{ "vercy": "1.0-draft", "publication": { "status": "research-draft", "adjudicationStatus": "unreviewed", "publishableCanonical": false, "generatedAt": "2026-09-12T12:01:40Z", "providers": [ "Codex" ], "breadth": "recalled by Codex without web access - no source was read", "missingProviders": [], "pass": 2, "cost": { "grok": { "seconds": 18.4, "error": "Reading additional input from stdin...\nOpenAI Codex v0.153.4\n--------\nworkdir: R:\\02_PROJECTS\\02_Meta_Models_Platforms\\Ver.cy\\current\\thing-registry-backlog\nmodel: gpt-6-astra\nprovider: openai\napproval: never\nsandbox: read-only\nreasoning effort: none\nreasoning summaries: none\nsession id: 01a0957d-794f-7273-b455-e3bc86221426\n--------\nuser\nDescribe what is already known about one registered thing. Answer as JSON only, no prose around it.\n\nThing: perospirone\nSense to describe: (none recorded)\nDomain code: PHY.MAT\nAlso known as: (none)\n\n\nContext for this batch of 1001 things:\n# Batch 044: 1001 reg", "usd": 0.0, "recall": true }, "codex": { "seconds": 76.8, "error": "Reading additional input from stdin...\nOpenAI Codex v0.153.4\n--------\nworkdir: R:\\02_PROJECTS\\02_Meta_Models_Platforms\\Ver.cy\\current\\thing-registry-backlog\nmodel: gpt-6-astra\nprovider: openai\napproval: never\nsandbox: read-only\nreasoning effort: none\nreasoning summaries: none\nsession id: 01a0957d-7945-7bf3-b125-a49be87affb1\n--------\nuser\nYou are drafting a Vercy meta-model for one registered thing. Answer as JSON only, no prose around it.\n\nThing: perospirone\nRegistry id: vr.tr.perospirone\nPlane / domain: PHY / PHY.MAT\nRegistry definition: (none recorded)\nNames folded into this entry: (none)\n\n\n" } }, "enrichment": { "pass": 3, "engine": "claude", "producedAt": "2026-10-06T12:00:00Z", "ingestedAt": "2026-10-06T08:54:24+00:00", "fields": [ "agent_conduct", "ethics", "failure_modes_and_hazards", "owners", "visual_identification" ] }, "gate": { "passed": true, "version": "1.0", "at": "2026-10-07T10:10:32+00:00", "evidence": [ "completeness 1.00", "sense: Wikidata description", "2 live sources", "review by codex: pass" ] } }, "metaModel": { "id": "THING-Q6590349", "registryId": "vr.tr.perospirone", "name": "perospirone", "version": "0.1.0-research.1", "entryKind": "thing", "family": "Thing Registry", "domain": [ "PHY.MAT" ], "status": "research-draft" }, "canonicalUrl": "https://ver.cy/models/thing/q6590349/", "model": { "registry_id": "vr.tr.perospirone", "name": "perospirone", "purpose": "Enable an AI agent to recognise perospirone, assess the identity and condition of a particular material, and determine whether evidence supports its proposed analytical, research or pharmaceutical use.", "definition": "Perospirone is a synthetic small-molecule atypical antipsychotic whose pharmacological activity includes dopamine D2 and serotonin 5-HT2A receptor antagonism and serotonin 5-HT1A receptor partial agonism.", "scope_statement": "This model owns the substance identity of perospirone under vr.tr.perospirone in PHY / PHY.MAT, including explicit relationships to its hydrochloride and hydrated forms, material quality, biological activity and constraints on handling and use.", "in_scope": [ "Molecular identity, stereochemistry and identifiers qualified by chemical form", "Free-base, hydrochloride and hydrate distinctions within the registered substance boundary", "Composition, purity, solid state and condition of perospirone samples", "Measured physicochemical properties and analytical identification", "Evidence connecting perospirone to biological activity and permitted material uses" ], "out_of_scope": [ "Finished tablets, brands, packaging and excipient formulations", "Patient diagnosis, prescribing, dosing and treatment selection", "Manufacturing routes and production equipment", "Schizophrenia and other disease models", "Metabolites and impurities as independently characterised substances" ], "distinguishing_features": [ "Match the molecular structure and stereochemistry, using the free-base formula C23H30N4O2S and PubChem CID 115368 as corroborating identifiers rather than sufficient proof of identity. [PubChem](https://pubchem.ncbi.nlm.nih.gov/compound/Perospirone)", "Separate the parent substance from hydrochloride and hydrated hydrochloride records; their identifiers and formula masses are not interchangeable. [PubChem hydrochloride](https://pubchem.ncbi.nlm.nih.gov/compound/Perospirone-hydrochloride), [PubChem hydrate](https://pubchem.ncbi.nlm.nih.gov/compound/5282504)", "Require structural and analytical agreement to distinguish perospirone from similarly named antipsychotics or structurally related compounds; a pharmacological class label does not establish identity.", "Distinguish active-substance mass from tablet strength: the cited Japanese product contains 17.24 mg hydrated hydrochloride for a strength expressed as 16 mg perospirone hydrochloride. [PMDA product information](https://www.pmda.go.jp/PmdaSearch/iyakuDetail/ResultDataSetPDF/672173_1179043F1040_2_05)" ], "characteristics": [ { "name": "Chemical form and identifier agreement", "kind": "category", "unit_or_values": "Free base | hydrochloride | hydrochloride hydrate | unresolved; form-qualified CAS, PubChem and other identifiers", "why_it_matters": "Prevents identity matches and calculations from silently mixing parent, salt and hydrate records." }, { "name": "Molecular structure and stereochemical specification", "kind": "category", "unit_or_values": "Structure identifier with explicit stereochemical specification and supporting evidence", "why_it_matters": "Separates genuine perospirone identity from an approximate name or shared molecular formula." }, { "name": "Assay and reporting basis", "kind": "measurement", "unit_or_values": "% m/m or mg/g; as received, dried or anhydrous; expressed as specified chemical form", "why_it_matters": "Makes potency comparisons and preparation calculations interpretable." }, { "name": "Water and counterion content", "kind": "measurement", "unit_or_values": "% m/m water; mol H2O/mol substance; mol chloride/mol parent", "why_it_matters": "Tests the declared salt or hydrate composition and supports mass-basis conversion." }, { "name": "Solid-state identity", "kind": "state", "unit_or_values": "Crystalline form or amorphous state, phase mixture, hydrate state or unresolved", "why_it_matters": "Allows changes in the actual material to be distinguished from changes in molecular identity." }, { "name": "Solubility and thermal behaviour", "kind": "measurement", "unit_or_values": "Solubility in mg/mL or mol/L with solvent, pH and temperature; thermal events in °C with method and event assignment", "why_it_matters": "Supports sample preparation while avoiding confusion between melting, dehydration and decomposition." }, { "name": "Impurity profile", "kind": "measurement", "unit_or_values": "Named and unknown impurities in % m/m or explicitly qualified chromatographic area %; residual solvents in ppm", "why_it_matters": "Determines whether a batch meets its intended-use specification." }, { "name": "Biological activity evidence", "kind": "relation", "unit_or_values": "Target, assay, species, material form, functional response and potency with units", "why_it_matters": "Separates receptor binding from functional effects and clinical conclusions." }, { "name": "Use and handling status", "kind": "state", "unit_or_values": "Intended use, grade, jurisdiction, dated authority, applicable safety document and release status", "why_it_matters": "Prevents research-material availability or a product authorisation from being treated as unrestricted permission to use a particular sample." } ], "affordances": [ "Resolve a perospirone name or identifier to a structure and explicitly qualified chemical form.", "Compare sample evidence with a perospirone reference standard and intended-use specification.", "Calculate equivalent quantities between characterised forms using verified water content, stoichiometry and assay basis.", "Select a supported analytical preparation from form-specific solubility and stability evidence.", "Flag uncertain identity, degradation or missing release evidence for review before use." ], "agent_conduct": { "may": [ "Describe perospirone and its approved uses from medicines information.", "Report that it is authorized only in some countries and name the source." ], "must_not": [ "Recommend it, a dose or a switch of medicine for a person.", "Supply it outside the regulated prescription chain or across borders without authorization.", "Advise stopping it abruptly.", "Label a person as mentally ill because they take it." ], "requires_human": [ "Starting, stopping or changing a person's antipsychotic treatment." ] }, "ethics": { "considerations": [ "People with schizophrenia face stigma and may be treated without their full consent.", "Antipsychotics have serious side effects that need monitoring." ], "affected_parties": [ "Patients and their families", "Prescribers and carers" ] }, "owners": { "steward": "The marketing authorization holder; medicines regulators and prescribers control its use.", "master_systems": [ "Medicines regulators' product registers" ] }, "visual_identification": [ "Supplied as tablets; identified by label and imprint, not appearance." ], "failure_modes_and_hazards": [ "Can cause movement disorders, sedation and other adverse effects." ], "what_it_is_for": [ "Perospirone is encountered in pharmaceutical research, analytical testing and medicinal products used in psychiatric care in Japan.", "Laboratories distinguish the parent compound from its salts and formulated products when assessing identity, purity and suitability for a specified use." ], "standards_and_regulation": [ "Japan's Act on Securing Quality, Efficacy and Safety of Products Including Pharmaceuticals and Medical Devices, enacted by the National Diet and administered by the Ministry of Health, Labour and Welfare, governs perospirone medicinal products in Japan." ] }, "sources": [ { "id": "wikidata", "title": "Wikidata item Q6590349: perospirone", "url": "https://www.wikidata.org/wiki/Q6590349", "url_status": "live", "what_it_supports": "identity and sense of the item", "checked_by": "wikidata-api" }, { "id": "wikipedia-en", "title": "Wikipedia: Perospirone", "url": "https://en.wikipedia.org/wiki/Perospirone", "url_status": "live", "what_it_supports": "general description of the item", "checked_by": "wikidata-api sitelink" } ], "structure": { "bundles": [ { "id": "perospirone-identity", "name": "Perospirone identity and form boundary", "description": "Establish what the registry name denotes and which material form a record describes.", "rationale": "Parent, salt, hydrate and product names can otherwise collapse into one misleading identity.", "layers": [ { "id": "parent-structure", "name": "Parent structure", "description": "Anchor perospirone to molecular and stereochemical evidence.", "findings": [ { "id": "structure-qualified-identity", "name": "Structure-qualified identity", "description": "An identity assertion should connect the registry entry to a structure, its stereochemical specification and identifiers from an inspected authority.", "questions": [ { "text": "Which molecular structure and stereochemical specification define perospirone for this registry entry?", "kind": "definition", "id": "structure-qualified-identity-q01" }, { "text": "Which inspected authority supports each identifier, and does that identifier denote the parent or a salt?", "kind": "provenance", "id": "structure-qualified-identity-q02" } ] } ] }, { "id": "salt-hydrate-boundary", "name": "Salt and hydrate boundary", "description": "Keep chemically related forms explicit without automatically creating new registry things.", "findings": [ { "id": "declared-material-form", "name": "Declared material form", "description": "Each sample needs a declared form and evidence for its counterion and hydration state before formula masses or assay values are reused.", "questions": [ { "text": "Does this sample contain perospirone free base, hydrochloride or a characterised hydrated hydrochloride?", "kind": "boundary", "id": "declared-material-form-q01" }, { "text": "What measurements establish chloride stoichiometry and water content rather than merely repeating the supplier name?", "kind": "measurement", "id": "declared-material-form-q02" } ] } ] } ] }, { "id": "perospirone-material-state", "name": "Perospirone material state", "description": "Describe the physical form and condition under which measured properties apply.", "rationale": "Solubility and thermal observations are unusable if their salt, hydration state or measurement conditions are missing.", "layers": [ { "id": "solid-form-water", "name": "Solid form and water", "description": "Connect phase identity with hydration and environmental history.", "findings": [ { "id": "phase-assignment", "name": "Evidence for phase assignment", "description": "Record a solid-form assignment only with supporting measurements and relevant temperature and humidity conditions.", "questions": [ { "text": "What diffraction, thermal or spectroscopic evidence identifies the solid form of this perospirone sample?", "kind": "measurement", "id": "phase-assignment-q01" }, { "text": "Does measured water represent lattice hydration, adsorbed moisture or an unresolved combination?", "kind": "boundary", "id": "phase-assignment-q02" } ] } ] }, { "id": "preparation-properties", "name": "Properties for sample preparation", "description": "Make dissolution and thermal data usable for a specified material form.", "findings": [ { "id": "condition-qualified-properties", "name": "Condition-qualified properties", "description": "Solubility and thermal values require the tested form, method and conditions; decomposition must not be reported as an ordinary boiling or melting point.", "questions": [ { "text": "What solubility is measured for the specified form at the proposed solvent composition, pH and temperature?", "kind": "measurement", "id": "condition-qualified-properties-q01" }, { "text": "Which observed thermal events represent melting, water loss or decomposition, and what evidence separates them?", "kind": "measurement", "id": "condition-qualified-properties-q02" } ] } ] } ] }, { "id": "perospirone-analytical-quality", "name": "Perospirone analytical quality", "description": "Determine whether a sample is correctly identified and suitable for its declared purpose.", "rationale": "A perospirone label or chromatographic peak alone cannot establish identity, potency and acceptable impurity levels.", "layers": [ { "id": "identity-assay", "name": "Identity and assay", "description": "Relate analytical results to qualified standards and explicit mass conventions.", "findings": [ { "id": "traceable-assay-basis", "name": "Traceable assay basis", "description": "Record reference-standard qualification, method specificity and whether results refer to parent, hydrochloride or hydrated material.", "questions": [ { "text": "Which reference standard and independent identity checks support the perospirone assignment?", "kind": "provenance", "id": "traceable-assay-basis-q01" }, { "text": "Is the assay expressed as parent, hydrochloride or hydrate, and on what moisture basis?", "kind": "measurement", "id": "traceable-assay-basis-q02" } ] } ] }, { "id": "impurities-stability", "name": "Impurities and stability", "description": "Separate initial purity from deterioration during storage or preparation.", "findings": [ { "id": "fitness-for-intended-use", "name": "Fitness for intended use", "description": "Sample acceptance should depend on a stated specification and evidence that analytical methods distinguish perospirone from relevant impurities and degradation products.", "questions": [ { "text": "Which related substances, residual solvents and unknown peaks are controlled by the applicable specification?", "kind": "measurement", "id": "fitness-for-intended-use-q01" }, { "text": "What stability evidence supports using this batch or prepared solution after its recorded storage history?", "kind": "action", "id": "fitness-for-intended-use-q02" } ] } ] } ] }, { "id": "perospirone-biological-activity", "name": "Perospirone biological activity", "description": "Represent biological evidence without turning the substance model into treatment guidance.", "rationale": "An antipsychotic classification cannot substitute for target-specific assays or distinguish parent effects from metabolite effects.", "layers": [ { "id": "target-evidence", "name": "Target evidence", "description": "Organise investigations of dopamine and serotonin receptor activity.", "findings": [ { "id": "binding-functional-distinction", "name": "Binding versus functional activity", "description": "Assess reported D2, 5-HT2A and 5-HT1A activity using separate binding and functional evidence, with conditions attached to every numerical result.", "questions": [ { "text": "Which primary experiments establish perospirone activity at D2, 5-HT2A and 5-HT1A receptors?", "kind": "provenance", "id": "binding-functional-distinction-q01" }, { "text": "Does each reported value measure affinity, inhibition or functional efficacy, in which species and assay system?", "kind": "measurement", "id": "binding-functional-distinction-q02" } ] } ] }, { "id": "parent-metabolite-boundary", "name": "Parent and metabolite boundary", "description": "Keep measured parent exposure and effects distinct from those of transformation products.", "findings": [ { "id": "analyte-specific-evidence", "name": "Analyte-specific evidence", "description": "An exposure or activity claim must identify the measured chemical entity; metabolites remain related substances rather than alternate names for perospirone.", "questions": [ { "text": "Does the cited experiment measure parent perospirone, a metabolite or a combined signal?", "kind": "boundary", "id": "analyte-specific-evidence-q01" }, { "text": "What analytical evidence shows that the method separates parent perospirone from relevant metabolites?", "kind": "provenance", "id": "analyte-specific-evidence-q02" } ] } ] } ] }, { "id": "perospirone-use-controls", "name": "Perospirone handling and use controls", "description": "Connect a particular material to supported handling conditions and jurisdiction-specific use constraints.", "rationale": "Bulk substance hazards, pharmaceutical quality and finished-product authorisations answer different operational questions.", "layers": [ { "id": "material-handling", "name": "Material handling", "description": "Use safety evidence applicable to the actual form and operation.", "findings": [ { "id": "form-specific-safety", "name": "Form-specific safety evidence", "description": "Record documented classifications and handling controls with their source and applicability; missing information remains unknown.", "questions": [ { "text": "Which current safety document applies to this perospirone form, concentration and supplier material?", "kind": "provenance", "id": "form-specific-safety-q01" }, { "text": "What documented controls support the proposed weighing, dissolution, storage and disposal operations?", "kind": "action", "id": "form-specific-safety-q02" } ] } ] }, { "id": "quality-authorisation", "name": "Quality and authorisation", "description": "Distinguish material release from permissions attached to medicinal products.", "findings": [ { "id": "use-qualified-release", "name": "Use-qualified release", "description": "A decision to use perospirone should identify the intended purpose, material grade, applicable specification and relevant jurisdictional authority.", "questions": [ { "text": "What evidence qualifies this batch for its intended reference, research or pharmaceutical use?", "kind": "action", "id": "use-qualified-release-q01" }, { "text": "Does the cited regulatory record concern the substance, a manufacturing activity or a particular finished product?", "kind": "boundary", "id": "use-qualified-release-q02" } ] } ] } ] }, { "id": "evidence-and-external-alignment", "name": "Evidence and external alignment", "description": "What the world already says about this thing, gathered so the model can be checked against it.", "rationale": "A model that cannot be lined up against existing standards, identifiers and practice cannot be adopted by anyone who already uses them.", "layers": [ { "id": "reported-evidence", "name": "Reported evidence", "description": "Findings from the breadth pass, kept separate from the structural claims.", "findings": [ { "id": "evidence-confidence-notes", "name": "Check these first", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "This description is recalled knowledge, not a researched or source-verified record.", "Verify exact CAS and PubChem identifiers, stereochemistry, and marketed salt or hydrate form before linking chemical records.", "Check current Japanese prescribing information for approved indications, contraindications, interactions and adverse-effect frequencies; physical constants and substance-specific hazard classifications are not supplied here." ], "questions": [ { "id": "evidence-confidence-notes-q01", "text": "Which of these check these first hold for the sense of perospirone this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-kinds", "name": "Kinds and varieties", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "Perospirone free base", "Perospirone hydrochloride" ], "questions": [ { "id": "evidence-kinds-q01", "text": "Which of these kinds and varieties hold for the sense of perospirone this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-identifiers", "name": "Identifiers and schemes", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ { "scheme": "International Nonproprietary Name (INN)", "value_or_pattern": "perospirone", "note": "Names the active substance rather than a particular salt, formulation or brand." }, { "scheme": "Molecular formula", "value_or_pattern": "C23H32N4O2S", "note": "Formula of the neutral free base; salt and hydrate compositions differ." } ], "questions": [ { "id": "evidence-identifiers-q01", "text": "Which of these identifiers and schemes hold for the sense of perospirone this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-real-world-use", "name": "Real-world use", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "Oral antipsychotic treatment of schizophrenia in Japan." ], "questions": [ { "id": "evidence-real-world-use-q01", "text": "Which of these real-world use hold for the sense of perospirone this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-measurements", "name": "Typical measurements", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ { "quantity": "Molar mass of the free base", "typical_range": "428.59", "unit": "g/mol" } ], "questions": [ { "id": "evidence-measurements-q01", "text": "Which of these typical measurements hold for the sense of perospirone this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-failure-modes-and-hazards", "name": "Failure modes and hazards", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "Extrapyramidal adverse effects, including akathisia and parkinsonism.", "Sedation and dizziness.", "Orthostatic hypotension.", "Rare but serious neuroleptic malignant syndrome.", "Potential for tardive dyskinesia with prolonged exposure." ], "questions": [ { "id": "evidence-failure-modes-and-hazards-q01", "text": "Which of these failure modes and hazards hold for the sense of perospirone this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-regional-variation", "name": "Regional variation", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "Clinical use is associated principally with Japan; authorization and availability should be checked separately for each jurisdiction." ], "questions": [ { "id": "evidence-regional-variation-q01", "text": "Which of these regional variation hold for the sense of perospirone this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-neighbours", "name": "Neighbouring kinds and how to tell them apart", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ { "name": "Perospirone hydrochloride", "difference": "A salt form of perospirone with chloride as counterion; its formula and mass differ from those of the free base." }, { "name": "Risperidone", "difference": "A distinct antipsychotic molecule with overlapping D2 and 5-HT2A antagonist activity; the names do not denote interchangeable chemical substances." }, { "name": "Lurasidone", "difference": "A structurally related but distinct antipsychotic with a different molecular structure and receptor-binding profile." } ], "questions": [ { "id": "evidence-neighbours-q01", "text": "Which of these neighbouring kinds and how to tell them apart hold for the sense of perospirone this model covers, and on what evidence?", "kind": "provenance" } ] } ] } ] } ] }, "openQuestions": [ "Which authoritative CAS, EC and stereochemical identifiers apply separately to the parent, hydrochloride and hydrate forms, and how should the registry represent those relationships?", "Which perospirone solid forms and hydration transitions are experimentally established, and what form-specific solubility, thermal and storage data are reliable?", "Which applicable compendial or validated specifications establish identity, assay basis, impurity limits and stability acceptance for the intended material grade?", "Which primary studies establish receptor function, relevant metabolites and their separate contributions to observed biological activity?", "What current jurisdiction-specific substance requirements, GHS classifications and occupational exposure limits exist for each material form, and where is authoritative information absent?" ], "statistics": { "bundles": 6, "layers": 11, "findings": 18, "questions": 28 } }