Research draft

immunity

vr.tr.immunity · thing-q1059

Enable an AI agent to recognise the immune system, explain its components and defensive functions, assess the limits of evidence about immune responses and protection, and identify decisions requiring qualified clinical judgement.

Thing Registry Physical world and living systems PHY.OBJ

Research draft, second pass

A second pass drafted this model: the structure a model of this thing needs, and what is known about it in the world. The line under this one says how the second half was obtained - researched against sources, or recalled without web access, in which case nothing here was read anywhere and every claim is a lead to verify. Unreviewed either way.

Researched by: Codex

Bundle → Layer → Finding → Questions Classifiers What it is Why it exists Distinguishing features What robots and AI may and may not do Moral aspects Owners Links to other meta-models Identity and identifiers Direct properties Recognition Capabilities and actions Hazards and failure modes Standards and interfaces Context of use Sources

Bundle → Layer → Finding → Questions Filled

5 bundles · 10 layers · 10 findings · 20 questions

Protection claim Defines whose immunity is being described, against what and with which meaning of protection.

Host and challenge

Establishes the biological bearer and target of the claim.

Bounded immunity target

Record the host, relevant compartment and challenge at the specificity justified by evidence.

Which host and anatomical compartment carry the claimed immunity? definition
Which challenge, variant or antigen is covered, and which related challenges remain outside the claim? boundary

Protected outcomes

Separates different meanings and degrees of protection.

Endpoint-specific protection

Record whether the claim concerns prevention, control or reduced harm, with any supported degree of protection.

Does protection mean preventing infection, controlling burden, preventing disease or reducing severity? definition
Under what exposure conditions and over what observation period was this outcome assessed? measurement

Defence and acquisition Records the contributions and origins proposed to account for protection.

Immune contributions

Identifies relevant innate, humoral and cellular contributions without requiring a complete immune-system model.

Supported defence mechanisms

Separate observed immune activity from mechanisms inferred to contribute to protection.

Which innate or adaptive contributions are observed, inferred or unresolved for this protection claim? definition
What evidence links each recorded contribution to the specified protective endpoint? provenance

Acquisition and memory

Distinguishes sources of protection and evidence of a retained response capacity.

Origin of protective capacity

Record relevant exposure, immunisation or transfer history, keeping acquisition history separate from demonstrated immunity.

Which documented events or constitutive defences are proposed to explain this immunity? provenance
What evidence distinguishes immune memory from currently present effectors or passively acquired components? measurement

Evidence and inference Connects immunity claims to measurements, observed outcomes and explicit inference limits.

Immune measurements

Preserves the context needed to interpret an immune indicator.

Interpretable assay evidence

Record assay identity, specimen, timing, result and the basis for any protective interpretation.

What was measured, in which specimen, by which method, at what time and in which units? measurement
What source supports using this indicator or threshold to infer protection for this host context, challenge and endpoint? provenance

Outcome-based support

Assesses whether observed outcomes justify the claimed protection.

Protection inference limits

Record directness of evidence, alternative explanations and uncertainty when applying outcomes to a host.

What exposure and outcome evidence supports protection, and could limited exposure or another factor explain the outcome? provenance
Does the evidence concern this host or a reference population, and what limits transfer between them? boundary

Persistence and context Tracks how the applicability of an immunity claim depends on time, host condition and challenge conditions.

Temporal course

Records observed onset, persistence and changes in evidence of protection.

Time-bounded protection

Distinguish measured change, inferred persistence and periods lacking evidence.

When was protective capacity assessed, and what repeated observations establish its course? measurement
Beyond which date or follow-up interval would continued protection be an unsupported extrapolation? boundary

Changed protection conditions

Identifies changes that may invalidate an earlier assessment.

Reassessment triggers

Record relevant changes in host condition, treatment, challenge identity or exposure context.

Which host or challenge conditions differ from those under which protection was established? boundary
Which documented change should trigger reassessment, and what evidence would resolve it? action

Decision use and limits Makes the consequences and limits of relying on an immunity claim explicit.

Claim-dependent actions

Connects a proposed action to the precise protection it requires.

Action evidence fit

Record the decision, its required protective endpoint and the authority governing its use.

What action depends on immunity, and does the available evidence address the endpoint and time horizon that action requires? action
Which applicable guidance or qualified decision-maker determines whether that evidence is sufficient? provenance

Unresolved or discordant status

Handles missing evidence, conflicting indicators and outcomes inconsistent with the claim.

Uncertainty resolution

Preserve disagreement and define an appropriate route to clarify immunity without silently converting uncertainty into a binary status.

Which measurements, histories or observed outcomes conflict, and which part of the protection claim remains unresolved? boundary
What additional record, validated assessment or qualified review could resolve the uncertainty relevant to the proposed action? action

Classifiers Filled

Family: Thing Registry
Category: Physical world and living systems
Entry kind: thing
Plane: PHY
Domain: PHY.OBJ
Other names and narrower kinds: lymphoid tissue, Bronchus-associated lymphoid tissue, tertiary lymphoid structure, diffuse lymphoid tissue, nodular lymphoid tissue, epithelium-associated lymphoid tissue, negative T cell selection, negative thymic T cell selection, negative extrathymic T cell selection, mononuclear phagocyte system, avian immune system, adaptive immune system

What it is Filled

In the supplied sense, immunity refers to the immune system, the biological system of cells, tissues, organs and molecules that coordinates innate and adaptive responses to pathogens and other threats.

In scope

Immune cells, tissues, organs and molecules and their relationships within a host are in scope.
Innate and adaptive immune functions and their coordination are in scope.
Immune recognition, response regulation, tolerance and memory are in scope.
Responses to exposure, immunisation and passive transfer are in scope.
Evidence about immune function and the limits of laboratory or observational indicators of protection are in scope.
Changes in immune function over time and under altered host or challenge conditions are in scope.
Immune dysfunction, including immunodeficiency, allergy and autoimmunity, is in scope at a general explanatory level.

Out of scope

Legal, diplomatic or institutional immunity is outside this model.
Pathogen identity, evolution and transmission beyond their relevance to immune system function are outside this model.
Diagnosis and treatment of infections, allergies, autoimmune disease or immunodeficiency are outside this model.
Vaccine and medicinal-product manufacture, prescribing and administration are outside this model.
Population-level herd protection and epidemic dynamics are outside this model.

Why it exists Filled

Distinguishing features Filled

The immune system is an organized biological system of interacting components, while immunity to a specified challenge describes a protective capacity.
Innate and adaptive mechanisms contribute to immune defence through distinct but coordinated functions.
Immune recognition and regulation support defence while limiting inappropriate responses against the host.
A detectable immune response does not by itself establish protection against infection or disease.
Absence of illness without evidence of exposure or protective capacity does not establish immunity.
This biological system concerns host defence; exemption from a rule, jurisdiction or obligation belongs to a different sense of the term.

What robots and AI may and may not do Filled

Must not

Tell a person they are immune from a single result or past illness.
Spread false claims about vaccines or natural immunity.
Use immunity status to exclude people beyond lawful public health rules.
Disclose a person's immune status without consent.

Only with a human decision

Decisions on vaccination or immune treatment for a person require qualified human judgement.

May

Explain immune system components, functions and their relationship to protection in general terms from medical sources.
Point people to clinicians and public health advice for vaccination and testing.

Moral aspects Filled

Immunity status has been used to grant or deny access to work and travel.
Misinformation about immunity puts vulnerable people at risk.

Who is affected

Immunocompromised people
Children
Health workers

Owners Filled

Steward

No organization owns the immune system as a biological concept; health services steward individual clinical records.

Master systems

Clinical records document individual assessments of immune function.
Vaccination registries record immunisation history.

Links to other meta-models Filled

parent

Q188193 - registry parent class
Q30336093 - registry parent class

What else AI and robots need to interact with it Filled

Sources Filled

Wikidata item Q1059: immune system - identity and sense of the item
Wikipedia: Immune system - general description of the item

Open questions

Does vr.tr.immunity intend biological immunity, and how should its placement in PHY.OBJ represent a capacity borne by a host?
Does an existing Vercy world model already own this concept, requiring a registry link instead of a separate publication?
Should this entry cover immunity across animals, plants and microorganisms, or should its initial applicability be explicitly narrower?
Where should the boundary lie between immunity, constitutive physical barriers, disease tolerance and noninfectious immune targets?
Which authoritative sources establish usable correlates of protection, interpretation limits and reassessment criteria for each supported host-challenge pair?

Machine files

Card as JSON Specification Card backlog vercy.card/1

Provenance

thing registry research (pass 2) · unreviewed

Built from: models/things/publications/thing-q1059/spec.json