{ "vercy": "1.0-draft", "publication": { "status": "research-draft", "adjudicationStatus": "unreviewed", "publishableCanonical": false, "generatedAt": "2026-09-12T08:31:18Z", "providers": [ "Codex" ], "breadth": "recalled by Codex without web access - no source was read", "missingProviders": [], "pass": 2, "cost": { "grok": { "seconds": 17.3, "error": "Reading additional input from stdin...\nOpenAI Codex v0.153.4\n--------\nworkdir: R:\\02_PROJECTS\\02_Meta_Models_Platforms\\Ver.cy\\current\\thing-registry-backlog\nmodel: gpt-6-astra\nprovider: openai\napproval: never\nsandbox: read-only\nreasoning effort: none\nreasoning summaries: none\nsession id: 01a094bc-e13a-7101-a9d6-4367dc7d5fe4\n--------\nuser\nDescribe what is already known about one registered thing. Answer as JSON only, no prose around it.\n\nThing: cephacetrile\nSense to describe: (none recorded)\nDomain code: PHY.MAT\nAlso known as: (none)\n\n\nContext for this batch of 1001 things:\n# Batch 043: 1001 re", "usd": 0.0, "recall": true }, "codex": { "seconds": 77.8, "error": "Reading additional input from stdin...\nOpenAI Codex v0.153.4\n--------\nworkdir: R:\\02_PROJECTS\\02_Meta_Models_Platforms\\Ver.cy\\current\\thing-registry-backlog\nmodel: gpt-6-astra\nprovider: openai\napproval: never\nsandbox: read-only\nreasoning effort: none\nreasoning summaries: none\nsession id: 01a094bc-e12f-7aa2-82a9-053bda88a10b\n--------\nuser\nYou are drafting a Vercy meta-model for one registered thing. Answer as JSON only, no prose around it.\n\nThing: cephacetrile\nRegistry id: vr.tr.cephacetrile\nPlane / domain: PHY / PHY.MAT\nRegistry definition: (none recorded)\nNames folded into this entry: (none)\n" } }, "enrichment": { "pass": 3, "engine": "claude", "producedAt": "2026-10-06T12:00:00Z", "ingestedAt": "2026-10-06T08:57:40+00:00", "fields": [ "agent_conduct", "ethics", "failure_modes_and_hazards", "owners", "standards_and_regulation", "visual_identification" ] }, "gate": { "passed": true, "version": "1.0", "at": "2026-10-07T10:10:31+00:00", "evidence": [ "completeness 1.00", "sense: Wikidata description", "2 live sources", "review by codex: pass" ] } }, "metaModel": { "id": "THING-Q4919176", "registryId": "vr.tr.cephacetrile", "name": "cephacetrile", "version": "0.1.0-research.1", "entryKind": "thing", "family": "Thing Registry", "domain": [ "PHY.MAT" ], "status": "research-draft" }, "canonicalUrl": "https://ver.cy/models/thing/q4919176/", "model": { "registry_id": "vr.tr.cephacetrile", "name": "cephacetrile", "purpose": "Enable an agent to recognise cephacetrile, assess the identity and condition of a material sample, and determine which handling or use decisions its evidence supports.", "definition": "Cephacetrile, also called cefacetrile, is a semisynthetic first-generation cephalosporin beta-lactam antibiotic that inhibits bacterial cell-wall synthesis.", "scope_statement": "This model owns the substance identity of cephacetrile under vr.tr.cephacetrile, its material forms, quality, stability, antibacterial character and substance-level constraints; salt forms remain explicitly related to the parent substance.", "in_scope": [ "Molecular identity, stereochemistry and reconciliation of cephacetrile with the spelling cefacetrile", "Parent-substance versus salt, hydrate, solvate and formulation boundaries", "Sample composition, assay basis, impurities and grade", "Physical state, solubility and stability under recorded conditions", "Antibacterial activity evidence and its experimental limits", "Substance-specific handling, disposal and regulatory identifiers" ], "out_of_scope": [ "Finished medicinal products, packaging and formulation design", "Patient diagnosis, prescribing, dosage and treatment selection", "Manufacturing process design and synthesis instructions", "Bacterial species and resistance mechanisms as independent models", "Clinical trial and marketing-authorisation records beyond linked evidence", "Other cephalosporins as independently characterised substances" ], "distinguishing_features": [ "Resolve the name against the stereochemically specified cefacetrile structure, CAS 10206-21-0 and PubChem CID 91562, rather than relying on spelling alone. [PubChem](https://pubchem.ncbi.nlm.nih.gov/compound/Cefacetrile)", "Check for the cephalosporin scaffold bearing a 7-position cyanoacetamido substituent and a 3-position acetoxymethyl substituent; the recorded structure specifies 6R,7R stereochemistry. [PubChem](https://pubchem.ncbi.nlm.nih.gov/compound/Cefacetrile)", "Use C13H13N3O6S and approximately 339.33 g/mol as consistency checks for the parent substance, while requiring structural evidence to exclude isomers. [PubChem](https://pubchem.ncbi.nlm.nih.gov/compound/Cefacetrile)", "Distinguish the parent substance from cephacetrile sodium, recorded separately as C13H12N3NaO6S and PubChem CID 23668837. [PubChem sodium record](https://pubchem.ncbi.nlm.nih.gov/compound/23668837)", "Require composition evidence to distinguish isolated cephacetrile from a branded preparation or a mixture containing it." ], "characteristics": [ { "name": "Chemical identity", "kind": "category", "unit_or_values": "Stereochemical structure identifier; CAS and database identifiers with provenance", "why_it_matters": "Prevents name similarity or catalogue conventions from substituting for molecular identity." }, { "name": "Material form", "kind": "category", "unit_or_values": "Parent substance; identified salt; hydrate or solvate if demonstrated; mixture; unresolved", "why_it_matters": "Determines which composition, molecular mass and property measurements apply." }, { "name": "Cephacetrile content", "kind": "measurement", "unit_or_values": "% mass fraction or mg/g; as-is, dried, anhydrous or parent-equivalent basis", "why_it_matters": "Makes assay results comparable without confusing chromatographic purity with mass content." }, { "name": "Related-substance profile", "kind": "measurement", "unit_or_values": "Individual and total impurities in % or mg/g; identification confidence and method", "why_it_matters": "Separates intact cephacetrile from structurally related impurities and degradation products." }, { "name": "Water and residual solvents", "kind": "measurement", "unit_or_values": "Water in % mass fraction; identified solvents in ppm or mg/g", "why_it_matters": "Explains assay-basis differences and contributes to material suitability assessments." }, { "name": "Physical state and thermal behaviour", "kind": "state", "unit_or_values": "Observed phase and solid form; thermal events in °C with method and decomposition status", "why_it_matters": "Prevents a decomposition event or measurement on another form from being treated as a universal melting point." }, { "name": "Solubility", "kind": "measurement", "unit_or_values": "mg/mL or mol/L with material form, solvent, pH, temperature and equilibration time", "why_it_matters": "Supports preparation decisions while exposing form-dependent and condition-dependent behaviour." }, { "name": "Chemical stability", "kind": "measurement", "unit_or_values": "Intact cephacetrile remaining in % versus time under specified storage or solution conditions", "why_it_matters": "Determines whether material still meets the intended assay or use requirements." }, { "name": "Antibacterial activity", "kind": "measurement", "unit_or_values": "MIC in µg/mL or another validated activity endpoint with organism, strain and assay conditions", "why_it_matters": "Keeps experimentally observed activity separate from assumed class-wide susceptibility." }, { "name": "Grade and intended-use qualification", "kind": "category", "unit_or_values": "Reference material; research reagent; qualified pharmaceutical substance; other documented grade; unverified", "why_it_matters": "A substance name or high assay alone does not establish suitability for a particular use." }, { "name": "Hazard and regulatory evidence", "kind": "relation", "unit_or_values": "Applicable SDS, classification record, inventory entry or restriction with jurisdiction, date and material form", "why_it_matters": "Keeps handling and permission decisions tied to the supplied material and applicable authority." } ], "affordances": [ "Reconcile cephacetrile and cefacetrile records against a verified molecular identity.", "Classify a sample as parent substance, related salt or cephacetrile-containing mixture.", "Compare batch assays after reconciling water, salt and parent-equivalent reporting bases.", "Assess whether documented storage or solution conditions support continued analytical use.", "Interpret antibacterial measurements within their strain, method and material-quality limits.", "Select evidence-supported handling and disposal controls, or flag missing qualification." ], "agent_conduct": { "may": [ "Identify cephacetrile by name, identifiers and documented properties, citing sources.", "Report its antibiotic class and regulatory status in a stated country from official sources.", "Check a material lot's certificate of analysis against its specification." ], "must_not": [ "Recommend it or a dose for a particular infection or patient.", "Downplay allergy risks, including in people allergic to penicillins.", "Supply it outside lawful pharmaceutical or veterinary channels.", "Encourage antibiotic use where it is not needed." ], "requires_human": [ "Any decision to treat a patient or animal.", "Releasing or destroying a material lot." ] }, "ethics": { "considerations": [ "Antibiotic misuse drives resistance that harms everyone.", "Allergic reactions to beta-lactams can be severe." ], "affected_parties": [ "Patients", "The public through antibiotic resistance", "Prescribers and veterinarians" ] }, "owners": { "steward": "The marketing authorization holder for each medicine; the national medicines regulator oversees it.", "master_systems": [ "National medicines registers" ] }, "visual_identification": [ "Identity rests on the label, batch record and certificate of analysis, not appearance.", "Also spelled cefacetrile on labels." ], "failure_modes_and_hazards": [ "Allergic reactions, including severe ones.", "Resistance from misuse.", "Occupational sensitization of manufacturing staff." ], "standards_and_regulation": [ "ICH Q7 Good Manufacturing Practice Guide for Active Pharmaceutical Ingredients, International Council for Harmonisation." ], "what_it_is_for": [ "Cephacetrile is encountered in pharmaceutical research, analytical reference materials and records of antibacterial medicines.", "Its antibiotic role concerns susceptible bacterial infections, while assessment of a sample requires evidence of chemical identity, purity and storage condition." ] }, "sources": [ { "id": "wikidata", "title": "Wikidata item Q4919176: cephacetrile", "url": "https://www.wikidata.org/wiki/Q4919176", "url_status": "live", "what_it_supports": "identity and sense of the item", "checked_by": "wikidata-api" }, { "id": "wikipedia-en", "title": "Wikipedia: Cefacetrile", "url": "https://en.wikipedia.org/wiki/Cefacetrile", "url_status": "live", "what_it_supports": "general description of the item", "checked_by": "wikidata-api sitelink" } ], "structure": { "bundles": [ { "id": "molecular-identity-and-form", "name": "Molecular identity and form", "description": "Establish what counts as cephacetrile and which supplied forms require explicit qualification.", "rationale": "Alternative spelling, stereochemistry and salt naming can otherwise collapse distinct records into one substance.", "layers": [ { "id": "name-and-structure", "name": "Name and structure", "description": "Connect the registry name to an independently verifiable molecular structure.", "findings": [ { "id": "identity-anchor", "name": "Identity anchor", "description": "Record the structure and identifiers used to recognise cephacetrile, preserving the source of synonym assertions.", "questions": [ { "text": "Which authoritative records establish that cephacetrile and cefacetrile identify the same stereochemical substance?", "kind": "provenance", "id": "identity-anchor-q01" }, { "text": "Does the sample's structural evidence support the specified stereochemistry and both characteristic side chains?", "kind": "measurement", "id": "identity-anchor-q02" } ] } ] }, { "id": "parent-and-related-forms", "name": "Parent and related forms", "description": "Separate parent identity from counterions, associated water or solvent, and formulated mixtures.", "findings": [ { "id": "form-assignment", "name": "Form assignment", "description": "Require an explicit form assignment before transferring identifiers, molecular masses or material properties.", "questions": [ { "text": "Is the material the parent substance, cephacetrile sodium, another demonstrated form or a mixture?", "kind": "boundary", "id": "form-assignment-q01" }, { "text": "What counterion, water or solvent measurements support that assignment and any conversion to parent-equivalent content?", "kind": "measurement", "id": "form-assignment-q02" } ] } ] } ] }, { "id": "composition-and-qualification", "name": "Composition and qualification", "description": "Describe how much intact cephacetrile is present and what the batch is qualified to support.", "rationale": "Chemical identity alone cannot establish purity, usable content or suitability as a reference or pharmaceutical substance.", "layers": [ { "id": "assay-and-impurities", "name": "Assay and impurities", "description": "Resolve intact-substance content and components that could distort its interpretation.", "findings": [ { "id": "content-and-related-substances", "name": "Content and related substances", "description": "Keep assay, chromatographic area purity and impurity identification distinct.", "questions": [ { "text": "What validated method quantifies intact cephacetrile, and is the result reported as-is, dried or as parent equivalent?", "kind": "measurement", "id": "content-and-related-substances-q01" }, { "text": "Which related substances, residual solvents and water contributions are measured, and which remain unidentified?", "kind": "measurement", "id": "content-and-related-substances-q02" } ] } ] }, { "id": "batch-grade", "name": "Batch grade", "description": "Connect a particular batch to its specification and demonstrated intended use.", "findings": [ { "id": "qualification-evidence", "name": "Qualification evidence", "description": "Base grade decisions on batch-specific evidence rather than supplier naming.", "questions": [ { "text": "Which certificate, reference standard and specification support the batch's claimed cephacetrile grade?", "kind": "provenance", "id": "qualification-evidence-q01" }, { "text": "What additional evidence is required before using this batch for quantitative calibration, biological testing or pharmaceutical manufacture?", "kind": "action", "id": "qualification-evidence-q02" } ] } ] } ] }, { "id": "physical-behaviour-and-stability", "name": "Physical behaviour and stability", "description": "Represent cephacetrile's observed material behaviour under explicit environmental and preparation conditions.", "rationale": "Measurements on different forms or degraded preparations cannot safely be treated as interchangeable constants.", "layers": [ { "id": "phase-and-solubility", "name": "Phase and solubility", "description": "Attach physical measurements to the tested form and conditions.", "findings": [ { "id": "conditioned-physical-properties", "name": "Conditioned physical properties", "description": "Record measured phase, dissolution and thermal behaviour without inventing missing constants.", "questions": [ { "text": "What solid form and thermal events are experimentally established, and does decomposition prevent reporting a conventional melting or boiling point?", "kind": "measurement", "id": "conditioned-physical-properties-q01" }, { "text": "What solubility is measured for the identified form at the intended solvent composition, pH and temperature?", "kind": "measurement", "id": "conditioned-physical-properties-q02" } ] } ] }, { "id": "degradation-and-storage", "name": "Degradation and storage", "description": "Connect storage and solution history to retained cephacetrile content.", "findings": [ { "id": "stability-envelope", "name": "Stability envelope", "description": "Determine the conditions and durations supported by chemical stability evidence.", "questions": [ { "text": "Which studies quantify intact cephacetrile and degradation products under relevant moisture, light, temperature and solution-pH conditions?", "kind": "provenance", "id": "stability-envelope-q01" }, { "text": "After a storage excursion or solution preparation, what evidence supports continued use, retesting or rejection?", "kind": "action", "id": "stability-envelope-q02" } ] } ] } ] }, { "id": "antibacterial-function", "name": "Antibacterial function", "description": "Capture cephacetrile-specific activity evidence without turning substance characterisation into prescribing guidance.", "rationale": "Antibiotic classification does not establish activity against a particular strain or the potency of a particular sample.", "layers": [ { "id": "mechanistic-evidence", "name": "Mechanistic evidence", "description": "Separate direct cephacetrile evidence from mechanisms inferred from related antibiotics.", "findings": [ { "id": "target-and-functional-effect", "name": "Target and functional effect", "description": "Track evidence connecting cephacetrile to bacterial targets and measured functional effects.", "questions": [ { "text": "Which experiments directly establish cephacetrile target engagement or effects on bacterial cell-wall synthesis?", "kind": "provenance", "id": "target-and-functional-effect-q01" }, { "text": "Which mechanistic statements are demonstrated for cephacetrile and which are extrapolated from the cephalosporin class?", "kind": "boundary", "id": "target-and-functional-effect-q02" } ] } ] }, { "id": "activity-and-resistance", "name": "Activity and resistance", "description": "Retain the experimental context needed to interpret antibacterial measurements.", "findings": [ { "id": "strain-specific-potency", "name": "Strain-specific potency", "description": "Represent susceptibility and resistance as evidence-bound relationships rather than universal properties.", "questions": [ { "text": "What MIC or other activity endpoint was measured, using which strain, medium, inoculum, incubation conditions and cephacetrile assay basis?", "kind": "measurement", "id": "strain-specific-potency-q01" }, { "text": "Which resistance determinants or degradation processes were tested directly for their effect on cephacetrile activity?", "kind": "provenance", "id": "strain-specific-potency-q02" }, { "text": "Does an applicable interpretive standard exist, or must the result remain an uninterpreted experimental measurement?", "kind": "boundary", "id": "strain-specific-potency-q03" } ] } ] } ] }, { "id": "handling-and-regulatory-boundaries", "name": "Handling and regulatory boundaries", "description": "Determine which controls and restrictions are supported for the identified cephacetrile material.", "rationale": "Supplier hazard information, antibiotic waste concerns and medicinal-product permissions address different decisions.", "layers": [ { "id": "exposure-and-waste", "name": "Exposure and waste", "description": "Connect exposure prevention and waste treatment to substance-specific evidence.", "findings": [ { "id": "supported-handling-controls", "name": "Supported handling controls", "description": "Record applicable hazard evidence and controls without assigning an unverified classification or exposure limit.", "questions": [ { "text": "What current SDS and supporting evidence address sensitisation, dust exposure and other hazards for this exact material form?", "kind": "provenance", "id": "supported-handling-controls-q01" }, { "text": "Is a cephacetrile-specific occupational exposure limit established in the relevant jurisdiction, and what controls apply if it is not?", "kind": "action", "id": "supported-handling-controls-q02" }, { "text": "Which approved waste route or validated treatment addresses residual cephacetrile and antibacterial activity?", "kind": "action", "id": "supported-handling-controls-q03" } ] } ] }, { "id": "jurisdiction-and-use-status", "name": "Jurisdiction and use status", "description": "Separate substance identification from permissions for products and intended uses.", "findings": [ { "id": "regulatory-applicability", "name": "Regulatory applicability", "description": "Attach regulatory conclusions to a jurisdiction, date, form and intended activity.", "questions": [ { "text": "Which verified inventory or regulatory identifiers apply to the parent substance and which apply specifically to its sodium salt?", "kind": "provenance", "id": "regulatory-applicability-q01" }, { "text": "Does the intended activity concern reagent handling, pharmaceutical manufacture or an authorised medicinal product, and which neighbouring record governs it?", "kind": "boundary", "id": "regulatory-applicability-q02" } ] } ] } ] }, { "id": "evidence-and-external-alignment", "name": "Evidence and external alignment", "description": "What the world already says about this thing, gathered so the model can be checked against it.", "rationale": "A model that cannot be lined up against existing standards, identifiers and practice cannot be adopted by anyone who already uses them.", "layers": [ { "id": "reported-evidence", "name": "Reported evidence", "description": "Findings from the breadth pass, kept separate from the structural claims.", "findings": [ { "id": "evidence-confidence-notes", "name": "Check these first", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "This account is recalled knowledge, not source-verified research.", "Check exact registry identifiers, salt form, purity specifications and physical constants before creating a substance record.", "Current availability, approved indications and jurisdiction-specific regulation require verification; the hazards listed are class-level concerns." ], "questions": [ { "id": "evidence-confidence-notes-q01", "text": "Which of these check these first hold for the sense of cephacetrile this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-identifiers", "name": "Identifiers and schemes", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ { "scheme": "International Nonproprietary Names (INN)", "value_or_pattern": "cefacetrile", "note": "Alternative spelling of the substance named cephacetrile." } ], "questions": [ { "id": "evidence-identifiers-q01", "text": "Which of these identifiers and schemes hold for the sense of cephacetrile this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-real-world-use", "name": "Real-world use", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "Historically used as an injectable antibiotic for infections caused by susceptible bacteria." ], "questions": [ { "id": "evidence-real-world-use-q01", "text": "Which of these real-world use hold for the sense of cephacetrile this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-failure-modes-and-hazards", "name": "Failure modes and hazards", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "Hypersensitivity reactions, including potentially severe reactions, are a cephalosporin-class hazard.", "Bacterial resistance, including beta-lactamase-mediated inactivation, can cause treatment failure.", "Antibiotic-associated disruption of normal microbial flora can cause diarrhoea and secondary infection." ], "questions": [ { "id": "evidence-failure-modes-and-hazards-q01", "text": "Which of these failure modes and hazards hold for the sense of cephacetrile this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-neighbours", "name": "Neighbouring kinds and how to tell them apart", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ { "name": "Cephalosporins", "difference": "Cephalosporins are the antibiotic family; cephacetrile is one specific compound within it." }, { "name": "Cefazolin", "difference": "Cefazolin is another first-generation cephalosporin with different molecular side chains and pharmacological properties." }, { "name": "Cephacetrile sodium", "difference": "The sodium salt is a distinct chemical form of cephacetrile; its formula and formula mass include the counterion." } ], "questions": [ { "id": "evidence-neighbours-q01", "text": "Which of these neighbouring kinds and how to tell them apart hold for the sense of cephacetrile this model covers, and on what evidence?", "kind": "provenance" } ] } ] } ] } ] }, "openQuestions": [ "Which current authoritative specifications or compendial monographs define cephacetrile and its sodium salt, including assay bases and impurity limits?", "Which physical constants, solid forms, solubility measurements and storage limits are experimentally established separately for the parent substance and salt?", "Which cephacetrile degradation products are confirmed, and how well do available analytical methods distinguish them from intact substance?", "What current cephacetrile-specific hazard classifications, exposure limits and regulatory inventory identifiers apply in the intended jurisdictions?", "Which antibacterial activity results and susceptibility interpretation criteria remain applicable, and what current product authorisations exist for any intended medicinal use?" ], "statistics": { "bundles": 6, "layers": 11, "findings": 15, "questions": 27 } }