fatty liver disease
Let an agent explain fatty liver disease in general terms, relay types, new nomenclature, risk factors, assessment and management from hepatology sources, route emergencies including acute fatty liver of pregnancy, point people to clinicians and alcohol support, describe the named forms, and distinguish fatty liver disease from viral hepatitis, cirrhosis as an end stage, gallbladder disease and foie gras production, without diagnosing individuals.
Research draft, second pass
A second pass drafted this model: the structure a model of this thing needs, and what is known about it in the world. The line under this one says how the second half was obtained - researched against sources, or recalled without web access, in which case nothing here was read anywhere and every claim is a lead to verify. Unreviewed either way.
written by Claude from model knowledge without web access - no source was read, every claim is a lead to verify
Researched by: Claude
Purpose and description
Let an agent explain fatty liver disease in general terms, relay types, new nomenclature, risk factors, assessment and management from hepatology sources, route emergencies including acute fatty liver of pregnancy, point people to clinicians and alcohol support, describe the named forms, and distinguish fatty liver disease from viral hepatitis, cirrhosis as an end stage, gallbladder disease and foie gras production, without diagnosing individuals.
A condition in which excess fat accumulates in liver cells, including metabolic dysfunction-associated steatotic liver disease, MASLD, the name adopted in 2023 by international liver societies to replace non-alcoholic fatty liver disease, linked to obesity, type 2 diabetes and metabolic risk factors, its inflammatory form metabolic dysfunction-associated steatohepatitis, formerly non-alcoholic steatohepatitis or NASH, alcoholic fatty liver from heavy drinking, focal fatty liver seen on imaging, and acute fatty liver of pregnancy, a rare obstetric emergency in the third trimester; steatohepatitis can progress to fibrosis, cirrhosis and liver cancer. Management centres on weight loss, exercise, reducing alcohol and treating risk factors, and jaundice, confusion, vomiting blood or severe abdominal pain, including in late pregnancy, needs emergency care.
What it is for: Not applicable; a group of liver conditions.
It can be explain types and nomenclature; relay risk factors and management in general terms; describe named forms; route emergencies.
Distinguishing features
Fat accumulation
Often silent
Metabolic and alcohol causes
Risk of progression
What it looks like
Usually no visible signs early; seen on ultrasound as a bright liver.
Physical character
MASLD nomenclature adopted: 2023 year - multi-society Delphi consensus
steatosis threshold: fat in at least 5 percent of hepatocytes note
first US-approved MASH drug: resmetirom, 2024 note - check current options
How it is recognised
Excess fat in the liver
Acute fatty liver of pregnancy, alcoholic fatty liver, metabolic dysfunction-associated steatotic liver disease, steatohepatitis, focal fatty liver, non-alcoholic steatohepatitis
Viral hepatitis is infectious; cirrhosis is scarring; gallbladder disease affects bile storage; foie gras is fattened animal liver
Related models
is a kind of - in registry terms
can progress to -
is related to -
is contrasted with -
In practice
Families and kinds
MASLD
MASH
alcohol-related fatty liver
MetALD overlap
acute fatty liver of pregnancy
focal fatty change
Standards and regulation
AASLD and EASL guidelines
Alcohol health guidance
Obstetric guidelines for acute fatty liver of pregnancy
Failure modes and hazards
Missing acute fatty liver of pregnancy
Stigmatising weight
Diagnosing individuals
Also called
Where this came from
wikidata · CC0 1.0
Drafted structure
Bundle to layer to finding to question, as the second pass will find it: 4 bundles · 8 layers · 8 findings · 16 questions.
Understand What fatty liver disease is.
Science.
Definition
Definition.
Definition
Definition.
- Is someone vomiting blood, confused, deeply jaundiced or a pregnant woman in late pregnancy with vomiting and abdominal pain, in which case seek emergency care now? boundary
- What is fatty liver disease, and how does it differ from viral hepatitis, cirrhosis, gallbladder disease and foie gras? definition
Forms
Named forms.
Forms
Forms.
- What are MASLD, MASH, alcoholic fatty liver, focal fatty liver and acute fatty liver of pregnancy? definition
- Which entry fits the specific form? action
Medicine Causes and assessment.
Science.
Nomenclature
Renaming.
Nomenclature
Nomenclature.
- Why did liver societies rename NAFLD to MASLD in 2023? provenance
- Which references are standard? provenance
Assessment
Assessment.
Assessment
Assessment.
- How are fibrosis scores and elastography used, in general terms? provenance
- Which sources are cited? provenance
Care Management.
Regulation.
Lifestyle
Lifestyle measures.
Lifestyle
Lifestyle.
- What do guidelines say about weight loss, exercise and alcohol, in general terms? provenance
- Which entry fits weight management? action
Drugs
Medicines.
Drugs
Drugs.
- Which medicines are approved or studied for MASH, checked against current sources? provenance
- Is the information current? boundary
Context Public health.
Attribution.
Prevalence
Global burden.
Prevalence
Prevalence.
- What do studies estimate about global prevalence, with figures attributed? provenance
- Is the presentation neutral and non-stigmatising? boundary
Children
Paediatric fatty liver.
Children
Children.
- How does fatty liver disease affect children and adolescents? provenance
- Which entry fits childhood obesity? action
What the second pass must settle
- Should acute fatty liver of pregnancy be a separate entry?
- How should the MASLD renaming be reflected across aliases?
- How should treatment approvals be kept current?