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perospirone

vr.tr.perospirone · thing-q6590349

Enable an AI agent to recognise perospirone, assess the identity and condition of a particular material, and determine whether evidence supports its proposed analytical, research or pharmaceutical use.

Thing Registry Physical world and living systems PHY.MAT

Bundle → Layer → Finding → Questions Filled

6 bundles · 11 layers · 18 findings · 28 questions

Perospirone identity and form boundary Establish what the registry name denotes and which material form a record describes.

Parent structure

Anchor perospirone to molecular and stereochemical evidence.

Structure-qualified identity

An identity assertion should connect the registry entry to a structure, its stereochemical specification and identifiers from an inspected authority.

  1. Which molecular structure and stereochemical specification define perospirone for this registry entry? definition
  2. Which inspected authority supports each identifier, and does that identifier denote the parent or a salt? provenance

Salt and hydrate boundary

Keep chemically related forms explicit without automatically creating new registry things.

Declared material form

Each sample needs a declared form and evidence for its counterion and hydration state before formula masses or assay values are reused.

  1. Does this sample contain perospirone free base, hydrochloride or a characterised hydrated hydrochloride? boundary
  2. What measurements establish chloride stoichiometry and water content rather than merely repeating the supplier name? measurement
Perospirone material state Describe the physical form and condition under which measured properties apply.

Solid form and water

Connect phase identity with hydration and environmental history.

Evidence for phase assignment

Record a solid-form assignment only with supporting measurements and relevant temperature and humidity conditions.

  1. What diffraction, thermal or spectroscopic evidence identifies the solid form of this perospirone sample? measurement
  2. Does measured water represent lattice hydration, adsorbed moisture or an unresolved combination? boundary

Properties for sample preparation

Make dissolution and thermal data usable for a specified material form.

Condition-qualified properties

Solubility and thermal values require the tested form, method and conditions; decomposition must not be reported as an ordinary boiling or melting point.

  1. What solubility is measured for the specified form at the proposed solvent composition, pH and temperature? measurement
  2. Which observed thermal events represent melting, water loss or decomposition, and what evidence separates them? measurement
Perospirone analytical quality Determine whether a sample is correctly identified and suitable for its declared purpose.

Identity and assay

Relate analytical results to qualified standards and explicit mass conventions.

Traceable assay basis

Record reference-standard qualification, method specificity and whether results refer to parent, hydrochloride or hydrated material.

  1. Which reference standard and independent identity checks support the perospirone assignment? provenance
  2. Is the assay expressed as parent, hydrochloride or hydrate, and on what moisture basis? measurement

Impurities and stability

Separate initial purity from deterioration during storage or preparation.

Fitness for intended use

Sample acceptance should depend on a stated specification and evidence that analytical methods distinguish perospirone from relevant impurities and degradation products.

  1. Which related substances, residual solvents and unknown peaks are controlled by the applicable specification? measurement
  2. What stability evidence supports using this batch or prepared solution after its recorded storage history? action
Perospirone biological activity Represent biological evidence without turning the substance model into treatment guidance.

Target evidence

Organise investigations of dopamine and serotonin receptor activity.

Binding versus functional activity

Assess reported D2, 5-HT2A and 5-HT1A activity using separate binding and functional evidence, with conditions attached to every numerical result.

  1. Which primary experiments establish perospirone activity at D2, 5-HT2A and 5-HT1A receptors? provenance
  2. Does each reported value measure affinity, inhibition or functional efficacy, in which species and assay system? measurement

Parent and metabolite boundary

Keep measured parent exposure and effects distinct from those of transformation products.

Analyte-specific evidence

An exposure or activity claim must identify the measured chemical entity; metabolites remain related substances rather than alternate names for perospirone.

  1. Does the cited experiment measure parent perospirone, a metabolite or a combined signal? boundary
  2. What analytical evidence shows that the method separates parent perospirone from relevant metabolites? provenance
Perospirone handling and use controls Connect a particular material to supported handling conditions and jurisdiction-specific use constraints.

Material handling

Use safety evidence applicable to the actual form and operation.

Form-specific safety evidence

Record documented classifications and handling controls with their source and applicability; missing information remains unknown.

  1. Which current safety document applies to this perospirone form, concentration and supplier material? provenance
  2. What documented controls support the proposed weighing, dissolution, storage and disposal operations? action

Quality and authorisation

Distinguish material release from permissions attached to medicinal products.

Use-qualified release

A decision to use perospirone should identify the intended purpose, material grade, applicable specification and relevant jurisdictional authority.

  1. What evidence qualifies this batch for its intended reference, research or pharmaceutical use? action
  2. Does the cited regulatory record concern the substance, a manufacturing activity or a particular finished product? boundary
Evidence and external alignment What the world already says about this thing, gathered so the model can be checked against it.

Reported evidence

Findings from the breadth pass, kept separate from the structural claims.

Check these first

Recalled without web access and unsourced; every item is a lead to verify.

  1. Which of these check these first hold for the sense of perospirone this model covers, and on what evidence? provenance

Kinds and varieties

Recalled without web access and unsourced; every item is a lead to verify.

  1. Which of these kinds and varieties hold for the sense of perospirone this model covers, and on what evidence? provenance

Identifiers and schemes

Recalled without web access and unsourced; every item is a lead to verify.

  1. Which of these identifiers and schemes hold for the sense of perospirone this model covers, and on what evidence? provenance

Real-world use

Recalled without web access and unsourced; every item is a lead to verify.

  1. Which of these real-world use hold for the sense of perospirone this model covers, and on what evidence? provenance

Typical measurements

Recalled without web access and unsourced; every item is a lead to verify.

  1. Which of these typical measurements hold for the sense of perospirone this model covers, and on what evidence? provenance

Failure modes and hazards

Recalled without web access and unsourced; every item is a lead to verify.

  1. Which of these failure modes and hazards hold for the sense of perospirone this model covers, and on what evidence? provenance

Regional variation

Recalled without web access and unsourced; every item is a lead to verify.

  1. Which of these regional variation hold for the sense of perospirone this model covers, and on what evidence? provenance

Neighbouring kinds and how to tell them apart

Recalled without web access and unsourced; every item is a lead to verify.

  1. Which of these neighbouring kinds and how to tell them apart hold for the sense of perospirone this model covers, and on what evidence? provenance

Classifiers Filled

Family
Thing Registry
Category
Physical world and living systems
Entry kind
thing
Plane
PHY
Domain
PHY.MAT

What it is Filled

Perospirone is a synthetic small-molecule atypical antipsychotic whose pharmacological activity includes dopamine D2 and serotonin 5-HT2A receptor antagonism and serotonin 5-HT1A receptor partial agonism.

In scope

  • Molecular identity, stereochemistry and identifiers qualified by chemical form
  • Free-base, hydrochloride and hydrate distinctions within the registered substance boundary
  • Composition, purity, solid state and condition of perospirone samples
  • Measured physicochemical properties and analytical identification
  • Evidence connecting perospirone to biological activity and permitted material uses

Out of scope

  • Finished tablets, brands, packaging and excipient formulations
  • Patient diagnosis, prescribing, dosing and treatment selection
  • Manufacturing routes and production equipment
  • Schizophrenia and other disease models
  • Metabolites and impurities as independently characterised substances

Why it exists Filled

Enable an AI agent to recognise perospirone, assess the identity and condition of a particular material, and determine whether evidence supports its proposed analytical, research or pharmaceutical use.

Distinguishing features Filled

  • Match the molecular structure and stereochemistry, using the free-base formula C23H30N4O2S and PubChem CID 115368 as corroborating identifiers rather than sufficient proof of identity. [PubChem](https://pubchem.ncbi.nlm.nih.gov/compound/Perospirone)
  • Separate the parent substance from hydrochloride and hydrated hydrochloride records; their identifiers and formula masses are not interchangeable. [PubChem hydrochloride](https://pubchem.ncbi.nlm.nih.gov/compound/Perospirone-hydrochloride), [PubChem hydrate](https://pubchem.ncbi.nlm.nih.gov/compound/5282504)
  • Require structural and analytical agreement to distinguish perospirone from similarly named antipsychotics or structurally related compounds; a pharmacological class label does not establish identity.
  • Distinguish active-substance mass from tablet strength: the cited Japanese product contains 17.24 mg hydrated hydrochloride for a strength expressed as 16 mg perospirone hydrochloride. [PMDA product information](https://www.pmda.go.jp/PmdaSearch/iyakuDetail/ResultDataSetPDF/672173_1179043F1040_2_05)

What robots and AI may and may not do Filled

Must not

  • Recommend it, a dose or a switch of medicine for a person.
  • Supply it outside the regulated prescription chain or across borders without authorization.
  • Advise stopping it abruptly.
  • Label a person as mentally ill because they take it.

Only with a human decision

  • Starting, stopping or changing a person's antipsychotic treatment.

May

  • Describe perospirone and its approved uses from medicines information.
  • Report that it is authorized only in some countries and name the source.

Moral aspects Filled

  • People with schizophrenia face stigma and may be treated without their full consent.
  • Antipsychotics have serious side effects that need monitoring.

Who is affected

  • Patients and their families
  • Prescribers and carers

Owners Filled

Steward

The marketing authorization holder; medicines regulators and prescribers control its use.

Master systems

  • Medicines regulators' product registers

Links to other meta-models Filled

parent

  • Q193430 - registry parent class

What else AI and robots need to interact with it Filled

Identity and identifiers required Filled

  • Vercy registry: vr.tr.perospirone
  • Wikidata: Q6590349 (https://www.wikidata.org/wiki/Q6590349)

Direct properties required Filled

  • Chemical form and identifier agreement: Free base | hydrochloride | hydrochloride hydrate | unresolved; form-qualified CAS, PubChem and other identifiers
  • Molecular structure and stereochemical specification: Structure identifier with explicit stereochemical specification and supporting evidence
  • Assay and reporting basis: % m/m or mg/g; as received, dried or anhydrous; expressed as specified chemical form
  • Water and counterion content: % m/m water; mol H2O/mol substance; mol chloride/mol parent
  • Solid-state identity: Crystalline form or amorphous state, phase mixture, hydrate state or unresolved
  • Solubility and thermal behaviour: Solubility in mg/mL or mol/L with solvent, pH and temperature; thermal events in °C with method and event assignment
  • Impurity profile: Named and unknown impurities in % m/m or explicitly qualified chromatographic area %; residual solvents in ppm
  • Biological activity evidence: Target, assay, species, material form, functional response and potency with units
  • Use and handling status: Intended use, grade, jurisdiction, dated authority, applicable safety document and release status

Recognition required Filled

  • Supplied as tablets; identified by label and imprint, not appearance.

Capabilities and actions required Filled

  • Resolve a perospirone name or identifier to a structure and explicitly qualified chemical form.
  • Compare sample evidence with a perospirone reference standard and intended-use specification.
  • Calculate equivalent quantities between characterised forms using verified water content, stoichiometry and assay basis.
  • Select a supported analytical preparation from form-specific solubility and stability evidence.
  • Flag uncertain identity, degradation or missing release evidence for review before use.

Hazards and failure modes required Filled

  • Can cause movement disorders, sedation and other adverse effects.

Standards and interfaces required Filled

  • Japan's Act on Securing Quality, Efficacy and Safety of Products Including Pharmaceuticals and Medical Devices, enacted by the National Diet and administered by the Ministry of Health, Labour and Welfare, governs perospirone medicinal products in Japan.

Context of use required Filled

  • Perospirone is encountered in pharmaceutical research, analytical testing and medicinal products used in psychiatric care in Japan.
  • Laboratories distinguish the parent compound from its salts and formulated products when assessing identity, purity and suitability for a specified use.

Sources Filled

  1. Wikidata item Q6590349: perospirone - identity and sense of the item
  2. Wikipedia: Perospirone - general description of the item

Open questions

  • Which authoritative CAS, EC and stereochemical identifiers apply separately to the parent, hydrochloride and hydrate forms, and how should the registry represent those relationships?
  • Which perospirone solid forms and hydration transitions are experimentally established, and what form-specific solubility, thermal and storage data are reliable?
  • Which applicable compendial or validated specifications establish identity, assay basis, impurity limits and stability acceptance for the intended material grade?
  • Which primary studies establish receptor function, relevant metabolites and their separate contributions to observed biological activity?
  • What current jurisdiction-specific substance requirements, GHS classifications and occupational exposure limits exist for each material form, and where is authoritative information absent?

Machine files

Provenance

thing registry research (pass 2) · unreviewed

Built from: models/things/publications/thing-q6590349/spec.json