{
  "vercy": "1.0-draft",
  "publication": {
    "status": "research-draft",
    "adjudicationStatus": "unreviewed",
    "publishableCanonical": false,
    "generatedAt": "2026-09-12T08:29:28Z",
    "providers": [
      "Codex"
    ],
    "breadth": "recalled by Codex without web access - no source was read",
    "missingProviders": [],
    "pass": 2,
    "cost": {
      "grok": {
        "seconds": 22.0,
        "error": "Reading additional input from stdin...\nOpenAI Codex v0.153.4\n--------\nworkdir: R:\\02_PROJECTS\\02_Meta_Models_Platforms\\Ver.cy\\current\\thing-registry-backlog\nmodel: gpt-6-astra\nprovider: openai\napproval: never\nsandbox: read-only\nreasoning effort: none\nreasoning summaries: none\nsession id: 01a094bb-2fb4-7042-a563-a511b6bb7a23\n--------\nuser\nDescribe what is already known about one registered thing. Answer as JSON only, no prose around it.\n\nThing: cefmenoxime\nSense to describe: (none recorded)\nDomain code: PHY.MAT\nAlso known as: (none)\n\n\nContext for this batch of 1001 things:\n# Batch 043: 1001 reg",
        "usd": 0.0,
        "recall": true
      },
      "codex": {
        "seconds": 78.3,
        "error": "Reading additional input from stdin...\nOpenAI Codex v0.153.4\n--------\nworkdir: R:\\02_PROJECTS\\02_Meta_Models_Platforms\\Ver.cy\\current\\thing-registry-backlog\nmodel: gpt-6-astra\nprovider: openai\napproval: never\nsandbox: read-only\nreasoning effort: none\nreasoning summaries: none\nsession id: 01a094bb-2fbe-7620-974a-9a6670a500b4\n--------\nuser\nYou are drafting a Vercy meta-model for one registered thing. Answer as JSON only, no prose around it.\n\nThing: cefmenoxime\nRegistry id: vr.tr.cefmenoxime\nPlane / domain: PHY / PHY.MAT\nRegistry definition: (none recorded)\nNames folded into this entry: (none)\n\n\n"
      }
    },
    "enrichment": {
      "pass": 3,
      "engine": "claude",
      "producedAt": "2026-10-06T12:00:00Z",
      "ingestedAt": "2026-10-06T08:54:14+00:00",
      "fields": [
        "agent_conduct",
        "ethics",
        "failure_modes_and_hazards",
        "owners",
        "visual_identification"
      ]
    },
    "gate": {
      "passed": true,
      "version": "1.0",
      "at": "2026-10-07T10:10:31+00:00",
      "evidence": [
        "completeness 1.00",
        "sense: Wikidata description",
        "2 live sources",
        "review by codex: pass"
      ]
    }
  },
  "metaModel": {
    "id": "THING-Q4921166",
    "registryId": "vr.tr.cefmenoxime",
    "name": "cefmenoxime",
    "version": "0.1.0-research.1",
    "entryKind": "thing",
    "family": "Thing Registry",
    "domain": [
      "PHY.MAT"
    ],
    "status": "research-draft"
  },
  "canonicalUrl": "https://ver.cy/models/thing/q4921166/",
  "model": {
    "registry_id": "vr.tr.cefmenoxime",
    "name": "cefmenoxime",
    "purpose": "Enable an AI agent to recognise cefmenoxime, assess the identity and condition of a material containing it, and determine which analytical, handling or downstream-use decisions the evidence supports.",
    "definition": "Cefmenoxime is a semisynthetic third-generation cephalosporin beta-lactam antibiotic that inhibits bacterial cell-wall synthesis by binding penicillin-binding proteins.",
    "scope_statement": "This model owns the substance identity of cefmenoxime under vr.tr.cefmenoxime in PHY / PHY.MAT, including its defining molecular structure, material forms, quality, stability and evidence governing substance-level actions.",
    "in_scope": [
      "Cefmenoxime molecular identity, stereochemistry and identifier mappings",
      "Relationships between cefmenoxime and explicitly characterised salt, hydrate or solvate forms",
      "Lot-specific assay, impurities, water content and intended-use grade",
      "Physical state, solution behaviour and stability under recorded conditions",
      "Antibacterial activity evidence and substance-level handling constraints"
    ],
    "out_of_scope": [
      "Finished medicinal products, excipient compositions and packaging specifications",
      "Patient-specific prescribing, dosing and treatment selection",
      "Manufacturing routes, production equipment and process validation",
      "Independent models of other cephalosporins or cefminox",
      "Organism taxonomy and general antimicrobial-resistance surveillance"
    ],
    "distinguishing_features": [
      "Match the complete molecular structure and stereochemistry, with parent formula C16H17N9O5S3 and PubChem CID 9570757 as corroborating identifiers. [PubChem](https://pubchem.ncbi.nlm.nih.gov/compound/Cefmenoxime)",
      "Require the cefmenoxime combination of a 7-position aminothiazolyl methoxyimino side chain and a 3-position methylthiotetrazole-containing substituent; a cephalosporin scaffold alone is insufficient. [PubChem](https://pubchem.ncbi.nlm.nih.gov/compound/Cefmenoxime)",
      "Distinguish cefminox by its different molecular formula and side-chain structure rather than accepting the similar name as a synonym. [PubChem cefminox](https://pubchem.ncbi.nlm.nih.gov/compound/Cefminox)",
      "Distinguish the parent substance from hydrochloride material: PubChem separately records cefmenoxime hydrochloride as CID 11954009 with formula C32H35ClN18O10S6, requiring explicit stoichiometry rather than an assumed 1:1 salt. [PubChem hydrochloride](https://pubchem.ncbi.nlm.nih.gov/compound/11954009)",
      "Require an analytical identity match for a material lot; a product name, antibiotic-class label or antibacterial response alone does not establish cefmenoxime identity."
    ],
    "characteristics": [
      {
        "name": "Molecular identity",
        "kind": "category",
        "unit_or_values": "Complete stereochemical structure; parent formula C16H17N9O5S3; PubChem CID 9570757",
        "why_it_matters": "Anchors recognition to a defined chemical entity rather than a similar antibiotic name."
      },
      {
        "name": "Identifier applicability",
        "kind": "relation",
        "unit_or_values": "CAS, PubChem, EC or other identifier linked to its issuing source and exact chemical form",
        "why_it_matters": "Prevents identifiers for the parent and salt forms from being treated as interchangeable."
      },
      {
        "name": "Material form",
        "kind": "category",
        "unit_or_values": "Parent, specified salt, hydrate or solvate; stoichiometry; solid-form assignment or unknown",
        "why_it_matters": "Determines the basis for mass conversion, assay interpretation and comparison of physical properties."
      },
      {
        "name": "Cefmenoxime content",
        "kind": "measurement",
        "unit_or_values": "% m/m or mg/g; as received, dry basis or parent equivalent; method and uncertainty",
        "why_it_matters": "Separates weighed material from the amount of cefmenoxime it represents."
      },
      {
        "name": "Related substances",
        "kind": "measurement",
        "unit_or_values": "Individual and total impurities in % with method, reporting basis and identification confidence",
        "why_it_matters": "Supports detection of contamination, isomerisation or degradation without treating chromatographic area as automatically equivalent to mass."
      },
      {
        "name": "Water and residual solvents",
        "kind": "measurement",
        "unit_or_values": "Water in % m/m; named solvents in mg/kg; analytical method",
        "why_it_matters": "Affects assay correction, material-form interpretation and grade suitability."
      },
      {
        "name": "Physical and solution state",
        "kind": "state",
        "unit_or_values": "Solid or solution; solvent, concentration, pH, temperature, appearance and elapsed time",
        "why_it_matters": "Makes measurements and compatibility judgments conditional on the actual cefmenoxime preparation."
      },
      {
        "name": "Solubility and thermal behaviour",
        "kind": "measurement",
        "unit_or_values": "Solubility in mg/mL with conditions; thermal events in °C with method and decomposition assessment",
        "why_it_matters": "Avoids transferring constants across forms or reporting decomposition as a melting or boiling point."
      },
      {
        "name": "Antibacterial activity",
        "kind": "measurement",
        "unit_or_values": "MIC in µg/mL or validated potency units; organism, strain, method and material basis",
        "why_it_matters": "Allows bounded comparison of activity while retaining assay and susceptibility context."
      },
      {
        "name": "Use and handling status",
        "kind": "state",
        "unit_or_values": "Research, reference or pharmaceutical grade; released, quarantined or rejected; applicable SDS and jurisdiction",
        "why_it_matters": "Connects permitted actions to documented quality and current applicable requirements."
      }
    ],
    "affordances": [
      "Resolve a cefmenoxime-labelled record or sample against a verified structure and form-specific identifiers.",
      "Calculate cefmenoxime parent-equivalent quantities when salt stoichiometry, water content and assay basis are established.",
      "Assess a lot against an explicitly selected cefmenoxime specification and flag missing or failed evidence.",
      "Compare stability and compatibility evidence for a proposed solvent, concentration and storage interval.",
      "Interpret antibacterial measurements within their organism and assay conditions.",
      "Route material to release, quarantine, further testing or documented disposal based on applicable evidence."
    ],
    "agent_conduct": {
      "may": [
        "Describe cefmenoxime's class, mechanism and clinical use from authoritative sources.",
        "Note that availability differs by country."
      ],
      "must_not": [
        "Recommend, dose or supply it to a person without a prescriber's decision.",
        "Advise its use for viral infections or without a confirmed need.",
        "Ignore a reported beta-lactam allergy.",
        "Overlook the risk of reactions with alcohol linked to its side chain."
      ],
      "requires_human": [
        "Any decision to start, stop or change antibiotic treatment."
      ]
    },
    "ethics": {
      "considerations": [
        "Unnecessary antibiotic use drives resistance that harms the wider community."
      ],
      "affected_parties": [
        "Patients",
        "Communities exposed to resistant bacteria",
        "Prescribers"
      ]
    },
    "owners": {
      "steward": "The marketing authorisation holder where it is licensed; the prescriber answers for each use.",
      "master_systems": [
        "National medicines registers"
      ]
    },
    "visual_identification": [
      "A powder for injection or an eye or ear preparation; identity is confirmed by label and pharmacy records."
    ],
    "failure_modes_and_hazards": [
      "Allergic reactions, including in people with penicillin allergy.",
      "Flushing and sickness when combined with alcohol.",
      "Bleeding tendency from effects on clotting."
    ],
    "what_it_is_for": [
      "Cefmenoxime is encountered in antibacterial medicine, pharmaceutical analysis and research on cephalosporin antibiotics.",
      "Material testing distinguishes the active compound and its pharmaceutical forms while assessing purity, stability and suitability for an intended use."
    ],
    "standards_and_regulation": [
      "The Anatomical Therapeutic Chemical classification, maintained by the World Health Organization Collaborating Centre for Drug Statistics Methodology, classifies cefmenoxime among third-generation cephalosporins."
    ]
  },
  "sources": [
    {
      "id": "wikidata",
      "title": "Wikidata item Q4921166: cefmenoxime",
      "url": "https://www.wikidata.org/wiki/Q4921166",
      "url_status": "live",
      "what_it_supports": "identity and sense of the item",
      "checked_by": "wikidata-api"
    },
    {
      "id": "wikipedia-en",
      "title": "Wikipedia: Cefmenoxime",
      "url": "https://en.wikipedia.org/wiki/Cefmenoxime",
      "url_status": "live",
      "what_it_supports": "general description of the item",
      "checked_by": "wikidata-api sitelink"
    }
  ],
  "structure": {
    "bundles": [
      {
        "id": "cefmenoxime-identity-and-boundaries",
        "name": "Cefmenoxime identity and boundaries",
        "description": "Establish which molecular entity and related material form a record denotes.",
        "rationale": "Similar antibiotic names and separately identified salts can otherwise produce false matches and incorrect quantity conversions.",
        "layers": [
          {
            "id": "molecular-recognition",
            "name": "Molecular recognition",
            "description": "Recognise cefmenoxime using its complete structure rather than antibiotic class alone.",
            "findings": [
              {
                "id": "structure-based-identity",
                "name": "Structure-based identity",
                "description": "Identity evidence should resolve the cephem stereochemistry, oxime configuration and substituents against an authoritative cefmenoxime reference.",
                "questions": [
                  {
                    "text": "Which authoritative structure specifies the stereochemistry and oxime configuration accepted for cefmenoxime?",
                    "kind": "definition",
                    "id": "structure-based-identity-q01"
                  },
                  {
                    "text": "Which analytical results distinguish this material from cefminox, other cephalosporins and cefmenoxime isomers?",
                    "kind": "measurement",
                    "id": "structure-based-identity-q02"
                  }
                ]
              }
            ]
          },
          {
            "id": "parent-and-salt-mapping",
            "name": "Parent and salt mapping",
            "description": "Keep related forms attached to the registered substance while preserving their chemical differences.",
            "findings": [
              {
                "id": "form-specific-identifiers",
                "name": "Form-specific identifiers",
                "description": "Each identifier and composition statement must identify whether it describes cefmenoxime itself or a specified salt, hydrate or solvate.",
                "questions": [
                  {
                    "text": "Does the supplied CAS, PubChem or EC identifier denote the parent, hydrochloride or another explicitly documented form?",
                    "kind": "boundary",
                    "id": "form-specific-identifiers-q01"
                  },
                  {
                    "text": "What source establishes the counterion ratio and hydration state used to convert this material to cefmenoxime equivalents?",
                    "kind": "provenance",
                    "id": "form-specific-identifiers-q02"
                  }
                ]
              }
            ]
          }
        ]
      },
      {
        "id": "cefmenoxime-lot-quality",
        "name": "Cefmenoxime lot quality",
        "description": "Determine the amount, integrity and intended-use suitability of cefmenoxime material.",
        "rationale": "Correct chemical naming does not establish assay strength, impurity control or suitability for a particular use.",
        "layers": [
          {
            "id": "assay-and-reference-basis",
            "name": "Assay and reference basis",
            "description": "Make reported cefmenoxime content traceable and comparable.",
            "findings": [
              {
                "id": "interpretable-cefmenoxime-assay",
                "name": "Interpretable cefmenoxime assay",
                "description": "Content measurements need a reference standard, validated method and explicit correction for chemical form and moisture.",
                "questions": [
                  {
                    "text": "Is the assay expressed as cefmenoxime parent equivalent, salt content, dry-basis content or as-received content?",
                    "kind": "measurement",
                    "id": "interpretable-cefmenoxime-assay-q01"
                  },
                  {
                    "text": "Which reference-standard lot and assigned potency support the reported result?",
                    "kind": "provenance",
                    "id": "interpretable-cefmenoxime-assay-q02"
                  }
                ]
              }
            ]
          },
          {
            "id": "impurities-and-grade",
            "name": "Impurities and grade",
            "description": "Connect impurity evidence to the specification required by the intended use.",
            "findings": [
              {
                "id": "grade-supported-by-results",
                "name": "Grade supported by results",
                "description": "Evaluate related substances, water, solvents and any required microbiological attributes against a named specification; antibiotic activity does not demonstrate sterility.",
                "questions": [
                  {
                    "text": "Which cefmenoxime-related impurities are identified, which remain unidentified, and what limits and response factors apply?",
                    "kind": "measurement",
                    "id": "grade-supported-by-results-q01"
                  },
                  {
                    "text": "Which documented grade requirements must this lot satisfy before the proposed analytical or pharmaceutical use?",
                    "kind": "action",
                    "id": "grade-supported-by-results-q02"
                  }
                ]
              }
            ]
          }
        ]
      },
      {
        "id": "cefmenoxime-physical-state-and-stability",
        "name": "Cefmenoxime physical state and stability",
        "description": "Describe the actual material state and evidence for retaining cefmenoxime quality over time.",
        "rationale": "Properties and storage conclusions must remain tied to the chemical form and preparation conditions that were tested.",
        "layers": [
          {
            "id": "solid-form-properties",
            "name": "Solid-form properties",
            "description": "Characterise cefmenoxime solids without borrowing constants from a different salt or hydration state.",
            "findings": [
              {
                "id": "conditioned-physical-properties",
                "name": "Conditioned physical properties",
                "description": "Attach solubility, water uptake and thermal observations to the characterised form and measurement conditions.",
                "questions": [
                  {
                    "text": "Which solid form and water content were present when solubility or thermal behaviour was measured?",
                    "kind": "measurement",
                    "id": "conditioned-physical-properties-q01"
                  },
                  {
                    "text": "Does the reported thermal event represent melting, solvent loss or decomposition, and what method supports that interpretation?",
                    "kind": "measurement",
                    "id": "conditioned-physical-properties-q02"
                  }
                ]
              }
            ]
          },
          {
            "id": "solution-integrity-over-time",
            "name": "Solution integrity over time",
            "description": "Evaluate cefmenoxime preparations using condition-specific chemical stability evidence.",
            "findings": [
              {
                "id": "validated-preparation-window",
                "name": "Validated preparation window",
                "description": "Any permitted preparation or holding interval should be supported by cefmenoxime assay and degradation measurements under matching conditions.",
                "questions": [
                  {
                    "text": "What cefmenoxime assay and impurity changes occur at the proposed pH, solvent, concentration, temperature and light exposure?",
                    "kind": "measurement",
                    "id": "validated-preparation-window-q01"
                  },
                  {
                    "text": "What evidence supports the proposed container, storage duration and acceptance criteria for this preparation?",
                    "kind": "action",
                    "id": "validated-preparation-window-q02"
                  }
                ]
              }
            ]
          }
        ]
      },
      {
        "id": "cefmenoxime-antibacterial-evidence",
        "name": "Cefmenoxime antibacterial evidence",
        "description": "Represent the evidence connecting cefmenoxime identity and integrity to measured antibacterial behaviour.",
        "rationale": "An antibiotic classification alone cannot establish the activity of a particular lot or susceptibility of a particular organism.",
        "layers": [
          {
            "id": "mechanism-evidence",
            "name": "Mechanism evidence",
            "description": "Separate cefmenoxime-specific experimental evidence from claims inherited from the broader antibiotic class.",
            "findings": [
              {
                "id": "target-and-resistance-context",
                "name": "Target and resistance context",
                "description": "Record the experimental basis for target interactions and resistance-related behaviour with the tested organism or enzyme.",
                "questions": [
                  {
                    "text": "Which primary studies directly establish cefmenoxime interactions with bacterial penicillin-binding proteins?",
                    "kind": "provenance",
                    "id": "target-and-resistance-context-q01"
                  },
                  {
                    "text": "Which measured resistance mechanisms or enzyme interactions limit the applicability of a cefmenoxime activity claim?",
                    "kind": "boundary",
                    "id": "target-and-resistance-context-q02"
                  }
                ]
              }
            ]
          },
          {
            "id": "activity-measurement-context",
            "name": "Activity measurement context",
            "description": "Keep susceptibility and potency observations tied to reproducible assay conditions.",
            "findings": [
              {
                "id": "bounded-activity-interpretation",
                "name": "Bounded activity interpretation",
                "description": "Activity records require organism identity, method, controls and concentration basis; clinical interpretation requires separate applicable evidence.",
                "questions": [
                  {
                    "text": "What strain, medium, inoculum, endpoint and cefmenoxime concentration basis produced this MIC or potency result?",
                    "kind": "measurement",
                    "id": "bounded-activity-interpretation-q01"
                  },
                  {
                    "text": "Is a current cefmenoxime-specific interpretive criterion available for this organism and method, or must the result remain uninterpreted?",
                    "kind": "boundary",
                    "id": "bounded-activity-interpretation-q02"
                  }
                ]
              }
            ]
          }
        ]
      },
      {
        "id": "cefmenoxime-handling-and-use-controls",
        "name": "Cefmenoxime handling and use controls",
        "description": "Connect substance handling and release decisions to form-specific safety and regulatory evidence.",
        "rationale": "Neither antibiotic identity nor a supplier catalogue listing establishes handling requirements or authorisation for medicinal use.",
        "layers": [
          {
            "id": "hazard-and-exposure-evidence",
            "name": "Hazard and exposure evidence",
            "description": "Identify documented hazards and controls for the actual cefmenoxime material being handled.",
            "findings": [
              {
                "id": "applicable-safety-record",
                "name": "Applicable safety record",
                "description": "Use a current, applicable safety record to establish classification, exposure controls and disposal requirements without inventing absent limits.",
                "questions": [
                  {
                    "text": "Which SDS revision covers this cefmenoxime form and reports its GHS classification and sensitisation-related precautions?",
                    "kind": "provenance",
                    "id": "applicable-safety-record-q01"
                  },
                  {
                    "text": "What documented exposure limits, containment measures and antibiotic-waste procedures apply to the proposed operation?",
                    "kind": "action",
                    "id": "applicable-safety-record-q02"
                  }
                ]
              }
            ]
          },
          {
            "id": "use-eligibility-and-disposition",
            "name": "Use eligibility and disposition",
            "description": "Keep substance recognition separate from decisions to release a lot for a regulated or research use.",
            "findings": [
              {
                "id": "evidence-backed-release",
                "name": "Evidence-backed release",
                "description": "Disposition depends on intended use, jurisdiction, quality results and storage history; product authorisations remain linked external records.",
                "questions": [
                  {
                    "text": "Which current specification or regulatory record establishes requirements for this cefmenoxime material in the intended jurisdiction and use?",
                    "kind": "provenance",
                    "id": "evidence-backed-release-q01"
                  },
                  {
                    "text": "Do the lot results and storage history support release, or is quarantine, retesting or rejection required?",
                    "kind": "action",
                    "id": "evidence-backed-release-q02"
                  }
                ]
              }
            ]
          }
        ]
      },
      {
        "id": "evidence-and-external-alignment",
        "name": "Evidence and external alignment",
        "description": "What the world already says about this thing, gathered so the model can be checked against it.",
        "rationale": "A model that cannot be lined up against existing standards, identifiers and practice cannot be adopted by anyone who already uses them.",
        "layers": [
          {
            "id": "reported-evidence",
            "name": "Reported evidence",
            "description": "Findings from the breadth pass, kept separate from the structural claims.",
            "findings": [
              {
                "id": "evidence-confidence-notes",
                "name": "Check these first",
                "description": "Recalled without web access and unsourced; every item is a lead to verify.",
                "evidence": [
                  "This description is recalled knowledge; no sources were consulted.",
                  "Verify exact CAS and PubChem identifiers, salt stoichiometry and applicable pharmacopoeial monographs before assigning regulatory identity.",
                  "Physicochemical constants, purity specifications, GHS classification and jurisdiction-specific authorization have not been established here."
                ],
                "questions": [
                  {
                    "id": "evidence-confidence-notes-q01",
                    "text": "Which of these check these first hold for the sense of cefmenoxime this model covers, and on what evidence?",
                    "kind": "provenance"
                  }
                ]
              },
              {
                "id": "evidence-kinds",
                "name": "Kinds and varieties",
                "description": "Recalled without web access and unsourced; every item is a lead to verify.",
                "evidence": [
                  "Cefmenoxime parent compound",
                  "Cefmenoxime hydrochloride salt"
                ],
                "questions": [
                  {
                    "id": "evidence-kinds-q01",
                    "text": "Which of these kinds and varieties hold for the sense of cefmenoxime this model covers, and on what evidence?",
                    "kind": "provenance"
                  }
                ]
              },
              {
                "id": "evidence-identifiers",
                "name": "Identifiers and schemes",
                "description": "Recalled without web access and unsourced; every item is a lead to verify.",
                "evidence": [
                  {
                    "scheme": "International Nonproprietary Name (INN)",
                    "value_or_pattern": "cefmenoxime",
                    "note": "Names the active substance; salt forms and formulated products require additional specification."
                  },
                  {
                    "scheme": "CAS Registry Number",
                    "value_or_pattern": "digits-digits-check digit",
                    "note": "The parent compound and hydrochloride salt require distinct identity checks; no numerical identifier is asserted here."
                  }
                ],
                "questions": [
                  {
                    "id": "evidence-identifiers-q01",
                    "text": "Which of these identifiers and schemes hold for the sense of cefmenoxime this model covers, and on what evidence?",
                    "kind": "provenance"
                  }
                ]
              },
              {
                "id": "evidence-real-world-use",
                "name": "Real-world use",
                "description": "Recalled without web access and unsourced; every item is a lead to verify.",
                "evidence": [
                  "Active ingredient in antibacterial medicines for infections caused by susceptible bacteria.",
                  "Reference substance in analytical testing and antimicrobial susceptibility research."
                ],
                "questions": [
                  {
                    "id": "evidence-real-world-use-q01",
                    "text": "Which of these real-world use hold for the sense of cefmenoxime this model covers, and on what evidence?",
                    "kind": "provenance"
                  }
                ]
              },
              {
                "id": "evidence-measurements",
                "name": "Typical measurements",
                "description": "Recalled without web access and unsourced; every item is a lead to verify.",
                "evidence": [
                  {
                    "quantity": "Minimum inhibitory concentration against a specified bacterial isolate",
                    "typical_range": "Dependent on organism, resistance mechanisms and test method; no universal range.",
                    "unit": "mg/L"
                  }
                ],
                "questions": [
                  {
                    "id": "evidence-measurements-q01",
                    "text": "Which of these typical measurements hold for the sense of cefmenoxime this model covers, and on what evidence?",
                    "kind": "provenance"
                  }
                ]
              },
              {
                "id": "evidence-failure-modes-and-hazards",
                "name": "Failure modes and hazards",
                "description": "Recalled without web access and unsourced; every item is a lead to verify.",
                "evidence": [
                  "Bacterial resistance can result from beta-lactamase activity, altered penicillin-binding proteins or reduced access to the bacterial target.",
                  "Beta-lactam hypersensitivity reactions, including anaphylaxis, can occur.",
                  "Antibiotic-associated disruption of intestinal flora can lead to Clostridioides difficile infection.",
                  "Its N-methylthiotetrazole side chain is associated with potential hypoprothrombinemia and alcohol-related disulfiram-like reactions.",
                  "Hydrolysis of the beta-lactam ring can reduce potency; stability depends on formulation and storage conditions."
                ],
                "questions": [
                  {
                    "id": "evidence-failure-modes-and-hazards-q01",
                    "text": "Which of these failure modes and hazards hold for the sense of cefmenoxime this model covers, and on what evidence?",
                    "kind": "provenance"
                  }
                ]
              },
              {
                "id": "evidence-regional-variation",
                "name": "Regional variation",
                "description": "Recalled without web access and unsourced; every item is a lead to verify.",
                "evidence": [
                  "Marketing authorization, available formulations and approved indications depend on jurisdiction."
                ],
                "questions": [
                  {
                    "id": "evidence-regional-variation-q01",
                    "text": "Which of these regional variation hold for the sense of cefmenoxime this model covers, and on what evidence?",
                    "kind": "provenance"
                  }
                ]
              },
              {
                "id": "evidence-neighbours",
                "name": "Neighbouring kinds and how to tell them apart",
                "description": "Recalled without web access and unsourced; every item is a lead to verify.",
                "evidence": [
                  {
                    "name": "Cefotaxime",
                    "difference": "A related third-generation cephalosporin distinguished by its substituent at position 3 of the cephem nucleus."
                  },
                  {
                    "name": "Cefmenoxime hydrochloride",
                    "difference": "A salt form of cefmenoxime, distinguished from the parent compound by counterion content and salt stoichiometry."
                  },
                  {
                    "name": "Cefmenoxime medicinal product",
                    "difference": "A formulated preparation containing the active substance plus specified excipients, strength and dosage form."
                  }
                ],
                "questions": [
                  {
                    "id": "evidence-neighbours-q01",
                    "text": "Which of these neighbouring kinds and how to tell them apart hold for the sense of cefmenoxime this model covers, and on what evidence?",
                    "kind": "provenance"
                  }
                ]
              }
            ]
          }
        ]
      }
    ]
  },
  "openQuestions": [
    "Which authoritative CAS and EC records apply to cefmenoxime parent and the relevant hydrochloride forms, and how do they distinguish stoichiometry and hydration?",
    "Which current cefmenoxime monographs or validated specifications define assay, related substances, reference standards and grade-dependent acceptance limits?",
    "What experimentally supported solid-form, solubility, thermal and solution-stability data exist for each relevant cefmenoxime form?",
    "Which current jurisdiction-specific SDS classifications and occupational exposure limits, if any, apply to the actual supplied material?",
    "Which primary cefmenoxime activity studies and current susceptibility standards support organism-specific interpretation without extrapolation from other cephalosporins?"
  ],
  "statistics": {
    "bundles": 6,
    "layers": 11,
    "findings": 18,
    "questions": 28
  }
}
