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quinazoline alkaloid

vr.tr.quinazoline-alkaloid · thing-q23498511

Let an agent explain quinazoline alkaloids and their structure, relay sources, biosynthesis and reported activities from natural product chemistry references, describe derived drugs, and distinguish quinazoline alkaloids from synthetic quinazoline drugs and from quinoline and quinazolinone compounds.

Thing Registry Physical world and living systems PHY.MAT
Bundle → Layer → Finding → QuestionsClassifiersWhat it isWhy it existsDistinguishing featuresWhat robots and AI may and may not doMoral aspectsOwnersLinks to other meta-modelsIdentity and identifiersDirect propertiesRecognitionCapabilities and actionsHazards and failure modesStandards and interfacesContext of useSources

Bundle → Layer → Finding → Questions Filled

4 bundles · 8 layers · 8 findings · 16 questions

Understand What quinazoline alkaloids are.

Definition

Definition and structure.

Definition

Definition.

  1. What are quinazoline alkaloids, and how do they differ from synthetic quinazoline drugs, quinolines and quinazolinones? definition
  2. Is the question about the class, a specific compound or a synthetic drug? boundary

Members

Members.

Members

Members.

  1. What are vasicine, febrifugine, tryptoquivalines, fumiquinazolines and the spiro-fused compounds named in the registry? definition
  2. Which entry fits the specific compound? action
Biology Sources and biosynthesis.

Sources

Sources.

Sources

Sources.

  1. Which plants, fungi and bacteria produce quinazoline alkaloids? provenance
  2. Which references are standard? provenance

Biosynthesis

Biosynthesis.

Biosynthesis

Biosynthesis.

  1. How are quinazoline alkaloids made from anthranilic acid and amino acids? provenance
  2. Which sources are cited? provenance
Research Activities and drugs.

Activity

Reported activities.

Activity

Activity.

  1. What bronchodilator, antimalarial and cytotoxic activities have been reported, and at what stage of evidence, with findings attributed? provenance
  2. Is the presentation careful not to overstate clinical relevance? boundary

Drugs

Derived drugs.

Drugs

Drugs.

  1. How did febrifugine lead to halofuginone, and what other drugs derive from the class? provenance
  2. Which entry fits halofuginone? action
Context Traditional use and history.

Traditional

Traditional medicine.

Traditional

Traditional.

  1. How have Adhatoda and Dichroa been used in Ayurvedic and Chinese medicine, as sources describe, and what evidence exists? provenance
  2. Is the user asking about their own use of herbal products, which needs a clinician? boundary

History

History.

History

History.

  1. How were quinazoline alkaloids discovered and studied? provenance
  2. Which entry fits the history of natural products? action

Classifiers Filled

Family
Thing Registry
Category
Physical world and living systems
Entry kind
thing
Plane
PHY
Domain
PHY.MAT
Other names and narrower kinds
2-(quinoline-3-carbonyl)quinazolin-4-ol, 15-hydroxy-16,16-dimethylspiro[14-oxa-2,10-diazatetracyclo[8.7.0.03,8.011,15]heptadeca-1,3,5,7-tetraene-13,3'-1H-indole]-2',9,17-trione, 3-(4-Hydroxy-2,2-dimethyl-1-oxo-3,3a-dihydroimidazo[1,2-a]indol-4-yl)-2-(4-oxoquinazolin-3-yl)propanoic acid, 12'-methylspiro[1H-indole-3,16'-2,10,13-triazatetracyclo[10.2.2.02,11.04,9]hexadeca-4,6,8,10-tetraene]-2,3',14'-trione, 2,4,5-trihydroxy-3-[2-hydroxy-5-(8-hydroxy-4-oxo-3H-quinazolin-2-yl)anilino]-6-iminocyclohexene-1-carboxamide, 3',15-dihydroxy-2',2',16,16-tetramethylspiro[14-oxa-2,10-diazatetracyclo[8.7.0.03,8.011,15]heptadeca-1,3,5,7-tetraene-13,4'-3aH-imidazo[1,2-a]indole]-1',9,17-trione, [1-[3-[2,2-dimethyl-3-oxidanyl-1,2''-bis(oxidanylidene)spiro[3aH-imidazo[1,2-a]indole-4,5''-oxolane]-3''-yl]-4-oxidanylidene-quinazolin-2-yl]-2-methyl-propyl] ethanoate, 2-(heptan-3-yl)quinazolin-4-ol, Amethysione, NSC-746369; NSC 746369; NSC746369, 2,2-Dimethyl-3'-(4-oxoquinazolin-3-yl)spiro[3,3a-dihydroimidazo[1,2-a]indole-4,5'-oxolane]-1,2'-dione, 19-hydroxy-3,13,21-triazapentacyclo[11.8.0.0²,¹⁰.0⁴,⁹.0¹⁵,²⁰]henicosa-1(21),2(10),4,6,8,15,17,19-octaen-14-one

What it is Filled

A class of alkaloids containing the quinazoline ring system, a fused benzene and pyrimidine bicycle, produced by plants such as Adhatoda vasica, Peganum harmala and Dichroa febrifuga and by fungi and microorganisms, including vasicine, febrifugine, tryptoquivaline and fumiquinazoline types and complex spiro-fused compounds such as those named systematically in the registry aliases; quinazoline alkaloids show bronchodilator, antimalarial and cytotoxic activities in research and inspired synthetic drugs.

Why it exists Filled

Let an agent explain quinazoline alkaloids and their structure, relay sources, biosynthesis and reported activities from natural product chemistry references, describe derived drugs, and distinguish quinazoline alkaloids from synthetic quinazoline drugs and from quinoline and quinazolinone compounds.

Distinguishing features Filled

  • Quinazoline core
  • Plant and fungal origin
  • Anthranilate biosynthesis
  • Drug inspiration

What robots and AI may and may not do Filled

Must not

  • Give guidance on extracting, concentrating or dosing these alkaloids from plants.
  • Recommend plants such as Peganum harmala or Dichroa febrifuga as remedies.
  • Present laboratory activity of an alkaloid as a proven treatment.
  • Confuse natural quinazoline alkaloids with approved synthetic quinazoline drugs.

Only with a human decision

  • Any use of these compounds or source plants with people or animals.

May

  • Describe the quinazoline alkaloid class, its ring system and the plants and fungi that make it.
  • Report published findings with their source, stating whether they are laboratory or clinical.

Moral aspects Filled

  • Some of these alkaloids are toxic, and the plants that hold them are used in traditional medicine where harm can follow.
  • Traditional knowledge of source plants belongs to communities who should share in its benefits.

Who is affected

  • People using herbal remedies
  • Communities holding traditional plant knowledge
  • Researchers

Owners Filled

Steward

Nobody owns the class; the holder of a regulated product answers for that product.

Master systems

  • Chemical compound databases

Links to other meta-models Filled

parent

  • Q57263546 - registry parent class
  • Q70702 - registry parent class

related

  • alkaloid - in registry terms
  • quinazoline - derivatives in registry terms
  • Justicia adhatoda - among other plants
  • halofuginone - a synthetic derivative

What else AI and robots need to interact with it Filled

Identity and identifiers required Filled

  • Vercy registry: vr.tr.quinazoline-alkaloid
  • Wikidata: Q23498511 (https://www.wikidata.org/wiki/Q23498511)

Direct properties required Filled

  • core: quinazoline, benzo-fused pyrimidine structure
  • sources: Acanthaceae, Zygophyllaceae, Hydrangeaceae, Aspergillus list
  • biosynthetic precursor: anthranilic acid note

Recognition required Filled

  • Alkaloids with a quinazoline core
  • Vasicine, febrifugine, tryptoquivalines, fumiquinazolines, spiro-fused indole quinazolines
  • Synthetic quinazolines such as gefitinib are drugs; quinolines are a different bicycle; quinazolinones are oxidised forms
  • Not a visible object; crystalline compounds from plants and fungi.

Capabilities and actions required Filled

  • explain structure and sources
  • relay biosynthesis and activities
  • describe derived drugs
  • distinguish related compounds

Hazards and failure modes required Filled

  • Confusing natural alkaloids with synthetic quinazoline drugs
  • Overstating laboratory activities as clinical effects
  • Toxicity of febrifugine and related compounds

Standards and interfaces required Filled

  • Herbal medicine regulations for vasicine-containing plants
  • Research chemical handling rules

Context of use required Filled

  • Not applicable; a chemical class.
  • simple quinazoline alkaloids such as vasicine and vasicinone
  • febrifugine and halofuginone types
  • fungal quinazolines such as tryptoquivalines and fumiquinazolines
  • spiro-fused indole quinazolines such as those named in the registry
  • pyrroloquinazolines and other fused types

Sources Filled

  1. Wikidata item Q23498511: quinazoline alkaloid - identity and sense of the item
  2. Wikipedia: Quinazoline alkaloids - general description of the item

Open questions

  • Should vasicine and febrifugine be separate primary entries?
  • How should natural product references be linked?
  • The registry entry has merged aliases naming compounds by systematic names; should they be split off?

Machine files

Card as JSON Specification Card backlog vercy.card/1

Provenance

thing registry research (pass 2) · unreviewed

Built from: models/things/publications/thing-q23498511/spec.json