levomethorphan
Enable an agent to identify levomethorphan, assess the identity and condition of a material sample, and determine which handling or transfer decisions require further evidence.
Bundle → Layer → Finding → Questions Filled
6 bundles · 11 layers · 16 findings · 26 questions
Stereochemical identity Establish what makes a material levomethorphan and how neighbouring morphinan identities are excluded.
Structure and identifiers
Connect the registry entry to an explicitly stereochemical chemical identity.
Identifier and structure consistency
Require agreement between names, authority identifiers and a structure that retains stereochemistry.
- Which stereochemically explicit structure defines levomethorphan, and which naming convention assigns its stereocentre labels? definition
- Which authoritative records verify its CAS number, PubChem CID and any applicable EC number, and do they identify the same material form? provenance
Neighbouring morphinans
Specify the identity boundaries around dextromethorphan, racemethorphan and levorphanol.
Enantiomer and substituent boundaries
Distinguish changes in stereochemistry, enantiomeric composition and oxygen substitution.
- What evidence distinguishes the sample from dextromethorphan and racemethorphan when non-chiral identity tests agree? boundary
- Which structural or analytical evidence distinguishes levomethorphan's methoxy group from levorphanol's hydroxy group? measurement
Material form and quality Describe the actual material containing levomethorphan and the evidence supporting its composition.
Form and quantity basis
Separate the parent substance from counterions, solvent and other sample constituents.
Composition accounting
Define the sample form and the basis on which levomethorphan content is expressed.
- Is the sample free base, a specified salt or a solution, and what evidence establishes counterion, stoichiometry and water or solvent content? definition
- On what basis is assay reported, and what verified composition supports any conversion to free-base-equivalent mass? measurement
Analytical specificity
Evaluate whether testing resolves both chemical and stereochemical composition.
Assay and enantiomer evidence
Treat levomethorphan assay, opposite-enantiomer content and related substances as distinct measurements.
- Which validated method measures dextromethorphan in levomethorphan, and what are its selectivity and quantification limits? measurement
- Which reference materials, chromatograms and uncertainty statements support the reported assay and impurity profile? provenance
Physical state and stability Tie levomethorphan property measurements and sample integrity to a specified form and environment.
Form-specific properties
Record only physical-property values whose material identity and conditions are known.
Qualified property values
Distinguish measured values from estimates and thermal decomposition from boiling or melting.
- What measured melting interval, decomposition behaviour and, if available, boiling point apply to the identified levomethorphan form? measurement
- What solubility measurements specify solvent, pH, temperature and whether the tested material was free base or a salt? measurement
Storage and change
Connect sample history to evidence of retained composition and suitability.
Stability-supported disposition
Require evidence before assigning storage limits, retest intervals or degradation conclusions.
- Which stability studies support temperature, light, moisture and container requirements for this levomethorphan form? provenance
- Which storage excursions or analytical changes require quarantine, retesting or rejection under the applicable specification? action
Biological activity and exposure Organize levomethorphan-specific pharmacological and exposure evidence without importing clinical instructions.
Activity and metabolism evidence
Identify which biological claims are demonstrated for levomethorphan itself.
Compound-specific biological claims
Separate direct measurements, metabolite effects and extrapolations from related substances.
- Which primary studies establish levomethorphan receptor activity, and under what species and assay conditions? provenance
- What evidence establishes conversion to levorphanol and distinguishes parent-compound effects from metabolite effects? boundary
Occupational hazard evidence
Link handling decisions to the actual sample and supported exposure hazards.
Exposure controls and limits
Record source-qualified classifications and distinguish established limits from unavailable information.
- Which current safety data or primary toxicology sources support hazard classifications for this levomethorphan form and concentration? provenance
- Is a substance-specific occupational exposure limit established, and what approved handling assessment applies if none is available? action
Controlled-substance status Connect levomethorphan's precise identity to dated legal controls and evidence needed for a proposed activity.
Jurisdiction and form coverage
Determine which current legal entries cover the identified material.
Dated control determination
Separate international listing evidence from applicable domestic requirements.
- Which current international and domestic instruments name levomethorphan, and what are their effective dates and territorial scope? provenance
- How do those instruments treat salts, preparations and stereoisomers, including the distinction from dextromethorphan? boundary
Authorized material movement
Identify the evidence needed to possess, transfer or dispose of a particular levomethorphan quantity.
Activity-specific authorization
Tie a proposed activity to the identified material, quantity and responsible parties.
- What licenses, permits or exemptions cover the proposed possession, transfer, import, export or disposal of this material? action
- Which batch identity, quantity basis and custody records must accompany the activity under the applicable rules? provenance
Evidence and external alignment What the world already says about this thing, gathered so the model can be checked against it.
Reported evidence
Findings from the breadth pass, kept separate from the structural claims.
Check these first
Recalled without web access and unsourced; every item is a lead to verify.
- Which of these check these first hold for the sense of levomethorphan this model covers, and on what evidence? provenance
Identifiers and schemes
Recalled without web access and unsourced; every item is a lead to verify.
- Which of these identifiers and schemes hold for the sense of levomethorphan this model covers, and on what evidence? provenance
Real-world use
Recalled without web access and unsourced; every item is a lead to verify.
- Which of these real-world use hold for the sense of levomethorphan this model covers, and on what evidence? provenance
Typical measurements
Recalled without web access and unsourced; every item is a lead to verify.
- Which of these typical measurements hold for the sense of levomethorphan this model covers, and on what evidence? provenance
Failure modes and hazards
Recalled without web access and unsourced; every item is a lead to verify.
- Which of these failure modes and hazards hold for the sense of levomethorphan this model covers, and on what evidence? provenance
Neighbouring kinds and how to tell them apart
Recalled without web access and unsourced; every item is a lead to verify.
- Which of these neighbouring kinds and how to tell them apart hold for the sense of levomethorphan this model covers, and on what evidence? provenance
Classifiers Filled
- Family
- Thing Registry
- Category
- Physical world and living systems
- Entry kind
- thing
- Plane
- PHY
- Domain
- PHY.MAT
What it is Filled
Levomethorphan is the levorotatory enantiomer of methorphan, a synthetic morphinan opioid with potent analgesic activity, chemically distinguished as the 3-methyl ether of levorphanol.
In scope
- Stereochemically explicit identity and identifiers for levomethorphan
- Free-base identity and relationships to salts, solvates and mixtures
- Chemical assay, enantiomeric composition and sample-specific impurities
- Physical properties, stability and storage condition evidence
- Biological hazard evidence and substance-specific regulatory status
Out of scope
- Dextromethorphan, racemethorphan and levorphanol as independently identified substances
- Finished medicinal products and their formulation specifications
- Clinical diagnosis, prescribing and patient-specific dosing
- Manufacturing routes and synthesis procedures
- Institutional licensing systems and laboratory equipment models
Why it exists Filled
Enable an agent to identify levomethorphan, assess the identity and condition of a material sample, and determine which handling or transfer decisions require further evidence.
Distinguishing features Filled
- Require stereochemical evidence to distinguish levomethorphan from its enantiomer dextromethorphan; a molecular formula alone cannot establish the distinction. [PubChem](https://pubchem.ncbi.nlm.nih.gov/compound/Levomethorphan)
- Check enantiomeric composition to distinguish a levomethorphan sample from racemethorphan or another mixture of methorphan enantiomers.
- Verify the 3-methoxy substituent rather than the 3-hydroxy substituent associated with levorphanol. [INCB Yellow List](https://www.incb.org/incb/uploads/documents/Narcotic-Drugs/Yellow_List/63rd_edition/YL_63rd_E.pdf)
- Determine whether identifiers and measured properties refer to the free base or a specified salt; levomethorphan tartrate has a separate compound record. [PubChem](https://pubchem.ncbi.nlm.nih.gov/compound/71587015)
What robots and AI may and may not do Filled
Must not
- Assist in making, obtaining, converting or concentrating it.
- Give dosing or use advice outside a supervised medical or research setting.
- Help divert it from licensed stock or move it across borders unlawfully.
- Treat it as interchangeable with over-the-counter cough medicine.
Only with a human decision
- Any transfer, destruction or release of licensed stock.
- Responding to a suspected overdose, beyond calling emergency services.
May
- State what levomethorphan is and that it is a controlled opioid.
- Explain how it differs from dextromethorphan so the two are not confused.
- Check holdings against licences in an inventory it is authorized to manage.
Moral aspects Filled
- Potent opioids cause fatal overdoses; confusion with a common cough medicine is dangerous.
- Controls must not block legitimate research or pain relief.
Who is affected
- People at risk of opioid harm
- Families and communities
- Licensed researchers
Owners Filled
Steward
The licensed holder; national drug control authorities regulate it under international treaties.
Master systems
- National controlled substance registers
Links to other meta-models Filled
parent
- Q27163511 - registry parent class
What else AI and robots need to interact with it Filled
Identity and identifiers required Filled
- Vercy registry: vr.tr.levomethorphan
- Wikidata: Q60998690 (https://www.wikidata.org/wiki/Q60998690)
Direct properties required Filled
- Stereochemical substance identity: Stereochemically explicit structure with identifier authority; PubChem CID 5362449
- Material form: Free base; named salt with stoichiometry; specified solvate or hydrate; solution; unresolved
- Levomethorphan assay: % mass fraction or mg/mL, with as-received, dry or free-base-equivalent basis
- Enantiomeric composition: Levomethorphan and dextromethorphan fractions in %, with optional explicitly defined enantiomeric excess
- Related substances and residuals: Named analytes in %, ppm or mg/g, with detection and quantification limits
- Condition-dependent physical properties: Melting or decomposition interval in °C; solubility in g/L; boiling point in °C at stated pressure, if established
- Sample integrity: Within documented specification; suspect; degraded; expired; unassessed
- Biological activity evidence: Links to receptor, metabolism and toxicity studies with species, assay and exposure context
- Hazard classification: Source-specific GHS classes and statements, jurisdiction, material form and revision date; unresolved when unavailable
- Regulatory identity and status: Authority, substance identifier, jurisdiction, effective date, applicable schedule and covered forms
Recognition required Filled
- Identity cannot be settled by appearance; it needs the label and laboratory analysis.
- Licensed stock carries controlled-drug labelling and register entries.
Capabilities and actions required Filled
- Resolve a supplier label or analytical record to the stereochemically explicit levomethorphan identity.
- Assess whether analytical evidence distinguishes levomethorphan from dextromethorphan and mixed-enantiomer material.
- Compare a batch against a stated assay, impurity and material-form specification.
- Normalize reported quantities to a documented free-base-equivalent basis when composition is established.
- Flag missing stability, hazard or authorization evidence before a proposed handling or transfer activity.
Hazards and failure modes required Filled
- Opioid overdose can stop breathing.
- Mix-ups with dextromethorphan can cause serious harm.
Standards and interfaces required Filled
- Single Convention on Narcotic Drugs, 1961, United Nations.
Context of use required Filled
- This compound is encountered in opioid pharmacology literature, analytical reference collections and forensic chemistry.
- Research and identification work distinguish it from related compounds and its opposite enantiomer because their biological activities differ.
Sources Filled
- Wikidata item Q60998690: levomethorphan - identity and sense of the item
- Wikipedia: Levomethorphan - general description of the item
Open questions
- Which authoritative records settle the CAS and EC identifiers for the free base and distinguish identifiers assigned to individual salts?
- Which primary measurements establish form-specific melting, decomposition, solubility and stability values, and is a defensible boiling-point value available?
- Which validated methods and reference materials establish levomethorphan enantiomeric purity and relevant impurity acceptance limits?
- What primary evidence supports receptor activity, metabolism to levorphanol and human toxicity, and which frequently repeated potency claims remain unverified?
- Which current jurisdiction-specific controls, GHS classifications and occupational exposure limits apply to the intended material form and activity?
Machine files
Provenance
thing registry research (pass 2) · unreviewed
Built from: models/things/publications/thing-q60998690/spec.json