{
  "vercy": "1.0-draft",
  "publication": {
    "status": "research-draft",
    "adjudicationStatus": "unreviewed",
    "publishableCanonical": false,
    "generatedAt": "2026-09-13T14:57:11Z",
    "providers": [
      "Claude"
    ],
    "breadth": "written by Claude from model knowledge without web access - no source was read, every claim is a lead to verify",
    "pass": 2,
    "wave": 4,
    "engine": "claude"
  },
  "metaModel": {
    "id": "THING-Q83692",
    "registryId": "vr.tr.bone-tissue",
    "name": "bone tissue",
    "version": "0.2.0-wave.4",
    "entryKind": "thing",
    "family": "Thing Registry",
    "domain": [
      "PHY.LIV"
    ],
    "status": "research-draft"
  },
  "canonicalUrl": "https://ver.cy/models/thing/q83692/",
  "model": {
    "registry_id": "vr.tr.bone-tissue",
    "name": "bone tissue",
    "purpose": "Let an agent explain bone tissue and its structure, relay cell types, composition, remodelling and disease from histology and physiology sources in general terms, describe the tissue of specific bones as the registry aliases name them, and distinguish bone tissue from bones as organs, from cartilage and from bone marrow.",
    "definition": "The hard mineralised connective tissue that forms the skeleton of vertebrates, composed of cells such as osteoblasts, osteocytes and osteoclasts in a matrix of collagen and hydroxyapatite, organised as compact and spongy bone and constantly remodelled; the registry aliases name the bone tissue of particular bones such as the vertebrae, sacrum, coccyx, sternum and scapula, which are anatomical entities made of this tissue.",
    "what_it_is_for": "Not applicable; a body tissue.",
    "affordances": [
      "explain structure and cells",
      "relay physiology and remodelling",
      "describe tissue in specific bones",
      "distinguish related concepts"
    ],
    "distinguishing_features": [
      "Mineralised matrix",
      "Living cells",
      "Compact and spongy",
      "Remodelled"
    ],
    "appearance": "A hard, white to yellowish tissue, dense at the surface and porous inside.",
    "visual_identification": [
      "Mineralised connective tissue of the skeleton",
      "Bone tissue of vertebrae, sacrum, coccyx, sternum and scapula",
      "Bones are organs containing the tissue; cartilage is unmineralised; marrow fills cavities"
    ],
    "physical_properties": [
      {
        "quantity": "mineral content",
        "typical_range": "about 60-70",
        "unit": "percent",
        "note": "hydroxyapatite"
      },
      {
        "quantity": "compressive strength",
        "typical_range": "about 170",
        "unit": "MPa",
        "note": "cortical bone"
      },
      {
        "quantity": "remodelling",
        "typical_range": "about 10 percent per year",
        "unit": "note",
        "note": "adult skeleton"
      }
    ],
    "families_and_kinds": [
      "compact or cortical bone",
      "spongy or trabecular bone",
      "woven and lamellar bone",
      "bone tissue of specific bones such as vertebrae, sternum and scapula",
      "bone tissue in growth and healing"
    ],
    "related_models": [
      {
        "relation": "is a kind of",
        "target": "hard tissue",
        "why": "in registry terms"
      },
      {
        "relation": "is a kind of",
        "target": "regular connective tissue",
        "why": "in registry terms"
      },
      {
        "relation": "composes",
        "target": "bone",
        "why": "as an organ"
      },
      {
        "relation": "is contrasted with",
        "target": "cartilage",
        "why": "unmineralised"
      }
    ],
    "identifiers": [
      {
        "scheme": "MeSH",
        "value_or_pattern": "D001842",
        "note": "Bone and Bones"
      },
      {
        "scheme": "UBERON",
        "value_or_pattern": "UBERON:0002481",
        "note": "bone tissue"
      }
    ],
    "standards_and_regulation": [
      "Clinical guidelines for bone disease",
      "Histology nomenclature"
    ],
    "failure_modes_and_hazards": [
      "Confusing tissue with organ",
      "Agents giving personal medical advice",
      "Registry aliases naming tissue of specific bones"
    ],
    "in_scope": [],
    "out_of_scope": [],
    "characteristics": []
  },
  "sources": [],
  "structure": {
    "bundles": [
      {
        "id": "understand",
        "name": "Understand",
        "description": "What bone tissue is.",
        "rationale": "Science.",
        "layers": [
          {
            "id": "definition",
            "name": "Definition",
            "description": "Definition.",
            "findings": [
              {
                "id": "definition-finding",
                "name": "Definition",
                "description": "Definition.",
                "questions": [
                  {
                    "text": "What is bone tissue, and how does it differ from bones as organs, cartilage and marrow?",
                    "kind": "definition"
                  },
                  {
                    "text": "Is the question about histology, physiology, a specific bone or a personal medical concern needing a clinician?",
                    "kind": "boundary"
                  }
                ]
              }
            ]
          },
          {
            "id": "structure",
            "name": "Structure",
            "description": "Structure.",
            "findings": [
              {
                "id": "structure-finding",
                "name": "Structure",
                "description": "Structure.",
                "questions": [
                  {
                    "text": "What are compact and spongy bone, osteons, lamellae and bone cells?",
                    "kind": "definition"
                  },
                  {
                    "text": "Which entry fits the specific structure?",
                    "kind": "action"
                  }
                ]
              }
            ]
          }
        ]
      },
      {
        "id": "physiology",
        "name": "Physiology",
        "description": "Physiology.",
        "rationale": "Science.",
        "layers": [
          {
            "id": "remodelling",
            "name": "Remodelling",
            "description": "Remodelling.",
            "findings": [
              {
                "id": "remodelling-finding",
                "name": "Remodelling",
                "description": "Remodelling.",
                "questions": [
                  {
                    "text": "How do osteoblasts and osteoclasts remodel bone, and how is it regulated?",
                    "kind": "provenance"
                  },
                  {
                    "text": "Which references are standard?",
                    "kind": "provenance"
                  }
                ]
              }
            ]
          },
          {
            "id": "growth",
            "name": "Growth",
            "description": "Growth and healing.",
            "findings": [
              {
                "id": "growth-finding",
                "name": "Growth",
                "description": "Growth.",
                "questions": [
                  {
                    "text": "How does bone form, grow and heal after fracture?",
                    "kind": "provenance"
                  },
                  {
                    "text": "Which sources are cited?",
                    "kind": "provenance"
                  }
                ]
              }
            ]
          }
        ]
      },
      {
        "id": "clinical",
        "name": "Clinical",
        "description": "Disease.",
        "rationale": "Clinical.",
        "layers": [
          {
            "id": "disease",
            "name": "Disease",
            "description": "Disease.",
            "findings": [
              {
                "id": "disease-finding",
                "name": "Disease",
                "description": "Disease.",
                "questions": [
                  {
                    "text": "What are osteoporosis, osteomalacia and other bone tissue diseases, in general terms?",
                    "kind": "provenance"
                  },
                  {
                    "text": "Which entry fits the specific disease?",
                    "kind": "action"
                  }
                ]
              }
            ]
          },
          {
            "id": "imaging",
            "name": "Imaging",
            "description": "Imaging and measurement.",
            "findings": [
              {
                "id": "imaging-finding",
                "name": "Imaging",
                "description": "Imaging.",
                "questions": [
                  {
                    "text": "How is bone density measured and imaged?",
                    "kind": "provenance"
                  },
                  {
                    "text": "Which entry fits bone densitometry?",
                    "kind": "action"
                  }
                ]
              }
            ]
          }
        ]
      },
      {
        "id": "context",
        "name": "Context",
        "description": "Bones and beyond.",
        "rationale": "Context.",
        "layers": [
          {
            "id": "bones",
            "name": "Bones",
            "description": "Specific bones.",
            "findings": [
              {
                "id": "bones-finding",
                "name": "Bones",
                "description": "Bones.",
                "questions": [
                  {
                    "text": "How does the tissue of vertebrae, sternum, scapula and coccyx differ in structure?",
                    "kind": "provenance"
                  },
                  {
                    "text": "Which entry fits the specific bone?",
                    "kind": "action"
                  }
                ]
              }
            ]
          },
          {
            "id": "materials",
            "name": "Materials",
            "description": "Materials science.",
            "findings": [
              {
                "id": "materials-finding",
                "name": "Materials",
                "description": "Materials.",
                "questions": [
                  {
                    "text": "How is bone studied as a biomaterial and mimicked in implants?",
                    "kind": "provenance"
                  },
                  {
                    "text": "Which entry fits biomaterial?",
                    "kind": "action"
                  }
                ]
              }
            ]
          }
        ]
      }
    ]
  },
  "openQuestions": [
    "Should compact and spongy bone be separate primary entries?",
    "How should histology sources be linked?",
    "The registry entry has merged aliases naming the tissue of specific bones; should they be split off?"
  ],
  "statistics": {
    "bundles": 4,
    "layers": 8,
    "findings": 8,
    "questions": 16
  }
}