{ "vercy": "1.0-draft", "publication": { "status": "research-draft", "adjudicationStatus": "unreviewed", "publishableCanonical": false, "generatedAt": "2026-09-12T11:34:56Z", "providers": [ "Codex" ], "breadth": "recalled by Codex without web access - no source was read", "missingProviders": [], "pass": 2, "cost": { "grok": { "seconds": 16.6, "error": "Reading additional input from stdin...\nOpenAI Codex v0.153.4\n--------\nworkdir: R:\\02_PROJECTS\\02_Meta_Models_Platforms\\Ver.cy\\current\\thing-registry-backlog\nmodel: gpt-6-astra\nprovider: openai\napproval: never\nsandbox: read-only\nreasoning effort: none\nreasoning summaries: none\nsession id: 01a09565-0a27-7582-a324-07e1ec4c96fa\n--------\nuser\nDescribe what is already known about one registered thing. Answer as JSON only, no prose around it.\n\nThing: nicodicodine\nSense to describe: (none recorded)\nDomain code: PHY.MAT\nAlso known as: (none)\n\n\nContext for this batch of 1001 things:\n# Batch 044: 1001 re", "usd": 0.0, "recall": true }, "codex": { "seconds": 74.8, "error": "Reading additional input from stdin...\nOpenAI Codex v0.153.4\n--------\nworkdir: R:\\02_PROJECTS\\02_Meta_Models_Platforms\\Ver.cy\\current\\thing-registry-backlog\nmodel: gpt-6-astra\nprovider: openai\napproval: never\nsandbox: read-only\nreasoning effort: none\nreasoning summaries: none\nsession id: 01a09565-0a27-72e0-9fc4-b825eeba6eae\n--------\nuser\nYou are drafting a Vercy meta-model for one registered thing. Answer as JSON only, no prose around it.\n\nThing: nicodicodine\nRegistry id: vr.tr.nicodicodine\nPlane / domain: PHY / PHY.MAT\nRegistry definition: (none recorded)\nNames folded into this entry: (none)\n" } }, "enrichment": { "pass": 3, "engine": "claude", "producedAt": "2026-10-06T12:00:00Z", "ingestedAt": "2026-10-06T08:51:29+00:00", "fields": [ "agent_conduct", "ethics", "failure_modes_and_hazards", "owners", "standards_and_regulation", "visual_identification" ] }, "gate": { "passed": true, "version": "1.0", "at": "2026-10-07T10:10:32+00:00", "evidence": [ "completeness 1.00", "sense: Wikidata description", "2 live sources", "review by codex: pass" ] } }, "metaModel": { "id": "THING-Q7028925", "registryId": "vr.tr.nicodicodine", "name": "nicodicodine", "version": "0.1.0-research.1", "entryKind": "thing", "family": "Thing Registry", "domain": [ "PHY.MAT" ], "status": "research-draft" }, "canonicalUrl": "https://ver.cy/models/thing/q7028925/", "model": { "registry_id": "vr.tr.nicodicodine", "name": "nicodicodine", "purpose": "Enable an agent to recognise nicodicodine, assess the identity and condition of a sample, and determine which handling or use decisions have adequate evidence and authorization.", "definition": "Nicodicodine is a semisynthetic opioid derived from dihydrocodeine by esterifying its 6-hydroxyl group with nicotinic acid.", "scope_statement": "This model owns the substance identity of nicodicodine under vr.tr.nicodicodine in PHY / PHY.MAT, including its chemical forms, sample quality, stability, biological evidence and substance-specific restrictions.", "in_scope": [ "Molecular connectivity, stereochemistry, synonyms and external identifiers", "Free-base identity and relationships to documented salts or solvates", "Analytical identification, assay basis and related-substance impurities", "Physical properties and stability under recorded conditions", "Evidence for biological activity, exposure hazards and applicable controls" ], "out_of_scope": [ "Finished medicines, formulations, brands and packaging", "Patient diagnosis, prescribing and dosing decisions", "Manufacturing processes and synthesis instructions", "Independent models of dihydrocodeine, nicocodine and nicotinic acid", "Organization-wide licensing and laboratory management" ], "distinguishing_features": [ "Require the dihydrocodeine scaffold with a nicotinic-acid ester at the 6-position; nicodicodine is not merely a mixture of dihydrocodeine and nicotinic acid. [NIST nicodicodine](https://webbook.nist.gov/cgi/cbook.cgi?ID=C808242&Units=SI)", "Check the 7,8 saturation state: nicocodine is the corresponding codeine ester and has formula C24H24N2O4. [NIST nicocodine](https://webbook.nist.gov/cgi/cbook.cgi?ID=C3688662&Units=SI)", "Cross-check the neutral substance against formula C24H26N2O4 and CAS 808-24-2. [NIST nicodicodine](https://webbook.nist.gov/cgi/cbook.cgi?ID=C808242&Units=SI)", "Require stereochemical evidence before treating a connectivity-only database match as confirmation of the intended substance.", "Distinguish covalent nicotinate ester identity from any counterion associated with a salt sample." ], "characteristics": [ { "name": "Molecular identity", "kind": "category", "unit_or_values": "Structure, stereochemical specification, formula and identifier crosswalk", "why_it_matters": "Prevents substitution of nicocodine, dihydrocodeine or an incompletely specified stereoisomer." }, { "name": "Material form", "kind": "category", "unit_or_values": "Free base; documented salt with stoichiometry; hydrate or solvate; unresolved", "why_it_matters": "Determines whether mass, assay and physical-property comparisons refer to equivalent material." }, { "name": "Nicodicodine assay", "kind": "measurement", "unit_or_values": "% mass fraction or mg/g; as-is, dry or free-base-equivalent basis", "why_it_matters": "Separates measured nicodicodine content from water, counterions and other constituents." }, { "name": "Related-substance profile", "kind": "measurement", "unit_or_values": "Individual impurities in % mass fraction or mg/g, with identification confidence and quantification limits", "why_it_matters": "Supports detection of related alkaloids and possible ester-cleavage products." }, { "name": "Physical and solution behavior", "kind": "measurement", "unit_or_values": "Melting or decomposition temperature in °C; solubility in mg/mL with solvent, pH and temperature", "why_it_matters": "Supports sample preparation and storage decisions without transferring constants between chemical forms." }, { "name": "Stability status", "kind": "state", "unit_or_values": "Within supported specification; degraded; untested; indeterminate", "why_it_matters": "Indicates whether the sample still represents the assayed substance after storage or preparation." }, { "name": "Biological evidence relationship", "kind": "relation", "unit_or_values": "Parent substance or identified metabolite linked to study, endpoint, species and exposure route", "why_it_matters": "Prevents activity inferred from related opioids from being recorded as directly measured nicodicodine activity." }, { "name": "Applicable control status", "kind": "category", "unit_or_values": "Jurisdiction, effective date, covered chemical form, regulated activity and supporting authority", "why_it_matters": "Allows handling decisions to use the relevant rule rather than a globally assumed classification." } ], "affordances": [ "Resolve a substance label to nicodicodine and flag conflicting names or structures.", "Compare analytical evidence with an authenticated nicodicodine reference.", "Calculate free-base-equivalent content when salt stoichiometry, hydration and assay basis are established.", "Assess sample suitability against documented purity and stability requirements.", "Retrieve substance-specific hazard and control evidence for a proposed activity.", "Identify unsupported biological claims and request the missing primary evidence." ], "agent_conduct": { "may": [ "Identify nicodicodine by name, identifiers and its controlled status, citing official sources.", "Report its legal status in a stated country from official schedules." ], "must_not": [ "Assist anyone to make, obtain, convert or use it outside lawful medical or research channels.", "Give dosing, routes of use or ways to boost or combine its effects.", "Help evade controls on opioids, such as prescriptions, import rules or testing.", "Recommend it for any particular person's pain or cough." ], "requires_human": [ "Any handling, transfer or destruction of controlled stocks.", "Reporting a suspected diversion to authorities." ] }, "ethics": { "considerations": [ "Opioids cause dependence and overdose deaths; controls exist to protect people.", "People who use drugs deserve dignity and access to help, not stigma." ], "affected_parties": [ "People at risk of overdose or dependence", "Families and communities", "Patients needing pain relief" ] }, "owners": { "steward": "Licensed holders under national drug control law; the national drug control authority regulates it.", "master_systems": [ "National controlled substances registers" ] }, "visual_identification": [ "Identity can only be settled by laboratory analysis and official documentation.", "Lawful stocks carry licensed labels and are kept in controlled storage." ], "failure_modes_and_hazards": [ "Breathing depression and overdose, especially combined with other sedatives.", "Dependence and withdrawal.", "Diverted or mislabelled material causes unpredictable harm." ], "standards_and_regulation": [ "Single Convention on Narcotic Drugs, 1961, United Nations, under which it is internationally controlled." ], "what_it_is_for": [ "Nicodicodine is encountered in opioid pharmacology literature and analytical work concerned with dihydrocodeine derivatives.", "Its identification is relevant to documenting controlled substances and interpreting chemical or toxicological findings." ] }, "sources": [ { "id": "wikidata", "title": "Wikidata item Q7028925: nicodicodine", "url": "https://www.wikidata.org/wiki/Q7028925", "url_status": "live", "what_it_supports": "identity and sense of the item", "checked_by": "wikidata-api" }, { "id": "wikipedia-en", "title": "Wikipedia: Nicodicodine", "url": "https://en.wikipedia.org/wiki/Nicodicodine", "url_status": "live", "what_it_supports": "general description of the item", "checked_by": "wikidata-api sitelink" } ], "structure": { "bundles": [ { "id": "nicodicodine-identity", "name": "Nicodicodine identity", "description": "Establish the exact ester and stereochemical entity represented by the registry entry.", "rationale": "Similar alkaloid names and ambiguous use of nicotinate can produce consequential identity errors.", "layers": [ { "id": "ester-and-scaffold", "name": "Ester and scaffold", "description": "Resolve the molecular features separating nicodicodine from nearby substances.", "findings": [ { "id": "structural-discrimination", "name": "Structural discrimination", "description": "Require evidence for ester position, nicotinoyl connectivity and scaffold saturation.", "questions": [ { "text": "Does the assigned structure contain the 6-O-nicotinoyl ester of dihydrocodeine?", "kind": "definition", "id": "structural-discrimination-q01" }, { "text": "Which structural evidence excludes nicocodine, unesterified dihydrocodeine and alternative pyridinecarboxylate esters?", "kind": "boundary", "id": "structural-discrimination-q02" } ] } ] }, { "id": "stereochemistry-and-records", "name": "Stereochemistry and records", "description": "Reconcile chemical names and database records without losing stereochemical specificity.", "findings": [ { "id": "identifier-concordance", "name": "Identifier concordance", "description": "Record which identifiers establish full identity and which establish only connectivity.", "questions": [ { "text": "Which authoritative record establishes the complete stereochemical structure intended by nicodicodine?", "kind": "provenance", "id": "identifier-concordance-q01" }, { "text": "Do the CAS, PubChem, EC and structure identifiers refer to the same stereochemical entity and chemical form?", "kind": "boundary", "id": "identifier-concordance-q02" } ] } ] } ] }, { "id": "material-form-and-assay", "name": "Material form and assay", "description": "Connect the registered substance to the composition and analytical identity of an actual sample.", "rationale": "A correctly named sample can still have an unresolved salt form, misleading assay basis or related-alkaloid contamination.", "layers": [ { "id": "base-salt-and-solvate", "name": "Base, salt and solvate", "description": "Specify the constituents needed to interpret sample mass and concentration.", "findings": [ { "id": "chemical-form-accounting", "name": "Chemical form accounting", "description": "Establish form-specific composition before comparing quantities.", "questions": [ { "text": "Is this sample free-base nicodicodine or a documented salt, hydrate or solvate, and what establishes its stoichiometry?", "kind": "definition", "id": "chemical-form-accounting-q01" }, { "text": "What water, solvent and counterion measurements support its reported free-base-equivalent content?", "kind": "measurement", "id": "chemical-form-accounting-q02" } ] } ] }, { "id": "identity-and-related-substances", "name": "Identity and related substances", "description": "Assess whether analytical methods distinguish nicodicodine from plausible confounders.", "findings": [ { "id": "selective-assay-evidence", "name": "Selective assay evidence", "description": "Require authenticated references and sufficient analytical selectivity for identification and quantification.", "questions": [ { "text": "Which reference material and complementary analytical observations support the nicodicodine assignment?", "kind": "provenance", "id": "selective-assay-evidence-q01" }, { "text": "Can the assay resolve nicocodine, dihydrocodeine, nicotinic acid and other observed impurities at the required reporting limits?", "kind": "measurement", "id": "selective-assay-evidence-q02" } ] } ] } ] }, { "id": "physical-state-and-ester-stability", "name": "Physical state and ester stability", "description": "Describe form-dependent properties and evidence of chemical change during storage or analysis.", "rationale": "The ester functionality and variable sample forms require explicit stability and measurement conditions.", "layers": [ { "id": "form-dependent-properties", "name": "Form-dependent properties", "description": "Attach physical constants to the actual nicodicodine material tested.", "findings": [ { "id": "conditioned-property-record", "name": "Conditioned property record", "description": "Separate observed properties from predictions and values borrowed from related substances.", "questions": [ { "text": "Which melting, decomposition and solubility measurements exist for the specified nicodicodine form, and under what conditions?", "kind": "measurement", "id": "conditioned-property-record-q01" }, { "text": "Are any reported boiling points or partition properties predictions, extrapolations or measurements of a different form?", "kind": "provenance", "id": "conditioned-property-record-q02" } ] } ] }, { "id": "ester-integrity-over-time", "name": "Ester integrity over time", "description": "Track whether storage and sample preparation preserve the assigned substance.", "findings": [ { "id": "degradation-and-retest", "name": "Degradation and retest", "description": "Treat ester cleavage as a stability question requiring direct evidence.", "questions": [ { "text": "Under the tested pH, temperature, moisture and storage duration, does nicodicodine decline or do dihydrocodeine and nicotinic acid increase?", "kind": "measurement", "id": "degradation-and-retest-q01" }, { "text": "Which stability results justify the container, storage conditions, prepared-solution lifetime and retest interval?", "kind": "action", "id": "degradation-and-retest-q02" } ] } ] } ] }, { "id": "biological-activity-and-exposure", "name": "Biological activity and exposure", "description": "Organize evidence about nicodicodine activity, transformation and exposure consequences.", "rationale": "Claims about this derivative need separation from assumptions based on its parent scaffold or proposed metabolites.", "layers": [ { "id": "parent-and-metabolites", "name": "Parent and metabolites", "description": "Distinguish observations on intact nicodicodine from observations on transformation products.", "findings": [ { "id": "activity-attribution", "name": "Activity attribution", "description": "Connect each pharmacological claim to the measured chemical species and experimental context.", "questions": [ { "text": "Which primary studies measure intact nicodicodine activity, and which instead measure or infer metabolite activity?", "kind": "provenance", "id": "activity-attribution-q01" }, { "text": "What evidence establishes conversion to dihydrocodeine or other metabolites, including species, route and time course?", "kind": "measurement", "id": "activity-attribution-q02" } ] } ] }, { "id": "exposure-evidence", "name": "Exposure evidence", "description": "Assess substance-specific support for hazard statements and handling precautions.", "findings": [ { "id": "hazard-evidence-strength", "name": "Hazard evidence strength", "description": "Identify measured exposure effects separately from precautionary assumptions based on related opioids.", "questions": [ { "text": "Which nicodicodine-specific evidence supports respiratory, neurological or dependence-related hazard statements?", "kind": "provenance", "id": "hazard-evidence-strength-q01" }, { "text": "What exposure limits, containment measures and incident procedures are supported for the actual form and handling activity?", "kind": "action", "id": "hazard-evidence-strength-q02" } ] } ] } ] }, { "id": "substance-controls-and-disposition", "name": "Substance controls and disposition", "description": "Connect nicodicodine identity and material form to applicable restrictions and permitted disposition.", "rationale": "A chemical name alone does not establish which rules govern a particular sample or activity.", "layers": [ { "id": "jurisdictional-coverage", "name": "Jurisdictional coverage", "description": "Establish dated legal coverage for the substance and its documented forms.", "findings": [ { "id": "applicable-instrument", "name": "Applicable instrument", "description": "Require an authoritative instrument before assigning a control category.", "questions": [ { "text": "Which current authority explicitly lists nicodicodine or covers it through a defined chemical class in the relevant jurisdiction?", "kind": "provenance", "id": "applicable-instrument-q01" }, { "text": "How does that instrument treat salts, stereoisomers and preparations containing nicodicodine?", "kind": "boundary", "id": "applicable-instrument-q02" } ] } ] }, { "id": "sample-disposition", "name": "Sample disposition", "description": "Resolve what may be done with an identified quantity of nicodicodine.", "findings": [ { "id": "activity-eligibility", "name": "Activity eligibility", "description": "Evaluate a proposed activity using substance identity, quantity and applicable authorization.", "questions": [ { "text": "What authorization and records are required for the proposed possession, analysis, transfer or disposal of this sample?", "kind": "action", "id": "activity-eligibility-q01" }, { "text": "Which verified classification governs its labeling, transport and waste route, and does unresolved identity prevent disposition?", "kind": "action", "id": "activity-eligibility-q02" } ] } ] } ] }, { "id": "evidence-and-external-alignment", "name": "Evidence and external alignment", "description": "What the world already says about this thing, gathered so the model can be checked against it.", "rationale": "A model that cannot be lined up against existing standards, identifiers and practice cannot be adopted by anyone who already uses them.", "layers": [ { "id": "reported-evidence", "name": "Reported evidence", "description": "Findings from the breadth pass, kept separate from the structural claims.", "findings": [ { "id": "evidence-confidence-notes", "name": "Check these first", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "This is recall only; no sources were consulted.", "Verify the exact registry identifiers, salt forms, physical constants and jurisdiction-specific legal status.", "Historical therapeutic use and compound-specific toxicity data need verification; the hazards listed reflect opioid-class concerns." ], "questions": [ { "id": "evidence-confidence-notes-q01", "text": "Which of these check these first hold for the sense of nicodicodine this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-identifiers", "name": "Identifiers and schemes", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ { "scheme": "Chemical structural name", "value_or_pattern": "6-nicotinoyldihydrocodeine", "note": "Describes the nicotinic acid ester of dihydrocodeine." } ], "questions": [ { "id": "evidence-identifiers-q01", "text": "Which of these identifiers and schemes hold for the sense of nicodicodine this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-real-world-use", "name": "Real-world use", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "Reported historical use as an opioid antitussive." ], "questions": [ { "id": "evidence-real-world-use-q01", "text": "Which of these real-world use hold for the sense of nicodicodine this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-failure-modes-and-hazards", "name": "Failure modes and hazards", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "Opioid effects can include respiratory depression, sedation and dependence.", "Concurrent use with alcohol or other central nervous system depressants can increase opioid toxicity." ], "questions": [ { "id": "evidence-failure-modes-and-hazards-q01", "text": "Which of these failure modes and hazards hold for the sense of nicodicodine this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-neighbours", "name": "Neighbouring kinds and how to tell them apart", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ { "name": "Dihydrocodeine", "difference": "Dihydrocodeine has a free 6-hydroxyl group; nicodicodine has a nicotinic acid ester at that position." }, { "name": "Nicocodeine", "difference": "Nicocodeine is the corresponding nicotinic acid ester of codeine and retains the 7,8-double bond that is reduced in nicodicodine." }, { "name": "Nicotinic acid", "difference": "Nicotinic acid supplies the esterifying group but is a distinct substance without the opioid morphinan skeleton." } ], "questions": [ { "id": "evidence-neighbours-q01", "text": "Which of these neighbouring kinds and how to tell them apart hold for the sense of nicodicodine this model covers, and on what evidence?", "kind": "provenance" } ] } ] } ] } ] }, "openQuestions": [ "Which authoritative stereochemical structure and identifier crosswalk resolve any connectivity-only or form-ambiguous nicodicodine records?", "Which salts, solvates and reference materials are documented, and what validated assays distinguish them from related alkaloids?", "What experimentally supported physical constants, ester-hydrolysis behavior and storage limits exist for each documented form?", "What primary evidence establishes human pharmacology, metabolite contributions and exposure hazards without extrapolation from related opioids?", "Which current jurisdiction-specific controls, GHS classifications and occupational exposure limits apply, and where are these absent or unresolved?" ], "statistics": { "bundles": 6, "layers": 11, "findings": 15, "questions": 25 } }