{ "vercy": "1.0-draft", "publication": { "status": "research-draft", "adjudicationStatus": "unreviewed", "publishableCanonical": false, "generatedAt": "2026-09-13T05:44:28Z", "providers": [ "Claude" ], "breadth": "written by Claude from model knowledge without web access - no source was read, every claim is a lead to verify", "pass": 2, "wave": 3, "engine": "claude", "enrichment": { "pass": 3, "engine": "claude", "producedAt": "2026-10-06T10:00:00Z", "ingestedAt": "2026-10-06T07:09:42+00:00", "fields": [ "agent_conduct", "ethics", "owners" ] }, "revisions": [ { "at": "2026-10-06T22:57:18+00:00", "engine": "codex", "fields": [ "definition" ], "answering_review": "601b11c0a97cf416637ea614557b757acd7f6852343159109484ffb82a6e2860" } ], "gate": { "passed": true, "version": "1.0", "at": "2026-10-07T10:10:32+00:00", "evidence": [ "completeness 1.00", "sense: Wikidata description", "2 live sources", "review by codex: pass" ] } }, "metaModel": { "id": "THING-Q6853", "registryId": "vr.tr.hepatitis-b", "name": "hepatitis B", "version": "0.2.0-wave.3", "entryKind": "thing", "family": "Thing Registry", "domain": [ "XCT.QLT" ], "status": "research-draft" }, "canonicalUrl": "https://ver.cy/models/thing/q6853/", "model": { "registry_id": "vr.tr.hepatitis-b", "name": "hepatitis B", "purpose": "Let an agent explain hepatitis B and its course in neutral clinical terms, relay transmission, prevention, testing and treatment from public health and hepatology sources, describe hepatitis D co-infection, and route people at risk or with symptoms to testing and clinicians.", "definition": "A viral infection of the liver caused by the hepatitis B virus, transmitted through blood, sexual contact and from mother to child at birth, which may be acute and self-limiting or become chronic, especially when acquired in infancy, leading over decades to cirrhosis and liver cancer, and which can be complicated by co-infection with the hepatitis D virus, a defective virus that requires hepatitis B surface proteins for infectious particle assembly and transmission but not for replication of its RNA, and causes severe forms such as the Labrea fever of the Amazon; hepatitis B is preventable by vaccination and treatable with antiviral drugs.", "what_it_is_for": "Not applicable; a disease.", "affordances": [ "explain the disease and course", "relay prevention and treatment", "describe hepatitis D", "route to testing and care" ], "distinguishing_features": [ "Blood-borne and perinatal", "Chronic carriage", "Vaccine-preventable", "Hepatitis D dependence" ], "appearance": "Not a visible object; jaundice in some acute cases, often silent.", "visual_identification": [ "Liver infection by hepatitis B virus", "Acute and chronic hepatitis B, hepatitis D co-infection and superinfection, Labrea fever", "Hepatitis A and E spread by food and water; hepatitis C is a different blood-borne virus" ], "physical_properties": [ { "quantity": "people with chronic infection", "typical_range": "about 250", "unit": "million", "note": "WHO estimates" }, { "quantity": "annual deaths", "typical_range": "about 1", "unit": "million", "note": "mostly cirrhosis and cancer" }, { "quantity": "vaccine introduced", "typical_range": "1982", "unit": "year", "note": "" }, { "quantity": "hepatitis D discovered", "typical_range": "1977", "unit": "year", "note": "" } ], "families_and_kinds": [ "acute hepatitis B", "chronic hepatitis B", "hepatitis D co-infection and superinfection including chronic hepatitis D", "severe regional forms such as Labrea fever", "occult and resolved infection", "hepatitis B genotypes" ], "related_models": [ { "relation": "is a kind of", "target": "viral hepatitis", "why": "in registry terms" }, { "relation": "is a kind of", "target": "Hepadnaviridae infectious disease", "why": "in registry terms" }, { "relation": "is caused by", "target": "hepatitis B virus", "why": "of the Hepadnaviridae" }, { "relation": "is prevented by", "target": "hepatitis B vaccine", "why": "in infancy and at-risk groups" } ], "identifiers": [ { "scheme": "ICD-11", "value_or_pattern": "1E51.0", "note": "chronic hepatitis B" }, { "scheme": "MeSH", "value_or_pattern": "D006509", "note": "hepatitis B" } ], "standards_and_regulation": [ "WHO guidelines on hepatitis B prevention, testing and treatment", "Universal infant vaccination programmes", "Blood donation screening rules", "Notifiable disease reporting" ], "failure_modes_and_hazards": [ "Agents giving personal medical advice", "Stigma toward people living with hepatitis B", "Missed diagnosis of silent chronic infection" ], "in_scope": [], "out_of_scope": [], "characteristics": [], "agent_conduct": { "may": [ "Explain hepatitis B, its transmission and prevention by vaccination, citing health authorities.", "Point people to testing and treatment services." ], "must_not": [ "Disclose a person's hepatitis B status without consent.", "Diagnose infection or advise on treatment for an individual.", "Spread myths that stigmatize people with the infection.", "Discourage vaccination against scientific evidence." ], "requires_human": [ "Any advice affecting treatment of a pregnant person or newborn." ] }, "ethics": { "considerations": [ "People with hepatitis B face stigma and discrimination in work and migration.", "Vaccination and testing access are unequal across the world." ], "affected_parties": [ "People living with hepatitis B", "Newborns", "Health workers" ] }, "owners": { "steward": "Nobody owns the disease; public health authorities track it.", "master_systems": [ "Notifiable disease surveillance systems" ] } }, "sources": [ { "id": "wikidata", "title": "Wikidata item Q6853: hepatitis B", "url": "https://www.wikidata.org/wiki/Q6853", "url_status": "live", "what_it_supports": "identity and sense of the item", "checked_by": "wikidata-api" }, { "id": "wikipedia-en", "title": "Wikipedia: Hepatitis B", "url": "https://en.wikipedia.org/wiki/Hepatitis_B", "url_status": "live", "what_it_supports": "general description of the item", "checked_by": "wikidata-api sitelink" } ], "structure": { "bundles": [ { "id": "help", "name": "Help", "description": "Testing and care first.", "rationale": "Safety.", "layers": [ { "id": "testing", "name": "Testing", "description": "Who should test.", "findings": [ { "id": "testing-finding", "name": "Testing", "description": "Testing.", "questions": [ { "text": "Why do people with risk exposures, or from high-prevalence regions, or with symptoms such as jaundice, need testing and clinical care?", "kind": "action" }, { "text": "Is the user asking about their own exposure or result, which needs a clinician?", "kind": "boundary" } ] } ] }, { "id": "living", "name": "Living", "description": "Living with hepatitis B.", "findings": [ { "id": "living-finding", "name": "Living", "description": "Living.", "questions": [ { "text": "What support and monitoring do people with chronic hepatitis B receive, and how is stigma addressed?", "kind": "provenance" }, { "text": "Is the presentation free of stigma?", "kind": "boundary" } ] } ] } ] }, { "id": "understand", "name": "Understand", "description": "The disease.", "rationale": "Clinical.", "layers": [ { "id": "course", "name": "Course", "description": "Course.", "findings": [ { "id": "course-finding", "name": "Course", "description": "Course.", "questions": [ { "text": "How does hepatitis B progress from acute infection to chronic disease, cirrhosis and cancer?", "kind": "definition" }, { "text": "Is the question about hepatitis B, hepatitis D or another hepatitis?", "kind": "boundary" } ] } ] }, { "id": "transmission", "name": "Transmission", "description": "Transmission.", "findings": [ { "id": "transmission-finding", "name": "Transmission", "description": "Transmission.", "questions": [ { "text": "How is hepatitis B transmitted, and how does hepatitis D depend on it?", "kind": "definition" }, { "text": "Which entry fits hepatitis D?", "kind": "action" } ] } ] } ] }, { "id": "prevent", "name": "Prevent", "description": "Prevention and treatment.", "rationale": "Public health.", "layers": [ { "id": "vaccine", "name": "Vaccine", "description": "Vaccination.", "findings": [ { "id": "vaccine-finding", "name": "Vaccine", "description": "Vaccine.", "questions": [ { "text": "How do vaccination, birth-dose programmes and screening prevent hepatitis B, according to WHO?", "kind": "provenance" }, { "text": "Which references are standard?", "kind": "provenance" } ] } ] }, { "id": "treatment", "name": "Treatment", "description": "Treatment.", "findings": [ { "id": "treatment-finding", "name": "Treatment", "description": "Treatment.", "questions": [ { "text": "How are chronic hepatitis B and hepatitis D treated with antivirals and newer drugs, in general terms?", "kind": "provenance" }, { "text": "Which sources are cited?", "kind": "provenance" } ] } ] } ] }, { "id": "context", "name": "Context", "description": "Epidemiology and research.", "rationale": "Context.", "layers": [ { "id": "epidemiology", "name": "Epidemiology", "description": "Epidemiology.", "findings": [ { "id": "epidemiology-finding", "name": "Epidemiology", "description": "Epidemiology.", "questions": [ { "text": "Where is hepatitis B most common, and what are elimination targets, with data attributed?", "kind": "provenance" }, { "text": "Which entry fits viral hepatitis elimination?", "kind": "action" } ] } ] }, { "id": "research", "name": "Research", "description": "Research.", "findings": [ { "id": "research-finding", "name": "Research", "description": "Research.", "questions": [ { "text": "What research pursues a cure for hepatitis B and treatments for hepatitis D?", "kind": "provenance" }, { "text": "Which entry fits hepatitis B virus?", "kind": "action" } ] } ] } ] } ] }, "openQuestions": [ "Should hepatitis D be a separate primary entry?", "How should public health guidelines be linked?", "The registry entry has merged hepatitis D aliases; should they be split off?" ], "statistics": { "bundles": 4, "layers": 8, "findings": 8, "questions": 16 } }