fumagillin
Enable an agent to recognise fumagillin, assess the identity and condition of a particular material, and determine which handling or use decisions its evidence supports.
Bundle → Layer → Finding → Questions Filled
6 bundles · 11 layers · 17 findings · 27 questions
Molecular identity and boundaries Establishes which chemical entity the fumagillin registry entry denotes.
Structure and identifiers
Connects registry identity to a resolved chemical structure.
Stereochemical identity
Record the structure, stereochemistry and identifier evidence used to recognise fumagillin.
- Which authoritative record establishes the structure and stereochemistry intended by vr.tr.fumagillin? definition
- Do the sample's analytical results distinguish that structure from related compounds or unresolved isomers? measurement
Salt and product boundaries
Separates fumagillin identity from counterions, analogues and formulation ingredients.
Free-acid equivalence
Make material form and reporting basis explicit before transferring properties or quantities.
- Does this record describe fumagillin free acid, an identified salt or a product containing it? boundary
- What counterion stoichiometry, water content and assay basis support conversion to fumagillin-equivalent mass? measurement
Lot quality and authentication Establishes what a particular fumagillin material contains and how that is known.
Origin and reference material
Links material history to the evidence used for authentication.
Traceable authentication
Record lot origin and the reference material or independent analytical evidence supporting identity.
- Which producer, lot and certificate identify this material, and what origin is actually documented? provenance
- Which reference standard and analytical methods support the fumagillin assignment? provenance
Content and impurity profile
Separates fumagillin quantity from accompanying substances.
Assay basis and related substances
Require an interpretable content assay and impurity profile rather than an unexplained purity percentage.
- Is the stated purity a mass assay, chromatographic area percentage or biological potency measurement? measurement
- Which related substances, residual solvents and counterion contributions were measured, and which remain unresolved? measurement
Physical state and stability Determines whether fumagillin remains characterised and usable under actual conditions.
Phase and solution behaviour
Records thermal observations and dissolved-state measurements for the specified form.
Conditioned physical properties
Treat phase, thermal events and solubility as measurements with conditions and methods.
- What phase and melting or decomposition behaviour were measured for this fumagillin form? measurement
- At the intended solvent composition, pH and temperature, how much intact fumagillin is demonstrably dissolved? measurement
Storage and degradation
Relates exposure history to intact fumagillin content.
Remaining intact material
Use stability-indicating evidence to evaluate stored solids and prepared solutions.
- How do documented light, temperature, solvent and pH conditions affect intact fumagillin over the relevant interval? measurement
- What measured change or evidence gap requires reassay, quarantine or disposal? action
Biological activity and evidence Connects fumagillin to measured target effects and application-specific evidence.
Target-level activity
Qualifies enzyme inhibition by target identity and experimental conditions.
Methionine aminopeptidase inhibition
Fumagillin inhibits type II methionyl aminopeptidase; record the tested enzyme and evidence behind any more specific mechanism claim. [MEROPS](https://www.ebi.ac.uk/merops/cgi-bin/famsum?family=m24)
- Which species, enzyme form and assay establish the reported inhibition? provenance
- What concentration, incubation time and endpoint define the activity measurement? measurement
Organism and host context
Keeps biological outcomes attached to their tested setting.
Limits of activity transfer
Record organism-level effects separately from enzyme inhibition and host tolerability.
- Which organism, life stage, host and endpoint support each claimed biological effect? provenance
- What evidence supports extending that result to the proposed application, and what remains untested? boundary
Exposure, residues and use constraints Supports handling and use decisions through form-specific hazard and regulatory evidence.
Hazard and exposure evidence
Associates safety information with the actual fumagillin material.
Form-specific hazard assessment
Separate evidence about fumagillin from hazards attributable to counterions or formulation ingredients.
- Which current safety data and toxicological sources apply to this chemical form and exposure route? provenance
- What handling controls follow from those sources for the proposed quantity and operation? action
Use status and residue identity
Relates the intended application to dated jurisdictional decisions and defined residue analytes.
Applicable permission and residue basis
Record applicable authority decisions without inferring permission from historical use or commercial availability.
- Which jurisdiction, date, product and intended use determine the applicable authorization or restriction? action
- Where residue assessment applies, does the governing definition measure parent fumagillin, specified transformation products or another stated analyte set? definition
Evidence and external alignment What the world already says about this thing, gathered so the model can be checked against it.
Reported evidence
Findings from the breadth pass, kept separate from the structural claims.
Check these first
Recalled without web access and unsourced; every item is a lead to verify.
- Which of these check these first hold for the sense of fumagillin this model covers, and on what evidence? provenance
Identifiers and schemes
Recalled without web access and unsourced; every item is a lead to verify.
- Which of these identifiers and schemes hold for the sense of fumagillin this model covers, and on what evidence? provenance
Real-world use
Recalled without web access and unsourced; every item is a lead to verify.
- Which of these real-world use hold for the sense of fumagillin this model covers, and on what evidence? provenance
Typical measurements
Recalled without web access and unsourced; every item is a lead to verify.
- Which of these typical measurements hold for the sense of fumagillin this model covers, and on what evidence? provenance
Failure modes and hazards
Recalled without web access and unsourced; every item is a lead to verify.
- Which of these failure modes and hazards hold for the sense of fumagillin this model covers, and on what evidence? provenance
Regional variation
Recalled without web access and unsourced; every item is a lead to verify.
- Which of these regional variation hold for the sense of fumagillin this model covers, and on what evidence? provenance
Neighbouring kinds and how to tell them apart
Recalled without web access and unsourced; every item is a lead to verify.
- Which of these neighbouring kinds and how to tell them apart hold for the sense of fumagillin this model covers, and on what evidence? provenance
Classifiers Filled
- Family
- Thing Registry
- Category
- Physical world and living systems
- Entry kind
- thing
- Plane
- PHY
- Domain
- PHY.MAT
What it is Filled
Fumagillin is a fungal natural-product antibiotic originally isolated from Aspergillus fumigatus that inhibits methionine aminopeptidase 2 and exhibits antimicrosporidial and antiangiogenic activity.
In scope
- Stereochemically resolved fumagillin identity and authoritative identifiers
- Free-acid identity and relationships to salts, derivatives and formulated products
- Lot composition, purity, provenance and analytical confirmation
- Physical state, solubility and stability under recorded conditions
- Evidence for biological activity, exposure hazards and applicable substance restrictions
Out of scope
- Manufacturing or fermentation processes as operational systems
- Complete specifications for medicines, bee treatments or other formulated products
- Diagnosis, prescribing and treatment protocols
- Biology of producing fungi, target organisms or treated hosts
- Independent models of fumagillol, fumagillin salts and semisynthetic analogues
Why it exists Filled
Enable an agent to recognise fumagillin, assess the identity and condition of a particular material, and determine which handling or use decisions its evidence supports.
Distinguishing features Filled
- Match the resolved structure and stereochemistry to fumagillin, using CAS 23110-15-8 and PubChem CID 6917655 as corroborating identifiers; its molecular formula is C26H34O7. [PubChem](https://pubchem.ncbi.nlm.nih.gov/compound/fumagillin)
- Confirm the fumagillol-derived ester of an all-E conjugated tetraenedioic acid, rather than identifying fumagillol alone as fumagillin. [PubChem](https://pubchem.ncbi.nlm.nih.gov/compound/fumagillin)
- Check whether the material contains a counterion: bicyclohexylammonium fumagillin has a separate compound record and must not inherit the free acid's mass basis automatically. [PubChem salt record](https://pubchem.ncbi.nlm.nih.gov/compound/Bicyclohexylammonium-Fumagillin)
- Require structural or analytical evidence beyond a product name or biological effect; methionine aminopeptidase II inhibition is a documented activity, not a unique identity test. [MEROPS](https://www.ebi.ac.uk/merops/cgi-bin/famsum?family=m24)
What robots and AI may and may not do Filled
Must not
- Recommend using it in beehives or animals where it is not authorized.
- Recommend it as a treatment for a person.
- Supply or describe ways to obtain it outside lawful channels.
- Discharge it or treated material where it can enter food, honey or water.
Only with a human decision
- Any treatment of animals with it.
- Disposing of stock or treated material.
May
- Identify fumagillin and describe its documented uses, such as in research and in some veterinary contexts, citing sources.
- Report where its use in animals is restricted or not authorized.
Moral aspects Filled
- Residues in honey and food can reach consumers who never agreed to exposure.
- Unauthorized use undermines rules that protect food safety.
Who is affected
- Consumers of honey and animal products
- Beekeepers and farmers
- Laboratory workers
Owners Filled
Steward
The laboratory, veterinarian or authorized user holding it; regulators decide where it may be used.
Links to other meta-models Filled
parent
- Q47006373 - registry parent class
What else AI and robots need to interact with it Filled
Identity and identifiers required Filled
- Vercy registry: vr.tr.fumagillin
- Wikidata: Q120199 (https://www.wikidata.org/wiki/Q120199)
Direct properties required Filled
- Resolved molecular identity: Stereochemical structure, InChIKey, CAS and PubChem identifiers
- Material form: Free acid; identified salt; mixture containing fumagillin; unresolved
- Fumagillin content: Mass fraction %, mg/g or mol/L, with assay method and free-acid-equivalent basis
- Related substances and residual impurities: Named analytes in %, mg/kg or below a stated detection limit
- Physical and thermal state: Observed phase and appearance at °C; melting or decomposition event with method
- Solubility: mg/mL or mol/L with solvent, pH, temperature and equilibration method
- Stability under storage or preparation: Intact fumagillin remaining %, elapsed time, temperature, light exposure, pH and solvent
- Biological activity: IC50 or other defined endpoint, concentration unit, target species and assay conditions
- Lot provenance: Supplier, producer, lot, certificate, reference standard and analytical records
- Hazard and permitted-use status: Dated, jurisdiction-specific classifications, restrictions and unresolved determinations
Recognition required Filled
- A pale yellow crystalline solid as a substance, not identifiable by sight.
- Products are labelled with the active substance; analysis settles identity.
Capabilities and actions required Filled
- Reconcile a labelled sample with the stereochemically defined fumagillin identity.
- Calculate fumagillin-equivalent content when salt composition and assay basis are established.
- Compare lots or reference materials using comparable analytical methods.
- Assess whether storage history and current measurements support continued use.
- Associate activity evidence with the tested target, concentration and experimental context.
- Flag a proposed use for rejection or further review when quality, exposure or regulatory evidence is insufficient.
Hazards and failure modes required Filled
- Residues in food products where it is used without authorization.
- Toxic effects in exposed people and animals.
- Degradation by light, giving ineffective material.
Standards and interfaces required Filled
- Globally Harmonized System of Classification and Labelling of Chemicals (GHS), United Nations.
Context of use required Filled
- Fumagillin is encountered in natural-product chemistry and research on microsporidia, methionine aminopeptidase 2 and blood vessel formation.
- It also appears in literature on microsporidial infections in humans and honey bees, where the host, formulation and intended application determine the relevant evidence.
Sources Filled
- Wikidata item Q120199: fumagillin - identity and sense of the item
- Wikipedia: Fumagillin - general description of the item
Open questions
- Which authoritative EC identifier, hazard classifications and occupational exposure limits, if any, apply specifically to fumagillin free acid rather than a salt or product?
- Which reliable measurements establish form-specific solubility and thermal behaviour, including whether decomposition prevents a meaningful boiling-point determination?
- What stability-indicating studies establish storage and solution-use intervals under relevant light, temperature, solvent and pH conditions?
- Which impurities or transformation products materially affect identity, potency or hazard, and what analytical acceptance criteria are justified?
- For each proposed application, what current jurisdictional authorization, residue definition and efficacy evidence apply to the exact material and target context?
Machine files
Provenance
thing registry research (pass 2) · unreviewed
Built from: models/things/publications/thing-q120199/spec.json