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imidazole alkaloid

vr.tr.imidazole-alkaloid · thing-q84737692

Let an agent explain imidazole alkaloids as a class, relay examples, sources and pharmacology from natural product references, describe medical uses in general terms, and distinguish imidazole alkaloids from other alkaloid classes.

Thing Registry Physical world and living systems PHY.MAT
Bundle → Layer → Finding → QuestionsClassifiersWhat it isWhy it existsDistinguishing featuresWhat robots and AI may and may not doMoral aspectsOwnersLinks to other meta-modelsIdentity and identifiersDirect propertiesRecognitionCapabilities and actionsHazards and failure modesStandards and interfacesContext of useSources

Bundle → Layer → Finding → Questions Filled

4 bundles · 8 layers · 8 findings · 16 questions

Understand What imidazole alkaloids are.

Definition

Definition and structure.

Definition

Definition.

  1. What defines an imidazole alkaloid, and how does the imidazole ring shape its chemistry? definition
  2. Is the question about imidazole alkaloids or another alkaloid or imidazole class? boundary

Examples

Examples.

Examples

Examples.

  1. What are pilocarpine, the naamidines, isonaamidines, kurstakins and crathridine, and where are they found? definition
  2. Which entry fits the specific compound? action
Biology Biology and pharmacology.

Pharmacology

Pharmacology.

Pharmacology

Pharmacology.

  1. What pharmacological activities do imidazole alkaloids show, such as pilocarpine muscarinic action? provenance
  2. Which references are standard? provenance

Ecology

Chemical ecology.

Ecology

Ecology.

  1. What roles do these alkaloids play in sponges, plants and bacteria? provenance
  2. Which entry fits chemical ecology? action
Medicine Medicine.

Drugs

Drugs.

Drugs

Drugs.

  1. How is pilocarpine used in glaucoma and dry mouth, in general terms? provenance
  2. Is the user asking about their own medication, which needs a clinician or pharmacist? boundary

Research

Drug discovery.

Research

Research.

  1. What research explores marine imidazole alkaloids as drug leads, with findings attributed? provenance
  2. Which sources are cited? provenance
Context Chemistry and history.

Synthesis

Synthesis and analysis.

Synthesis

Synthesis.

  1. How are imidazole alkaloids isolated, characterised and synthesised, in general terms? provenance
  2. Which entry fits natural product chemistry? action

History

History.

History

History.

  1. How were jaborandi and pilocarpine discovered and adopted in medicine? provenance
  2. Which entry fits the history of pharmacognosy? action

Classifiers Filled

Family
Thing Registry
Category
Physical world and living systems
Entry kind
thing
Plane
PHY
Domain
PHY.MAT
Other names and narrower kinds
4-{13-(3-{[Acetamido(amino)methylidene]amino}propyl)-5-hydroxy-7-[(1H-imidazol-5-yl)methyl]-1,8,11,14,19-pentaoxohexadecahydro-1H-3,6-methanopyrrolo[2,1-c][1,4,7,10,13]pentaazacyclohexadecin-10-yl}butanoic acid, Kurstakin 3, Crathridine, naamidine H, Isonaamidine A, 5-({4,5-bis[(4-methoxyphenyl)methyl]-1H-imidazol-2-yl}imino)-2-hydroxy-3-methylimidazol-4-one, 5-[4,5-Bis(1,3-benzodioxol-5-ylmethyl)-1-methylimidazol-2-yl]imino-3-methylimidazolidine-2,4-dione, Isonaamine E, N(1)Gly-DL-Phe-DL-xiIle-Gly-DL-Trp-Gly-DL-Asn-DL-Asp(1)-DL-xiIle-DL-Phe-Gly-DL-Ala(imidazol-2-yl)-DL-Tyr-DL-Ser-Gly-DL-Asp-DL-Phe-OH, (5Z)-5-[4-[(4-hydroxyphenyl)methyl]-1-methylimidazol-2-yl]imino-3-methylimidazolidine-2,4-dione, Isonaamidine C, (5Z)-5-[1,4-bis[(4-hydroxyphenyl)methyl]imidazol-2-yl]imino-3-methylimidazolidine-2,4-dione

What it is Filled

An alkaloid whose structure contains an imidazole ring, a class including pilocarpine from jaborandi used to treat glaucoma and dry mouth, histamine-related compounds, and many marine natural products such as the naamidines and isonaamidines from sponges and compounds such as crathridine; containing an imidazole-bearing amino acid residue does not by itself make a peptide an imidazole alkaloid; imidazole alkaloids are studied for pharmacological activity and as chemical ecology signals.

Why it exists Filled

Let an agent explain imidazole alkaloids as a class, relay examples, sources and pharmacology from natural product references, describe medical uses in general terms, and distinguish imidazole alkaloids from other alkaloid classes.

Distinguishing features Filled

  • Imidazole ring
  • Diverse natural sources
  • Pharmacological activity
  • Marine prominence

What robots and AI may and may not do Filled

Must not

  • Give dosing or self-medication advice for pilocarpine or any alkaloid.
  • Describe how to extract or concentrate alkaloids from plants or sponges.
  • Present marine alkaloids under study as proven medicines.
  • Encourage harvesting of protected plants or marine sponges.

Only with a human decision

  • Use of any alkaloid in treatment for a patient.

May

  • Describe the imidazole alkaloid class and its main members from chemical and pharmacological sources.
  • Note that pilocarpine is a prescription medicine used under medical supervision.
  • Handle unwieldy systematic aliases by linking them to the class or to a named compound.

Moral aspects Filled

  • Some alkaloids are toxic, and self-medication can cause poisoning.
  • Bioprospecting can take resources from source countries without fair benefit sharing.

Who is affected

  • Patients
  • Communities in source regions
  • Marine ecosystems

Owners Filled

Steward

Nobody owns the class; manufacturers and medicines regulators answer for approved drugs.

Links to other meta-models Filled

parent

  • Q1659847 - registry parent class
  • Q70702 - registry parent class

related

  • alkaloid - in registry terms
  • imidazole - in registry terms, as derivatives
  • pilocarpine - a glaucoma drug
  • sponge - among marine sources

What else AI and robots need to interact with it Filled

Identity and identifiers required Filled

  • Vercy registry: vr.tr.imidazole-alkaloid
  • Wikidata: Q84737692 (https://www.wikidata.org/wiki/Q84737692)

Direct properties required Filled

  • pilocarpine isolated: 1874 year
  • imidazole ring: five-membered with two nitrogens structure

Recognition required Filled

  • Imidazole alkaloids contain an imidazole ring.
  • Examples include pilocarpine, naamidines, isonaamidines and crathridine.
  • Indole, pyrrolizidine and isoquinoline alkaloids have different ring systems, while histamine itself is usually classed as a biogenic amine.
  • Not a visible object; compounds within plants, sponges and microbes.

Capabilities and actions required Filled

  • explain the class
  • relay examples and sources
  • describe pharmacology
  • distinguish from other classes

Hazards and failure modes required Filled

  • Toxicity of some alkaloids
  • Agents giving personal medication advice
  • Registry aliases with unwieldy systematic names

Standards and interfaces required Filled

  • Drug regulation of pilocarpine and related medicines
  • Natural product nomenclature conventions
  • Biodiversity access rules for marine sampling

Context of use required Filled

  • Not applicable; a class of natural compounds.
  • plant imidazole alkaloids such as pilocarpine
  • marine sponge alkaloids such as naamidines and isonaamidines
  • bacterial imidazole-containing peptides such as kurstakins
  • other natural products such as crathridine
  • synthetic imidazole derivatives as related compounds

Sources Filled

  1. Wikidata item Q84737692: imidazole alkaloid - identity and sense of the item
  2. Wikipedia: Imidazole alkaloids - general description of the item

Open questions

  • Should pilocarpine be a separate primary entry?
  • How should natural product databases be linked?
  • The registry entry has merged aliases with long systematic names; should they be split off?

Machine files

Card as JSON Specification Card backlog vercy.card/1

Provenance

thing registry research (pass 2) · unreviewed

Built from: models/things/publications/thing-q84737692/spec.json