endocrine system

Documented hormone-producing tissues

Record participating glands and cell populations, their hormone products, and the basis for including them.

1. Which species and life stage define the endocrine system being modelled? definition
2. What evidence establishes hormone production and endocrine participation for each included tissue or cell population? provenance

Endocrine role boundary

Record which activities belong to endocrine signalling and which remain owned by neighbouring models.

1. For each included signal, what release route and target relationship justify treating it as endocrine? boundary
2. Which exocrine, neural, paracrine, or autocrine activities share these tissues but require separate representation? boundary

Secretory capacity and drive

Record evidence about hormone production and release, distinguishing direct observations from inferred capacity.

1. Which observations support the tissue's ability to produce and release this hormone? provenance
2. Which measured stimuli or suppressive conditions accompanied the observed hormone level? measurement

Available hormone form

Record relevant circulating fractions, molecular forms, and evidence of altered disposition.

1. Does the observation measure total hormone, free hormone, a precursor, or a metabolite, and in which specimen? measurement
2. What evidence supports a contribution from binding, conversion, or clearance to the observed level? provenance

Supported feedback relationships

Record the direction, context, and evidential basis of endocrine regulatory connections.

1. Which upstream signals, endocrine tissues, downstream hormones, and feedback targets define each represented axis? definition
2. Which source supports each stimulatory or inhibitory relationship in this species and physiological context? provenance

Signal-response concordance

Record whether observed target responses align with hormone exposure, preserving alternative explanations.

1. Which tissue-specific response measurements accompany the hormone observations, and over what interval? measurement
2. What evidence distinguishes altered target responsiveness from altered hormone availability or a non-endocrine cause? provenance

Interpretable hormone observation

Record sufficient analytical and contextual information to judge whether a result supports comparison or inference.

1. What specimen, collection time, units, assay method, and relevant collection conditions accompany this result? measurement
2. What source supports the chosen reference interval or decision threshold, and does it apply to this organism and context? provenance
3. Which documented assay interference or specimen limitation could affect interpretation? measurement

Time-dependent endocrine pattern

Record temporal patterns and relevant developmental or physiological transitions without assuming one sample represents a stable state.

1. How do sampling times relate to relevant sleep, feeding, pulse, daily, or reproductive timing? measurement
2. Which longitudinal observations distinguish a persistent change from a transient response or physiological transition? measurement

Bounded endocrine assessment

Record the supported functional interpretation, its time window, confidence, and unresolved causes.

1. Which paired hormone and physiological observations support the stated functional assessment of this axis? measurement
2. What remains unresolved among altered gland function, upstream regulation, hormone disposition, target response, and measurement error? boundary

Endocrine action basis

Record relevant exposures and interventions, their temporal relationship to findings, and the authority and evidence for next steps.

1. Which exogenous hormones, medicines, procedures, or other documented exposures preceded the endocrine changes? provenance
2. Which applicable protocol and authorised decision-maker determine whether further sampling, dynamic testing, specialist review, or intervention is appropriate? action
3. Which endocrine signals and target responses should be followed to assess the outcome of an authorised intervention? action

Kinds and varieties

Reported by the breadth pass; each item needs checking against its source before it becomes normative.

1. Which of these kinds and varieties hold for the sense of endocrine system this model covers, and on what evidence? provenance

Identifiers and schemes

Reported by the breadth pass; each item needs checking against its source before it becomes normative.

1. Which of these identifiers and schemes hold for the sense of endocrine system this model covers, and on what evidence? provenance

Standards and regulation

Reported by the breadth pass; each item needs checking against its source before it becomes normative.

1. Which of these standards and regulation hold for the sense of endocrine system this model covers, and on what evidence? provenance

Real-world use

Reported by the breadth pass; each item needs checking against its source before it becomes normative.

1. Which of these real-world use hold for the sense of endocrine system this model covers, and on what evidence? provenance

Typical measurements

Reported by the breadth pass; each item needs checking against its source before it becomes normative.

1. Which of these typical measurements hold for the sense of endocrine system this model covers, and on what evidence? provenance

Failure modes and hazards

Reported by the breadth pass; each item needs checking against its source before it becomes normative.

1. Which of these failure modes and hazards hold for the sense of endocrine system this model covers, and on what evidence? provenance

Regional variation

Reported by the breadth pass; each item needs checking against its source before it becomes normative.

1. Which of these regional variation hold for the sense of endocrine system this model covers, and on what evidence? provenance

Neighbouring kinds and how to tell them apart

Reported by the breadth pass; each item needs checking against its source before it becomes normative.

1. Which of these neighbouring kinds and how to tell them apart hold for the sense of endocrine system this model covers, and on what evidence? provenance