_and_regulation": [ "The International Organization for Standardization issues ISO 15189, which sets quality and competence requirements for medical laboratories producing eosinophil count results." ], "failure_modes_and_hazards": [ "Treating an isolated low eosinophil count as a diagnosis can cause unnecessary concern or inappropriate clinical decisions.", "Confusing an eosinophil percentage with an absolute count can lead to incorrect interpretation.", "Ignoring laboratory limitations or the broader clinical context can lead to misleading conclusions about the finding." ], "facets_not_applicable": { "recognition": "Eosinopenia has no specific visible identifying features and is established through blood testing." } }, "sources": [ { "id": "wikidata", "title": "Wikidata item Q490539: eosinopenia", "url": "https://www.wikidata.org/wiki/Q490539", "url_status": "live", "what_it_supports": "identity and sense of the item", "checked_by": "wikidata-api" }, { "id": "wikipedia-en", "title": "Wikipedia: Eosinopenia", "url": "https://en.wikipedia.org/wiki/Eosinopenia", "url_status": "live", "what_it_supports": "general description of the item", "checked_by": "wikidata-api sitelink" } ], "structure": { "bundles": [ { "id": "eosinopenia-definition", "name": "Eosinopenia definition", "description": "Determines which blood-count observations qualify as this registered state.", "rationale": "Low eosinophil counts need an explicit operational boundary; percentages, baseline declines and absolute deficits are different observations.", "layers": [ { "id": "low-count-boundary", "name": "Low-count boundary", "description": "Records the criterion under which a circulating eosinophil count is called low.", "findings": [ { "id": "criterion-bound-classification", "name": "Criterion-bound classification", "description": "Eosinopenia denotes a low blood eosinophil count; the model must retain the criterion used for each classification. [Merck Manual](https://www.merckmanuals.com/home/blood-disorders/white-blood-cell-disorders/eosinophilic-disorders)", "questions": [ { "text": "Which threshold, units and comparison operator define eosinopenia for this observation?", "kind": "definition", "id": "criterion-bound-classification-q01" }, { "text": "Which laboratory reference interval or published operational definition supports that threshold for this population?", "kind": "provenance", "id": "criterion-bound-classification-q02" } ] } ] }, { "id": "absolute-relative-distinction", "name": "Absolute and relative distinction", "description": "Separates the eosinophil concentration from its share of the leukocyte differential.", "findings": [ { "id": "percentage-denominator-check", "name": "Percentage denominator check", "description": "When deriving an absolute count, multiply the same-specimen total leukocyte count by the eosinophil percentage divided by 100; retain the inputs and their reporting precision.", "questions": [ { "text": "Is the low result an absolute count, a percentage, or both?", "kind": "measurement", "id": "percentage-denominator-check-q01" }, { "text": "Does the absolute count meet the selected criterion, or is only the percentage reduced?", "kind": "boundary", "id": "percentage-denominator-check-q02" } ] } ] } ] }, { "id": "low-count-measurement", "name": "Low-count measurement", "description": "Establishes whether the laboratory result supports a reliable low-count observation.", "rationale": "Interpretation near zero depends on measurement method, reporting precision and specimen provenance.", "layers": [ { "id": "specimen-and-method", "name": "Specimen and method", "description": "Connects the eosinophil result to its specimen and differential-count procedure.", "findings": [ { "id": "traceable-eosinophil-result", "name": "Traceable eosinophil result", "description": "Retain collection time, specimen identity, laboratory, differential method and relevant quality flags so the observation can be checked and compared.", "questions": [ { "text": "When was the specimen collected, and was the eosinophil differential automated, manual or otherwise measured?", "kind": "provenance", "id": "traceable-eosinophil-result-q01" }, { "text": "Were specimen-quality issues, analyser flags or reporting corrections recorded for this result?", "kind": "measurement", "id": "traceable-eosinophil-result-q02" } ] } ] }, { "id": "zero-and-precision", "name": "Zero and precision", "description": "Interprets very low results without overstating what the assay established.", "findings": [ { "id": "reported-zero-interpretation", "name": "Reported-zero interpretation", "description": "Preserve whether zero is a rounded numerical report, a below-limit result or no eosinophils observed in a finite manual differential.", "questions": [ { "text": "What reporting increment, quantification limit or manual differential cell total applies to this result?", "kind": "measurement", "id": "reported-zero-interpretation-q01" }, { "text": "Does the available report support a quantified low count, a bounded result or only an unresolved reported zero?", "kind": "boundary", "id": "reported-zero-interpretation-q02" } ] } ] } ] }, { "id": "eosinopenia-course-and-exposures", "name": "Eosinopenia course and exposures", "description": "Places low counts within an individual timeline and evaluates exposure-related explanations.", "rationale": "A single low result and a sustained change have different evidential support, and medication timing can materially affect interpretation.", "layers": [ { "id": "serial-eosinophil-course", "name": "Serial eosinophil course", "description": "Distinguishes the observed episode from isolated measurements and baseline variation.", "findings": [ { "id": "dated-low-count-episode", "name": "Dated low-count episode", "description": "Describe onset, recurrence and resolution using dated measurements, retaining changes in laboratory method or low-count criterion.", "questions": [ { "text": "Which earlier and subsequent absolute counts establish the baseline and duration of the observed reduction?", "kind": "measurement", "id": "dated-low-count-episode-q01" }, { "text": "Are collection times, laboratories and classification criteria sufficiently comparable to support the assigned course?", "kind": "boundary", "id": "dated-low-count-episode-q02" } ] } ] }, { "id": "glucocorticoid-and-treatment-context", "name": "Glucocorticoid and treatment context", "description": "Examines the relationship between eosinophil-lowering exposures and blood sampling.", "findings": [ { "id": "exposure-linked-count-reduction", "name": "Exposure-linked count reduction", "description": "Glucocorticoids can rapidly lower circulating eosinophils; mechanistic research supports CXCR4-dependent bone-marrow migration, so a falling blood count must not automatically be interpreted as cellular destruction. [Primary study](https://pubmed.ncbi.nlm.nih.gov/32659786/)", "questions": [ { "text": "Which glucocorticoids or eosinophil-targeting therapies preceded the sample, at what doses and intervals?", "kind": "provenance", "id": "exposure-linked-count-reduction-q01" }, { "text": "Do pretreatment and follow-up counts support an exposure-related explanation, and what competing explanations remain?", "kind": "boundary", "id": "exposure-linked-count-reduction-q02" } ] } ] } ] }, { "id": "clinical-meaning-and-review", "name": "Clinical meaning and review", "description": "Constrains what an agent may infer from eosinopenia and identifies the evidence needed for further review.", "rationale": "A low eosinophil count is a contextual finding whose cause and clinical importance require evidence beyond the count itself.", "layers": [ { "id": "associated-conditions", "name": "Associated conditions", "description": "Records relevant illness and endocrine context without converting association into diagnosis.", "findings": [ { "id": "nonspecific-clinical-association", "name": "Nonspecific clinical association", "description": "Low eosinophil counts can occur with sepsis, Cushing syndrome and corticosteroid treatment; the count alone does not identify which explanation applies. [Merck Manual](https://www.merckmanuals.com/home/blood-disorders/white-blood-cell-disorders/eosinophilic-disorders)", "questions": [ { "text": "Which concurrent illnesses or endocrine findings are independently documented at the time of sampling?", "kind": "provenance", "id": "nonspecific-clinical-association-q01" }, { "text": "What evidence beyond eosinopenia supports each proposed cause or use as an illness marker?", "kind": "boundary", "id": "nonspecific-clinical-association-q02" } ] } ] }, { "id": "review-and-resolution", "name": "Review and resolution", "description": "Relates follow-up decisions to measurement confidence, persistence and the broader clinical presentation.", "findings": [ { "id": "context-led-follow-up", "name": "Context-led follow-up", "description": "Record whether the low count needs report clarification, repeat measurement or clinician review, with a stated reason; count normalisation alone does not establish resolution of a linked illness.", "questions": [ { "text": "What uncertainty, persistence or accompanying clinical finding justifies clarification, repeat testing or clinician review?", "kind": "action", "id": "context-led-follow-up-q01" }, { "text": "Which observations would establish resolution of the low-count state, and which separate evidence is needed to reassess its proposed cause?", "kind": "action", "id": "context-led-follow-up-q02" } ] } ] } ] }, { "id": "evidence-and-external-alignment", "name": "Evidence and external alignment", "description": "What the world already says about this thing, gathered so the model can be checked against it.", "rationale": "A model that cannot be lined up against existing standards, identifiers and practice cannot be adopted by anyone who already uses them.", "layers": [ { "id": "reported-evidence", "name": "Reported evidence", "description": "Findings from the breadth pass, kept separate from the structural claims.", "findings": [ { "id": "evidence-confidence-notes", "name": "Check these first", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "Verify the reference interval and operational cutoff for the laboratory, population, and intended use.", "Associations with infection and prognosis depend on clinical context and do not establish a standalone diagnostic role.", "This is a recall-based description; no sources or coding identifiers were checked." ], "questions": [ { "id": "evidence-confidence-notes-q01", "text": "Which of these check these first hold for the sense of eosinopenia this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-kinds", "name": "Kinds and varieties", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "Absolute eosinopenia: a reduced absolute eosinophil count", "Relative eosinopenia: a reduced proportion of eosinophils among circulating leukocytes" ], "questions": [ { "id": "evidence-kinds-q01", "text": "Which of these kinds and varieties hold for the sense of eosinopenia this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-real-world-use", "name": "Real-world use", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "Interpreting a complete blood count with leukocyte differential", "Assessing blood-count changes associated with glucocorticoid exposure or acute physiological stress", "Investigating eosinopenia as an adjunctive marker of acute infection or illness severity, without treating it as diagnostic by itself", "Monitoring eosinophil depletion during therapies directed against eosinophils" ], "questions": [ { "id": "evidence-real-world-use-q01", "text": "Which of these real-world use hold for the sense of eosinopenia this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-measurements", "name": "Typical measurements", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ { "quantity": "Absolute blood eosinophil count", "typical_range": "No universal diagnostic cutoff; fewer than 50 cells/µL is one commonly used operational threshold, while some laboratory reference intervals include zero", "unit": "cells/µL" }, { "quantity": "Relative blood eosinophil count", "typical_range": "Expressed as a percentage of total leukocytes; a low percentage does not necessarily indicate a low absolute count", "unit": "%" } ], "questions": [ { "id": "evidence-measurements-q01", "text": "Which of these typical measurements hold for the sense of eosinopenia this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-failure-modes-and-hazards", "name": "Failure modes and hazards", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "Inferring infection or sepsis from eosinopenia alone despite its limited specificity", "Confusing a low eosinophil percentage caused by increases in other leukocytes with an absolute eosinophil deficit", "Ignoring glucocorticoid treatment, endogenous cortisol effects, or time-of-day variation", "Interpreting a reported zero as proof that eosinophils are absent from the body", "Assuming that blood eosinophil depletion establishes the absence of tissue eosinophils or eosinophilic disease" ], "questions": [ { "id": "evidence-failure-modes-and-hazards-q01", "text": "Which of these failure modes and hazards hold for the sense of eosinopenia this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-regional-variation", "name": "Regional variation", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "Laboratories differ in reference intervals and reporting units, including cells/µL and ×10^9/L" ], "questions": [ { "id": "evidence-regional-variation-q01", "text": "Which of these regional variation hold for the sense of eosinopenia this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-neighbours", "name": "Neighbouring kinds and how to tell them apart", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ { "name": "Eosinophilia", "difference": "Eosinophilia denotes an increased eosinophil count; eosinopenia denotes a decreased count." }, { "name": "Leukopenia", "difference": "Leukopenia concerns the total white blood cell count; eosinopenia concerns the eosinophil subset and can occur with a normal or elevated total count." }, { "name": "Neutropenia", "difference": "Neutropenia is a reduction in neutrophils, a different granulocyte population." }, { "name": "Hypercortisolism", "difference": "Hypercortisolism is excessive cortisol exposure and may cause eosinopenia; an eosinophil count alone does not establish it." } ], "questions": [ { "id": "evidence-neighbours-q01", "text": "Which of these neighbouring kinds and how to tell them apart hold for the sense of eosinopenia this model covers, and on what evidence?", "kind": "provenance" } ] } ] } ] } ] }, "openQuestions": [ "Which low-count definitions are supported for the intended age groups, laboratories and clinical settings, particularly where reference intervals include zero?", "How should counts near zero be classified across automated analysers and manual differentials with different reporting limits?", "What observation period and sampling comparability should be required before labelling eosinopenia persistent or recurrent?", "In which patient populations does eosinopenia add validated diagnostic or prognostic information beyond other clinical observations, after accounting for corticosteroid exposure?", "What evidence supports further evaluation of persistent isolated eosinopenia when other blood counts and the clinical assessment are unremarkable?" ], "statistics": { "bundles": 5, "layers": 9, "findings": 15, "questions": 23 } }