{
  "vercy": "1.0-draft",
  "publication": {
    "status": "research-draft",
    "adjudicationStatus": "unreviewed",
    "publishableCanonical": false,
    "generatedAt": "2026-09-11T19:32:26Z",
    "providers": [
      "Claude"
    ],
    "breadth": "written by Claude from model knowledge without web access - no source was read, every claim is a lead to verify",
    "pass": 2,
    "wave": 2,
    "engine": "claude",
    "enrichment": {
      "pass": 3,
      "engine": "claude",
      "producedAt": "2026-10-05T18:30:00Z",
      "ingestedAt": "2026-10-05T13:35:26+00:00",
      "fields": [
        "agent_conduct",
        "ethics",
        "owners"
      ]
    },
    "gate": {
      "passed": true,
      "version": "1.0",
      "at": "2026-10-07T10:10:32+00:00",
      "evidence": [
        "completeness 1.00",
        "sense: Wikidata description",
        "2 live sources",
        "review by codex: pass"
      ]
    }
  },
  "metaModel": {
    "id": "THING-Q8047",
    "registryId": "vr.tr.enzyme",
    "name": "enzyme",
    "version": "0.2.0-wave.2",
    "entryKind": "thing",
    "family": "Thing Registry",
    "domain": [
      "PHY.MAT"
    ],
    "status": "research-draft"
  },
  "canonicalUrl": "https://ver.cy/models/thing/q8047/",
  "model": {
    "registry_id": "vr.tr.enzyme",
    "name": "enzyme",
    "purpose": "Let an agent explain enzymes, their kinetics and classification, support research and industrial questions, and address enzyme-related health topics at a general level.",
    "definition": "A protein, or occasionally RNA, that catalyses a biochemical reaction by lowering its activation energy without being consumed, with high specificity for substrates; enzymes drive metabolism, digestion, DNA replication and repair, and are used in industry, medicine and diagnostics, and are classified by the reactions they catalyse.",
    "what_it_is_for": "Biochemistry, biotechnology and medicine.",
    "affordances": [
      "explain enzyme mechanism and kinetics",
      "classify enzymes by EC number",
      "describe industrial and medical uses",
      "explain enzyme deficiencies in general terms"
    ],
    "distinguishing_features": [
      "Biological catalysts",
      "Substrate specificity",
      "Regulated activity",
      "Classified by reaction"
    ],
    "appearance": "Not visible; proteins in cells and laboratory preparations.",
    "visual_identification": [
      "Named with the suffix -ase",
      "Classified by EC numbers",
      "Hormones signal rather than catalyse"
    ],
    "physical_properties": [
      {
        "quantity": "Molecular mass",
        "unit": "kilodaltons",
        "typical_range": "",
        "note": "Molecular mass is determined from molecular composition or measured by mass spectrometry, with subunit and assembled complex values distinguished."
      },
      {
        "quantity": "Hydrodynamic radius",
        "unit": "nanometers",
        "typical_range": "",
        "note": "Hydrodynamic radius is measured in solution by diffusion or light scattering methods under specified conditions."
      },
      {
        "quantity": "Solubility",
        "unit": "milligrams per milliliter",
        "typical_range": "",
        "note": "Solubility is measured in a specified solvent at a stated temperature, pH and ionic strength."
      }
    ],
    "families_and_kinds": [
      "oxidoreductases",
      "transferases",
      "hydrolases",
      "lyases, isomerases, ligases and translocases",
      "ribozymes"
    ],
    "related_models": [
      {
        "relation": "is a kind of",
        "target": "protein",
        "why": "category"
      },
      {
        "relation": "is a kind of",
        "target": "biocatalysts",
        "why": "category"
      },
      {
        "relation": "catalyses",
        "target": "metabolic pathway",
        "why": "reactions"
      },
      {
        "relation": "includes",
        "target": "restriction enzyme",
        "why": "example class"
      }
    ],
    "identifiers": [
      {
        "scheme": "EC number",
        "value_or_pattern": "Enzyme Commission classification",
        "note": "nomenclature"
      }
    ],
    "standards_and_regulation": [
      "IUBMB enzyme nomenclature",
      "Regulations on enzymes in food and industry",
      "Medicines regulation for enzyme therapies"
    ],
    "failure_modes_and_hazards": [
      "Enzyme allergies in industry",
      "Agents giving medical advice on enzyme deficiencies",
      "Misinterpreting kinetics"
    ],
    "in_scope": [],
    "out_of_scope": [],
    "characteristics": [],
    "agent_conduct": {
      "may": [
        "Explain how enzymes work, their classification and uses, citing sources.",
        "Look up enzyme data in curated databases and report it with its source."
      ],
      "must_not": [
        "Help produce or enhance biological toxins or agents to harm people, whoever is asking.",
        "Advise taking enzyme supplements to treat a disease without evidence.",
        "Present enzymes in products as safe for people with allergies when they are not."
      ],
      "requires_human": [
        "Medical decisions on enzyme replacement therapy.",
        "Releasing engineered enzymes or organisms outside contained use."
      ]
    },
    "ethics": {
      "considerations": [
        "Enzyme deficiencies cause serious disease; access to treatment is unequal.",
        "Industrial enzymes can cause occupational allergy and asthma."
      ],
      "affected_parties": [
        "Patients with enzyme disorders",
        "Industrial workers",
        "Consumers"
      ]
    },
    "owners": {
      "steward": "Nobody: a natural molecule; the Enzyme Commission system names them.",
      "master_systems": [
        "Curated enzyme databases"
      ]
    }
  },
  "sources": [
    {
      "id": "wikidata",
      "title": "Wikidata item Q8047: enzyme",
      "url": "https://www.wikidata.org/wiki/Q8047",
      "url_status": "live",
      "what_it_supports": "identity and sense of the item",
      "checked_by": "wikidata-api"
    },
    {
      "id": "wikipedia-en",
      "title": "Wikipedia: Enzyme",
      "url": "https://en.wikipedia.org/wiki/Enzyme",
      "url_status": "live",
      "what_it_supports": "general description of the item",
      "checked_by": "wikidata-api sitelink"
    }
  ],
  "structure": {
    "bundles": [
      {
        "id": "mechanism",
        "name": "Mechanism",
        "description": "How enzymes work.",
        "rationale": "Catalysis.",
        "layers": [
          {
            "id": "catalysis",
            "name": "Catalysis",
            "description": "Lowering activation energy.",
            "findings": [
              {
                "id": "catalysis-finding",
                "name": "Catalysis",
                "description": "Catalysis.",
                "questions": [
                  {
                    "text": "How does this enzyme catalyse its reaction, and what is its active site?",
                    "kind": "definition"
                  },
                  {
                    "text": "Which cofactors does it need?",
                    "kind": "provenance"
                  }
                ]
              }
            ]
          },
          {
            "id": "kinetics",
            "name": "Kinetics",
            "description": "Rates.",
            "findings": [
              {
                "id": "kinetics-finding",
                "name": "Kinetics",
                "description": "Kinetics.",
                "questions": [
                  {
                    "text": "What are the Km and Vmax of this enzyme, and what do they mean?",
                    "kind": "measurement"
                  },
                  {
                    "text": "How do inhibitors affect the rate?",
                    "kind": "definition"
                  }
                ]
              }
            ]
          }
        ]
      },
      {
        "id": "classify",
        "name": "Classify",
        "description": "Nomenclature.",
        "rationale": "EC numbers.",
        "layers": [
          {
            "id": "ec",
            "name": "EC",
            "description": "EC classification.",
            "findings": [
              {
                "id": "ec-finding",
                "name": "EC",
                "description": "Classification.",
                "questions": [
                  {
                    "text": "What is the EC number of this enzyme, and what does each part mean?",
                    "kind": "provenance"
                  },
                  {
                    "text": "Which database records it?",
                    "kind": "provenance"
                  }
                ]
              }
            ]
          },
          {
            "id": "regulation",
            "name": "Regulation",
            "description": "Control of activity.",
            "findings": [
              {
                "id": "regulation-finding",
                "name": "Regulation",
                "description": "Regulation.",
                "questions": [
                  {
                    "text": "How is this enzyme regulated, by allostery, modification or expression?",
                    "kind": "provenance"
                  },
                  {
                    "text": "What conditions affect its activity?",
                    "kind": "definition"
                  }
                ]
              }
            ]
          }
        ]
      },
      {
        "id": "uses",
        "name": "Uses",
        "description": "Applications.",
        "rationale": "Enzymes at work.",
        "layers": [
          {
            "id": "industry",
            "name": "Industry",
            "description": "Industrial enzymes.",
            "findings": [
              {
                "id": "industry-finding",
                "name": "Industry",
                "description": "Industry.",
                "questions": [
                  {
                    "text": "How are enzymes used in food, detergents, textiles and biofuels?",
                    "kind": "provenance"
                  },
                  {
                    "text": "Which safety rules apply to workers?",
                    "kind": "provenance"
                  }
                ]
              }
            ]
          },
          {
            "id": "medicine",
            "name": "Medicine",
            "description": "Diagnostics and therapy.",
            "findings": [
              {
                "id": "medicine-finding",
                "name": "Medicine",
                "description": "Medicine.",
                "questions": [
                  {
                    "text": "How are enzymes used in diagnostics and as therapies, in general terms?",
                    "kind": "provenance"
                  },
                  {
                    "text": "Is the user asking about their own enzyme test results?",
                    "kind": "boundary"
                  }
                ]
              }
            ]
          }
        ]
      },
      {
        "id": "learn",
        "name": "Learn",
        "description": "Study.",
        "rationale": "Resources exist.",
        "layers": [
          {
            "id": "deficiency",
            "name": "Deficiency",
            "description": "Enzyme deficiencies.",
            "findings": [
              {
                "id": "deficiency-finding",
                "name": "Deficiency",
                "description": "Deficiencies.",
                "questions": [
                  {
                    "text": "What is known about this enzyme deficiency, according to medical sources?",
                    "kind": "provenance"
                  },
                  {
                    "text": "Which specialist should be consulted?",
                    "kind": "provenance"
                  }
                ]
              }
            ]
          },
          {
            "id": "teach",
            "name": "Teach",
            "description": "Teaching.",
            "findings": [
              {
                "id": "teach-finding",
                "name": "Teach",
                "description": "Teaching.",
                "questions": [
                  {
                    "text": "How can enzyme action be demonstrated safely in class?",
                    "kind": "action"
                  },
                  {
                    "text": "Which misconceptions arise?",
                    "kind": "provenance"
                  }
                ]
              }
            ]
          }
        ]
      }
    ]
  },
  "openQuestions": [
    "Should each enzyme class be a separate entry?",
    "How should enzyme databases be linked?",
    "How should clinical guidance be linked?"
  ],
  "statistics": {
    "bundles": 4,
    "layers": 8,
    "findings": 8,
    "questions": 16
  }
}