{
  "vercy": "1.0-draft",
  "publication": {
    "status": "research-draft",
    "adjudicationStatus": "unreviewed",
    "publishableCanonical": false,
    "generatedAt": "2026-09-12T00:23:59Z",
    "providers": [
      "Claude"
    ],
    "breadth": "written by Claude from model knowledge without web access - no source was read, every claim is a lead to verify",
    "pass": 2,
    "wave": 2,
    "engine": "claude",
    "enrichment": {
      "pass": 3,
      "engine": "claude",
      "producedAt": "2026-10-05T23:50:00Z",
      "ingestedAt": "2026-10-05T20:48:05+00:00",
      "fields": [
        "agent_conduct",
        "ethics",
        "owners"
      ]
    },
    "gate": {
      "passed": true,
      "version": "1.0",
      "at": "2026-10-07T10:10:31+00:00",
      "evidence": [
        "completeness 1.00",
        "sense: Wikidata description",
        "2 live sources",
        "review by codex: pass"
      ]
    }
  },
  "metaModel": {
    "id": "THING-Q56296907",
    "registryId": "vr.tr.aporphine-alkaloids",
    "name": "aporphine alkaloids",
    "version": "0.2.0-wave.2",
    "entryKind": "thing",
    "family": "Thing Registry",
    "domain": [
      "PHY.MAT"
    ],
    "status": "research-draft"
  },
  "canonicalUrl": "https://ver.cy/models/thing/q56296907/",
  "model": {
    "registry_id": "vr.tr.aporphine-alkaloids",
    "name": "aporphine alkaloids",
    "purpose": "Let an agent explain aporphine alkaloids as a chemical class, describe their plant sources and biosynthesis, summarise documented biological activities with attribution, and route medicinal questions to professionals.",
    "definition": "A class of isoquinoline alkaloids with a tetracyclic aporphine skeleton, found in plants of families such as Annonaceae, Lauraceae, Magnoliaceae and Papaveraceae, including compounds such as laurotetanine, luteanine, glaucine, boldine and nuciferine; aporphine alkaloids show diverse biological activities studied in pharmacology and natural products chemistry, some are used in traditional medicine and a few in licensed medicines, and this entry gives general information only.",
    "what_it_is_for": "Alkaloids with the aporphine skeleton.",
    "affordances": [
      "explain the chemical class",
      "describe sources and biosynthesis",
      "summarise activities with attribution",
      "route medicinal questions"
    ],
    "distinguishing_features": [
      "Aporphine skeleton",
      "Plant origin",
      "Diverse activities",
      "Research interest"
    ],
    "appearance": "Not physical as a class; crystalline compounds in the laboratory.",
    "visual_identification": [
      "Tetracyclic aporphine skeleton",
      "Isoquinoline origin",
      "Morphinan alkaloids have a different skeleton"
    ],
    "physical_properties": [
      {
        "quantity": "Molar mass",
        "unit": "g/mol",
        "typical_range": "",
        "note": "Calculate the value from the molecular formula of the identified compound, specifying any salt or solvate form."
      },
      {
        "quantity": "Melting temperature",
        "unit": "degrees Celsius",
        "typical_range": "",
        "note": "Measure the identified solid using capillary melting analysis or differential scanning calorimetry, recording decomposition where observed."
      },
      {
        "quantity": "Solubility",
        "unit": "g/L",
        "typical_range": "",
        "note": "Measure the dissolved concentration at equilibrium while specifying the compound form, solvent, temperature and pH."
      }
    ],
    "families_and_kinds": [
      "simple aporphines such as nuciferine",
      "oxoaporphines",
      "dehydroaporphines and proaporphines",
      "dimeric aporphines",
      "aporphines used in medicines such as glaucine"
    ],
    "related_models": [
      {
        "relation": "is a kind of",
        "target": "isoquinoline alkaloid",
        "why": "category"
      },
      {
        "relation": "is related to",
        "target": "morphinan alkaloid",
        "why": "another isoquinoline-derived class"
      },
      {
        "relation": "is related to",
        "target": "alternative medicine",
        "why": "traditional uses"
      },
      {
        "relation": "is related to",
        "target": "gene expression",
        "why": "biosynthetic regulation"
      }
    ],
    "identifiers": [],
    "standards_and_regulation": [
      "Pharmacopoeial standards for compounds used in medicines",
      "Herbal medicine regulation",
      "Chemical nomenclature conventions"
    ],
    "failure_modes_and_hazards": [
      "Toxicity of some compounds",
      "Unproven medicinal claims",
      "Confusing alkaloid classes"
    ],
    "in_scope": [],
    "out_of_scope": [],
    "characteristics": [],
    "agent_conduct": {
      "may": [
        "Describe the aporphine class, its plant sources and representative compounds at reference level.",
        "Distinguish aporphines from other isoquinoline alkaloid classes."
      ],
      "must_not": [
        "Recommend aporphine-containing plants or compounds as remedies.",
        "Advise on dosing or preparing any compound in the class.",
        "Repeat unproven medicinal claims as established."
      ],
      "requires_human": [
        "Any decision to use a compound from this class on a person or animal."
      ]
    },
    "ethics": {
      "considerations": [
        "Some aporphines are toxic or psychoactive; unproven claims put people at risk."
      ],
      "affected_parties": [
        "People using herbal products",
        "Researchers"
      ]
    },
    "owners": {
      "steward": "Nobody owns the class; medicine regulators control compounds approved as drugs.",
      "master_systems": []
    }
  },
  "sources": [
    {
      "id": "wikidata",
      "title": "Wikidata item Q56296907: aporphine alkaloids",
      "url": "https://www.wikidata.org/wiki/Q56296907",
      "url_status": "live",
      "what_it_supports": "identity and sense of the item",
      "checked_by": "wikidata-api"
    },
    {
      "id": "wikipedia-en",
      "title": "Wikipedia: Aporphine alkaloids",
      "url": "https://en.wikipedia.org/wiki/Aporphine_alkaloids",
      "url_status": "live",
      "what_it_supports": "general description of the item",
      "checked_by": "wikidata-api sitelink"
    }
  ],
  "structure": {
    "bundles": [
      {
        "id": "understand",
        "name": "Understand",
        "description": "The chemical class.",
        "rationale": "Chemistry.",
        "layers": [
          {
            "id": "structure",
            "name": "Structure",
            "description": "Skeleton and subclasses.",
            "findings": [
              {
                "id": "structure-finding",
                "name": "Structure",
                "description": "Structure.",
                "questions": [
                  {
                    "text": "What is the aporphine skeleton, and how do simple, oxo, dehydro and dimeric aporphines differ?",
                    "kind": "definition"
                  },
                  {
                    "text": "Which entry fits a specific compound?",
                    "kind": "action"
                  }
                ]
              }
            ]
          },
          {
            "id": "sources",
            "name": "Sources",
            "description": "Plant sources and biosynthesis.",
            "findings": [
              {
                "id": "sources-finding",
                "name": "Sources",
                "description": "Sources.",
                "questions": [
                  {
                    "text": "Which plants produce aporphine alkaloids, and how are they biosynthesised from benzylisoquinoline precursors?",
                    "kind": "provenance"
                  },
                  {
                    "text": "Which entry fits a specific plant?",
                    "kind": "action"
                  }
                ]
              }
            ]
          }
        ]
      },
      {
        "id": "activity",
        "name": "Activity",
        "description": "Biological activity.",
        "rationale": "Attribution.",
        "layers": [
          {
            "id": "pharmacology",
            "name": "Pharmacology",
            "description": "Documented activities.",
            "findings": [
              {
                "id": "pharmacology-finding",
                "name": "Pharmacology",
                "description": "Pharmacology.",
                "questions": [
                  {
                    "text": "What biological activities of aporphine alkaloids are documented in research, and how strong is the evidence?",
                    "kind": "provenance"
                  },
                  {
                    "text": "Which findings are preliminary?",
                    "kind": "boundary"
                  }
                ]
              }
            ]
          },
          {
            "id": "medicine",
            "name": "Medicine",
            "description": "Medicinal use.",
            "findings": [
              {
                "id": "medicine-finding",
                "name": "Medicine",
                "description": "Medicine.",
                "questions": [
                  {
                    "text": "Which aporphines are used in licensed or traditional medicines, and what do regulators say?",
                    "kind": "provenance"
                  },
                  {
                    "text": "Is the user asking about their own use of a herbal product, which needs a professional?",
                    "kind": "boundary"
                  }
                ]
              }
            ]
          }
        ]
      },
      {
        "id": "analyse",
        "name": "Analyse",
        "description": "Analysis and research.",
        "rationale": "Practice.",
        "layers": [
          {
            "id": "methods",
            "name": "Methods",
            "description": "Analytical methods.",
            "findings": [
              {
                "id": "methods-finding",
                "name": "Methods",
                "description": "Methods.",
                "questions": [
                  {
                    "text": "How are aporphine alkaloids isolated, identified and quantified?",
                    "kind": "provenance"
                  },
                  {
                    "text": "Which databases document them?",
                    "kind": "provenance"
                  }
                ]
              }
            ]
          },
          {
            "id": "toxicity",
            "name": "Toxicity",
            "description": "Toxicity.",
            "findings": [
              {
                "id": "toxicity-finding",
                "name": "Toxicity",
                "description": "Toxicity.",
                "questions": [
                  {
                    "text": "Which aporphine alkaloids are toxic, and what safety data exist?",
                    "kind": "provenance"
                  },
                  {
                    "text": "Is a poisoning emergency present, requiring a poison centre?",
                    "kind": "boundary"
                  }
                ]
              }
            ]
          }
        ]
      },
      {
        "id": "learn",
        "name": "Learn",
        "description": "History and teaching.",
        "rationale": "Education.",
        "layers": [
          {
            "id": "history",
            "name": "History",
            "description": "History.",
            "findings": [
              {
                "id": "history-finding",
                "name": "History",
                "description": "History.",
                "questions": [
                  {
                    "text": "How were aporphine alkaloids discovered and characterised?",
                    "kind": "provenance"
                  },
                  {
                    "text": "Which references are standard?",
                    "kind": "provenance"
                  }
                ]
              }
            ]
          },
          {
            "id": "teach",
            "name": "Teach",
            "description": "Teaching.",
            "findings": [
              {
                "id": "teach-finding",
                "name": "Teach",
                "description": "Teaching.",
                "questions": [
                  {
                    "text": "How can alkaloid classes be taught in natural products chemistry?",
                    "kind": "action"
                  },
                  {
                    "text": "Which misconceptions arise?",
                    "kind": "provenance"
                  }
                ]
              }
            ]
          }
        ]
      }
    ]
  },
  "openQuestions": [
    "Should each compound be a separate entry?",
    "How should natural product databases be linked?",
    "How should herbal regulation be linked?"
  ],
  "statistics": {
    "bundles": 4,
    "layers": 8,
    "findings": 8,
    "questions": 16
  }
}