keratoconus
Let an agent explain keratoconus and its course, relay diagnosis, treatment and genetics from ophthalmology sources in general terms, describe the forms and stages the registry aliases name, and distinguish keratoconus from regular astigmatism, other corneal ectasias and corneal dystrophies, routing people to eye care professionals.
Research draft, second pass
A second pass drafted this model: the structure a model of this thing needs, and what is known about it in the world. The line under this one says how the second half was obtained - researched against sources, or recalled without web access, in which case nothing here was read anywhere and every claim is a lead to verify. Unreviewed either way.
written by Claude from model knowledge without web access - no source was read, every claim is a lead to verify
Researched by: Claude
Purpose and description
Let an agent explain keratoconus and its course, relay diagnosis, treatment and genetics from ophthalmology sources in general terms, describe the forms and stages the registry aliases name, and distinguish keratoconus from regular astigmatism, other corneal ectasias and corneal dystrophies, routing people to eye care professionals.
A progressive eye condition in which the cornea thins and bulges into a cone shape, causing distorted vision and irregular astigmatism, usually beginning in adolescence, with genetic contributions mapped as keratoconus 1, 2, 3 and further loci, syndromic forms associated with conditions such as Down syndrome, a stable stage in adulthood and acute hydrops when the inner corneal layer ruptures; treatment ranges from contact lenses and corneal cross-linking to transplantation. The model routes symptoms to eye care professionals.
What it is for: Not applicable; a condition.
It can be explain the condition; relay diagnosis and treatment; route to eye care; distinguish related conditions.
Distinguishing features
Corneal ectasia
Irregular astigmatism
Genetic and environmental
Cross-linking treatment
What it looks like
Not a visible object; a cone-shaped cornea on imaging.
Physical character
prevalence: about 1 in 2000 note - estimates vary widely
onset: adolescence to early adulthood note
cross-linking approved, US: 2016 year
keratoconus loci: multiple, e.g. KTCN1-4 note
How it is recognised
Cone-shaped thinning of the cornea
Keratoconus 1, 2 and 3 loci, syndromic keratoconus, stable keratoconus, acute hydrops
Regular astigmatism is symmetric; pellucid marginal degeneration is another ectasia; dystrophies are different
Related models
is a kind of - in registry terms
is a kind of - in registry terms
is treated by - to halt progression
is contrasted with - the regular form
In practice
Families and kinds
sporadic keratoconus
familial keratoconus with mapped loci such as keratoconus 1, 2 and 3
syndromic keratoconus
progressive and stable stages
acute corneal hydrops
Identifiers
ICD-10 H18.6 keratoconus
OMIM 148300 keratoconus 1
MeSH D007640 Keratoconus
Standards and regulation
Ophthalmology treatment guidelines
Regulatory approval of cross-linking devices
Failure modes and hazards
Agents giving personal medical advice
Eye rubbing as a risk factor
Registry aliases mixing loci and stages
Also called
Where this came from
wikidata · CC0 1.0
Drafted structure
Bundle to layer to finding to question, as the second pass will find it: 4 bundles · 8 layers · 8 findings · 16 questions.
Understand What keratoconus is.
Clinical.
Definition
Definition.
Definition
Definition.
- What is keratoconus, and how does it differ from regular astigmatism, other ectasias and dystrophies? definition
- Is the user describing personal vision changes, which need an eye care professional? boundary
Forms
Forms and stages.
Forms
Forms.
- What are keratoconus 1, 2 and 3, syndromic keratoconus, the stable stage and acute hydrops? definition
- Which entry fits the specific form? action
Care Diagnosis and treatment.
Clinical.
Diagnosis
Diagnosis.
Diagnosis
Diagnosis.
- How is keratoconus diagnosed with corneal topography and tomography, as guidelines describe? provenance
- Which references are standard? provenance
Treatment
Treatment.
Treatment
Treatment.
- How do contact lenses, cross-linking, intracorneal rings and transplantation help, in general terms? provenance
- Which sources are cited? provenance
Science Science.
Science.
Genetics
Genetics.
Genetics
Genetics.
- What is known about genetic loci and heritability? provenance
- Which entry fits the specific locus? action
Risk
Risk factors.
Risk
Risk.
- What roles do eye rubbing, allergy and connective tissue conditions play, as research reports? provenance
- Which entry fits corneal ectasia? action
Context Living and history.
Context.
Living
Living with keratoconus.
Living
Living.
- How does keratoconus affect daily life, and what support exists? provenance
- Which entry fits visual impairment? action
History
History.
History
History.
- How did understanding and treatment of keratoconus develop? provenance
- Which entry fits the history of ophthalmology? action
What the second pass must settle
- Should acute hydrops and the genetic loci be separate primary entries?
- How should ophthalmology sources be linked?
- The registry entry has merged aliases naming loci, stages and complications; should they be split off?