analgesic
Enable an AI agent to recognise an analgesic, record the properties and evidence relevant to pain relief, and identify constraints on its handling and authorised use.
Research draft, second pass
A second pass drafted this model: the structure a model of this thing needs, and what is known about it in the world. The line under this one says how the second half was obtained - researched against sources, or recalled without web access, in which case nothing here was read anywhere and every claim is a lead to verify. Unreviewed either way.
recalled by Codex without web access - no source was read
Researched by: Codex
Purpose and description
Enable an AI agent to recognise an analgesic, record the properties and evidence relevant to pain relief, and identify constraints on its handling and authorised use.
An analgesic is a drug that reduces or relieves pain without requiring loss of consciousness, classified by its therapeutic effect rather than by a single chemical structure or mechanism.
It can be Identify an analgesic and distinguish its ingredient, formulation and marketed presentation.; Compare source-supported pain-relief roles while preserving indication and formulation differences.; Detect overlapping active ingredients across products for professional review.; Flag documented interaction, contraindication or handling constraints against an externally supplied context.; Check a supplied presentation against expiry, storage, recall and provenance information.; Route unresolved suitability or substitution decisions to an authorised clinical or pharmacy workflow..
Distinguishing features
The substance or preparation has an identified medicinal pain-relief role; pain relief is not inferred solely from sedation or reduced responsiveness.
Its classification is grounded in an analgesic indication or established therapeutic role, rather than assuming every medicine that treats a painful disease is an analgesic.
Analgesia is distinguished from loss of consciousness, although a substance may participate in both analgesic and anaesthetic practice.
Anti-inflammatory or fever-reducing activity is recorded separately: neither property alone defines an analgesic.
A medicinal substance or preparation is distinguished from a physical pain-relief intervention such as a stimulation device or heat application.
Scope
+ Analgesic identity, active ingredients and membership in pain-relieving medicine classes
+ Pain-relief role, mechanism and evidence for a specified indication
+ Formulation, strength, route and release characteristics
+ Analgesic-specific hazards, interactions and restrictions
+ Product integrity, storage requirements and traceable medicinal provenance
- Diagnosis and classification of pain conditions
- Patient-specific prescribing, dosing and treatment plans
- Nonmedicinal pain-relief devices and procedures
- Complete molecular models of individual active substances
- Full manufacturing, pharmacy and controlled-substance governance models
Characteristics
- Active ingredient composition
- Links to identified active substances, including relevant salt or chemical form; single ingredient or combination Supports identity checks and detection of repeated ingredients across differently named products.
- Analgesic class
- Source-defined therapeutic and pharmacological classes; multiple memberships permitted Separates therapeutic role from mechanism and avoids forcing unlike analgesics into one behavioural category.
- Therapeutic role
- Primary analgesic role; adjuvant pain-relief role; disputed or unresolved classification Makes the boundary with medicines used selectively for pain explicit.
- Pain indication
- Links to source-supported pain indications, populations and treatment contexts Prevents a general pain-relief label from implying suitability for every pain condition.
- Ingredient strength
- Per ingredient, using the labelled basis, such as mg/tablet, mg/mL or micrograms/hour Distinguishes ingredient amount, concentration and delivery rate; these are not interchangeable measures.
- Dosage form and route
- Source-specified form and permitted route, recorded as a compatible pair The same active ingredient can have presentations with different administration constraints.
- Release profile
- Immediate release; modified release with specified subtype; not applicable; unknown Helps identify handling and substitution constraints.
- Analgesic onset and duration
- Minutes or hours, with formulation, route, endpoint, population and evidence source Makes timing claims conditional on the context in which they were established.
- Safety constraints
- Links to product-specific contraindications, warnings, interactions and population restrictions Supports recognition of situations requiring professional review.
- Supply and control status
- Jurisdiction-specific prescription, nonprescription and controlled-substance status, with effective date Determines applicable access and handling constraints without assuming universal legal status.
- Presentation integrity
- Verified usable; expired; damaged; recalled; suspect; unknown, with supporting observations Separates what the medicine is from whether a particular supply can be considered for use.
Also called
Where this came from
wikidata · CC0 1.0
Also registered as vr.tr.analgesic
Drafted structure
Bundle to layer to finding to question, as the second pass will find it: 6 bundles · 11 layers · 18 findings · 30 questions.
Analgesic identity and boundaries Establishes what qualifies as an analgesic and which medicinal entity a record describes.
Pain relief is a therapeutic role that can span substances and preparations; identity must remain precise across those levels.
Pain-relief membership
Defines inclusion by therapeutic role and records uncertain boundary cases.
Basis for analgesic classification
Record the authority and therapeutic context supporting classification as an analgesic.
- What definition supports including this substance or preparation as an analgesic? definition
- Does inclusion depend on a primary analgesic role, an adjuvant role or a disputed use? boundary
Ingredient and preparation identity
Separates active substances from combinations and marketed presentations.
Composition and record level
Record active ingredient identities and whether the described entity is a substance, combination or particular formulation.
- Which active ingredients and chemical forms define the preparation? definition
- Which names identify the same entity, and which instead identify a brand, strength or formulation? boundary
Pain-relief role and evidence Connects analgesic action to the pain contexts and outcomes for which evidence exists.
An analgesic designation alone cannot establish effectiveness for a particular pain condition.
Mechanism and therapeutic role
Records the supported mechanism and distinguishes pain relief from associated effects.
Supported analgesic action
Capture the established or proposed basis of analgesia without treating mechanistic plausibility as clinical proof.
- What mechanism is supported, and which parts remain uncertain? definition
- How is analgesic action distinguished from sedation, anti-inflammatory action or treatment of the underlying disease? boundary
Indication and outcome evidence
Makes effectiveness claims traceable to indications, populations and measured outcomes.
Contextual pain-relief evidence
Record the scope and limitations of evidence for pain reduction and related functional outcomes.
- Which sources support use for each pain indication, population and treatment duration? provenance
- Which pain or functional endpoints were measured, against what comparator and over what interval? measurement
- Is the stated use authorised in the relevant jurisdiction, supported outside the label or still investigational? boundary
Formulation and delivery Describes how the analgesic is presented and delivered, including differences that affect interpretation and handling.
Shared ingredients do not establish equivalence across strengths, routes or release profiles.
Strength, form and route
Captures the labelled presentation with an explicit measurement basis.
Labelled delivery specification
Record strength separately for each ingredient and bind it to dosage form and route.
- What is each ingredient's labelled strength, unit and denominator? measurement
- Which dosage form and administration route does the source specify? definition
Release and timing
Connects release design and observed timing to formulation-specific constraints.
Release-dependent use constraints
Record release characteristics, contextual timing evidence and documented restrictions on manipulation.
- What evidence establishes onset and duration of analgesia for this formulation and route? measurement
- What do authoritative product instructions permit or prohibit regarding splitting, crushing, opening or otherwise altering this presentation? action
Analgesic safety and review Organises product-specific hazards and conditions requiring qualified review.
Analgesics differ substantially in toxicity, interaction patterns and risks associated with repeated exposure.
Hazards and susceptibility
Links documented harms to the ingredients, formulations and populations to which they apply.
Documented safety profile
Capture contraindications, major warnings and uncertainty without assigning every class hazard to every analgesic.
- Which authoritative sources establish the major warnings and contraindications for this ingredient and formulation? provenance
- Which population characteristics or clinical conditions trigger additional assessment under those sources? action
Combined and repeated exposure
Addresses overlapping products, interactions and risks associated with patterns of use.
Exposure pattern review
Record evidence for duplicate-ingredient exposure, interactions and repeated-use concerns where applicable.
- Which concurrent products duplicate an active ingredient or create a documented interaction requiring review? action
- What evidence supports concerns about tolerance, dependence, withdrawal or medication-overuse headache for this analgesic and use context? provenance
- Which documented warning signs or suspected exposure events require escalation to an urgent clinical workflow? action
Authorised supply and integrity Connects the medicinal presentation to applicable supply rules and evidence of usable condition.
An identified analgesic may still have restricted access or a supply condition that prevents its use.
Jurisdiction and product authority
Records which authority governs the particular presentation and its availability.
Current authorisation and control
Bind authorisation, supply category and control status to jurisdiction, presentation and date.
- Which regulator or official register establishes this presentation's authorisation and supply status? provenance
- What access, custody or disposal restrictions apply in the stated jurisdiction on the recorded date? action
Medicinal supply condition
Defines the checks needed when applying this kind-level model to a supplied package or unit.
Traceability and usable condition
Record evidence linking a supplied analgesic to its label, batch, expiry and required storage conditions.
- What label, batch and supplier evidence establishes the identity and provenance of the supplied medicine? provenance
- Do expiry, storage history, packaging condition or recall information require withholding the supply from use pending review? action
Evidence and external alignment What the world already says about this thing, gathered so the model can be checked against it.
A model that cannot be lined up against existing standards, identifiers and practice cannot be adopted by anyone who already uses them.
Reported evidence
Findings from the breadth pass, kept separate from the structural claims.
Check these first
Recalled without web access and unsourced; every item is a lead to verify.
- The sense covered is a drug substance or drug class used for pain relief, not a particular formulation, brand or physical dose.
- The listed kinds are practical groupings rather than mutually exclusive chemical categories; inclusion of adjuvant agents varies by taxonomy.
- Dose, onset, duration, efficacy and regulatory status require substance- and product-specific verification; no class-wide numerical ranges are asserted.
- Which of these check these first hold for the sense of analgesic this model covers, and on what evidence? provenance
Kinds and varieties
Recalled without web access and unsourced; every item is a lead to verify.
- Opioid analgesics
- Nonsteroidal anti-inflammatory drugs (NSAIDs)
- Paracetamol (acetaminophen)
- Adjuvant analgesics, including selected antidepressants and anticonvulsants
- Which of these kinds and varieties hold for the sense of analgesic this model covers, and on what evidence? provenance
Identifiers and schemes
Recalled without web access and unsourced; every item is a lead to verify.
- WHO Anatomical Therapeutic Chemical (ATC) classification - N02 - The analgesics group; some drugs used for analgesia are classified elsewhere, including many NSAIDs under M01A.
- International Nonproprietary Names (INN) - An assigned generic name for an individual active substance - Identifies substances rather than the analgesic class or a branded medicinal product.
- CAS Registry Number - Digits in three hyphen-separated groups: 2-7 digits, 2 digits, 1 check digit - Applies to individual chemical substances; analgesics as a therapeutic class have no single CAS number.
- Which of these identifiers and schemes hold for the sense of analgesic this model covers, and on what evidence? provenance
Real-world use
Recalled without web access and unsourced; every item is a lead to verify.
- Relief of acute pain after injury or surgery
- Management of cancer-related pain
- Relief of headache and musculoskeletal pain
- Management of selected neuropathic pain conditions
- Use in multimodal pain management combining different mechanisms of action
- Which of these real-world use hold for the sense of analgesic this model covers, and on what evidence? provenance
Typical measurements
Recalled without web access and unsourced; every item is a lead to verify.
- Patient-reported pain intensity on an eleven-point numerical rating scale - 0-10, from no pain to worst imaginable pain - scale points
- Which of these typical measurements hold for the sense of analgesic this model covers, and on what evidence? provenance
Failure modes and hazards
Recalled without web access and unsourced; every item is a lead to verify.
- Insufficient pain relief when the drug's mechanism does not match the pain condition
- Opioid-related sedation, respiratory depression, dependence and overdose
- NSAID-related gastrointestinal bleeding and kidney injury
- Paracetamol-related liver injury from excessive exposure
- Accidental excessive exposure through duplicate active ingredients in combination products
- Which of these failure modes and hazards hold for the sense of analgesic this model covers, and on what evidence? provenance
Regional variation
Recalled without web access and unsourced; every item is a lead to verify.
- Paracetamol is commonly called acetaminophen in the United States.
- Availability, prescription requirements and controlled-drug restrictions vary by jurisdiction and product.
- Which of these regional variation hold for the sense of analgesic this model covers, and on what evidence? provenance
Neighbouring kinds and how to tell them apart
Recalled without web access and unsourced; every item is a lead to verify.
- anesthetic - Anesthesia involves loss of sensation or awareness; analgesia specifically concerns relief of pain, although some agents produce both.
- anti-inflammatory drug - Defined by reducing inflammation; an analgesic need not have a clinically substantial anti-inflammatory effect.
- antipyretic - Defined by reducing fever; some drugs are both antipyretic and analgesic.
- analgesia - The state or effect of pain relief, whereas an analgesic is an agent producing that effect.
- Which of these neighbouring kinds and how to tell them apart hold for the sense of analgesic this model covers, and on what evidence? provenance
What the second pass must settle
- Which authoritative definition should govern inclusion of adjuvant analgesics and local anaesthetics within this registry entry?
- Does an existing Vercy world model already own this concept or the medicine-level properties to which this model should link?
- Which classification sources best reconcile therapeutic role, pharmacological mechanism and combination preparations?
- Which evidence sources and thresholds should govern indication, onset and duration claims across formulations and populations?
- Which jurisdictions should be researched first for product authorisation, supply restrictions and current safety information?