{ "vercy": "1.0-draft", "publication": { "status": "research-draft", "adjudicationStatus": "unreviewed", "publishableCanonical": false, "generatedAt": "2026-09-12T09:17:43Z", "providers": [ "Codex" ], "breadth": "recalled by Codex without web access - no source was read", "missingProviders": [], "pass": 2, "cost": { "grok": { "seconds": 23.5, "error": "Reading additional input from stdin...\nOpenAI Codex v0.153.4\n--------\nworkdir: R:\\02_PROJECTS\\02_Meta_Models_Platforms\\Ver.cy\\current\\thing-registry-backlog\nmodel: gpt-6-astra\nprovider: openai\napproval: never\nsandbox: read-only\nreasoning effort: none\nreasoning summaries: none\nsession id: 01a094e7-4da9-71d0-92c1-4fbc10100c3a\n--------\nuser\nDescribe what is already known about one registered thing. Answer as JSON only, no prose around it.\n\nThing: doramectin\nSense to describe: (none recorded)\nDomain code: PHY.MAT\nAlso known as: (none)\n\n\nContext for this batch of 1001 things:\n# Batch 043: 1001 regi", "usd": 0.0, "recall": true }, "codex": { "seconds": 82.5, "error": "Reading additional input from stdin...\nOpenAI Codex v0.153.4\n--------\nworkdir: R:\\02_PROJECTS\\02_Meta_Models_Platforms\\Ver.cy\\current\\thing-registry-backlog\nmodel: gpt-6-astra\nprovider: openai\napproval: never\nsandbox: read-only\nreasoning effort: none\nreasoning summaries: none\nsession id: 01a094e7-4d98-7aa2-a11d-beb511efad75\n--------\nuser\nYou are drafting a Vercy meta-model for one registered thing. Answer as JSON only, no prose around it.\n\nThing: doramectin\nRegistry id: vr.tr.doramectin\nPlane / domain: PHY / PHY.MAT\nRegistry definition: (none recorded)\nNames folded into this entry: (none)\n\n\nCo" } }, "enrichment": { "pass": 3, "engine": "claude", "producedAt": "2026-10-06T12:00:00Z", "ingestedAt": "2026-10-06T08:55:52+00:00", "fields": [ "agent_conduct", "ethics", "failure_modes_and_hazards", "owners", "visual_identification" ] }, "gate": { "passed": true, "version": "1.0", "at": "2026-10-07T10:10:33+00:00", "evidence": [ "completeness 1.00", "sense: Wikidata description", "2 live sources", "review by codex: pass" ] } }, "metaModel": { "id": "THING-Q906534", "registryId": "vr.tr.doramectin", "name": "doramectin", "version": "0.1.0-research.1", "entryKind": "thing", "family": "Thing Registry", "domain": [ "PHY.MAT" ], "status": "research-draft" }, "canonicalUrl": "https://ver.cy/models/thing/q906534/", "model": { "registry_id": "vr.tr.doramectin", "name": "doramectin", "purpose": "Enable an agent to identify doramectin, assess the quality and condition of a material containing it, and determine which handling or veterinary-use decisions require further evidence.", "definition": "Doramectin is an avermectin-class macrocyclic lactone used as a veterinary antiparasitic active substance against susceptible nematodes and arthropod parasites.", "scope_statement": "This model owns doramectin as the chemical substance registered as vr.tr.doramectin in PHY / PHY.MAT, including molecular identity, material quality, physicochemical state, biological activity and substance-specific constraints.", "in_scope": [ "Doramectin molecular identity, stereochemistry and identifier reconciliation", "Bulk substance and reference-standard grades, assay and related impurities", "Physical properties, stability and storage conditions with measurement context", "Antiparasitic activity and evidence of susceptibility or resistance", "Substance hazards, environmental fate and links to veterinary authorizations" ], "out_of_scope": [ "Finished injectable or pour-on products, their excipients and packaging", "Individual animal diagnosis, prescribing and treatment administration", "Fermentation equipment and manufacturing-process operation", "Parasite taxonomy and complete parasite life-cycle models", "Farm parasite-control programs and food-product release decisions" ], "distinguishing_features": [ "Match the complete stereochemical structure and CAS 117704-25-3; the formula C50H74O14 alone cannot establish identity. [KEGG doramectin record](https://www.kegg.jp/entry/D01129)", "Require an analytical identity test that distinguishes doramectin from ivermectin, abamectin and other related macrocyclic lactones.", "Check whether the record describes the active substance or a formulated medicine: Dectomax injection contains doramectin plus formulation ingredients. [Dectomax label](https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=44b8a743-4f00-457a-8b7e-5f3a557c04f1)", "Distinguish intact doramectin from epimers, degradation products and metabolites using a method capable of resolving the relevant species." ], "characteristics": [ { "name": "Chemical identity", "kind": "category", "unit_or_values": "CAS 117704-25-3; formula C50H74O14; stereochemical structure and verified database identifiers", "why_it_matters": "Prevents substitution of a related avermectin or an incorrectly mapped structure." }, { "name": "Material grade", "kind": "category", "unit_or_values": "Veterinary API, analytical reference standard, research material or unspecified; governing specification", "why_it_matters": "Determines which uses the supporting quality evidence can justify." }, { "name": "Doramectin assay", "kind": "measurement", "unit_or_values": "% mass fraction, with as-is or dry basis and analytical method", "why_it_matters": "Separates measured active content from nominal purity and chromatographic area percentage." }, { "name": "Related-substance profile", "kind": "measurement", "unit_or_values": "Individual and total impurities in % or mg/kg; identities, detection limits and method", "why_it_matters": "Reveals contamination, degradation or unresolved related compounds." }, { "name": "Physical form and thermal behavior", "kind": "state", "unit_or_values": "Observed phase and solid form; transition or decomposition temperature in °C with method", "why_it_matters": "Supports material recognition and prevents treating decomposition as an ordinary boiling point." }, { "name": "Solubility and partitioning", "kind": "measurement", "unit_or_values": "Solubility in mg/L with solvent, temperature and pH; partition coefficient with method", "why_it_matters": "Informs sample preparation, formulation compatibility and exposure assessment." }, { "name": "Stability status", "kind": "state", "unit_or_values": "Within supported storage period, excursion pending assessment, degraded or unassessed", "why_it_matters": "Connects storage history to current assay and impurity evidence." }, { "name": "Parasite susceptibility", "kind": "relation", "unit_or_values": "Parasite species, life stage and population linked to assay endpoint, exposure and result", "why_it_matters": "Prevents activity claims from being generalized across parasites or resistant populations." }, { "name": "Hazard and authorization evidence", "kind": "relation", "unit_or_values": "Dated SDS classifications, exposure limits and authority records linked to material or product scope", "why_it_matters": "Keeps substance handling constraints separate from product-specific permission to treat animals." } ], "affordances": [ "Reconcile a supplier material or analytical result with the registered doramectin identity.", "Assess a lot against its declared doramectin grade and impurity specification.", "Select a supported analytical preparation and identity or assay method.", "Flag storage excursions or degradation evidence for material reassessment.", "Retrieve applicable product authorization and residue evidence before a veterinary-use decision.", "Identify handling and disposal controls from material-specific hazard and environmental evidence." ], "agent_conduct": { "may": [ "Describe doramectin and its approved veterinary uses from regulatory sources.", "Report withdrawal periods for meat and milk as stated on the product label." ], "must_not": [ "Recommend it or a dose for an animal without a veterinarian's direction.", "Advise using livestock products on dogs, especially breeds sensitive to avermectins.", "Advise selling meat or milk from treated animals before the withdrawal period ends.", "Advise disposing of it where it can reach water or dung fauna." ], "requires_human": [ "Any decision to treat an animal or a herd with it." ] }, "ethics": { "considerations": [ "Wrong use can kill sensitive dogs and leave residues in food.", "Avermectins harm dung beetles and aquatic life that farmland depends on." ], "affected_parties": [ "Treated animals", "Dogs of sensitive breeds", "Consumers", "Dung beetles and aquatic life" ] }, "owners": { "steward": "The marketing authorization holder; veterinary medicines regulators and veterinarians control its use.", "master_systems": [ "Veterinary medicines product registers" ] }, "visual_identification": [ "Supplied as injectable solutions or pour-on liquids for livestock; identified by label." ], "failure_modes_and_hazards": [ "Toxic to some dog breeds and to aquatic organisms.", "Overuse drives parasite resistance." ], "what_it_is_for": [ "Doramectin is encountered in veterinary medicines for controlling susceptible internal and external parasites in approved animal species.", "It is also encountered in pharmaceutical quality testing and residue monitoring associated with treated food-producing animals.", "Its suitability depends on the animal species, formulation, authorized indication and applicable veterinary requirements." ], "standards_and_regulation": [ "Regulation (EU) 2019/6, issued by the European Parliament and the Council of the European Union, governs veterinary medicinal products containing doramectin in the European Union.", "Commission Regulation (EU) No 37/2010, issued by the European Commission, lists doramectin within the framework for pharmacologically active substances and maximum residue limits in foodstuffs of animal origin." ] }, "sources": [ { "id": "wikidata", "title": "Wikidata item Q906534: doramectin", "url": "https://www.wikidata.org/wiki/Q906534", "url_status": "live", "what_it_supports": "identity and sense of the item", "checked_by": "wikidata-api" }, { "id": "wikipedia-en", "title": "Wikipedia: Doramectin", "url": "https://en.wikipedia.org/wiki/Doramectin", "url_status": "live", "what_it_supports": "general description of the item", "checked_by": "wikidata-api sitelink" } ], "structure": { "bundles": [ { "id": "doramectin-identity", "name": "Doramectin identity", "description": "Establish the precise chemical entity represented by the registry entry.", "rationale": "Related avermectins and differing structure records make name-only matching insufficient.", "layers": [ { "id": "molecular-definition", "name": "Molecular definition", "description": "Resolve the structure and identifiers that define doramectin.", "findings": [ { "id": "structure-identifier-agreement", "name": "Structure and identifier agreement", "description": "Require agreement among the accepted stereochemical structure, chemical name and identifier records.", "questions": [ { "text": "Which stereochemical structure and canonical identifiers define doramectin for this registry entry?", "kind": "definition", "id": "structure-identifier-agreement-q01" }, { "text": "Which authoritative records support the CAS, PubChem and EC mappings, and do their structures agree?", "kind": "provenance", "id": "structure-identifier-agreement-q02" } ] } ] }, { "id": "related-compound-boundaries", "name": "Related-compound boundaries", "description": "Separate doramectin from neighbouring substances and formulated medicines.", "findings": [ { "id": "identity-discrimination", "name": "Identity discrimination", "description": "Define the evidence needed to distinguish the intact active substance from related avermectins, epimers and products.", "questions": [ { "text": "Which structural and analytical features distinguish doramectin from ivermectin, abamectin and doramectin epimers?", "kind": "boundary", "id": "identity-discrimination-q01" }, { "text": "Does the assessed sample represent bulk doramectin, a reference standard or a finished formulation?", "kind": "boundary", "id": "identity-discrimination-q02" } ] } ] } ] }, { "id": "doramectin-material-quality", "name": "Doramectin material quality", "description": "Assess whether a particular lot supports its declared identity, grade and intended use.", "rationale": "Chemical identity alone does not establish API suitability or analytical-standard reliability.", "layers": [ { "id": "grade-and-lot-evidence", "name": "Grade and lot evidence", "description": "Connect the material to specifications and traceable quality records.", "findings": [ { "id": "grade-qualification", "name": "Grade qualification", "description": "Record the declared grade, lot provenance and evidence supporting acceptance.", "questions": [ { "text": "Which specification governs this doramectin lot, and which intended uses does it support?", "kind": "boundary", "id": "grade-qualification-q01" }, { "text": "Which manufacturer, lot record and certificate of analysis establish its provenance?", "kind": "provenance", "id": "grade-qualification-q02" } ] } ] }, { "id": "assay-and-impurities", "name": "Assay and impurities", "description": "Establish active content and resolve substances that compromise quality.", "findings": [ { "id": "analytical-quality-assessment", "name": "Analytical quality assessment", "description": "Evaluate assay basis, related substances, water and residual solvents without equating peak area with mass purity.", "questions": [ { "text": "What doramectin content is measured, on what basis, and with what reference standard and uncertainty?", "kind": "measurement", "id": "analytical-quality-assessment-q01" }, { "text": "Which related substances, residual solvents and water levels are measured, and does the method resolve relevant epimers and degradation products?", "kind": "measurement", "id": "analytical-quality-assessment-q02" }, { "text": "Do the results justify accepting the lot, further testing it or withholding it from the intended use?", "kind": "action", "id": "analytical-quality-assessment-q03" } ] } ] } ] }, { "id": "doramectin-physical-state", "name": "Doramectin physical state and stability", "description": "Characterize the material under explicit physical and storage conditions.", "rationale": "Bulk-substance properties must be distinguished from those of solvent-containing veterinary products.", "layers": [ { "id": "phase-and-solution-behavior", "name": "Phase and solution behavior", "description": "Capture condition-dependent properties needed for identification and preparation.", "findings": [ { "id": "measured-physical-properties", "name": "Measured physical properties", "description": "Record observed solid form, thermal behavior and solvent-specific solubility with experimental context.", "questions": [ { "text": "What phase, solid form and melting or decomposition behavior are experimentally established for the assessed doramectin material?", "kind": "measurement", "id": "measured-physical-properties-q01" }, { "text": "What solubility and partitioning measurements exist, and which solvent, temperature and pH conditions apply?", "kind": "measurement", "id": "measured-physical-properties-q02" } ] } ] }, { "id": "degradation-and-storage", "name": "Degradation and storage", "description": "Relate exposure history to retained identity and quality.", "findings": [ { "id": "stability-supported-condition", "name": "Stability-supported condition", "description": "Use material-specific stability evidence to assess storage, preparation and retest decisions.", "questions": [ { "text": "Which light, temperature, moisture or oxidation exposures change doramectin assay or impurity levels?", "kind": "measurement", "id": "stability-supported-condition-q01" }, { "text": "Which storage and retest conditions are supported for this bulk grade or prepared analytical solution?", "kind": "provenance", "id": "stability-supported-condition-q02" }, { "text": "What evidence is required to assess a storage excursion before continued use?", "kind": "action", "id": "stability-supported-condition-q03" } ] } ] } ] }, { "id": "doramectin-antiparasitic-activity", "name": "Doramectin antiparasitic activity", "description": "Connect biological activity to parasite targets and the conditions under which effects were demonstrated.", "rationale": "A macrocyclic-lactone class association cannot establish effectiveness for every parasite, host or exposure.", "layers": [ { "id": "mechanism-and-spectrum", "name": "Mechanism and spectrum", "description": "Separate mechanistic evidence from demonstrated parasite control.", "findings": [ { "id": "target-specific-activity", "name": "Target-specific activity", "description": "The product label describes chloride-channel modulation in nematodes and arthropods; the model must distinguish class-level mechanism from doramectin-specific evidence. [Dectomax label](https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=44b8a743-4f00-457a-8b7e-5f3a557c04f1)", "questions": [ { "text": "Which molecular-target studies directly establish doramectin activity rather than infer it from the macrocyclic-lactone class?", "kind": "provenance", "id": "target-specific-activity-q01" }, { "text": "Which parasite species and life stages have measured susceptibility, using which endpoints and exposures?", "kind": "measurement", "id": "target-specific-activity-q02" } ] } ] }, { "id": "exposure-and-resistance", "name": "Exposure and resistance", "description": "Qualify activity by achieved exposure and parasite population.", "findings": [ { "id": "effectiveness-transfer-limits", "name": "Effectiveness transfer limits", "description": "Require supporting evidence before transferring efficacy between formulations, routes, hosts or parasite populations.", "questions": [ { "text": "Which host, formulation and route produced the exposure underlying the reported effect?", "kind": "boundary", "id": "effectiveness-transfer-limits-q01" }, { "text": "What doramectin susceptibility or resistance evidence exists for the relevant parasite population, including cross-resistance testing?", "kind": "measurement", "id": "effectiveness-transfer-limits-q02" } ] } ] } ] }, { "id": "doramectin-safety-and-permitted-use", "name": "Doramectin safety and permitted use", "description": "Identify material handling constraints, environmental concerns and the external records governing veterinary use.", "rationale": "Worker exposure, environmental release and food-animal residues require different evidence and cannot be reduced to one safety status.", "layers": [ { "id": "handling-and-environment", "name": "Handling and environment", "description": "Evaluate exposure pathways for bulk material, contaminated waste and excreted residues.", "findings": [ { "id": "exposure-controls", "name": "Exposure controls", "description": "Capture material-specific hazards alongside environmental evidence; the product label identifies aquatic-organism and dung-insect concerns. [Dectomax label](https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=44b8a743-4f00-457a-8b7e-5f3a557c04f1)", "questions": [ { "text": "Which dated SDS establishes the applicable GHS classifications, handling controls and any occupational exposure limit for this material?", "kind": "provenance", "id": "exposure-controls-q01" }, { "text": "What measured fate and toxicity endpoints describe doramectin in soil, water, sediment and dung?", "kind": "measurement", "id": "exposure-controls-q02" }, { "text": "Which containment and disposal measures address the actual material and release pathway?", "kind": "action", "id": "exposure-controls-q03" } ] } ] }, { "id": "authorization-and-residue-links", "name": "Authorization and residue links", "description": "Link the substance to dated product permissions and food-residue assessments.", "findings": [ { "id": "contextual-use-constraints", "name": "Contextual use constraints", "description": "Treat authorization, host restrictions and withdrawal periods as jurisdiction- and product-dependent evidence rather than universal substance constants.", "questions": [ { "text": "Which current authority record covers the proposed product, jurisdiction, host class, route and indication?", "kind": "provenance", "id": "contextual-use-constraints-q01" }, { "text": "Which marker-residue definition, tissue or milk limit and product-specific withdrawal evidence apply?", "kind": "boundary", "id": "contextual-use-constraints-q02" }, { "text": "Which unresolved authorization or residue condition must be settled before the linked treatment model can proceed?", "kind": "action", "id": "contextual-use-constraints-q03" } ] } ] } ] }, { "id": "evidence-and-external-alignment", "name": "Evidence and external alignment", "description": "What the world already says about this thing, gathered so the model can be checked against it.", "rationale": "A model that cannot be lined up against existing standards, identifiers and practice cannot be adopted by anyone who already uses them.", "layers": [ { "id": "reported-evidence", "name": "Reported evidence", "description": "Findings from the breadth pass, kept separate from the structural claims.", "findings": [ { "id": "evidence-confidence-notes", "name": "Check these first", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "This description is recalled knowledge; no sources were consulted.", "Verify jurisdiction-specific authorizations, residue limits and withdrawal periods before practical use.", "Purity specifications, physical constants, exposure limits and formal hazard classifications are omitted because they are not confidently recalled." ], "questions": [ { "id": "evidence-confidence-notes-q01", "text": "Which of these check these first hold for the sense of doramectin this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-identifiers", "name": "Identifiers and schemes", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ { "scheme": "CAS Registry Number", "value_or_pattern": "117704-25-3", "note": "Identifies doramectin as a chemical substance, rather than a formulated veterinary product." }, { "scheme": "Molecular formula", "value_or_pattern": "C50H74O14", "note": "Describes elemental composition but does not uniquely encode structure or stereochemistry." }, { "scheme": "International Nonproprietary Name (INN)", "value_or_pattern": "doramectin", "note": "Nonproprietary name for the active substance." } ], "questions": [ { "id": "evidence-identifiers-q01", "text": "Which of these identifiers and schemes hold for the sense of doramectin this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-real-world-use", "name": "Real-world use", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "Active ingredient in veterinary medicines for control of susceptible gastrointestinal and pulmonary nematodes in livestock.", "Control of certain mites, lice and other arthropod parasites, depending on the host species and authorized product.", "Formulated in injectable and pour-on products; these formulations are distinct from the substance itself." ], "questions": [ { "id": "evidence-real-world-use-q01", "text": "Which of these real-world use hold for the sense of doramectin this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-measurements", "name": "Typical measurements", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ { "quantity": "Molar mass", "typical_range": "Approximately 899.13", "unit": "g/mol" } ], "questions": [ { "id": "evidence-measurements-q01", "text": "Which of these typical measurements hold for the sense of doramectin this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-failure-modes-and-hazards", "name": "Failure modes and hazards", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "Parasite resistance can reduce effectiveness, including cross-resistance within the macrocyclic lactone class.", "Excessive exposure can cause neurological toxicity; susceptibility varies by animal species and individual.", "Residues in edible tissues require product-specific withdrawal periods for food-producing animals.", "Excreted residues can affect dung-associated invertebrates.", "Environmental contamination can harm aquatic invertebrates." ], "questions": [ { "id": "evidence-failure-modes-and-hazards-q01", "text": "Which of these failure modes and hazards hold for the sense of doramectin this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-regional-variation", "name": "Regional variation", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "Authorized animal species, indications, formulations and withdrawal periods differ between jurisdictions and products.", "Restrictions for animals producing milk for human consumption require checking against the applicable product authorization." ], "questions": [ { "id": "evidence-regional-variation-q01", "text": "Which of these regional variation hold for the sense of doramectin this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-neighbours", "name": "Neighbouring kinds and how to tell them apart", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ { "name": "Ivermectin", "difference": "A related avermectin active substance with a different chemical identity; conventional ivermectin consists principally of two closely related components." }, { "name": "Abamectin", "difference": "An avermectin B1 mixture with a different composition and regulatory identity." }, { "name": "Moxidectin", "difference": "A macrocyclic lactone antiparasitic in the milbemycin family rather than the avermectin family." }, { "name": "Doramectin veterinary formulation", "difference": "A finished product containing doramectin plus excipients at a specified concentration and intended route of administration." } ], "questions": [ { "id": "evidence-neighbours-q01", "text": "Which of these neighbouring kinds and how to tell them apart hold for the sense of doramectin this model covers, and on what evidence?", "kind": "provenance" } ] } ] } ] } ] }, "openQuestions": [ "Which stereochemically explicit reference structure reconciles differing database mappings, and is an EC identifier verified for that exact entity?", "Which recognized API specification and analytical methods establish doramectin assay, epimer discrimination and impurity acceptance limits?", "Which measured solid-form, solubility and thermal data are reliable, and is a boiling-point value meaningful before decomposition?", "Which bulk-material stability studies, GHS classifications and occupational exposure limits are applicable to the grade being assessed?", "Which current jurisdiction-specific authorizations, residue requirements, parasite-resistance data and environmental endpoints are needed for the intended use?" ], "statistics": { "bundles": 6, "layers": 11, "findings": 17, "questions": 31 } }