{ "vercy": "1.0-draft", "publication": { "status": "research-draft", "adjudicationStatus": "unreviewed", "publishableCanonical": false, "generatedAt": "2026-09-13T03:39:09Z", "providers": [ "Claude" ], "breadth": "written by Claude from model knowledge without web access - no source was read, every claim is a lead to verify", "pass": 2, "wave": 3, "engine": "claude", "enrichment": { "pass": 3, "engine": "claude", "producedAt": "2026-10-06T10:00:00Z", "ingestedAt": "2026-10-06T07:06:37+00:00", "fields": [ "agent_conduct", "ethics", "owners" ] }, "revisions": [ { "at": "2026-10-06T23:00:35+00:00", "engine": "codex", "fields": [ "definition", "visual_identification" ], "answering_review": "c17f41d31d351a6a2e55c782c77ab58fb601cd3b563c5fc623cab2c46aa5d25b" } ], "gate": { "passed": true, "version": "1.0", "at": "2026-10-07T10:10:33+00:00", "evidence": [ "completeness 1.00", "sense: Wikidata description", "2 live sources", "review by codex: pass" ] } }, "metaModel": { "id": "THING-Q84737692", "registryId": "vr.tr.imidazole-alkaloid", "name": "imidazole alkaloid", "version": "0.2.0-wave.3", "entryKind": "thing", "family": "Thing Registry", "domain": [ "PHY.MAT" ], "status": "research-draft" }, "canonicalUrl": "https://ver.cy/models/thing/q84737692/", "model": { "registry_id": "vr.tr.imidazole-alkaloid", "name": "imidazole alkaloid", "purpose": "Let an agent explain imidazole alkaloids as a class, relay examples, sources and pharmacology from natural product references, describe medical uses in general terms, and distinguish imidazole alkaloids from other alkaloid classes.", "definition": "An alkaloid whose structure contains an imidazole ring, a class including pilocarpine from jaborandi used to treat glaucoma and dry mouth, histamine-related compounds, and many marine natural products such as the naamidines and isonaamidines from sponges and compounds such as crathridine; containing an imidazole-bearing amino acid residue does not by itself make a peptide an imidazole alkaloid; imidazole alkaloids are studied for pharmacological activity and as chemical ecology signals.", "what_it_is_for": "Not applicable; a class of natural compounds.", "affordances": [ "explain the class", "relay examples and sources", "describe pharmacology", "distinguish from other classes" ], "distinguishing_features": [ "Imidazole ring", "Diverse natural sources", "Pharmacological activity", "Marine prominence" ], "appearance": "Not a visible object; compounds within plants, sponges and microbes.", "visual_identification": [ "Imidazole alkaloids contain an imidazole ring.", "Examples include pilocarpine, naamidines, isonaamidines and crathridine.", "Indole, pyrrolizidine and isoquinoline alkaloids have different ring systems, while histamine itself is usually classed as a biogenic amine." ], "physical_properties": [ { "quantity": "pilocarpine isolated", "typical_range": "1874", "unit": "year", "note": "" }, { "quantity": "imidazole ring", "typical_range": "five-membered with two nitrogens", "unit": "structure", "note": "" } ], "families_and_kinds": [ "plant imidazole alkaloids such as pilocarpine", "marine sponge alkaloids such as naamidines and isonaamidines", "bacterial imidazole-containing peptides such as kurstakins", "other natural products such as crathridine", "synthetic imidazole derivatives as related compounds" ], "related_models": [ { "relation": "is a kind of", "target": "alkaloid", "why": "in registry terms" }, { "relation": "is a kind of", "target": "imidazole", "why": "in registry terms, as derivatives" }, { "relation": "is exemplified by", "target": "pilocarpine", "why": "a glaucoma drug" }, { "relation": "is produced by", "target": "sponge", "why": "among marine sources" } ], "identifiers": [], "standards_and_regulation": [ "Drug regulation of pilocarpine and related medicines", "Natural product nomenclature conventions", "Biodiversity access rules for marine sampling" ], "failure_modes_and_hazards": [ "Toxicity of some alkaloids", "Agents giving personal medication advice", "Registry aliases with unwieldy systematic names" ], "in_scope": [], "out_of_scope": [], "characteristics": [], "agent_conduct": { "may": [ "Describe the imidazole alkaloid class and its main members from chemical and pharmacological sources.", "Note that pilocarpine is a prescription medicine used under medical supervision.", "Handle unwieldy systematic aliases by linking them to the class or to a named compound." ], "must_not": [ "Give dosing or self-medication advice for pilocarpine or any alkaloid.", "Describe how to extract or concentrate alkaloids from plants or sponges.", "Present marine alkaloids under study as proven medicines.", "Encourage harvesting of protected plants or marine sponges." ], "requires_human": [ "Use of any alkaloid in treatment for a patient." ] }, "ethics": { "considerations": [ "Some alkaloids are toxic, and self-medication can cause poisoning.", "Bioprospecting can take resources from source countries without fair benefit sharing." ], "affected_parties": [ "Patients", "Communities in source regions", "Marine ecosystems" ] }, "owners": { "steward": "Nobody owns the class; manufacturers and medicines regulators answer for approved drugs.", "master_systems": [] } }, "sources": [ { "id": "wikidata", "title": "Wikidata item Q84737692: imidazole alkaloid", "url": "https://www.wikidata.org/wiki/Q84737692", "url_status": "live", "what_it_supports": "identity and sense of the item", "checked_by": "wikidata-api" }, { "id": "wikipedia-en", "title": "Wikipedia: Imidazole alkaloids", "url": "https://en.wikipedia.org/wiki/Imidazole_alkaloids", "url_status": "live", "what_it_supports": "general description of the item", "checked_by": "wikidata-api sitelink" } ], "structure": { "bundles": [ { "id": "understand", "name": "Understand", "description": "What imidazole alkaloids are.", "rationale": "Science.", "layers": [ { "id": "definition", "name": "Definition", "description": "Definition and structure.", "findings": [ { "id": "definition-finding", "name": "Definition", "description": "Definition.", "questions": [ { "text": "What defines an imidazole alkaloid, and how does the imidazole ring shape its chemistry?", "kind": "definition" }, { "text": "Is the question about imidazole alkaloids or another alkaloid or imidazole class?", "kind": "boundary" } ] } ] }, { "id": "examples", "name": "Examples", "description": "Examples.", "findings": [ { "id": "examples-finding", "name": "Examples", "description": "Examples.", "questions": [ { "text": "What are pilocarpine, the naamidines, isonaamidines, kurstakins and crathridine, and where are they found?", "kind": "definition" }, { "text": "Which entry fits the specific compound?", "kind": "action" } ] } ] } ] }, { "id": "biology", "name": "Biology", "description": "Biology and pharmacology.", "rationale": "Science.", "layers": [ { "id": "pharmacology", "name": "Pharmacology", "description": "Pharmacology.", "findings": [ { "id": "pharmacology-finding", "name": "Pharmacology", "description": "Pharmacology.", "questions": [ { "text": "What pharmacological activities do imidazole alkaloids show, such as pilocarpine muscarinic action?", "kind": "provenance" }, { "text": "Which references are standard?", "kind": "provenance" } ] } ] }, { "id": "ecology", "name": "Ecology", "description": "Chemical ecology.", "findings": [ { "id": "ecology-finding", "name": "Ecology", "description": "Ecology.", "questions": [ { "text": "What roles do these alkaloids play in sponges, plants and bacteria?", "kind": "provenance" }, { "text": "Which entry fits chemical ecology?", "kind": "action" } ] } ] } ] }, { "id": "medicine", "name": "Medicine", "description": "Medicine.", "rationale": "Clinical.", "layers": [ { "id": "drugs", "name": "Drugs", "description": "Drugs.", "findings": [ { "id": "drugs-finding", "name": "Drugs", "description": "Drugs.", "questions": [ { "text": "How is pilocarpine used in glaucoma and dry mouth, in general terms?", "kind": "provenance" }, { "text": "Is the user asking about their own medication, which needs a clinician or pharmacist?", "kind": "boundary" } ] } ] }, { "id": "research", "name": "Research", "description": "Drug discovery.", "findings": [ { "id": "research-finding", "name": "Research", "description": "Research.", "questions": [ { "text": "What research explores marine imidazole alkaloids as drug leads, with findings attributed?", "kind": "provenance" }, { "text": "Which sources are cited?", "kind": "provenance" } ] } ] } ] }, { "id": "context", "name": "Context", "description": "Chemistry and history.", "rationale": "Context.", "layers": [ { "id": "synthesis", "name": "Synthesis", "description": "Synthesis and analysis.", "findings": [ { "id": "synthesis-finding", "name": "Synthesis", "description": "Synthesis.", "questions": [ { "text": "How are imidazole alkaloids isolated, characterised and synthesised, in general terms?", "kind": "provenance" }, { "text": "Which entry fits natural product chemistry?", "kind": "action" } ] } ] }, { "id": "history", "name": "History", "description": "History.", "findings": [ { "id": "history-finding", "name": "History", "description": "History.", "questions": [ { "text": "How were jaborandi and pilocarpine discovered and adopted in medicine?", "kind": "provenance" }, { "text": "Which entry fits the history of pharmacognosy?", "kind": "action" } ] } ] } ] } ] }, "openQuestions": [ "Should pilocarpine be a separate primary entry?", "How should natural product databases be linked?", "The registry entry has merged aliases with long systematic names; should they be split off?" ], "statistics": { "bundles": 4, "layers": 8, "findings": 8, "questions": 16 } }