{ "vercy": "1.0-draft", "publication": { "status": "research-draft", "adjudicationStatus": "unreviewed", "publishableCanonical": false, "generatedAt": "2026-09-12T06:07:39Z", "providers": [ "Claude" ], "breadth": "written by Claude from model knowledge without web access - no source was read, every claim is a lead to verify", "pass": 2, "wave": 2, "engine": "claude", "enrichment": { "pass": 3, "engine": "claude", "producedAt": "2026-10-06T00:10:00Z", "ingestedAt": "2026-10-05T20:52:02+00:00", "fields": [ "agent_conduct", "ethics", "owners" ] }, "revisions": [ { "at": "2026-10-07T11:42:17+00:00", "engine": "codex", "fields": [ "definition" ], "answering_review": "8736c7366c66afedc0bea59f0de072dc7eeaf72bed97d4507c5c9bad6f105619" } ], "gate": { "passed": true, "version": "1.0", "at": "2026-10-07T12:16:35+00:00", "evidence": [ "completeness 1.00", "sense: Wikidata description", "2 live sources", "review by codex: pass" ] } }, "metaModel": { "id": "THING-Q96032533", "registryId": "vr.tr.carbazole-alkaloid", "name": "carbazole alkaloid", "version": "0.2.0-wave.2", "entryKind": "thing", "family": "Thing Registry", "domain": [ "PHY.MAT" ], "status": "research-draft" }, "canonicalUrl": "https://ver.cy/models/thing/q96032533/", "model": { "registry_id": "vr.tr.carbazole-alkaloid", "name": "carbazole alkaloid", "purpose": "Let an agent explain carbazole alkaloids as a natural product class, describe their sources, structures and reported biological activities with attribution, support chemistry and pharmacology learning, and route medical questions to professionals.", "definition": "A class of alkaloids containing the carbazole ring system, a tricyclic aromatic structure of two benzene rings fused to a pyrrole, produced by plants of the citrus family, by cyanobacteria and other microorganisms, and by marine organisms, including indolocarbazole alkaloids such as staurosporine and quinonocarbazole alkaloids such as calothrixins, and studied for antimicrobial, antimalarial and anticancer activity; carbazole alkaloids are natural products of interest in chemistry and pharmacology and are described here without synthesis or dosing detail.", "what_it_is_for": "Alkaloids with a carbazole core.", "affordances": [ "explain the class and structures", "describe sources", "describe activities with attribution", "support learning" ], "distinguishing_features": [ "Carbazole core", "Natural products", "Diverse sources", "Pharmacological interest" ], "appearance": "Not physical in the everyday sense; molecules.", "visual_identification": [ "Alkaloids containing a carbazole ring", "Plant, cyanobacterial, microbial and marine sources", "Indole alkaloids are the wider class; carbazole itself is not an alkaloid" ], "physical_properties": [ { "quantity": "Molar mass", "unit": "g/mol", "typical_range": "", "note": "Calculate molar mass from the molecular formula of the identified compound, specifying any salt or solvate form." }, { "quantity": "Melting temperature", "unit": "K", "typical_range": "", "note": "Determine the melting interval experimentally for the identified compound and record any decomposition or dependence on crystal form." }, { "quantity": "Solubility", "unit": "g/L", "typical_range": "", "note": "Measure equilibrium solubility for the identified compound in a specified solvent at a stated temperature and pH where relevant." } ], "families_and_kinds": [ "plant carbazole alkaloids from the citrus family", "indolocarbazole alkaloids", "calothrixins from cyanobacteria", "marine carbazole alkaloids", "synthetic derivatives studied as drugs" ], "related_models": [ { "relation": "is a kind of", "target": "indole alkaloid", "why": "category" }, { "relation": "is a kind of", "target": "carbazoles", "why": "category" }, { "relation": "is related to", "target": "furanocoumarin", "why": "another class of plant natural products" }, { "relation": "is related to", "target": "kinase", "why": "a target of indolocarbazole compounds" } ], "identifiers": [], "standards_and_regulation": [ "Chemical nomenclature", "Drug regulation for derived medicines", "Laboratory safety standards" ], "failure_modes_and_hazards": [ "Agents providing synthesis or dosing detail, which must be declined", "Overstating preliminary activities", "Confusing with the industrial chemical carbazole" ], "in_scope": [], "out_of_scope": [], "characteristics": [], "agent_conduct": { "may": [ "Explain the carbazole ring system and the organisms that produce these alkaloids.", "Summarise published research on their biological activity with citations." ], "must_not": [ "Present a carbazole alkaloid as a proven treatment for any disease without clinical evidence.", "Recommend consuming plant extracts containing these alkaloids as medicine.", "Help extract or prepare these compounds for use on people outside regulated research.", "Overstate early laboratory findings as established effects in humans." ], "requires_human": [ "Any use of these compounds in people or animals, which belongs to qualified researchers and regulators." ] }, "ethics": { "considerations": [ "Promising natural products attract hype that can lead patients away from proven care.", "Bioprospecting can take traditional knowledge and plant resources without fair benefit to source communities." ], "affected_parties": [ "Patients seeking treatments", "Communities holding traditional plant knowledge" ] }, "owners": { "steward": "Nobody owns the class; researchers and institutions answer for their samples and claims.", "master_systems": [] } }, "sources": [ { "id": "wikidata", "title": "Wikidata item Q96032533: carbazole alkaloid", "url": "https://www.wikidata.org/wiki/Q96032533", "url_status": "live", "what_it_supports": "identity and sense of the item", "checked_by": "wikidata-api" }, { "id": "wikipedia-en", "title": "Wikipedia: Carbazole alkaloids", "url": "https://en.wikipedia.org/wiki/Carbazole_alkaloids", "url_status": "live", "what_it_supports": "general description of the item", "checked_by": "wikidata-api sitelink" } ], "structure": { "bundles": [ { "id": "understand", "name": "Understand", "description": "What carbazole alkaloids are.", "rationale": "Chemistry.", "layers": [ { "id": "structure", "name": "Structure", "description": "Structure and class.", "findings": [ { "id": "structure-finding", "name": "Structure", "description": "Structure.", "questions": [ { "text": "What defines carbazole alkaloids, and how do plant, indolocarbazole and calothrixin types differ in structure?", "kind": "definition" }, { "text": "Is the request seeking synthesis detail, which must be declined?", "kind": "boundary" } ] } ] }, { "id": "sources", "name": "Sources", "description": "Natural sources.", "findings": [ { "id": "sources-finding", "name": "Sources", "description": "Sources.", "questions": [ { "text": "Which plants, cyanobacteria, microorganisms and marine organisms produce carbazole alkaloids, and how?", "kind": "provenance" }, { "text": "Which entry fits a specific source organism?", "kind": "action" } ] } ] } ] }, { "id": "activity", "name": "Activity", "description": "Biological activity.", "rationale": "Attribution.", "layers": [ { "id": "activities", "name": "Activities", "description": "Reported activities.", "findings": [ { "id": "activities-finding", "name": "Activities", "description": "Activities.", "questions": [ { "text": "What antimicrobial, antimalarial and anticancer activities have been reported, with findings attributed and their preliminary status noted?", "kind": "provenance" }, { "text": "Is the user asking about treatment, which needs a clinician?", "kind": "boundary" } ] } ] }, { "id": "drugs", "name": "Drugs", "description": "Derived medicines.", "findings": [ { "id": "drugs-finding", "name": "Drugs", "description": "Drugs.", "questions": [ { "text": "Which approved or investigational medicines derive from carbazole or indolocarbazole scaffolds, according to regulators?", "kind": "provenance" }, { "text": "Which entry fits a specific drug?", "kind": "action" } ] } ] } ] }, { "id": "research", "name": "Research", "description": "Research methods.", "rationale": "Science.", "layers": [ { "id": "isolation", "name": "Isolation", "description": "Isolation and characterisation.", "findings": [ { "id": "isolation-finding", "name": "Isolation", "description": "Isolation.", "questions": [ { "text": "How are carbazole alkaloids isolated and characterised in natural product chemistry, in general terms?", "kind": "provenance" }, { "text": "Which entry fits natural product chemistry?", "kind": "action" } ] } ] }, { "id": "biosynthesis", "name": "Biosynthesis", "description": "Biosynthesis.", "findings": [ { "id": "biosynthesis-finding", "name": "Biosynthesis", "description": "Biosynthesis.", "questions": [ { "text": "How are carbazole alkaloids biosynthesised in plants and microbes?", "kind": "provenance" }, { "text": "Which findings are contested?", "kind": "boundary" } ] } ] } ] }, { "id": "learn", "name": "Learn", "description": "History and teaching.", "rationale": "Education.", "layers": [ { "id": "history", "name": "History", "description": "History.", "findings": [ { "id": "history-finding", "name": "History", "description": "History.", "questions": [ { "text": "How were carbazole alkaloids discovered and named?", "kind": "provenance" }, { "text": "Which references are standard?", "kind": "provenance" } ] } ] }, { "id": "teach", "name": "Teach", "description": "Teaching.", "findings": [ { "id": "teach-finding", "name": "Teach", "description": "Teaching.", "questions": [ { "text": "How can natural product classes like carbazole alkaloids be taught?", "kind": "action" }, { "text": "Which misconceptions arise?", "kind": "provenance" } ] } ] } ] } ] }, "openQuestions": [ "Should indolocarbazoles be a separate entry?", "How should natural product databases be linked?", "How should pharmacology literature be linked?" ], "statistics": { "bundles": 4, "layers": 8, "findings": 8, "questions": 16 } }