{ "vercy": "1.0-draft", "publication": { "status": "research-draft", "adjudicationStatus": "unreviewed", "publishableCanonical": false, "generatedAt": "2026-09-13T13:11:03Z", "providers": [ "Claude" ], "breadth": "written by Claude from model knowledge without web access - no source was read, every claim is a lead to verify", "pass": 2, "wave": 4, "engine": "claude", "enrichment": { "pass": 3, "engine": "claude", "producedAt": "2026-10-06T12:00:00Z", "ingestedAt": "2026-10-06T07:34:49+00:00", "fields": [ "agent_conduct", "ethics", "owners" ] }, "revisions": [ { "at": "2026-10-06T23:01:12+00:00", "engine": "codex", "fields": [ "definition", "distinguishing_features" ], "answering_review": "993df1222a70baeccce4da8936dec27969d8e7fb888e2fc855b37b059111fa92" } ], "gate": { "passed": true, "version": "1.0", "at": "2026-10-07T10:10:33+00:00", "evidence": [ "completeness 1.00", "sense: Wikidata description", "2 live sources", "review by codex: pass" ] } }, "metaModel": { "id": "THING-Q890200", "registryId": "vr.tr.blood-coagulation-disease", "name": "blood coagulation disease", "version": "0.2.0-wave.4", "entryKind": "thing", "family": "Thing Registry", "domain": [ "INF.KNW" ], "status": "research-draft" }, "canonicalUrl": "https://ver.cy/models/thing/q890200/", "model": { "registry_id": "vr.tr.blood-coagulation-disease", "name": "blood coagulation disease", "purpose": "Let an agent explain blood coagulation diseases and their kinds, relay mechanisms, diagnosis and treatment from haematology references in general terms, route people with bleeding or a diagnosis to clinicians and emergency services, and distinguish coagulation disorders from platelet disorders, vascular bleeding and thrombophilia.", "definition": "A condition in which the blood's ability to coagulate and form clots is impaired, including inherited coagulation factor deficiencies such as haemophilia A and B and von Willebrand disease, the rare hereditary combined deficiency of vitamin K-dependent factors, acquired conditions such as vitamin K deficiency bleeding of the newborn, liver disease and consumption coagulopathy, and drug-induced disorders; serious bleeding is an emergency and these conditions are managed by haematologists.", "what_it_is_for": "Not applicable; a disease group.", "affordances": [ "route emergencies first", "explain kinds and mechanisms", "relay diagnosis and treatment", "distinguish related disorders" ], "distinguishing_features": [ "Blood clot formation is impaired.", "Conditions may be inherited or acquired.", "Impaired coagulation creates a bleeding tendency.", "These conditions require specialist care." ], "appearance": "Not a visible object; bruising, prolonged bleeding or clotting.", "visual_identification": [ "Disorder of the clotting cascade", "Haemophilia, von Willebrand disease, factor deficiencies, vitamin K deficiency bleeding, consumption coagulopathy", "Platelet disorders affect primary haemostasis; thrombophilia favours clots; vascular bleeding is vessel weakness" ], "physical_properties": [ { "quantity": "haemophilia A prevalence", "typical_range": "about 1 in 5000", "unit": "male births", "note": "" }, { "quantity": "von Willebrand disease", "typical_range": "most common inherited bleeding disorder", "unit": "note", "note": "" }, { "quantity": "coagulation factors", "typical_range": "13 numbered", "unit": "count", "note": "traditional numbering" } ], "families_and_kinds": [ "inherited factor deficiencies such as haemophilia A and B", "von Willebrand disease", "rare deficiencies including combined vitamin K-dependent factor deficiency", "vitamin K deficiency bleeding of the newborn", "acquired coagulopathies from liver disease, anticoagulants and DIC", "coagulation protein disorders causing thrombosis" ], "related_models": [ { "relation": "is a kind of", "target": "hemic system symptom", "why": "in registry terms" }, { "relation": "is a kind of", "target": "blood disorder", "why": "in general terms" }, { "relation": "is exemplified by", "target": "haemophilia", "why": "the best known inherited form" }, { "relation": "is contrasted with", "target": "platelet disorder", "why": "affecting primary haemostasis" } ], "identifiers": [ { "scheme": "ICD-10", "value_or_pattern": "D65-D69", "note": "coagulation defects and other haemorrhagic conditions" }, { "scheme": "MeSH", "value_or_pattern": "D001778", "note": "Blood Coagulation Disorders" } ], "standards_and_regulation": [ "WFH and national haemophilia guidelines", "Newborn vitamin K prophylaxis recommendations", "Blood product and factor concentrate regulation" ], "failure_modes_and_hazards": [ "Delayed treatment of serious bleeding", "Agents giving personal medical advice", "Confusing coagulation and platelet disorders" ], "in_scope": [], "out_of_scope": [], "characteristics": [], "agent_conduct": { "may": [ "Explain the kinds of clotting disorders, inherited and acquired, from medical sources.", "Point people to haemophilia and bleeding disorder centres.", "Distinguish bleeding from clotting tendencies." ], "must_not": [ "Diagnose a coagulation disorder or interpret a person's clotting tests.", "Advise starting, stopping or changing anticoagulants or factor therapy.", "Disclose a person's bleeding disorder or carrier status without consent.", "Advise a person with a bleeding disorder on surgery or injections without their care team." ], "requires_human": [ "Any treatment decision for a person with a bleeding or clotting disorder." ] }, "ethics": { "considerations": [ "Wrong advice on blood thinners or clotting factors can cause fatal bleeding or clots.", "Carrier status is genetic information that affects whole families." ], "affected_parties": [ "Patients and carriers", "Families", "Clinicians" ] }, "owners": { "steward": "Nobody owns the condition; treating haematologists answer for care, and haemophilia centres keep patient registers.", "master_systems": [ "National haemophilia and bleeding disorder registries" ] } }, "sources": [ { "id": "wikidata", "title": "Wikidata item Q890200: blood coagulation disease", "url": "https://www.wikidata.org/wiki/Q890200", "url_status": "live", "what_it_supports": "identity and sense of the item", "checked_by": "wikidata-api" }, { "id": "wikipedia-en", "title": "Wikipedia: Coagulopathy", "url": "https://en.wikipedia.org/wiki/Coagulopathy", "url_status": "live", "what_it_supports": "general description of the item", "checked_by": "wikidata-api sitelink" } ], "structure": { "bundles": [ { "id": "emergency", "name": "Emergency", "description": "Serious bleeding.", "rationale": "Clinical.", "layers": [ { "id": "act", "name": "Act", "description": "Act now.", "findings": [ { "id": "act-finding", "name": "Act", "description": "Act.", "questions": [ { "text": "Does the user describe heavy or uncontrolled bleeding, head injury or bleeding in a known disorder, which needs emergency care?", "kind": "boundary" }, { "text": "Has the agent directed the user to emergency services or their haemophilia centre before anything else?", "kind": "action" } ] } ] }, { "id": "signs", "name": "Signs", "description": "Warning signs.", "findings": [ { "id": "signs-finding", "name": "Signs", "description": "Signs.", "questions": [ { "text": "What signs suggest a bleeding disorder, as authorities list them?", "kind": "definition" }, { "text": "Which entry fits emergency medical services?", "kind": "action" } ] } ] } ] }, { "id": "understand", "name": "Understand", "description": "What these diseases are.", "rationale": "Clinical.", "layers": [ { "id": "definition", "name": "Definition", "description": "Definition and kinds.", "findings": [ { "id": "definition-finding", "name": "Definition", "description": "Definition.", "questions": [ { "text": "What are blood coagulation diseases, and how do inherited, acquired, newborn and consumption forms differ?", "kind": "definition" }, { "text": "Is the question about the group or a personal case needing a clinician?", "kind": "boundary" } ] } ] }, { "id": "mechanism", "name": "Mechanism", "description": "Mechanism.", "findings": [ { "id": "mechanism-finding", "name": "Mechanism", "description": "Mechanism.", "questions": [ { "text": "How does the coagulation cascade work, and how do factor deficiencies and vitamin K affect it?", "kind": "provenance" }, { "text": "Which entry fits the specific disorder?", "kind": "action" } ] } ] } ] }, { "id": "care", "name": "Care", "description": "Diagnosis and treatment.", "rationale": "Clinical.", "layers": [ { "id": "diagnosis", "name": "Diagnosis", "description": "Diagnosis.", "findings": [ { "id": "diagnosis-finding", "name": "Diagnosis", "description": "Diagnosis.", "questions": [ { "text": "How are coagulation disorders diagnosed with clotting times, factor assays and genetics, in general terms?", "kind": "provenance" }, { "text": "Which references are standard?", "kind": "provenance" } ] } ] }, { "id": "treatment", "name": "Treatment", "description": "Treatment.", "findings": [ { "id": "treatment-finding", "name": "Treatment", "description": "Treatment.", "questions": [ { "text": "What treatments exist, from factor replacement and gene therapy to vitamin K and management of DIC, as guidelines state?", "kind": "provenance" }, { "text": "Which sources are cited?", "kind": "provenance" } ] } ] } ] }, { "id": "context", "name": "Context", "description": "Living and history.", "rationale": "Context.", "layers": [ { "id": "living", "name": "Living", "description": "Living with a disorder.", "findings": [ { "id": "living-finding", "name": "Living", "description": "Living.", "questions": [ { "text": "How do people with bleeding disorders manage daily life, and where are support organisations?", "kind": "action" }, { "text": "Which entry fits haemophilia organisations?", "kind": "action" } ] } ] }, { "id": "history", "name": "History", "description": "History.", "findings": [ { "id": "history-finding", "name": "History", "description": "History.", "questions": [ { "text": "How did understanding and treatment of haemophilia develop, including the contaminated blood scandals, as historians describe?", "kind": "provenance" }, { "text": "Which entry fits the history of haematology?", "kind": "action" } ] } ] } ] } ] }, "openQuestions": [ "Should haemophilia, von Willebrand disease and DIC be separate primary entries?", "How should haematology references be linked?", "The registry entry has merged aliases naming distinct disorders; should they be split off?" ], "statistics": { "bundles": 4, "layers": 8, "findings": 8, "questions": 16 } }