{
  "vercy": "1.0-draft",
  "publication": {
    "status": "research-draft",
    "adjudicationStatus": "unreviewed",
    "publishableCanonical": false,
    "generatedAt": "2026-09-14T03:25:52Z",
    "providers": [
      "Claude"
    ],
    "breadth": "written by Claude from model knowledge without web access - no source was read, every claim is a lead to verify",
    "pass": 2,
    "wave": 4,
    "engine": "claude",
    "enrichment": {
      "pass": 3,
      "engine": "claude",
      "producedAt": "2026-10-06T12:00:00Z",
      "ingestedAt": "2026-10-06T07:46:44+00:00",
      "fields": [
        "agent_conduct",
        "ethics",
        "owners"
      ]
    },
    "gate": {
      "passed": true,
      "version": "1.0",
      "at": "2026-10-06T19:52:01+00:00",
      "evidence": [
        "completeness 1.00",
        "sense: Wikidata description",
        "2 live sources",
        "review by codex: pass"
      ]
    }
  },
  "metaModel": {
    "id": "THING-Q74419",
    "registryId": "vr.tr.epithelial-to-mesenchymal-transition",
    "name": "epithelial to mesenchymal transition",
    "version": "0.2.0-wave.4",
    "entryKind": "thing",
    "family": "Thing Registry",
    "domain": [
      "ACT.PRC"
    ],
    "status": "research-draft"
  },
  "canonicalUrl": "https://ver.cy/models/thing/q74419/",
  "model": {
    "registry_id": "vr.tr.epithelial-to-mesenchymal-transition",
    "name": "epithelial to mesenchymal transition",
    "purpose": "Let an agent explain epithelial to mesenchymal transition, relay its role in development, healing and disease from biology sources at a general level, describe the specific instances its aliases name, and distinguish it from the reverse transition.",
    "definition": "A biological process in which epithelial cells, which normally stick together in sheets, lose their adhesion and take on the mobile, migratory character of mesenchymal cells; it is essential to normal embryonic development and wound healing, and a related process contributes to how some cancers spread. The registry aliases name specific developmental instances such as neural crest formation and cardiac and gastrulation transitions. This is a scientific topic described at a general level.",
    "what_it_is_for": "Converting adherent epithelial cells into migratory mesenchymal cells.",
    "affordances": [
      "explain the process",
      "relay its role in development",
      "relay its role in disease generally",
      "distinguish it from the reverse process"
    ],
    "distinguishing_features": [
      "Loss of cell adhesion",
      "Gain of migratory character",
      "Key in development",
      "Linked to cancer spread"
    ],
    "appearance": "Not a visible object; a cellular change observed under the microscope as cells detach and migrate.",
    "visual_identification": [
      "Epithelial cells becoming migratory mesenchymal cells",
      "Neural crest formation, cardiac and gastrulation transitions",
      "The reverse mesenchymal to epithelial transition restores adhesion"
    ],
    "physical_properties": [
      {
        "quantity": "starting cells",
        "typical_range": "epithelial cells",
        "unit": "note",
        "note": ""
      },
      {
        "quantity": "resulting cells",
        "typical_range": "mesenchymal cells",
        "unit": "note",
        "note": ""
      },
      {
        "quantity": "registry parent",
        "typical_range": "mesenchymal cell differentiation",
        "unit": "note",
        "note": ""
      }
    ],
    "families_and_kinds": [
      "developmental transition",
      "wound-healing transition",
      "cancer-associated transition"
    ],
    "related_models": [
      {
        "relation": "is a kind of",
        "target": "cell differentiation",
        "why": "related"
      },
      {
        "relation": "is contrasted with",
        "target": "mesenchymal to epithelial transition",
        "why": ""
      },
      {
        "relation": "occurs in",
        "target": "embryonic development",
        "why": ""
      },
      {
        "relation": "is associated with",
        "target": "wound healing",
        "why": ""
      }
    ],
    "identifiers": [],
    "standards_and_regulation": [
      "Scientific consensus in cell biology"
    ],
    "failure_modes_and_hazards": [
      "Overstating the cancer link",
      "Confusing with the reverse transition",
      "Conflating developmental instances"
    ],
    "in_scope": [],
    "out_of_scope": [],
    "characteristics": [],
    "agent_conduct": {
      "may": [
        "Explain epithelial to mesenchymal transition and its roles in development, healing and disease.",
        "Distinguish it from the reverse transition.",
        "Cite research findings with sources."
      ],
      "must_not": [
        "Overstate its link to cancer or claim it as a cure target.",
        "Give personal medical advice based on research findings.",
        "Present preliminary laboratory results as established.",
        "Promote unproven treatments claiming to block it."
      ],
      "requires_human": [
        "Using research on it in a clinical decision."
      ]
    },
    "ethics": {
      "considerations": [
        "Cancer patients are vulnerable to hype and false hope.",
        "Accurate science communication protects trust."
      ],
      "affected_parties": [
        "Patients",
        "Researchers",
        "Readers of health news"
      ]
    },
    "owners": {
      "steward": "Nobody: a biological process; researchers study it.",
      "master_systems": []
    }
  },
  "sources": [
    {
      "id": "wikidata",
      "title": "Wikidata item Q74419: epithelial to mesenchymal transition",
      "url": "https://www.wikidata.org/wiki/Q74419",
      "url_status": "live",
      "what_it_supports": "identity and sense of the item",
      "checked_by": "wikidata-api"
    },
    {
      "id": "wikipedia-en",
      "title": "Wikipedia: Epithelial–mesenchymal transition",
      "url": "https://en.wikipedia.org/wiki/Epithelial%E2%80%93mesenchymal_transition",
      "url_status": "live",
      "what_it_supports": "general description of the item",
      "checked_by": "wikidata-api sitelink"
    }
  ],
  "structure": {
    "bundles": [
      {
        "id": "understand",
        "name": "Understand",
        "description": "What the transition is.",
        "rationale": "Definition.",
        "layers": [
          {
            "id": "definition",
            "name": "Definition",
            "description": "Definition.",
            "findings": [
              {
                "id": "definition-finding",
                "name": "Definition",
                "description": "Definition.",
                "questions": [
                  {
                    "text": "What is epithelial to mesenchymal transition, and how does it differ from the reverse process?",
                    "kind": "definition"
                  },
                  {
                    "text": "Is the question about a specific developmental instance?",
                    "kind": "boundary"
                  }
                ]
              }
            ]
          },
          {
            "id": "instances",
            "name": "Instances",
            "description": "Named instances.",
            "findings": [
              {
                "id": "instances-finding",
                "name": "Instances",
                "description": "Instances.",
                "questions": [
                  {
                    "text": "What are neural crest formation and cardiac and gastrulation transitions?",
                    "kind": "definition"
                  },
                  {
                    "text": "Which entry fits the specific instance?",
                    "kind": "action"
                  }
                ]
              }
            ]
          }
        ]
      },
      {
        "id": "development",
        "name": "Development",
        "description": "Development.",
        "rationale": "Sources.",
        "layers": [
          {
            "id": "embryo",
            "name": "Embryo",
            "description": "Embryonic role.",
            "findings": [
              {
                "id": "embryo-finding",
                "name": "Embryo",
                "description": "Embryo.",
                "questions": [
                  {
                    "text": "How does the transition shape embryonic development?",
                    "kind": "provenance"
                  },
                  {
                    "text": "Which references are standard?",
                    "kind": "provenance"
                  }
                ]
              }
            ]
          },
          {
            "id": "healing",
            "name": "Healing",
            "description": "Wound healing.",
            "findings": [
              {
                "id": "healing-finding",
                "name": "Healing",
                "description": "Healing.",
                "questions": [
                  {
                    "text": "How does the transition support wound healing?",
                    "kind": "provenance"
                  },
                  {
                    "text": "Which sources are cited?",
                    "kind": "provenance"
                  }
                ]
              }
            ]
          }
        ]
      },
      {
        "id": "disease",
        "name": "Disease",
        "description": "Disease.",
        "rationale": "Sources.",
        "layers": [
          {
            "id": "cancer",
            "name": "Cancer",
            "description": "Cancer link.",
            "findings": [
              {
                "id": "cancer-finding",
                "name": "Cancer",
                "description": "Cancer.",
                "questions": [
                  {
                    "text": "How is a related transition linked to how cancers spread, as sources describe?",
                    "kind": "provenance"
                  },
                  {
                    "text": "Is the link stated at a general level?",
                    "kind": "boundary"
                  }
                ]
              }
            ]
          },
          {
            "id": "fibrosis",
            "name": "Fibrosis",
            "description": "Fibrosis.",
            "findings": [
              {
                "id": "fibrosis-finding",
                "name": "Fibrosis",
                "description": "Fibrosis.",
                "questions": [
                  {
                    "text": "How is the transition associated with fibrosis?",
                    "kind": "provenance"
                  },
                  {
                    "text": "Which sources are cited?",
                    "kind": "provenance"
                  }
                ]
              }
            ]
          }
        ]
      },
      {
        "id": "context",
        "name": "Context",
        "description": "Mechanism.",
        "rationale": "Context.",
        "layers": [
          {
            "id": "mechanism",
            "name": "Mechanism",
            "description": "Mechanism.",
            "findings": [
              {
                "id": "mechanism-finding",
                "name": "Mechanism",
                "description": "Mechanism.",
                "questions": [
                  {
                    "text": "What molecular signals drive the transition, in general terms?",
                    "kind": "provenance"
                  },
                  {
                    "text": "Which sources are cited?",
                    "kind": "provenance"
                  }
                ]
              }
            ]
          },
          {
            "id": "reverse",
            "name": "Reverse",
            "description": "Reverse process.",
            "findings": [
              {
                "id": "reverse-finding",
                "name": "Reverse",
                "description": "Reverse.",
                "questions": [
                  {
                    "text": "What is the reverse mesenchymal to epithelial transition?",
                    "kind": "provenance"
                  },
                  {
                    "text": "Which entry fits the reverse process?",
                    "kind": "action"
                  }
                ]
              }
            ]
          }
        ]
      }
    ]
  },
  "openQuestions": [
    "Should developmental instances be separate entries?",
    "How should the cancer link be qualified?",
    "How should the reverse process be linked?"
  ],
  "statistics": {
    "bundles": 4,
    "layers": 8,
    "findings": 8,
    "questions": 16
  }
}