Crohn's disease
Let an agent explain Crohn disease in general terms, relay diagnosis, treatment and support information from gastroenterology bodies and patient organisations, distinguish it from ulcerative colitis and irritable bowel syndrome, and route personal questions to clinicians.
Research draft, second pass
A second pass drafted this model: the structure a model of this thing needs, and what is known about it in the world. The line under this one says how the second half was obtained - researched against sources, or recalled without web access, in which case nothing here was read anywhere and every claim is a lead to verify. Unreviewed either way.
written by Claude from model knowledge without web access - no source was read, every claim is a lead to verify
Researched by: Claude
Purpose and description
Let an agent explain Crohn disease in general terms, relay diagnosis, treatment and support information from gastroenterology bodies and patient organisations, distinguish it from ulcerative colitis and irritable bowel syndrome, and route personal questions to clinicians.
A chronic inflammatory bowel disease that can affect any part of the digestive tract, most often the end of the small intestine and the colon, causing abdominal pain, diarrhoea, weight loss and fatigue with periods of flare and remission; its cause involves genetic, immune and environmental factors, and it is managed with anti-inflammatory and immune-modifying medicines, nutrition and sometimes surgery.
What it is for: Not applicable; a disease.
It can be explain the disease and its course; distinguish it from related conditions; relay treatment and support information; route personal questions to clinicians.
Distinguishing features
Any part of the digestive tract
Patchy transmural inflammation
Flares and remissions
Complications such as strictures and fistulas
What it looks like
Not visible as an object; abdominal symptoms, weight loss and fatigue in the affected person.
Physical character
prevalence: about 100-300 per 100000 - in high-income countries; rising elsewhere
onset: often 15-35 years of age - with a second peak later
How it is recognised
Chronic inflammation anywhere in the digestive tract
Patchy, transmural inflammation
Ulcerative colitis affects only the colon; irritable bowel syndrome has no inflammation
Related models
is a kind of - the category
is confused with - the other main inflammatory bowel disease
is confused with - a functional disorder
is treated by - the specialty
In practice
Families and kinds
ileal, colonic and ileocolonic disease
upper gastrointestinal Crohn disease
perianal disease
paediatric Crohn disease
pouchitis and related conditions
Identifiers
ICD-10 K50
ICD-11 DD70
Standards and regulation
Clinical guidelines from gastroenterology societies
Medicines regulation for biologics
Disability and workplace accommodation law
Failure modes and hazards
Strictures, fistulas and abscesses
Malnutrition and growth failure in children
Infection risk from treatment
Agents giving personal medical advice
Also called
Where this came from
wikidata · CC0 1.0
Drafted structure
Bundle to layer to finding to question, as the second pass will find it: 4 bundles · 8 layers · 8 findings · 16 questions.
Understand What Crohn disease is.
General information.
Definition
Definition and course.
Definition
Definition.
- What is Crohn disease, and how does it progress with flares and remissions? definition
- Is the user asking about their own symptoms, which needs a clinician? boundary
Distinguish
Related conditions.
Distinguish
Distinguish.
- How is it distinguished from ulcerative colitis and irritable bowel syndrome? definition
- Which entry fits ulcerative colitis? action
Diagnose Diagnosis.
Clinical.
Tests
Investigations.
Tests
Tests.
- How is Crohn disease diagnosed, in general terms from guidelines? provenance
- Which entry fits endoscopy? action
Causes
Causes.
Causes
Causes.
- What is known about genetic, immune and environmental causes, with findings attributed? provenance
- Which references are standard? provenance
Treat Treatment and living.
Care.
Treatment
Treatment.
Treatment
Treatment.
- What treatments do guidelines describe, from medicines to surgery? provenance
- Is the presentation free of personal treatment advice? boundary
Living
Living with the disease.
Living
Living.
- What diet, support and rights information do patient organisations provide? provenance
- Which entry fits patient support? action
Study Research and teaching.
Study.
Research
Research.
Research
Research.
- What research and new therapies are under way, with attribution? provenance
- Which entry fits inflammatory bowel disease research? action
Teach
Teaching.
Teach
Teaching.
- How is Crohn disease taught, and which misconceptions arise? provenance
- Which entry fits gastroenterology? action
What the second pass must settle
- Should paediatric Crohn disease be a separate entry?
- How should guidelines be linked?
- The registry entry has merged aliases for site-specific forms and pouchitis; should they be split off?