autoimmune disease
Let an agent explain autoimmune diseases as a category and their main mechanisms in general terms, relay diagnosis, treatment and support information from health authorities, distinguish autoimmunity from immunodeficiency and allergy, and route personal questions to clinicians.
Research draft, second pass
A second pass drafted this model: the structure a model of this thing needs, and what is known about it in the world. The line under this one says how the second half was obtained - researched against sources, or recalled without web access, in which case nothing here was read anywhere and every claim is a lead to verify. Unreviewed either way.
written by Claude from model knowledge without web access - no source was read, every claim is a lead to verify
Researched by: Claude
Purpose and description
Let an agent explain autoimmune diseases as a category and their main mechanisms in general terms, relay diagnosis, treatment and support information from health authorities, distinguish autoimmunity from immunodeficiency and allergy, and route personal questions to clinicians.
A condition in which the immune system attacks the body own cells and tissues, producing inflammation and damage in one organ or throughout the body; more than 80 autoimmune diseases are recognised, including type 1 diabetes, rheumatoid arthritis, lupus, multiple sclerosis, coeliac disease and autoimmune thyroid disease, and they are managed with immune-modifying treatments and specialist care.
What it is for: Not applicable; a category of disease.
It can be explain the category and mechanisms; list major diseases and their features in general terms; relay treatment and support information; route personal questions to clinicians.
Distinguishing features
Loss of self-tolerance
Organ-specific and systemic forms
Chronic and often relapsing
Treated by immune modulation
What it looks like
Not visible as a category; each disease has its own signs, from joint swelling to rashes and fatigue.
Physical character
recognised diseases: over 80 conditions
population affected: about 5-10 percent - estimates vary; more common in women
How it is recognised
Immune attack on the body own tissues
Organ-specific or systemic
Immunodeficiency is failure of immunity; allergy is reaction to external substances
Related models
is a kind of - the category
is contrasted with - failure rather than misdirection of immunity
includes - a major example
is treated by - and targeted therapies
In practice
Families and kinds
organ-specific diseases such as type 1 diabetes and autoimmune thyroiditis
systemic diseases such as lupus and rheumatoid arthritis
autoimmune skin diseases
neurological autoimmune diseases such as multiple sclerosis
autoinflammatory diseases, a related but distinct group
immunodeficiencies with autoimmune features
Identifiers
ICD-11 chapter 4 and organ chapters by disease
MeSH D001327 autoimmune diseases
Standards and regulation
Clinical guidelines by disease from specialist societies
Medicines regulation for biologics and immunosuppressants
Disability and workplace accommodation law
Failure modes and hazards
Delayed diagnosis
Infection risk from immunosuppression
Unproven treatments and diets
Agents giving personal medical advice
Also called
Where this came from
wikidata · CC0 1.0
Also registered as vr.tr.autoimmune-disease
Drafted structure
Bundle to layer to finding to question, as the second pass will find it: 4 bundles · 8 layers · 8 findings · 16 questions.
Understand What autoimmune disease is.
General information.
Mechanism
Mechanism and category.
Mechanism
Mechanism.
- What goes wrong in autoimmunity, and how does it differ from immunodeficiency and allergy? definition
- Is the user asking about their own symptoms or results, which needs a clinician? boundary
Diseases
Major diseases.
Diseases
Diseases.
- What are the major autoimmune diseases and their general features? definition
- Which entry fits the specific disease? action
Diagnose Diagnosis.
Clinical.
Tests
Tests and criteria.
Tests
Tests.
- How are autoimmune diseases diagnosed, and what do autoantibody tests mean, in general terms? provenance
- Which entry fits immunology tests? action
Causes
Causes and risk.
Causes
Causes.
- What is known about genetic and environmental causes, with findings attributed? provenance
- Which references are standard? provenance
Treat Treatment and living.
Care.
Treatment
Treatment.
Treatment
Treatment.
- What treatments do guidelines describe, from immunosuppressants to biologics? provenance
- Is the presentation free of personal treatment advice? boundary
Living
Living with the condition.
Living
Living.
- What support, rights and self-management information do health bodies provide? provenance
- Which entry fits patient support? action
Study Research and teaching.
Study.
Research
Research.
Research
Research.
- What research is under way on causes and therapies, with attribution? provenance
- Which entry fits immunology? action
Teach
Teaching.
Teach
Teaching.
- How is autoimmunity taught, and which misconceptions arise? provenance
- Which entry fits medical education? action
What the second pass must settle
- Should each disease be a separate entry only?
- How should guidelines be linked by disease?
- The registry entry has merged aliases for immunodeficiencies and autoinflammatory diseases; should they be split off?